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重症医院获得性肺炎
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  severe hospital acquired pneumonia
     Application of thymosin alpha1 to the patients with severe hospital acquired pneumonia
     胸腺肽α1在重症医院获得性肺炎中的应用
短句来源
     Objective To investigate the effects of thymosin alpha1 on CD14+ monocyte human leukocyte antigen DR(HLA-DR),T lymphocytes subpopulation and NK cell and clinical significance in the patients with severe hospital acquired pneumonia(SHAP) in intensive care unit(ICU).
     目的探讨胸腺肽α1治疗对重症监护病房(ICU)内重症医院获得性肺炎(SHAP)患者CD14+单核细胞人类白细胞抗原DR(HLA-DR)、T细胞亚群和自然杀伤(NK)细胞的影响及其临床意义。
短句来源
     OBJECTIVE To investigate the effects of thymosin alpha 1 on monocyte human leukocyte antigen DR(HLA-DR) and other immune parameters and the clinical significance in patients with acute cerebral infarction(ACI) and severe hospital acquired pneumonia(SHAP).
     目的:探讨胸腺肽α1治疗对脑梗死并发重症医院获得性肺炎(SHAP)患者单核细胞人类白细胞抗原DR(HLA-DR)等免疫指标的影响及其临床意义。
短句来源
     Objective To investigate the relationship between macrophage migration inhibitory factor (MIF), tumor necrosis factor α(TNF α) and cortisol in elderly patients with severe hospital acquired pneumonia(SHAP), and to determine whether their levels correlate with patients' prognosis.
     目的 探讨老年重症医院获得性肺炎 (SHAP)患者巨噬细胞移动抑制因子 (MIF)、肿瘤坏死因子 α(TNF а)和皮质醇血清水平变化和相互关系以及对预后的影响。
短句来源
     Effects of thymosin alpha 1 on immune function in patients with acute cerebral infarction and severe hospital acquired pneumonia
     胸腺肽α_1对脑梗死并发重症医院获得性肺炎患者免疫功能的影响
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  severe hospital-acquired pneumonia
     Conclusion: The therapeutic effect of cefoperazone/sulbactam in the treatment of severe hospital-acquired pneumonia is the same as that of imipenem/cilastatin.
     结论:头孢哌酮/舒巴坦与亚胺培南/西司他丁治疗重症医院获得性肺炎疗效相近。
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  “重症医院获得性肺炎”译为未确定词的双语例句
     Objective: To compare efficacy of cefoperazone/sulbactam and imipenem in the treatment of patients with serious hospital-acquired pneumonia.
     目的:比较头孢哌酮/舒巴坦(舒普深)与亚胺培南/西司他丁(泰能)对重症医院获得性肺炎(HAP)的疗效。
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  severe hospital-acquired pneumonia
Gram-negative bacilli (GNB) are a common cause of severe hospital-acquired pneumonia.
      


Objective:To evaluate the important role of Cefepime as empiric antibiotic therapy on aged patients with severe hospital acquired pneumonia (SHAP) Methods: 115 patients with SHAP, receiving no prior antibiotic therapy, were divided into two groups: Cefepime (CFP) group and Imipenem/cilastatin (IMP) group the clinical efficacy and the bacteriological characteristic were analyzed in both groups Results: ①there was no statistical significant difference in clinical efficacy between CFP group (86 4%, the effective...

Objective:To evaluate the important role of Cefepime as empiric antibiotic therapy on aged patients with severe hospital acquired pneumonia (SHAP) Methods: 115 patients with SHAP, receiving no prior antibiotic therapy, were divided into two groups: Cefepime (CFP) group and Imipenem/cilastatin (IMP) group the clinical efficacy and the bacteriological characteristic were analyzed in both groups Results: ①there was no statistical significant difference in clinical efficacy between CFP group (86 4%, the effective rate) and IMP group (89 3%,the effective rate), P =0 641 ②The occurrence rate of bacteria in the sputum was 91 5% in CFP group and 91 7% in IMP group, with a predominance of Gram negative bacilli in the two groups (80 5% vs 85 7%) Pseudomonas aeruginosa, Acinetobacter, Enterobacter cloacae, Klebsiella pneumoniae and Staphylococcus epidermidis were the major pathogens in both groups, and showed the similar susceptibility to Cefepime and Imipenem/cilastatin ③The bacteriological effective rate was 88 9% in CFP group and 88% in IMP group ( P =0 916), and the bacteriological clearance rates were 89 6% and 91 4% ( P =0 708) respectively ④There were 7 isolates of Candida(12 5%) and 3 isolates of Stenotrophomonas maltophilia (5 4%) in IMP group after treating, but nothing in CFP group, P =0 005 ⑤The effectiveness/cost ratio was 0 137‰ in CFP group and 0 127‰ in IMP group ( P >0 05) Conclusion: Cefepime, with antibacterial spectrum, antibiotic activity and clinical efficacy similar to Imipenem/cilastatin, could be used as the idea single drug to empirically treat the aged patients with SHAP

目的 :探讨头孢吡肟在老年重症医院获得性肺炎 (SHAP)的经验性抗菌治疗中的价值。方法 :未接受其它抗生素治疗的 115例老年SHAP患者被分为头孢吡肟治疗组 (CFP组 )和泰能治疗组 (IMP组 ) ,并对比分析其临床疗效和细菌学特征。结果 :①两组临床有效率分别为 86 4 %和 89 3% ,无显著性差异 (P =0 6 4 1)。②两组痰中细菌检出率分别为 91 5 %和 91 7% ,均以G 菌为主 ,分别为 80 5 %和 85 7% ,铜绿假单胞菌、不动杆菌属、阴沟肠杆菌、肺炎克雷伯菌和表皮葡萄球菌居前五位 ,它们对头孢吡肟及泰能的敏感性相似。③两组以病例计细菌学有效率分别为 88 9%和 88 2 % ,无显著性差异 (P =0 916 ) ;以菌株计细菌学清除率分别为 89 6 %和 91 4 % ,无显著性差异 (P =0 70 8)。④治疗结束时 ,IMP组有 7例 (12 5 % )患者各分离出 1株念珠菌属 ,3例 (5 4 % )患者菌群交替 (嗜麦芽窄食单胞菌各 1株 ) ;CFP组则无此现象 ;二者差异显著 (P =0 0 0 5 )。⑤两组效...

目的 :探讨头孢吡肟在老年重症医院获得性肺炎 (SHAP)的经验性抗菌治疗中的价值。方法 :未接受其它抗生素治疗的 115例老年SHAP患者被分为头孢吡肟治疗组 (CFP组 )和泰能治疗组 (IMP组 ) ,并对比分析其临床疗效和细菌学特征。结果 :①两组临床有效率分别为 86 4 %和 89 3% ,无显著性差异 (P =0 6 4 1)。②两组痰中细菌检出率分别为 91 5 %和 91 7% ,均以G 菌为主 ,分别为 80 5 %和 85 7% ,铜绿假单胞菌、不动杆菌属、阴沟肠杆菌、肺炎克雷伯菌和表皮葡萄球菌居前五位 ,它们对头孢吡肟及泰能的敏感性相似。③两组以病例计细菌学有效率分别为 88 9%和 88 2 % ,无显著性差异 (P =0 916 ) ;以菌株计细菌学清除率分别为 89 6 %和 91 4 % ,无显著性差异 (P =0 70 8)。④治疗结束时 ,IMP组有 7例 (12 5 % )患者各分离出 1株念珠菌属 ,3例 (5 4 % )患者菌群交替 (嗜麦芽窄食单胞菌各 1株 ) ;CFP组则无此现象 ;二者差异显著 (P =0 0 0 5 )。⑤两组效价比分别为 0 137‰和 0 12 7‰ ,无显著性差异 (P >0 0 5 )。结论 :头孢吡肟的抗菌谱、抗菌活性及临床疗效与泰能相似 ,且几乎不引起继发性真菌生长 ,可作为老年SHAP理想的经验性抗菌治疗的单一用药

Objective: To compare efficacy of cefoperazone/sulbactam and imipenem in the treatment of patients with serious hospital-acquired pneumonia. Methods: sixty patients with severe hospital-acquired pneumonia (M42, F 18; age 42- 89 years old) were divided into two groups, thirty patients of them were treated with cefoperazone/sulbactam (3.0g +0.9% normal saline 250mL ) , iv, drip, q12h for 7-10 days, thirty patients were treated with imipenem/cilastatin (0.5g +0.9%normal saline 250mL ) , iv, drip, q6h for 7-10 days....

Objective: To compare efficacy of cefoperazone/sulbactam and imipenem in the treatment of patients with serious hospital-acquired pneumonia. Methods: sixty patients with severe hospital-acquired pneumonia (M42, F 18; age 42- 89 years old) were divided into two groups, thirty patients of them were treated with cefoperazone/sulbactam (3.0g +0.9% normal saline 250mL ) , iv, drip, q12h for 7-10 days, thirty patients were treated with imipenem/cilastatin (0.5g +0.9%normal saline 250mL ) , iv, drip, q6h for 7-10 days. Results: The clinical effective rate of cefoperazone/sulbactam group was 70.0%, recovery rate was 60.0%; the cliniacal effects rate of imipenem/cilastatin group was 76.7%, recovery rate was 63.3%. No significant difference was found between cefoperazone/sulbactam group and imipenem/cilastatin one (P>0.05). Conclusion: The therapeutic effect of cefoperazone/sulbactam in the treatment of severe hospital-acquired pneumonia is the same as that of imipenem/cilastatin.

目的:比较头孢哌酮/舒巴坦(舒普深)与亚胺培南/西司他丁(泰能)对重症医院获得性肺炎(HAP)的疗效。方法:回顾性分析60例重症医院获得性肺炎(男42例,女18例,年龄42~89 a),其中30例用头孢哌酮/舒巴坦3.0 g加入0.9%生理盐水250mL静滴,q12h;30例用亚胺培南/西司他丁0.5g加入0.9%生理盐水250mL静滴,q 6 h,均7~10 d为一疗程。结果:头孢哌酮/舒巴坦组临床有效率70.0%,痊愈率60.0%;亚胺培南/西司他丁组临床有效率76.7%,痊愈率63.3%,两组间相差无统计学意义(P>0.05)。结论:头孢哌酮/舒巴坦与亚胺培南/西司他丁治疗重症医院获得性肺炎疗效相近。

Objective To investigate the relationship between macrophage migration inhibitory factor (MIF), tumor necrosis factor α(TNF α) and cortisol in elderly patients with severe hospital acquired pneumonia(SHAP), and to determine whether their levels correlate with patients' prognosis. Methods Twenty one patients who met the criteria for SHAP were included in the study. The patients were divided into 2 subgroups, survivors(n=11), nonsurvivors(n=10); 10 healthy volunteers served as control subjects. Serum...

Objective To investigate the relationship between macrophage migration inhibitory factor (MIF), tumor necrosis factor α(TNF α) and cortisol in elderly patients with severe hospital acquired pneumonia(SHAP), and to determine whether their levels correlate with patients' prognosis. Methods Twenty one patients who met the criteria for SHAP were included in the study. The patients were divided into 2 subgroups, survivors(n=11), nonsurvivors(n=10); 10 healthy volunteers served as control subjects. Serum MIF, TNF α, cortisol levels were measured serially when the patients were first identified as having SHAP (day 0), and on days 1 4. Results There were no differences in the clinical backgrounds between the two groups. The values of MIF and TNF α in the nonsurvivors were significantly elevated than those cytokines measured in the survivors and control subjects. Peak MIF levels significantly correlated with peak TNF α levels (r=0 621, 0 697, 0 544, 0 557;P<0 0001, P<0 0001, P=0 011, P=0 009), but did not correlate with peak levels of cortisol. Although the levels of cortisol showed a marked increase compared to those of control subjects, there were no differences in these variables between the survivors and the nonsurvivors. Conclusions High MIF and TNF α levels are closely linked with poor outcome in patients with SHAP. MIF and TNF α may act together and play important pathogenic roles in elderly patients with SHAP.

目的 探讨老年重症医院获得性肺炎 (SHAP)患者巨噬细胞移动抑制因子 (MIF)、肿瘤坏死因子 α(TNF а)和皮质醇血清水平变化和相互关系以及对预后的影响。 方法  2 1例SHAP患者分为存活组 ( 11例 )与死亡组 ( 10例 ) ;10名老年健康志愿者为健康对照组。一旦确诊为SHAP ,于病程第 1~ 5天定时取血检测MIF、TNF а、皮质醇水平 ,动态观察神志、血压、氧合指数、机械通气时间、应激性溃疡等指标直至治愈出院或死亡 ,并进行急性生理和慢性健康 (APACHEⅡ )评分。 结果 两组神志、血压、氧合指数、机械通气时间、应激性溃疡及APACHEⅡ评分等指标差异无显著性 (P>0 0 5 ) ;第 1、2、3天死亡组血清MIF水平显著高于存活组 (P =0 0 0 4、P =0 0 16、P =0 0 0 2 ) ,第4、5天差异无显著性 (P >0 0 5 ) ,两组各时间点上述指标均高于健康对照组 (P <0 0 5 ) ;死亡组血清TNF α水平高于存活组 (P <0 0 5 ) ,两组均高于健康对照组 (P <0 0 5 ) ;SHAP两组血清皮质醇水...

目的 探讨老年重症医院获得性肺炎 (SHAP)患者巨噬细胞移动抑制因子 (MIF)、肿瘤坏死因子 α(TNF а)和皮质醇血清水平变化和相互关系以及对预后的影响。 方法  2 1例SHAP患者分为存活组 ( 11例 )与死亡组 ( 10例 ) ;10名老年健康志愿者为健康对照组。一旦确诊为SHAP ,于病程第 1~ 5天定时取血检测MIF、TNF а、皮质醇水平 ,动态观察神志、血压、氧合指数、机械通气时间、应激性溃疡等指标直至治愈出院或死亡 ,并进行急性生理和慢性健康 (APACHEⅡ )评分。 结果 两组神志、血压、氧合指数、机械通气时间、应激性溃疡及APACHEⅡ评分等指标差异无显著性 (P>0 0 5 ) ;第 1、2、3天死亡组血清MIF水平显著高于存活组 (P =0 0 0 4、P =0 0 16、P =0 0 0 2 ) ,第4、5天差异无显著性 (P >0 0 5 ) ,两组各时间点上述指标均高于健康对照组 (P <0 0 5 ) ;死亡组血清TNF α水平高于存活组 (P <0 0 5 ) ,两组均高于健康对照组 (P <0 0 5 ) ;SHAP两组血清皮质醇水平差异无显著性 (P >0 0 5 ) ,均高于健康对照组 (P <0 0 5 ) ;第 1~ 4天血清MIF与TNF α水平呈显著正相关 (r =0 6 2 1、0 6 97、0 5 4 4、0 5 5 7;P <0 0 0 0 1,P <0 0 0 0 1,P =0 0 11,P =0 0 0 9) ;血清MIF与皮质醇水平无显著?

 
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