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   心脏成纤维细胞 的翻译结果: 查询用时:0.073秒
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心脏成纤维细胞     
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  cardiac fibroblasts
     (4) In the presence of 10 μrnol/L LPA,2.94-47.04 μg/ml PGs inhibited DNA synthesis of the cells at G0/G1 phase to 36%±11% -15% ±10% of control and the cells at G2 phase to 91% ±13% -3% ±1%, indicating that PGs inhibited LPA induced DNA synthesis of cardiac fibroblasts.
     (4)在10μmol/L LPA存在下,2.94-47.04μg/ml PGs使G0/G1期细胞和G2期细胞的DNA合成分别下降为对照的36%±11%-15%±10%和91%±13%-3%±1%,说明PGs可以抑制LPA诱导的心脏成纤维细胞DNA合成。
短句来源
     (3) At 1-80μmol/L,LPA promoted DNA synthesis of cultured rat cardiac fibroblasts at different cell cycle in a concentration-dependent manner. 50μmol/L LPA induced the increase of DNA synthesis at G0/G1 phase and G2 phase by 78%±24% and 122%±21% respectively.
     (3)1-80μmol/L范围内,LPA以浓度依赖方式促进不同细胞周期的心脏成纤维细胞DNA合成增加,50μmol/L LPA诱导G0/G1期和G2期细胞DNA合成的增加分别为78%±24%和122%±21%。
短句来源
     (2)PGs inhibited DNA synthesis of cardiac fibroblasts at both GO/G1 and G2 phases of cell cycles.
     (2)PGs对G0/G1期和G2期的心脏成纤维细胞的DNA合成均有抑制作用。
短句来源
     AIM: To investigate the effect of Angiotensin-(1-7) Ang-(1-7) on the cell proliferation and collagen synthesis of cardiac fibroblasts (CFs) induced by vasopressin(AVP).
     目的:研究血管紧张素-(1-7)[Ang-(1-7)]对血管加压素(AVP)诱导心脏成纤维细胞(CFs)增殖和胶原合成的影响.
短句来源
     AIM:To observe the effect of interleukin 6(IL 6) on proliferation and p27 expression in cardiac fibroblasts(CFs), and to explore the mechanism of IL 6 in CFs proliferation and cardiac fibrosis.
     目的:观察白细胞介素-6(interleukin-6,IL-6)对心脏成纤维细胞(cardiacfibroblasts,CFs)增殖及p27蛋白表达的影响,探讨IL-6促CFs增殖的细胞分子生物学机制。
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  cardiac fibroblast
     Results SAB of 10 and 100 μmol/L concentration could effectively inhibit the proliferation of cardiac fibroblast induced by Ang Ⅱ(P< 0.05),that of 1 and 10 μmol/L also could inhibit the mRNA expression of c-fos gene(P<0.05).
     结果 10μmol/L SA-B 和100μmol SA-B 可有效抑制由 AngⅡ引起的心脏成纤维细胞增殖(P<0.05)。 1μmol/L SA-B 和10μmol/L SA-B 也可有效抑制 c-fos 基因 mRNA的表达(P<0.05)。
短句来源
     Influence of perdipine on the proliferation and PYK_2 expression in cultured adult rat cardiac fibroblast stimulated by angiotensin Ⅱ
     盐酸尼卡地平对血管紧张素Ⅱ诱导成年大鼠心脏成纤维细胞增殖和PYK_2表达的影响
短句来源
     In order to understand the effects of two drugs,angiotensin converting enzyme inhibitor(lisinopril) and angiotensin Ⅱ type 1 receptor(AT1R)antagonist(losartan)in cardiac interstitial tissue,the experiments of detecting AT1R gene expression and ACE activity from neonatal rat cardiac fibroblast were carried out.
     为了解两种降压药物 -血管紧张素转换酶 (angiotensin converting enzyme,ACE)抑制剂(lisinopril)和血管紧张素 型受体 (AT1 R)拮抗剂 (losartan)在心脏间质组织中的作用 ,进行了药物对乳鼠心脏成纤维细胞 AT1 R基因表达和血管紧张素转换酶活力影响的实验 .
短句来源
     Results: Hypoxia(24 h) significantly increased the MTT A 490nm value of cardiac fibroblasts( P<0.05 vs control group). Both VNP(10 -7 mol/L) and 8 Bromo cGMP(10 -3 mol/L) decreased MTT A 490 nm value in cardiac fibroblast( P<0.05 vs hypoxia group) .
     结果 :低氧 2 4h可以使培养的乳鼠心脏成纤维细胞MTTA4 90nm值显著升高 (P <0 .0 5vs对照组 ) ,VNP(1 0 - 7mol/L)和 8 Bromo cGMP(1 0 - 3mol/L)均可以显著降低低氧刺激的心脏成纤维细胞MTTA4 90nm值 (P <0 .0 5vs低氧组 ) ;
短句来源
     Effect of Salvianolic Acid B on Proliferation of Cardiac Fibroblast and c-fos Gene Expression in Rats
     丹参酸乙对大鼠心脏成纤维细胞增殖和c-fos基因表达的影响
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  cultured cardiac fibroblasts
     AIM: To study the effect of interleukin-10(IL-10) on the proliferation and p27 expression in cultured cardiac fibroblasts(CFs) induced by arginine vasopressin(AVP).
     目的:研究白细胞介素10(IL10)对血管升压素(AVP)诱导大鼠心脏成纤维细胞(CFs)增殖及p27蛋白表达的影响.
短句来源
     Influence of angiotensin Ⅱ and aldosterone on type-Ⅲ collagen mRNA expression in cultured cardiac fibroblasts
     血管紧张素Ⅱ和醛固酮对心脏成纤维细胞Ⅲ型胶原mRNA表达的影响
短句来源
     (2)At 0, 1%, 2 5%, 5% and 10% FCS,the absorbance spectra(optical density) of BrdU incorporation and WST\|1 cleavage products on the cultured cardiac fibroblasts were following respectively:0 186±0 025, 0 300±0 073;
     (2 )在 0 ,1% ,2 .5 % ,5 %和 10 %的胎牛血清作用下 ,心脏成纤维细胞 Brd U ,WST- 1的 OD值分别是 0 .186± 0 .0 2 5 ,0 .30 0± 0 .0 73;
短句来源
     EFFECT OF 1-(2,6-DIMETHYLPHENOXY)-2-(3,4-DIMETHOXYPHENYL ETHYLAMINO) PROPANE HYDROCHLORIDE ON EXPRESSION OF COLLAGEN TYPE I AND TYPE III mRNA IN CULTURED CARDIAC FIBROBLASTS
     1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙胺基)丙烷盐酸盐对心脏成纤维细胞胶原Ⅰ,Ⅲ型mRNA表达的影响
短句来源
     Analogously, ET-1 enhanced 3 H-TdR and 3 H-Leu incorporation rate in cultured cardiac fibroblasts, which was attenuated by ANP.
     对于心脏成纤维细胞,ET-1促进3H-TdR、3H-Leu掺入,总蛋白含量增加,以上作用可被ANP明显抑制。
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  myocardial fibroblasts
     Results Five days after the transfection, the myocardial fibroblasts showed that: ①Some of them were morphologically similar to skeletal muscle cells, cell body elongated and cytoplasmic particles increased;
     结果 心脏成纤维细胞在导入MyoDcDNA 5d后可见 :①部分细胞形态发生改变 ,类似骨骼肌细胞 ,胞体伸展 ,胞浆颗粒增多 ;
短句来源
     Conclusions The coexistence of cardiac fibrosis and increased expression of Ob-Ra mRNA in myocardial fibroblasts were found in diabetic rats.
     结论 糖尿病大鼠心脏成纤维细胞短型瘦素受体表达增加与心脏纤维化并存。
短句来源
     The effects of Chinese herbs on the myocardial fibroblasts induced by angiotensinⅡin the cultured neonatal cardiac cells in vitro were observed. The efficient components of Danshensu, Ligustrazine, and Astrgalus Root injection were studied.
     方法通过在培养乳鼠心脏成纤维细胞增殖加入血管紧张素Ⅱ,观察细胞直径和细胞数;
短句来源
     Conclusion The results suggest that Chinese herbs with Qi-tonicity and promoting blood circulation could be able to inhibit the proliferation of the myocardial fibroblasts induced by angⅡin the cultured neonatal cardiac fibroblasts in vitro.
     结论活血药丹参素、川芎嗪可抑制AngⅡ引起的心脏成纤维细胞增殖并呈一定的量效关系;
短句来源
     Results LPA induced the increase of DNA synthesis and protein synthesis of rat myocardial fibroblasts in a concentration dependent manner.
     结果LPA以浓度依赖方式刺激乳鼠心脏成纤维细胞DNA合成和蛋白质合成;
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      cardiac fibroblasts
    In the second part, we examined AngII-induced signaling pathways both in cardiac myocytes and in cardiac fibroblasts.
          
    In cardiac fibroblasts AngII activated MAP kinases through a pathway including the Gβγ subunit of Gi protein, Src, Shc, Grb2, and Ras, while Gq and PKC activation was necessary in cardiac myocytes.
          
    Human cardiac fibroblasts and receptors for angiotensin II and bradykinin: A potential role for bradykinin in the modulation of
          
    Little is known as to the abundance of angiotensin II and BK receptors in human cardiac fibroblasts.
          
    Data presented in this study indicates that in cultured human cardiac fibroblasts there is apparently few angiotensin II receptors whereas as in other species there is evidence for the presence of BK receptors.
          
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      cardiac fibroblast
    In addition, cardiac fibroblast activation is responsible for the accumulation of fibrillar type I and type III collagens within the interstitium and adventitia of intramyocardial coronary arteries.
          
    Direct actions include the inhibition of cardiac fibroblast proliferation and collagen synthesis as well as hypertrophy of cardiomyocytes.
          
    The antifibrotic actions of ACEi are thought to be derived from their capacity to block the production of angiotensin II and, thus, its action on the cardiac fibroblast.
          
    Further studies need to be performed to establish the potential role that BK plays in modulating human cardiac fibroblast function.
          
    Inhibition of rat cardiac fibroblast growth by cAMP - but not by cGMP-dependent protein kinase
          
    更多          
      cultured cardiac fibroblasts
    The purpose of this study was to determine whether vasoactive factors endogenous to the heart affect the production of endothelin by cultured cardiac fibroblasts.
          
    Ventricular tissue from adult human heart was used successfully for the preparation of passagable (up to nine passages) cultured cardiac fibroblasts.
          
    α-Smooth muscle actin expression in cultured cardiac fibroblasts of newborn rat
          
    Nicotine regulates collagen gene expression, collagenase activity, and DNA synthesis in cultured cardiac fibroblasts
          
    To this end, we studied the effects of nicotine on cultured cardiac fibroblasts.
          
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      其他


    Objective: To determine the role of calcineurin dependent signal pathway in cardiac hypertrophy of rats. Methods: The rat model of pressure overload induced cardiac hypertrophy was produced by constriction of the abdominal aorta. The heart/body weight ratio and the atrial natriuretic peptide (ANP) levels in plasma and heart tissues of rats were investigated. The primary cardiac myocytes and fibroblasts were cultured under the standard conditions. Protein/DNA synthesis rate was assessed by 3H Leucine/...

    Objective: To determine the role of calcineurin dependent signal pathway in cardiac hypertrophy of rats. Methods: The rat model of pressure overload induced cardiac hypertrophy was produced by constriction of the abdominal aorta. The heart/body weight ratio and the atrial natriuretic peptide (ANP) levels in plasma and heart tissues of rats were investigated. The primary cardiac myocytes and fibroblasts were cultured under the standard conditions. Protein/DNA synthesis rate was assessed by 3H Leucine/ 3H TdR incorporation. Results: The heart/body weight ratio of each rat with abdominal aorta constriction was increased by 38% compared with that of the sham operated group, and cyclosporin A (CsA) treatment decreased 85%. The ANP levels in plasma and heart tissues of rats with abdominal aorta constriction were signicantly increased by 135% and 117% respectively, compared with that in the sham operated group, which was slightly reduced by CsA treatment. CsA(0.1 10 umol·L -1 ) decreased protein synthesis rate in AngⅡ treated cardiomyocytes and DNA synthesis rate in AngII treated fibroblasts in a dose dependent manner. Conclusion: Calcineurin dependent signal pathway may involve in pressure overload and AngII induced cardiac hypertrophy.

    目的:观察钙调神经磷酸酶(calcineurin,CaN)依赖的信号通路在大鼠心肌肥大中的作用。方法:通过腹主动脉缩窄复制大鼠压力超荷性心肌肥大模型,观察CaN特异性抑制剂环孢素A(cyclosporin A,CsA)对大鼠心系数以及血浆及心肌组织心钠素(aritrialnatriuretic peptide,ANP)水平的影响。同时,在培养的大鼠心肌细胞及心脏成纤维细胞上,观察CsA 对血管紧张素Ⅱ(angiotensin Ⅱ, AngⅡ) 刺激的3H亮氨酸及3H胸腺嘧啶参入的影响。结果:腹主动脉缩窄大鼠心系数较假手术组增高38% ( P< 0.01) 。应用CsA 治疗的大鼠心系数下降了85% ( P<0 .001)。同时,观察到腹主动脉缩窄大鼠心肌组织及血浆ANP含量较对照组分别增高135 % 和117 % (P< 0 .01) ,CsA 处理后,ANP分别下降了16 % 和14% 。在培养的大鼠心肌细胞及心脏成纤维细胞上,观察到CsA(0 .1 ~10μmol·L-1)可以浓度依赖的方式抑制血管紧张素Ⅱ刺激的3H亮氨酸及3H胸腺嘧啶参入的增加。结论:CaN 依赖的信号...

    目的:观察钙调神经磷酸酶(calcineurin,CaN)依赖的信号通路在大鼠心肌肥大中的作用。方法:通过腹主动脉缩窄复制大鼠压力超荷性心肌肥大模型,观察CaN特异性抑制剂环孢素A(cyclosporin A,CsA)对大鼠心系数以及血浆及心肌组织心钠素(aritrialnatriuretic peptide,ANP)水平的影响。同时,在培养的大鼠心肌细胞及心脏成纤维细胞上,观察CsA 对血管紧张素Ⅱ(angiotensin Ⅱ, AngⅡ) 刺激的3H亮氨酸及3H胸腺嘧啶参入的影响。结果:腹主动脉缩窄大鼠心系数较假手术组增高38% ( P< 0.01) 。应用CsA 治疗的大鼠心系数下降了85% ( P<0 .001)。同时,观察到腹主动脉缩窄大鼠心肌组织及血浆ANP含量较对照组分别增高135 % 和117 % (P< 0 .01) ,CsA 处理后,ANP分别下降了16 % 和14% 。在培养的大鼠心肌细胞及心脏成纤维细胞上,观察到CsA(0 .1 ~10μmol·L-1)可以浓度依赖的方式抑制血管紧张素Ⅱ刺激的3H亮氨酸及3H胸腺嘧啶参入的增加。结论:CaN 依赖的信号通路可能参与了压力超负荷及血管紧张素Ⅱ诱导的大鼠心?

    Objective To evaluate the possibility of converting cultured myocardial mesenchymal cells (mostly cardiac fibroblasts) of neonatal rat to skeletal muscle cells by the transfection with MyoD gene, one of the basic helix loop helix myogenic factors. Methods The plasmid MyoD cDNA was transferred into cultured myocardial mesenchymal cells of neonatal rat with liposome mediated method. Results Five days after the transfection, the myocardial fibroblasts showed that: ①Some of them were morphologically similar...

    Objective To evaluate the possibility of converting cultured myocardial mesenchymal cells (mostly cardiac fibroblasts) of neonatal rat to skeletal muscle cells by the transfection with MyoD gene, one of the basic helix loop helix myogenic factors. Methods The plasmid MyoD cDNA was transferred into cultured myocardial mesenchymal cells of neonatal rat with liposome mediated method. Results Five days after the transfection, the myocardial fibroblasts showed that: ①Some of them were morphologically similar to skeletal muscle cells, cell body elongated and cytoplasmic particles increased; ②The expression of downstream myogenic differentiation marker(myosin heavy chain mRNA) was observed, in 1.8% to 10.9% of the transfected cells with in situ hybridization with specific MyoD cDNA probe. Conclusion The myocardial fibroblasts can be converted to “skeletal muscle like” cell with potential function. These results suggest that it is possible to restore cardiac function via molecular cardiomyoplasty.

    目的 探讨运用MyoD基因转染使乳鼠心肌间质细胞转化为肌细胞的可能性。方法 MyoD基因是具有碱性螺旋 环 螺旋结构的生肌因子之一 ,用脂质体介导法将MyoDcDNA导入培养的乳鼠心肌间质细胞 (主要是成纤维细胞 )。结果 心脏成纤维细胞在导入MyoDcDNA 5d后可见 :①部分细胞形态发生改变 ,类似骨骼肌细胞 ,胞体伸展 ,胞浆颗粒增多 ;②经原位杂交证实 :1.8%~ 10 .9%的细胞有下游生肌分化标志即骨骼肌肌球蛋白重链mRNA的表达。结论 表明心肌成纤维细胞可转化为具有潜在功能的类骨骼肌细胞 ,提示在分子水平从心肌成形途径恢复心脏功能是有可能的

    An in vitro cell culture technique was used to study the effects of danshensu on the myocardial hypertrophy induced by angiotensin Ⅱ (Ang Ⅱ). The results showed that danshensu could inhibit the increase of the content and diameter of the total protein induced by Ang Ⅱ in cultured myocardial cells. Danshensu also showed an inhibiting effect on the proliferation of cardiac fibroblasts induced by Ang Ⅱ. The effects of danshensu manifested in the experiment was similar to those of Losartan, which implies that danshensu...

    An in vitro cell culture technique was used to study the effects of danshensu on the myocardial hypertrophy induced by angiotensin Ⅱ (Ang Ⅱ). The results showed that danshensu could inhibit the increase of the content and diameter of the total protein induced by Ang Ⅱ in cultured myocardial cells. Danshensu also showed an inhibiting effect on the proliferation of cardiac fibroblasts induced by Ang Ⅱ. The effects of danshensu manifested in the experiment was similar to those of Losartan, which implies that danshensu can inhibit myocardial hypertrophy.

    利用体外细胞培养技术 ,观察了丹参素对血管紧张素Ⅱ (AngⅡ )致心肌肥大的影响。结果表明 :丹参素抑制AngⅡ引起的培养心肌细胞总蛋白含量及直径的增加 ,对AngⅡ引起的心脏成纤维细胞的增殖也有抑制作用 ,其效果与AngⅡ受体 1阻滞剂Losartan相似 ,说明丹参素具有抑制心肌肥厚的作用

     
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