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   精神依赖 在 精神病学 分类中 的翻译结果: 查询用时:0.729秒
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精神依赖
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  psychological dependence
    Objective: To explore the role of NMDA receptors in both opiate physical and psychological dependence by investigating the effects of dizocilpine (MK-801) on morphine-induced conditioned place preference (CPP) and spontaneous withdrawal signs in SD rats.
    目的 通过测评NMDA受体拮抗剂地卓西平(Dizocilpine,MK-801)对慢性吗啡处理大鼠条件性位置偏爱(Conditioned Place Preference,CPP)及自然戒断体征(Spontaneous Withdrawal Signs)的影响,探讨NMDA受体在阿片精神依赖及躯体依赖中的作用。
短句来源
    Drug psychological dependence in a child on long-term medication of brown mixture
    儿童长期服用复方甘草合剂致药物精神依赖
短句来源
    It indicated that NMDA receptors played an important role in both opiate physical and psychological dependence.
    表明谷胺酸NMDA受体在吗啡躯体依赖及精神依赖中均有重要作用。
短句来源
    The inner - mechanism of physical and psychological dependence caused by opium, especially the psychological dependence mechanism which determine drug resumption, is still a dimness or at a guess stage basically.
    阿片类所致的身体依赖和精神依赖的内在机理仍很不清楚,特别是对复吸起决定性作用的精神依赖机理的研究,可以说是基本还处于揣测阶段。
短句来源
    The psychological dependence of mice was evaluated by conditioned place preference.
    小鼠精神依赖采用条件性位置偏爱模型进行评价。
短句来源
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  psychical dependence
    Aim To study the effects of forced swimming on neurotransmitters in brain of mice with psychical dependence on Morphine(Mor).
    目的 探讨强迫游泳对吗啡 (Mor)精神依赖小鼠脑内单胺类递质的影响。
短句来源
    Methods The model of psychical dependence in mice was established with the method of conditioned place preference(CPP).
    方法 利用条件性位置偏爱 (conditionedplacepreference,CPP)方法 ,建立小鼠吗啡精神依赖模型 ;
短句来源
    Conclusion GLU and GABA levels were changed in rat brain after training. The results suggest that GLU and/or GABA system may participate in the rewarding effect of morphine during establishment psychical dependence.
    结论大鼠对吗啡的精神依赖形成时,中枢GLU和GABA的含量变化集中于额叶皮层、下丘脑和伏隔核等与奖赏作用关系密切的脑区,证明了GLU和GABA系统参与了精神依赖形成时药物在脑内的奖赏作用。
短句来源
    Aim To establish the rat model of morphine-induced conditioned place preference (CPP) and to investigate the effects of morphine psychical dependence on the levels of neurosteroids in rat brain.
    目的建立大鼠条件性位置偏爱(CPP)模型,探讨吗啡精神依赖对大鼠脑内神经甾体水平的影响。
短句来源
    Conditioned place preference(CPP) was used to establish the morphine psychical dependence.
    条件性位置偏爱实验建立吗啡精神依赖模型。
短句来源
  psychic dependence
    Recent researches show antagonists of N methyl D aspartate (NMDA) receptors inhibit physical and psychic dependence on opioids.
    近年来研究发现 ,NMDA受体拮抗剂、抗体和反义核酸能抑制阿片躯体和精神依赖
短句来源
    Conclusion DRz 164 targeting per1 mRNA has the specific cleavage activity which increases with the time in vitro. Suppression of morphine-induced place preference occurs by pretreatment with the deoxyribozyme. Mice show a lack of morphine-induced reward,which alleviates the psychic dependence on the morphine.
    结论DRz164在体外能够切割per1mRNA,在一定范围内剪切活性随时间延长而升高,小鼠脑室注射DRz164可拮抗吗啡所引起的奖赏效应,缓解对吗啡的精神依赖
短句来源
    Conclusion DRz164 can highly block the expression of Period 1 gene, which cleaves the Period 1 mRNA in the transfected cells specifically. The suppression of morphine-induced place preference can be effected by pretreating the mice with intracerebroventricular injection of deoxyribozyme for alleviating their psychic dependence on morphine.
    结论脱氧核酶DRz164在胞内能够切割Period1mRNA,抑制Period1基因表达,小鼠脑室注射DRz164可拮抗吗啡所引起的奖赏效应,缓解其对吗啡的精神依赖
短句来源
  “精神依赖”译为未确定词的双语例句
    Study on the Effect of CREB in Morphine Psychological Addiction in Rat
    转录因子CREB在大鼠吗啡精神依赖过程中的作用研究
短句来源
    The duration when morphine and dihydro etorphine psychologically dependent mice stayed in the preferred compartment increased significantly from (6.1± 2.0)min and (8.0±0.7)min to (9.3±1. l)min and (9.5 ± 1.2) min by 4 mg·kg-1 NO2 Arg.
    NO2Arg 4 mg·kg-1可使吗啡、二氢埃托啡精神依赖小鼠在偏爱侧停留时间分别由(6.1±2.0)min、(8.0±0.7)min显著增加到(9.3±1.1)min、(9.5±1.2)min 。
短句来源
    (2)Compared with saline control,morphine-induced conditioned place preference elevated DHEA and PREG contents in rat striatum(P<0.01),while decreased DHEA level in rat plasma(P<0.01).
    (2)与生理盐水对照组比较,吗啡精神依赖大鼠的纹状体内DHEA和PREG的含量显著升高(P<0.01),血浆中DHEA的水平显著降低(P<0.01)。
短句来源
    With conditional place preference (CPP) of morphine dependent rats, the study focus on the effects of the DAD2 receptor in the orbital frontal cortex (OFC) in rat associated with the processing of opioid dependence.
    通过慢性吗啡处理方式建立起SD大鼠吗啡依赖的条件化位置偏好(CPP)模型,用行为学手段研究多巴胺(DA)D2受体拮抗剂及激动剂对SD大鼠CPP的影响,探讨眶额叶DAD2受体在阿片精神依赖中的作用。
短句来源
    Changes of Levels of Amino Acids in Brain Regions of Morphine Psychic Dependent Rats
    大鼠吗啡精神依赖时脑区氨基酸类神经递质的变化
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  psychological dependence
Physiological Mechanisms of the Effectiveness of Bilateral Stereotactic Cingulotomy against Strong Psychological Dependence in D
      
It is now generally believed that psychological dependence in drug addicts is determined not only socially, but also physiologically.
      
The neurochemistry of the psychological dependence syndrome in addictive diseases of chemical etiology
      
The syndrome of psychological dependence on psychoactive substances (SPD) is the most important element in the pathogenesis of the addictive diseases (narcoticism and alcoholism).
      
Although they are generally feared because of their potential for abuse, diversion, and psychological dependence, little attention is given to their neuroendocrine consequences.
      
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  psychic dependence
The patients with this form of alcohol withdrawal syndrome did not exhibit physical and psychic dependence on alcohol.
      
Chronically abusive use can lead to marked tolerance and psychic dependence with varying degrees of abnormal behavior.
      
Like other phenothiazines, it is not known to cause psychic dependence and does not produce tolerance or addiction.
      
Main finding in this survey was that buprenorphine produced low dependent potential, not only physical dependence, but psychic dependence.
      
Psychic dependence is believed to have no such underlying physiological mechanisms.
      
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We have studied the psychological dependence potential of DHE by using conditioned place preferance(CPP) paradigm in mice. Our data showed that at the dose of 0.6μg . kg~(-1) (ED_(50) of hot-plate method) sc, DHE produced a significant place preference and this preference was potentiated by increasing dose to 3 ED_(50)and 9 ED_(50). Aparently different from morphine, the preference of DHE could not be blocked by diprenorphine (3 mg . kg~(-1) ip). These results suggested that DHE be of relatively high psychological...

We have studied the psychological dependence potential of DHE by using conditioned place preferance(CPP) paradigm in mice. Our data showed that at the dose of 0.6μg . kg~(-1) (ED_(50) of hot-plate method) sc, DHE produced a significant place preference and this preference was potentiated by increasing dose to 3 ED_(50)and 9 ED_(50). Aparently different from morphine, the preference of DHE could not be blocked by diprenorphine (3 mg . kg~(-1) ip). These results suggested that DHE be of relatively high psychological de- pendence potential and its machenism may be unique.

本文报道应用条件性位置偏爱法,研究了DHE的精神依赖性的潜力及其与受体的关系。结果表明,DHE在1倍镇痛ED_(50)的剂量0.6μg·kg~(-1)sc下,就可产生明显的位置偏爱,且偏爱程度随药物剂量增加(3倍ED_(50),9倍ED_(50))而加强。但是DHE产生偏爱的受体机制可能与Mor不同,它不为M_(5050)(3 mg·kg~(-1)ip)所阻断。这些结果说明,DHE有较强的精神依赖潜力,而且在形成机制上,有其独特之处。

A comparative study of the efficacy of dihydroetorphine( DHE),

对自愿住院治疗、随机抽出的66例海洛因依赖患者,进行分组比较观察,结果发现:1.对戒断症状的控制程度,丁丙诺啡组优于联合用药组(丁丙诺啡、DHE),联合用药优于DHE组;2.疗程(x±s,d),使用DHE疗程较短(10.3±s 5.3),丁丙诺啡次之(11.3±s4.1),联合用药较长(14.3±s 10.1);3.用药总剂量,DHE组及联合用药组远远超过常规剂量,丁丙诺啡组低于常规剂量;4.寻药行为是躯体精神依赖的重要表现,本次发现使用DHE组寻药行为出现率72.73%,联合组40.91%,丁丙诺啡组18.18%。

Naltrexone 2. 0 - 4. 0 mg · kg-1 or 1. 8 - 3. 6 mg · kg-1 po blocks effectively the development of physical dependence on morphine or heroin in mice. Naltrexone 1.0-3.0 mg · kg-1 sc antagonizes the development of conditioned place preference (CPP) in mice and accelerates the disappearance of CPP after it has been induced by morphine. The results indicate that naltrexone can influence the development and disappearance of psychic dependence on morphine in mice. The possibility of low dose naltrexone for preventing...

Naltrexone 2. 0 - 4. 0 mg · kg-1 or 1. 8 - 3. 6 mg · kg-1 po blocks effectively the development of physical dependence on morphine or heroin in mice. Naltrexone 1.0-3.0 mg · kg-1 sc antagonizes the development of conditioned place preference (CPP) in mice and accelerates the disappearance of CPP after it has been induced by morphine. The results indicate that naltrexone can influence the development and disappearance of psychic dependence on morphine in mice. The possibility of low dose naltrexone for preventing relapse after opioid withdrawal was discussed in this paper.

本文观察了纳屈酮对吗啡和海洛因在大、小鼠产生依赖的影响。纳屈酮2.0-4.0mg·kg~(-1)或1.8-3.6mg·kg~(-1)po分别可对抗吗啡和海洛因在小鼠产生身体依赖;1.0-3.0mg·kg~(-1)sc可拮抗吗啡致小鼠条件性位置偏爱的形成。当吗啡诱发小鼠条件性位置偏爱形成后,纳屈酮可加速其消退。提示纳屈酮对小鼠吗啡精神依赖的产生和消退有一定影响。参考上述实验结果和人与动物间剂量折算,我们认为小剂量纳屈酮10-15mg·d~(-1)po防止阿片依赖病人戒毒后复吸是可行的。

 
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