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精神依赖
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  psychological dependence
     Objective: To explore the role of NMDA receptors in both opiate physical and psychological dependence by investigating the effects of dizocilpine (MK-801) on morphine-induced conditioned place preference (CPP) and spontaneous withdrawal signs in SD rats.
     目的 通过测评NMDA受体拮抗剂地卓西平(Dizocilpine,MK-801)对慢性吗啡处理大鼠条件性位置偏爱(Conditioned Place Preference,CPP)及自然戒断体征(Spontaneous Withdrawal Signs)的影响,探讨NMDA受体在阿片精神依赖及躯体依赖中的作用。
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     ObjectiveTo explore the role of diazepam binding inhibitor (DBI) in psychological dependence of rats.
     目的研究地西泮结合抑制因子(DBI)在大鼠吗啡精神依赖中所起的作用。
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     Drug addiction has two aspects: physical dependence and psychological dependence.
     药物成瘾包括身体依赖和精神依赖两个方面。
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     (2) DBI may play a role in psychological dependence.
     2.海马CA1区DBImRNA的表达和CPP有密切关系,推测DBI可能在精神依赖中起重要作用。
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     3.No psychological dependence exists after short-term administration of these agents in children with cancer pain.
     3)癌痛儿童因用药时间较短,一般不会发生精神依赖行为。
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  psychical dependence
     Intra-peritoneal injection of 5 mg·kg -1 NO 2Arg inhibited the development of psychical dependence i nduced by morphine and dihydroetorphine and the increases of NO,cAMP and cGMP co ntent in brains.
     腹腔注射NO2 Arg 5mg·kg- 1 可抑制吗啡、二氢埃托啡精神依赖升高小鼠脑内NO ,cAMP ,cGMP含量的作用。
短句来源
     OBJECTIVE To investigate the role of N-nitro - L-arginine (NO 2Arg) in the development of psychical dependence induced by morphine and dihydroetorphine.
     目的 研究N 硝基 L 精氨酸 (NO2 Arg)在吗啡、二氢埃托啡精神依赖形成中的作用。
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     The major results were described as follows:Part 1. Establishment of model of “relapse”of morphine related to psychical dependence in mice1 Effect of glucocorticoids on faded CPP induced by chronic morphine (Mor CPP)
     主要实验结果如下:一 Mor精神依赖复吸小鼠模型的建立1 糖皮质激素对于已消退的Mor CPP的作用
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     Aim To study the effect of total Ervatamia yunnansis alkaloids(TEYA) on reinstatement of conditioned place preference(CPP) ignited by morphine or hydrocortisone(Hyd) in mouse with psychical dependence on morphine(Mor).
     目的 研究云南狗牙花总碱 (totalErvatamiayunnansisalkaloids ,TEYA)阻断吗啡 (Morphine ,Mor)精神依赖小鼠位置偏爱再现的药理作用。
短句来源
     CONCLUSION NO 2Arg may suppress the develop ment of psychical dependence induced by morphine and dihydroetorphine in mice by inhibiting the synthesis of nitric oxide and regulating the cGMP/cAMP content.
     结论 NO在易化阿片类药物精神依赖形成中可能有一定作用 ; NO2 Arg抑制吗啡、二氢埃托啡精神依赖形成的作用可能是通过减少小鼠脑内NO合成和调节cGMP/cAMP水平介导的
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  psychic dependence
     Results By followed-up of 12 to 18 months,psychic dependence was eliminated completely in 25 addicts(73.5%),and 9 cases relapsed.
     结果随访12 ̄18个月,精神依赖完全消除25例(73.5%),复吸9例。
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     AIM To explore the effects of sinomenine (Sin) on psychic dependence induced by morphine (Mor) in mice and its relation to the cAMP content of the cerebral cortex.
     目的 观察中药单体成分青藤碱 (sinomenine ,Sin)对吗啡诱导的小鼠精神依赖及其中枢cAMP水平的变化的影响。
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     Conclusion DRz164 can highly block the expression of Period 1 gene, which cleaves the Period 1 mRNA in the transfected cells specifically. The suppression of morphine-induced place preference can be effected by pretreating the mice with intracerebroventricular injection of deoxyribozyme for alleviating their psychic dependence on morphine.
     结论脱氧核酶DRz164在胞内能够切割Period1mRNA,抑制Period1基因表达,小鼠脑室注射DRz164可拮抗吗啡所引起的奖赏效应,缓解其对吗啡的精神依赖
短句来源
     Medial septal diagonal band complex:a new target point of stereotaxic surgery for psychic dependence to opioids(report of 34 cases)
     内侧隔-斜角带核:阿片类药物精神依赖外科治疗的新靶点(附34例报告)
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     Drug addcition results from the long-term abuse of certain drugs, which has been a medical and social problem paid close attention to. But, treatment of psychic dependence of drug abuse is still troublesome presently. Based on the correlation between the circdian gene period 1 (per1) and drug addiction, the deoxyribozyme (DRz) targeting per1was used a tool of blocking the per1 expression in order to make a further resarch and explore a novel therapy anout drug addition.
     药物成瘾是长期滥用药物造成的,已成为全球关心的医学和社会问题,对药物的精神依赖至今尚无理想的治疗方法,本研究立足于近日基因period1(per1)和药物成瘾的关系,采用脱氧核酶阻断per1基因的表达,深入探讨per1基因对药物成瘾影响作用,进而寻求解决药物成瘾的基因疗法。
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  “精神依赖”译为未确定词的双语例句
     The duration when morphine and dihydro etorphine psychologically dependent mice stayed in the preferred compartment increased significantly from (6.1± 2.0)min and (8.0±0.7)min to (9.3±1. l)min and (9.5 ± 1.2) min by 4 mg·kg-1 NO2 Arg.
     NO2Arg 4 mg·kg-1可使吗啡、二氢埃托啡精神依赖小鼠在偏爱侧停留时间分别由(6.1±2.0)min、(8.0±0.7)min显著增加到(9.3±1.1)min、(9.5±1.2)min 。
短句来源
     Results: 4 mg/kg NO 2Arg could significantly increase the time in biased side in morphine and dihydroetorphine psychically dependent mice. The time in biased side was increased from (6.09±2.02), (7.98±0.72) min to (9.31±1.10), (9.48±1.21) min ( P <0.01).
     结果:4mg/kgNO2Arg使吗啡和二氢埃托啡精神依赖小鼠在偏爱侧停留时间分别由给予NO2Arg前的(6.09±2.02),(7.98±0.72)min增加到给予后的(9.31±1.10),(9.48±1.21)min(P<0.01)。
短句来源
     (2)Compared with saline control,morphine-induced conditioned place preference elevated DHEA and PREG contents in rat striatum(P<0.01),while decreased DHEA level in rat plasma(P<0.01).
     (2)与生理盐水对照组比较,吗啡精神依赖大鼠的纹状体内DHEA和PREG的含量显著升高(P<0.01),血浆中DHEA的水平显著降低(P<0.01)。
短句来源
     With conditional place preference (CPP) of morphine dependent rats, the study focus on the effects of the DAD2 receptor in the orbital frontal cortex (OFC) in rat associated with the processing of opioid dependence.
     通过慢性吗啡处理方式建立起SD大鼠吗啡依赖的条件化位置偏好(CPP)模型,用行为学手段研究多巴胺(DA)D2受体拮抗剂及激动剂对SD大鼠CPP的影响,探讨眶额叶DAD2受体在阿片精神依赖中的作用。
短句来源
     Study on the Effect of CREB in Morphine Psychological Addiction in Rat
     转录因子CREB在大鼠吗啡精神依赖过程中的作用研究
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  psychological dependence
Physiological Mechanisms of the Effectiveness of Bilateral Stereotactic Cingulotomy against Strong Psychological Dependence in D
      
It is now generally believed that psychological dependence in drug addicts is determined not only socially, but also physiologically.
      
The neurochemistry of the psychological dependence syndrome in addictive diseases of chemical etiology
      
The syndrome of psychological dependence on psychoactive substances (SPD) is the most important element in the pathogenesis of the addictive diseases (narcoticism and alcoholism).
      
Although they are generally feared because of their potential for abuse, diversion, and psychological dependence, little attention is given to their neuroendocrine consequences.
      
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  psychic dependence
The patients with this form of alcohol withdrawal syndrome did not exhibit physical and psychic dependence on alcohol.
      
Chronically abusive use can lead to marked tolerance and psychic dependence with varying degrees of abnormal behavior.
      
Like other phenothiazines, it is not known to cause psychic dependence and does not produce tolerance or addiction.
      
Main finding in this survey was that buprenorphine produced low dependent potential, not only physical dependence, but psychic dependence.
      
Psychic dependence is believed to have no such underlying physiological mechanisms.
      
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We have studied the psychological dependence potential of DHE by using conditioned place preferance(CPP) paradigm in mice. Our data showed that at the dose of 0.6μg . kg~(-1) (ED_(50) of hot-plate method) sc, DHE produced a significant place preference and this preference was potentiated by increasing dose to 3 ED_(50)and 9 ED_(50). Aparently different from morphine, the preference of DHE could not be blocked by diprenorphine (3 mg . kg~(-1) ip). These results suggested that DHE be of relatively high psychological...

We have studied the psychological dependence potential of DHE by using conditioned place preferance(CPP) paradigm in mice. Our data showed that at the dose of 0.6μg . kg~(-1) (ED_(50) of hot-plate method) sc, DHE produced a significant place preference and this preference was potentiated by increasing dose to 3 ED_(50)and 9 ED_(50). Aparently different from morphine, the preference of DHE could not be blocked by diprenorphine (3 mg . kg~(-1) ip). These results suggested that DHE be of relatively high psychological de- pendence potential and its machenism may be unique.

本文报道应用条件性位置偏爱法,研究了DHE的精神依赖性的潜力及其与受体的关系。结果表明,DHE在1倍镇痛ED_(50)的剂量0.6μg·kg~(-1)sc下,就可产生明显的位置偏爱,且偏爱程度随药物剂量增加(3倍ED_(50),9倍ED_(50))而加强。但是DHE产生偏爱的受体机制可能与Mor不同,它不为M_(5050)(3 mg·kg~(-1)ip)所阻断。这些结果说明,DHE有较强的精神依赖潜力,而且在形成机制上,有其独特之处。

A comparative study of the efficacy of dihydroetorphine( DHE),

对自愿住院治疗、随机抽出的66例海洛因依赖患者,进行分组比较观察,结果发现:1.对戒断症状的控制程度,丁丙诺啡组优于联合用药组(丁丙诺啡、DHE),联合用药优于DHE组;2.疗程(x±s,d),使用DHE疗程较短(10.3±s 5.3),丁丙诺啡次之(11.3±s4.1),联合用药较长(14.3±s 10.1);3.用药总剂量,DHE组及联合用药组远远超过常规剂量,丁丙诺啡组低于常规剂量;4.寻药行为是躯体精神依赖的重要表现,本次发现使用DHE组寻药行为出现率72.73%,联合组40.91%,丁丙诺啡组18.18%。

Naltrexone 2. 0 - 4. 0 mg · kg-1 or 1. 8 - 3. 6 mg · kg-1 po blocks effectively the development of physical dependence on morphine or heroin in mice. Naltrexone 1.0-3.0 mg · kg-1 sc antagonizes the development of conditioned place preference (CPP) in mice and accelerates the disappearance of CPP after it has been induced by morphine. The results indicate that naltrexone can influence the development and disappearance of psychic dependence on morphine in mice. The possibility of low dose naltrexone for preventing...

Naltrexone 2. 0 - 4. 0 mg · kg-1 or 1. 8 - 3. 6 mg · kg-1 po blocks effectively the development of physical dependence on morphine or heroin in mice. Naltrexone 1.0-3.0 mg · kg-1 sc antagonizes the development of conditioned place preference (CPP) in mice and accelerates the disappearance of CPP after it has been induced by morphine. The results indicate that naltrexone can influence the development and disappearance of psychic dependence on morphine in mice. The possibility of low dose naltrexone for preventing relapse after opioid withdrawal was discussed in this paper.

本文观察了纳屈酮对吗啡和海洛因在大、小鼠产生依赖的影响。纳屈酮2.0-4.0mg·kg~(-1)或1.8-3.6mg·kg~(-1)po分别可对抗吗啡和海洛因在小鼠产生身体依赖;1.0-3.0mg·kg~(-1)sc可拮抗吗啡致小鼠条件性位置偏爱的形成。当吗啡诱发小鼠条件性位置偏爱形成后,纳屈酮可加速其消退。提示纳屈酮对小鼠吗啡精神依赖的产生和消退有一定影响。参考上述实验结果和人与动物间剂量折算,我们认为小剂量纳屈酮10-15mg·d~(-1)po防止阿片依赖病人戒毒后复吸是可行的。

 
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