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gi蛋白
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  gi protein
     The results showed that the above migration process was markedly diminished by PTX (inhibitor of Gi protein),U73122 (inhibitor of PLC), Staurosporine (inhibitor of PKC ), PD98059 (inhibitor of ERK1/2) and SB203580(inhibitor of p38), and lightly by SP600125 (inhibitor of JNK).
     结果显示,PTX(Gi蛋白抑制剂)、U73122(PLC抑制剂)、staurosporine(PKC抑制剂)、PD98059(ERK1/2抑制剂)和SB203580(p38抑制剂)分别可拮抗上述AA诱导的SM3细胞迁移作用,而SP600125(JNK抑制剂)的作用较弱.
短句来源
     Our findings indicate that the endogenous histamine might be involved in the modulation of cardiac sympathetic neurotransmission by interacting with histamine H3-receptors and the receptors are probably coupled to a G0/Gi protein.
     以上结果表明,组胺H_3受体参与调节心交感神经冲动的传递,H_3受体可能与G0/Gi蛋白相耦联,内源性组胺经H_3受体介导参与调节心交感神经冲动的传递。
短句来源
     Taken together, it suggests that the signaling pathways are related to promoting the membrane translocation of PLCβ_2 by AA-activated Gi protein, furthermore resulting in migration of SM3 cells through enhancing phosphorylation levels of PKC (ε), ERK1/2, p38 and JNK, when phosphorylation of MLC20 was inhibited.
     上述结果表明,当肌球蛋白轻链的磷酸化被抑制后,AA可通过Gi蛋白的活化促进PLCβ2向细胞膜移位,进而通过激活PKC(ε)、ERK1/2、p38和JNK等信号转导途径而诱导SM3细胞发生迁移.
短句来源
     Newly discovered regulator of G-protein signaling (RGS) is a GTPase activating protein (GAP). It can accelerate GTP hydrolyzing of Giα and Gqα, consequently reduce the intensity and duration of Gq and Gi protein activation, and adjust the signal pathway.
     近年发现的G蛋白信号转导调节因子(Regulators of G-protein signaling)是细胞内GTP酶(GTPase)激活蛋白(GTPase activating proteins,GAPs),它可加速Giα和Gqα水解GTP,从而限制Gq和Gi蛋白激活的强度和持续时间,调节信号转导过程。
短句来源
     In the secretory function of complement stimulated M, Gi protein has a major role in the production of NO, Gs protein is mainly involved in the secretion of TNF-α.
     其中对PM生成NO的调控主要是通过Gi蛋白途径发挥作用,对PM分泌TNF-α的调控则以Gs蛋白信号通路为主。
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  gi-protein
     The myoinhabitory role of allatostatins may be mediated by a Gi-protein, which may be different from the receptor coupling with AS to inhibit the activity of CA.
     AS对肌肉收缩的抑制的作用可能由一个Gi蛋白受体介导,且这类受体与AS抑制CA活性时的受体可能完全不同。
短句来源
     Activation of PLA2 is regulated by many signaling pathways: Gi-protein, diacylglycerol, protein kinase A, proterin kinase C, mitogen-activated protein kinase and reaction oxygen species. In addition, the crosstalk between PLA2 and phospholipase C may occur by mediating of endogenous diacylglycerol.
     天然激动剂引起PLA2激活受Gi蛋白、甘油二酯、蛋白激酶A、蛋白激酶C、促分裂原蛋白激酶和活性氧等多条信号通路的调节,此外,磷脂酶A2与特异性磷酯酶C之间可以发生信号串话。
短句来源
     During inflammation,activation of chemokine receptors on neurons contributes to hyperalgesia by inhibiting μ-opioid receptors and concomitantly sensitizing TRPV1,via Gi-protein mediated signaling pathways.
     趋化因子受体诱导的这2种效应可以通过Gi蛋白信号传导通路增强生物体对痛觉的敏感度.
短句来源
  “gi蛋白”译为未确定词的双语例句
     RT-PCR, Western blotting, Northern blotting and immunohistochemical method on the content or express of T3NRmRNA, Gsα, Gi α, Go α, Goα mRNA and SS;
     运用RT-PCR、Western blotting、Northern blotting,免疫组化等技术分别检测其海马T_3MRmRNA、Gs蛋白α亚基、Gi蛋白α亚基、Go蛋白α亚基的含量,GoαmRNA及SS的表达;
短句来源
     Involvement of Giβγ subunits in carbacholstimulated phospholipase A2 activation in CCL137 cells
     Gi蛋白βγ亚单位在氨甲酰胆碱所致CCL137细胞磷脂酰A_2激活中的作用
短句来源
     The cardiac protective effect of β2AR is mediated by a signaling pathway sequentially involving Gi, Gβγ, PI3K and Akt.
     β2AR的心肌保护作用是通过激活Gi蛋白-Gβr-PI3K-Akt途径介导。
短句来源
     As a result, acute β1AR stimulation activates the Gs-adenylyl cyclase-cAMP-PKA signaling that can broadcast throughout the cell, whereas β2AR-evoked cAMP signaling is spatially and functionally compartmentalized, due to concurrent Gi activation.
     短时间激动β1AR,使Gs蛋白-腺苷酸环化酶-环苷腺酸-蛋白激酶A(Gs-adenylyl cyclase-cAMP-PKA)信号体系激活并广布于细胞内,而激动β2AR则同时激活Gi蛋白而产生空间及功能局限的cAMP信号;
短句来源
     The changes mentioned above are effectively abolished when p bromoacetophenone (PBA), pertussis toxin (PTX), dexamethasone (DEX) ,anti Giα and anti Gβγ serum are involved respectively in the reaction system .
     上述现象可分别被PLA2 特异性抑制剂对溴乙酰酚 (PBA)、地塞米松 (Dex)、Gi蛋白灭活剂百日咳毒素 (PTX)、抗Giα血清和抗Gβγ血清所抑制 ;
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  gi protein
These data provide evidence that the plasma membrane of starfish oocytes contains a 40-kDa GTP-binding protein with properties characteristic of the alpha subunit of the inhibitory Gi protein.
      
In cardiac fibroblasts AngII activated MAP kinases through a pathway including the Gβγ subunit of Gi protein, Src, Shc, Grb2, and Ras, while Gq and PKC activation was necessary in cardiac myocytes.
      
With the list of candidate genes for this disorder steadily increasing, the pertussis toxin-sensitive inhibitory G protein (Gi) protein β3 subunit (GNB3) gene has remained "sizzling," challenging the domination of the renin-angiotensin system.
      
Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells
      
They also confirm that the inhibitory action of dopamine is mediated through a Gi protein; and the stimulatory action of dopamine is mediated through a PTX-insensitive pathway.
      
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  gi-protein
Thus, in the experimental type 2 diabetes, disturbances in Gi-protein coupled signal cascades are primarily observed, through which hormones realize their inhibition of AC activity.
      
From these results, a scheme is proposed which, links the regulation of noradrenaline release by prejunctional α2-adrenoceptors and protein kinase C via an influence on a common inhibitory Gi-protein.
      
Expression of endothelin (ET)-1, a 21-amino acid peptide and major isoform of the endothelin peptide family, is produced by endothelial, vascular smooth muscle cells, and macrophages and acts through Gi-protein-coupled ETA and ETB receptors.
      
Several Gi-protein-coupled receptors normally expressed in islet β-cells inhibit insulin secretion on binding of their respective agonists.
      
Our results suggest that overexpression of a Gi-protein-coupled receptor in β-cells causes tonic inhibition of both insulin synthesis and secretion.
      
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Partially purified plasma membrane preparations of neoplastic and normal thyroid tissue were used to measure adenylate cyclase (AC) activity in basic, TSH or/and GTPγs stimulated condition. The AC activity indicated above in five cases of non-functioning thyroid tumours was not different from that of in their adjacent normal tissues, while it was significant increase in four eases of auton- omously functioning thyroid nodules(AFTN) compared to that of their adjacent normal tissues. This demonstrated that the...

Partially purified plasma membrane preparations of neoplastic and normal thyroid tissue were used to measure adenylate cyclase (AC) activity in basic, TSH or/and GTPγs stimulated condition. The AC activity indicated above in five cases of non-functioning thyroid tumours was not different from that of in their adjacent normal tissues, while it was significant increase in four eases of auton- omously functioning thyroid nodules(AFTN) compared to that of their adjacent normal tissues. This demonstrated that the high function of AFTN appears to be associated with the high sensitivity of TSH receptor and the increase of constitutional activity and amount of Gs/Gi protein in general.

通过测定基础状态、TSH和(或) GTPγs刺激后组纯化的甲状腺细胞膜蛋白腺苷酸环化酶(AC)活力,发现5例非功能性甲状腺肿瘤(NFTT)在以上三种情况下的AC活力与 其周围正常组织无差异,而4例自主功能性甲状腺结节(AFTN)的AC活力均高于其周围组织,表明 AFTN的高功能的形成与TSH受体的敏感性增高和Gs/Gi蛋白的活性及量的改变以及表现为Gs的功能特性增强有关。

This is the first time to report the existence of new presynaptic inhibitory autoreceptors-histamine H3- receptors in guinea pig myocardium.We found that(R)-α-methylhistamine(α-MeHA),a selective histamine H3-receptor agonist,attenuates the sympathetic inotropic response of isolated guinea pig atria elicited by electrical field stimulation.This inhibition was associated with a marked reduction in endogenous norepinephrine release.The above phenomenon was antagonised by selective histamine H3-receptor antagonists,and...

This is the first time to report the existence of new presynaptic inhibitory autoreceptors-histamine H3- receptors in guinea pig myocardium.We found that(R)-α-methylhistamine(α-MeHA),a selective histamine H3-receptor agonist,attenuates the sympathetic inotropic response of isolated guinea pig atria elicited by electrical field stimulation.This inhibition was associated with a marked reduction in endogenous norepinephrine release.The above phenomenon was antagonised by selective histamine H3-receptor antagonists,and inhibited by pretreatment with N- ethylmeleimide,The cardiac sympathetic response could be attenuated or facilitated by increase or decrease of endogenous histamine.Our findings indicate that the endogenous histamine might be involved in the modulation of cardiac sympathetic neurotransmission by interacting with histamine H3-receptors and the receptors are probably coupled to a G0/Gi protein.

本文首次报道豚鼠心肌存在一种新型突触前抑制性受体─-组胺H_3受体。选择性H_3受体激动剂α-MeHA可抑制电场刺激诱发的离体豚鼠右心房交感性正性变力效应,以及去甲肾上腺素的释放。以上效应可被H_3受体拮抗剂所拮抗。N-乙基马来酰亚胺可取消α-MeHA的作用。增加或减少心肌内源性组胺含量,可分别抑制或增强电场刺激诱发的心交感性反应。以上结果表明,组胺H_3受体参与调节心交感神经冲动的传递,H_3受体可能与G0/Gi蛋白相耦联,内源性组胺经H_3受体介导参与调节心交感神经冲动的传递。

In this paper,we study laser biostimulation from the viewpoint of biophotonics at the cellular level,and put forward the bioinformation model on laser biostimulation(BIML).BIML supposes the chromophore absorption allows the photon of lowenergy laser irradiation to act as a carrier of bioinformation as a hormone does.For membrane chromophore, BIML further supposes the chromophore absorption in the cell membrane couples with intracellular messenger and mediates the bioinformation function of lowenergy laser...

In this paper,we study laser biostimulation from the viewpoint of biophotonics at the cellular level,and put forward the bioinformation model on laser biostimulation(BIML).BIML supposes the chromophore absorption allows the photon of lowenergy laser irradiation to act as a carrier of bioinformation as a hormone does.For membrane chromophore, BIML further supposes the chromophore absorption in the cell membrane couples with intracellular messenger and mediates the bioinformation function of lowenergy laser irradiation as following: Hotcolor (red, orange, yellow) laser irradiation activates cAMP phosphodiesterase through G i protein,phosphoinositide phospholipase C through Gg protein,on proteinkinasecorrelated membrenebound receptors: cAMP↓;Coldcolor (green,blue,violet)laser irradiation activates adenylate cyclase through G s protein:cAMP↑.BIML is verified by its successful applications,and its reasonability is shown from the viewpoint of time quantum mechanics.

在细胞水平上,本文从生物光子学的角度研究了激光的生物刺激作用,提出了激光生物刺激作用的生物信息模型(BIML)。BIML假设,细胞生色团对弱激光的吸收允许弱激光光子象激素一样成为生物信息的载体。对于细胞膜上的生色团,BIML进一步假设红、橙、黄等暖色激光通过Gi蛋白活化cAMP的磷酸二酯酶,通过Gg蛋白活化磷酯酶C或活化蛋白激酶关联受体使胞内cAMP水平降低;绿、蓝、紫等冷色激光通过Gs蛋白活化腺苷酸环化酶使胞内cAMP水平升高。本文通过应用验证了BIML。本文还从时间量子力学的角度研究了BIML的合理性

 
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