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慢性精神分裂症
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  chronic schizophrenia
    Plasma prolactin level response to risperidone in chronic schizophrenia.
    利培酮对慢性精神分裂症泌乳素的影响
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    A comparative study of the activities'of superoxide dismutase (SOD),glutathione peroxidase (GPX) and catalase (CAT) in erythroete was carried out in 99 DSM-III-R-schizophrenic in patients including 49 cases in acute phase and 50 cases in chronic phase,and the values were compared with those of 51 normal subjects.
    对急、慢性精神分裂症病人99例和正常对照者51人的红细胞SOD、GPX及CAT活性进行了对比研究。
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  chronic schizophrenia
The results are discussed in connection with previous studies of chronic schizophrenia.
      
Eight foster home care groups for long-stay psychiatric patients were studied for one year during which time 64 men (mainly with chronic schizophrenia) lived in the homes and 13 of the men departed.
      
Premorbid abnormalities in mania, schizomania, acute schizophrenia and chronic schizophrenia
      
Cases were classified according to the relative chronicity of their illness into four non-overlapping groups: mania, schizomania, acute schizophrenia and chronic schizophrenia.
      
We conclude that the prevalence of premorbid abnormalities is highest among chronic schizophrenia, but similar disturbances also occur, to a lesser degree, in less disabling affective and non-affective psychotic disorders.
      
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A comparative study of the activities'of superoxide dismutase (SOD),glutathione peroxidase (GPX) and catalase (CAT) in erythroete was carried out in 99 DSM-III-R-schizophrenic in patients including 49 cases in acute phase and 50 cases in chronic phase,and the values were compared with those of 51 normal subjects.The results indicated that the activity of SOD in total patient group was higher significantly than that of control group,t=3.90~7.46,P<0.001.The SOD activity of the female group (n=25),was distinctly...

A comparative study of the activities'of superoxide dismutase (SOD),glutathione peroxidase (GPX) and catalase (CAT) in erythroete was carried out in 99 DSM-III-R-schizophrenic in patients including 49 cases in acute phase and 50 cases in chronic phase,and the values were compared with those of 51 normal subjects.The results indicated that the activity of SOD in total patient group was higher significantly than that of control group,t=3.90~7.46,P<0.001.The SOD activity of the female group (n=25),was distinctly elevated than that of male group (n=25) with P value less than 0.001.No significant difference in activities of GPX and CAT between the patient group and control group was found.A positive correlation between SOD activity and total BPRS scores was found (r=0.588,P< 0.05).the distinct increase in SOD activity in schizoprenic patients suggest that oxygen free radicals play a role in the pathogenesis of schizophrenia.

对急、慢性精神分裂症病人99例和正常对照者51人的红细胞SOD、GPX及CAT活性进行了对比研究。结果发现,病人红细胞SOD活性与正常人比较具有非常显著意义的升高(t=3.9~7.46,P<0.001),急性组女性病人红细胞SOD活性显著高于男性病人(t=3.80,P<0.001)。各组间的GPX、CAT活性则无明显差异(P>0.05)。研究发现精神分裂症病人红细胞SOD活性改变与BPRS总分呈正相关(γ=0.588,P<0.05)。本研究结果表明,精神分裂症病人红细胞SOD活性明显增高,提示氧自由基在精神分裂症病因学或其精神病理过程中可能具有一定的作用。

The erythrocyte immunologic function was measured in 32 patients with schizophrenia treated with calf thymus polypeptide (CTP). After the treatment with CTP, the rate of IC rosette formation and the activity of erythrocyte immunologic adhesion inhibitor were decreased (P<0.001), while the rates of C_3b and erythrocyte immunologic adhesion potentiator rosette formation were increased (P<0.001).

本文用牛胸腺肽(calf thymus polypeptide,CTP)治疗慢性精神分裂症患者32例,并与常规药物组进行了此较,结果经TP治疗组的复合物花环、抑制因子花环百分率下降;而C_3b花环、增强因子花环百分率明显升高(P均<0.001)。

The aim was to see the combined effect of antipsychotics and ginkgo biloba extracts (EGb 761). It was designed as a multicenter double-blind placebo controlled study on chronic schizophrenics with argumentation of EGb 761 with their previous used antipsychotics remaining unchanged. It was found that the augmentation effect of EGb761 on antipsychotics was different among different antipsychotic drugs. It increased the overall effect of clozapine,chlorpromazine,and sulpiride on schizophrenia. Furthermore, it increased...

The aim was to see the combined effect of antipsychotics and ginkgo biloba extracts (EGb 761). It was designed as a multicenter double-blind placebo controlled study on chronic schizophrenics with argumentation of EGb 761 with their previous used antipsychotics remaining unchanged. It was found that the augmentation effect of EGb761 on antipsychotics was different among different antipsychotic drugs. It increased the overall effect of clozapine,chlorpromazine,and sulpiride on schizophrenia. Furthermore, it increased the efficacy of clozapine, sulpiride on the negative symptoms of schizophrenia. EGb 761could also reduce the adverse reactions of clozapine like salivation,akathesia and constipation. We concluded that EGb 761 may be added in clozapine treatment in order to get higher efficacy and fewer adverse effects.

本研究旨在探讨银杏叶提取物(舒血宁)与不同抗精神病药物之间的协同作用。针对慢性精神分裂症病人,在既往抗精神病药物治疗不变的条件下加用舒血宁,进行多中心双盲安慰剂对照研究。结果发现,舒血宁与抗精神病药物的协同作用在不同药物有所不同。舒血宁增强氯氮平、氯丙嗪、舒必利对精神分裂症的总体疗效,增强氯氮平、舒必利对阴性症状的疗效。同时舒血宁能减轻氯氮平所致的不良反应如流涎和便秘。结果提示,在氯氮平治疗过程中最适合加用舒血宁以增强疗效,减少不良反应

 
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