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肿瘤生物学行为     
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  tumor biological behavior
     Objective To investigate the expression of c-erbB-2, MTA1 and E-cadherin and relationship between the expression of these proteins and the tumor biological behavior,as well as relationship between these proteins in gastric cardia cancer.
     目的探讨c-erbB-2、MTA1及E-cadherin蛋白在贲门癌组织中的表达与肿瘤生物学行为的相关性,以及它们三者之间的相关性。
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     The expressions of MMP 2 and MMP 9 were correlated with histological grade and lymph node metastasis ( P <0.05), MMPs may promote tumor invasion and metastasis. There was no relationship between the expression of TIMP 1 or TIMP 2 and tumor biological behavior.
     乳腺癌组织中 MMP- 2、MMP- 9的表达与组织学分级、淋巴结转移密切相关( P<0 .0 5 ) ,能促进乳腺癌的侵袭和转移 ,而 TIMP- 1、TIMP- 2的表达与肿瘤生物学行为无相关性( P>0 .0 5 )。
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     AIM:To investigate the expression of vascular endothelial growth factor(VEGF) in patients with pulmonary carcinoma and its relationship with hypoxia inducible factor 1α (HIF 1α ),tumor biological behavior and prognosis.
     目的:探讨血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)在肺癌患者的表达与缺氧诱导因子-1α(hypoxia-induciblefactor-1α,HIF-1α)及肿瘤生物学行为和预后的关系。
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     Conclusion: The low expressions of pkc-α and Caspase-3 protein played a significant role in the generation of colorectal carcinoma and may be used as the useful indicators for clinical assessment of tumor biological behavior and pathological diagnose in patients with colorectal carcinoma.
     结论:pkc-α和caspase-3蛋白的低表达在大肠癌的发生发展中起着重要的作用,可作为大肠癌临床评价肿瘤生物学行为及病理诊断的有用指标。
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     CONCLUSION Integrin α5β1 gene mRNA expression level in breast cancer tissues may serve as a new parameter for judging tumor biological behavior and judging prognosis.
     临床检测乳腺癌组织基因整合素α5β1mRNA的表达水平,可以作为判断肿瘤生物学行为和预后的新指标。
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  biological behavior of tumor
     Objective To study the expression of CD_ 44v6 and E-cadherin in transitional cell carcinoma of bladder(TCCB)and analyze their correlation with biological behavior of tumor.
     目的探讨CD44v6和上皮钙黏蛋白(E-cadherin)在膀胱移行细胞癌(TCCB)中的表达及其与肿瘤生物学行为间的关系。
短句来源
     The expression of p53 protein and mutation of p53 gene are significant parameters which can reflect biological behavior of tumor cells.
     p53蛋白表达和基因突变是反映肿瘤生物学行为的有用指标。
短句来源
     The nuclear shape factor also may be used as an indicator for the biological behavior of tumor aggression
     结论:细胞核DNA含量和倍体水平是影响卵巢癌患者预后的重要因素; 核形状因子亦可作为评估肿瘤生物学行为的一项指标。
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     Detecting both of them will assist clinical doctors in judging the biological behavior of tumor and directing therapy.
     结论 67LR、MMP-7表达水平升高是子宫内膜癌发生过程中的早期事件,对这两项指标的检测有助于临床判断肿瘤生物学行为、指导治疗。
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     [Objective] To study the correlation between angiogenesis and extracellular matrix in human prostate cancer and their relationship with the biological behavior of tumor.
     目的探讨前列腺癌(PC a)组织中血管生成与细胞外基质(ECM)的相关性,及其与肿瘤生物学行为之间的关系。
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  biologic behaviour of tumors
     Overexpression of p53 in squamous cell carcinoma of lung and the relationship between the biologic behaviour of tumors and its prognosis
     肺鳞状细胞癌p53 过度表达与肿瘤生物学行为及预后的关系
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     Expression of P53 in pancreatic carcinomas and the relation betweenthe biologic behaviour of tumors and its prognosis
     胰腺癌 P53蛋白的表达与肿瘤生物学行为及预后的关系
短句来源
     Objective:To investigate the overexpression of p53 in squamous cell carcinoma of lung and the relationship between the biologic behaviour of tumors and its prognosis.
     目的:探讨肺鳞状细胞癌组织p53 蛋白的过度表达与肿瘤生物学行为及预后的关系。
短句来源
     Objective:To investigate the expression of P53 in pancreatic carcinomas and the relation between the biologic behaviour of tumors and its prognosis.
     目的 :探讨胰腺癌组织 P5 3蛋白的过度表达与肿瘤生物学行为及预后的关系。
短句来源
  tumor biological behaviors
     Objective:To investigate the roles of pro apoptosis genes Fas and FasL in the pathogenesis of transitional cell cancer of bladder and their relationships with tumor biological behaviors and prognosis.
     目的 :探讨细胞凋亡基因Fas和FasL在膀胱癌发病中作用及与肿瘤生物学行为和预后之间关系。
短句来源
     Objecitve To investigate the role of transcription factor E2F-1 in pathogenesis of lung carcinoma and its relationships with tumor biological behaviors.
     目的 :探讨转录因子E2F 1在肺癌发病机制中的作用及其与肿瘤生物学行为之间的关系。
短句来源
     Objectives: To observe the relationship between the tumor cell surface glycoproteinand tumor biological behaviors in primary duodenal adenocarcinoma.
     目的:探讨原发性十二指肠癌细胞表面糖蛋白的变化与肿瘤生物学行为的关系。
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  tumor biological behavior
Type IV collagenase activity in ascites reflects tumor biological behavior to some extent and is related with malignant ascites.
      
  biological behavior of tumor
The genotype of the GNB3 C825T polymorphism appears to influence the biological behavior of tumor disease in non-smoking TCC patients.
      
PCNA, p-53 and TFG were found to be the markers that provided significant additional information about the biological behavior of tumor cells.
      
These findings emphasize that the presence of galectins beyond galectins-1 and -3 can influence the biological behavior of tumor cells.
      
The pathomorphological changes of tissues, which were due to the biological behavior of tumor, were the basis of radiological exhibition.
      
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The expression of Y antigen (EYA) of epithelial cells from 52 breast carcinomas (BC) , 5 malignant transformation of adenosis(MTA),46 adenosis and 5 normal breasts are assessed with ABC immunoperoxidase histocytochemical assay and Y hapten specific monoclonal antibody. The results show, no expression of Y antigen in both normal breast and epithelial hyperplastic grade (EHG) I of adenosis of breast. The positive ratio of EYA in EHG II, III, MTA and carcinoma of breast are 22.8%, 43.8%, 60%and78.8% respectively.The...

The expression of Y antigen (EYA) of epithelial cells from 52 breast carcinomas (BC) , 5 malignant transformation of adenosis(MTA),46 adenosis and 5 normal breasts are assessed with ABC immunoperoxidase histocytochemical assay and Y hapten specific monoclonal antibody. The results show, no expression of Y antigen in both normal breast and epithelial hyperplastic grade (EHG) I of adenosis of breast. The positive ratio of EYA in EHG II, III, MTA and carcinoma of breast are 22.8%, 43.8%, 60%and78.8% respectively.The EYA is different from various histologic types of breast carcinomas and shows unequal distribution in the same type of cancer. Y antigen, as a specific tumor-associated marker, may be used in diagnosis of breast cancer and in promotion of the study in biologic behaviour of cancer. The EYA detection in epithelial atypic hyperplasia of adenosis of breast is useful to determine the tendency towards malignant transformation and a help to find out breast cancer in the early stage.

Lewis Y血型抗原(简称Y抗原)是一种胚胎性肿瘤相关抗原。对108例女性乳腺疾病标本检测结果显示:在正常乳腺组织和乳腺腺病Ⅰ级上皮增生者均无Y抗原表达;Ⅱ级上皮增生、Ⅲ级上皮增生,乳脲腺病癌变和乳腺癌中阳性率分别为22.8%、43.8%、60%和78.8%。在不同组织学类型的乳腺癌中Y抗原表达有差异,相同类型的癌组织中其表达亦呈明显不一致性。作为一种较特异的肿瘤标记物,Y抗原在乳腺癌的诊断和对肿瘤生物学行为的研究方面具有一定意义。乳腺腺病部分不典型增生病变中Y抗原表达的变化可能有助于判断其恶变倾向,帮助早期发现癌变病例。

Four staining methods were used for the identification of thecomposition & quantity of acidic mucoproteins (sialic & sulfuricmucoproteins) in benign & malignant mucinous cystadenoma ofovary. It was found that mucinous cystadenocarcinoma containd muchmore acidic mucoprotein than that of mucinous cystadenoma &borderline mucinous cystadenoma. Compared with adenomatous epith-elium under malignant change, the content of sialic mucoprotein inbenign adenomatous epithelium was increased or both mucoproteinsdecreased....

Four staining methods were used for the identification of thecomposition & quantity of acidic mucoproteins (sialic & sulfuricmucoproteins) in benign & malignant mucinous cystadenoma ofovary. It was found that mucinous cystadenocarcinoma containd muchmore acidic mucoprotein than that of mucinous cystadenoma &borderline mucinous cystadenoma. Compared with adenomatous epith-elium under malignant change, the content of sialic mucoprotein inbenign adenomatous epithelium was increased or both mucoproteinsdecreased. These data suggest ed that during malignant change of ovar-ian cystadenoma, the quantity of acidic mucoproteins would increasegradually. Increase of the quantity of sialic mucoprotein (mixedwith sulfuric mucoprotein in some tumors) is histochemicallycharacteristic in mucinous cystadenocarcinoma, of the ovary. Theremay be a relationship between the quantity of acidic mucoproteins& biological behavior of the ovarian mucinous cystadenocarcinoma.

用4种酸性粘蛋白组织化学染色法,观察90例卵巢良性和恶性粘渡性囊腺瘤酸性粘蛋白的含量和成分。发现粘液性囊腺癌酸性粘蛋白含量明显高于交界性粘液性囊腺瘤和钻液性囊腺瘤。绝大多数粘液性囊腺瘤酸性粘蛋白的主要成分是唾液酸粘蛋白,或唾液酸和硫酸两种粘蛋白的混合,仅少数瘤含有较多硫酸粘蛋白。与囊腺癌上皮比较,良性囊腺瘤上皮中唾液酸粘蛋白含量增多,或两种酸性粘蛋白均减少。据认为:①当囊腺瘤恶变时,酸性粘蛋白逐渐增加;②唾液酸粘蛋白(部分肿瘤含硫酸粘蛋白)增多是卵巢粘液性囊腺癌的组化特点;③酸性粘蛋白含量可能与肿瘤生物学行为有关。

In 4 cases of breast cancer primary large colon carcinomas were found simulta- neouly. The incidence rate, the factors of incidence and the treatment principle of this disease are discussed. It is considered that the patients with breast cancer are more liable to develope colon carcinoma. This is thought to be related to high fatty diet, heredity and endocrine factors. The line of thought in the treatment includes exclusion of the lattcr being metastasis. The priority of operation depends upon the biological...

In 4 cases of breast cancer primary large colon carcinomas were found simulta- neouly. The incidence rate, the factors of incidence and the treatment principle of this disease are discussed. It is considered that the patients with breast cancer are more liable to develope colon carcinoma. This is thought to be related to high fatty diet, heredity and endocrine factors. The line of thought in the treatment includes exclusion of the lattcr being metastasis. The priority of operation depends upon the biological behavior of the tumor, the required size of the operative wound and the status o f recuperation of the patient. A routine ovariectomy is recommended.

本文报告4例乳腺癌伴原发性大肠癌,并对其发病率、发病因素、治疗原则进行探讨。作者认为乳腺癌病人是大肠癌高危人群,其原因可能与高脂肪饮食、遗传、内分泌因素有关。治疗原则1.排除转移癌。2.手术先后取决于肿瘤生物学行为,手术创伤大小,病人恢复情况而定。3.建议对这种病人常规切除卵巢。

 
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