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效应细胞
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  effector cell
    Using the spleen lymphocyte of the immunized mice as the effector cell and P815 cell expressing the structural protein of HIV-1 as the target cell,the specific CTL cytotoxicity activities of spleen lymphocytes in the immunized mice were measured by the method of lactate dehydrogenase(LDH) release assay.
    以免疫小鼠的脾淋巴细胞为效应细胞,以表达HIV- 1结构蛋白的P815细胞为靶细胞,用乳酸脱氢酶释放法测定免疫小鼠脾特异性CTL杀伤活性。
短句来源
    These evidences suggest that anti CGL McAbs are able to influence mRNA expressions of LPS induced cytokines by blockade of the combination of LPS with effector cell,and consequently reduce its production.
    提示抗细菌核心糖脂域McAb可通过与LPS的结合而中和LPS作用于效应细胞,从而降低或阻碍了效应细胞中IL-1mRNA的表达,达到抑制细胞释放IL-1的作用。
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    The results demonstrated that the release of chromium from target cells was an effector cell depended phenomenon and were similar to the CTL activities of mice infected with Hantaan virus.
    CTL活性检测结果表明 :靶细胞51Cr的释放是效应细胞依赖性的 ,并且与病毒感染组的淋巴细胞的细胞毒活性相似。
短句来源
  effector cells
    Effector cells (including splenocytes,peritoneal macrophages and LAK) were prepared from the inbred Km mice.
    并从近交系Km小鼠中制得效应细胞,包括小鼠脾淋巴细胞、腹腔巨噬细胞以及LAK细胞。
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    U14 cells were incubated with hybridoma culture supernatantcontaining AU1.41 at 370C for 30mm, and each of all three effector cells was added to thecultures respectively using effectors targets ratios of 25 1. MTT colorimetric assay wasapplied to the study of cytotoxicity of effector cells to U14 cells by incubation for 4hrs, 24hrs and48hrs respectively.
    将含AU_(14-1)的培养上清,与U14细胞在37℃孵育30分钟后,分别加入上述三种效应细胞,效:靶为25:1,用MTT比色法测试孵育4小时、24小时、48小时后的细胞毒效应。
短句来源
    The mature T cells also underwent a differentiation stage to develop into effector cells.
    成熟T细胞发展为效应细胞,方经历分化阶段。
短句来源
    Natural killer T cells (NKT) are a specialized population of α/β T cells that coexpress receptors of the natural killer (NK) lineage and have the unique potential to secret very rapidly large amounts of cytokines providing early help for effector cells and regulating the TH1 or TH2 differentiation in immune response.
    NKT细胞(natural killer T cells)是一类表达NK细胞表面分子标志的α/βT淋巴细胞,具有迅速分泌大量细胞因子的能力,能够对效应细胞提供早期的辅助以及在一些免疫反应中调控TH1或TH2辅助细胞的分化。
短句来源
    Results The frequency of effector cells to secrete IFN gamma in response to Flu peptide can be increased when the CD8 + T cells were separated from PBMC before antigen stimulation than the CD8 + T cells were separated from PBMC after antigen stimulation ( P <0.05).
    结果 CTL诱导时 ,效应细胞先分离出CD8+ T细胞组获得的Flu抗原特异的细胞频数要高于CTL诱导后再分离出CD8+ T细胞组 (P <0 .0 5 ) ;
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  “效应细胞”译为未确定词的双语例句
    A minima of SEB can stimulate 5%~20% T lymphocyte not specifically and induce a mass of cytokines(IL-2、IL-4、IL-10、INF-γ and TNF-α) release, promote CTL cells to functional cells and activate NK cells, lead to tumor cells lysis.
    因此微量的SEB就可非特异性地激活5-20%的T细胞,释放大量的细胞因子,促进CTL细胞成为效应细胞并激活NK细胞,从而产生强大的抗肿瘤效应。
短句来源
    Protein h P 2M was refolded with dialysis while protein HB with dilution at the presence of h P 2M and nonapeptide. After being condensed with ultrafiltration protein HB was added to the mixture cells of NK92 and K562 at a final concentration 10 μ g/ml in the solution.
    重组融合蛋白HLA-G1在与hβ 2M稀释法共复性,超滤浓缩后,在10μg/ml的浓度下,分别以NK92和K562细胞为效应细胞和靶细胞,在5:1和2.5:1的效靶比例下,用乳酸脱氢酶法(LDH法)测定NK细胞对K562细胞的杀伤活性。
短句来源
    When sensitized lymphoid cells were incubated with target cells at a ratio of 100:1,up to 80 percent of the incorporated label was released within 4.5 hour.
    效应细胞与靶细胞作用的条件是:效靶比100:1,作用时间4.5小时。
短句来源
    おactivated killer (TAK) cells were tumorkilling effectors with high cytolytic activity induced by antiCD3 monoclonal antibody and interleukin2 coactivation.
    TAK(Tactivatedkiler,TAK)细胞是由抗CD3单克隆抗体和rIL2共同激活诱生的具有高度溶细胞活性的肿瘤杀伤效应细胞
短句来源
    Results:The mutant H280I had higher IL 6 binding ability than that of wtsIL 6R,but showed antagonistic function on IL 6 signal transdution.
    结果:突变体H280I比天然sIL6R具有更高的IL6结合能力,但拮抗IL6在两种效应细胞系上的信号传递功能。
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  effector cell
These therapeutic strategies are designed to stimulate dendritic cell proliferation, promote antigen uptake and processing, stimulate an effector cell response via direct antigen presentation, or target tumor cells via antibody therapy.
      
Results indicate that schistosomes restrict effector cell adhesion through developmental, sexual, and regional differences in adhesive properties.
      
The structural rigidity of the effector cell is an important determinant of these functions.
      
The human lung mast cell is known to be a critical effector cell in the mediation of asthma.
      
Acute graft-versus-host disease (GVHD) conceptually may be divided into three evolutionary stages: allostimulation, effector cell homing to specific tissues, and cellular targeting and injury.
      
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  effector cells
And their suppression on the proliferation of CD4+CD25- T effector cells was analyzed by cell proliferation assay in vitro.
      
Opioidergic mechanisms are involved in responses to nociceptive and antigenic stimuli at all levels and stages (from peripheral nociceptors to the cerebral cortex and from the precursors of immunocompetent cells to mature effector cells).
      
Nitric oxide (NO) is a mobile, highly reactive signal molecule, and changes the expression of specific genes in effector cells.
      
The regulatory controls comprise the receptor cells recognizing the external and internal signals, the tissues of connection channels, the effector cells, and the feedback loop elements.
      
A novel cytokine fusion protein was constructed by fusing granulocyte macrophage colony stimulating factor (GM-CSF) with monocyte chemotactic activating factor (MCAF), which acts as a factor directing effector cells (monocytes) to a target site.
      
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The murine thymocyte subsets, defined by their physical properties coupled with cell surface markers, were extensively analyzed by using Flow Cytometry. The functional capability of the FACS sorted thymocyte subsets was quantitatively estimated by using our "Universal" limit-dilution assay, which gave clonal efficiency of 100% for spleen T cells. The small size cortical-type thymocytes were immunoincompetent, as assessed by the frequency of proliferstive T cell precursors (PTL-p) and of cytotoxic T cell precursors...

The murine thymocyte subsets, defined by their physical properties coupled with cell surface markers, were extensively analyzed by using Flow Cytometry. The functional capability of the FACS sorted thymocyte subsets was quantitatively estimated by using our "Universal" limit-dilution assay, which gave clonal efficiency of 100% for spleen T cells. The small size cortical-type thymocytes were immunoincompetent, as assessed by the frequency of proliferstive T cell precursors (PTL-p) and of cytotoxic T cell precursors (CTL-p). A small group of transitional cells in the thymus outer cortex expressed low function. 99% of functional precursors were enriched in the medullary-type thymocytes. Thymus migrants were fully functional. The functional dissection of T cell subsets was accomplished in the thymus medulla. A hypothesis of intra-thymic T cell differentiation pathway has been proposed.1 L 2 was not able to induce either pre-T cells or cortical thymocytes into function.The mature T cells also underwent a differentiation stage to develop into effector cells. The generation of CTL from CTL-P required the supply of exogeneous T cell differentiation factors. The effector CTL were revealed to express the characterization and function of NK cells, implying the functional modification could take place in the late phase of effector T cells.

按物理特征及细胞表面标志,应用流式细胞计,对小鼠胸腺细胞亚群进行了详尽的分析;应用高克隆效应的“万能”有限稀释试验系统,精确研究了FACS分离的各胸腺细胞亚群的功能状态。功能定量测定指标为各亚群细胞所表达的增殖T细胞前体频数及杀伤T细胞前体频数。小型胸腺皮质细胞是免疫无能的;胸腺外皮质区的大型迁移细胞有低微功能;99%功能细胞前体为髓质型胸腺细胞;胸腺迁出细胞已完全功能成熟。胸腺髓质细胞已完成T细胞亚群的功能分工,为此提出胸腺内T细胞功能分化假说,IL 2不足以介导 Pre-T及胸腺皮质细胞的分化。 成熟T细胞发展为效应细胞,方经历分化阶段。CTL-P分化为CTL,需要外源性T细胞分化因子的提供。效应 CTL可表现有NK细胞的特征及杀伤功能,表明T细胞在效应后期亦可修饰其功能作用。

The abilities of McAbs to enhance the phagocytosis of Plasmodium falciparum by peritoneal macrophages and the killing of parasites by peritoneal cells free of adherant cells were evaluated by in vitro assay. Four of six McAbs, which recognized parasite antigens expressed only on segmentors and free merozoites of P. falciparum by immuno-fluorescence, augmented the phagocytosis of the parasites 2-4 times that of SP2/0 ascitic fluid. Enhanced McAbs-media ted phagocytosis as a result of opsonization of the parasite...

The abilities of McAbs to enhance the phagocytosis of Plasmodium falciparum by peritoneal macrophages and the killing of parasites by peritoneal cells free of adherant cells were evaluated by in vitro assay. Four of six McAbs, which recognized parasite antigens expressed only on segmentors and free merozoites of P. falciparum by immuno-fluorescence, augmented the phagocytosis of the parasites 2-4 times that of SP2/0 ascitic fluid. Enhanced McAbs-media ted phagocytosis as a result of opsonization of the parasite was demonstrated by preincubating macrophages with McAbs prior to the phagocytic assay. Four of seven McAbs examined showed cytotoxic activity on P. Jalciparum. Peritoneal cells free of adherent cells were capable of killing the parasites in the presence of McAb. The results indicate that there may be "mono-function", "bifunction" and "multi-function" types of McAbs against P. Jalciparum. The putative protective antigen of malaria parasite purified by "multifunctional McAb" affinity chromatotraphy may have potential interest as a vaccine against the parasite or as an immunodiagnostic material.

采用吞噬试验和细胞毒试验,对抗恶性疟原虫红内期McAb的功能特性进行了进一步研究。在7株McAb中,93A3、94B5、94C3和94D1明显地促进免疫和正常小鼠腹腔巨噬细胞对疟原虫的吞噬。腹腔细胞与McAb预吸附试验表明,这种作用是McAb的调理作用。92D2、93A3、94B5和94C3等与腹腔细胞有协同抑制疟原虫生长的作用,并能加强效应细胞杀伤疟原虫而发挥细胞毒作用。用“多功能性McAb”纯化相应抗原,制备亚单位疫苗,以及作为诊断试剂开展血清流行病学研究,可能更有意义。

Take Japanese B encephalitis virus (JEV) infected BHK21 cells as targetcell, mice spleen cells as effect cell, measure the activities of 6 Japanese B encephalitis virus monoclonal antibodies ( JEV-McAb ) to mediate the ADCC effect. The result shows that the species specific and genus specific JEV-McAb such as 2H4, 2F2, nG2 and mG9 do not have the activities of mediating the releasing of 51Cr. The ADCC effect is mediated by two of the subgroup specific JEV-McAb mC3 and 2D2. And the activities of inC3 and 2D2...

Take Japanese B encephalitis virus (JEV) infected BHK21 cells as targetcell, mice spleen cells as effect cell, measure the activities of 6 Japanese B encephalitis virus monoclonal antibodies ( JEV-McAb ) to mediate the ADCC effect. The result shows that the species specific and genus specific JEV-McAb such as 2H4, 2F2, nG2 and mG9 do not have the activities of mediating the releasing of 51Cr. The ADCC effect is mediated by two of the subgroup specific JEV-McAb mC3 and 2D2. And the activities of inC3 and 2D2 are different in mediating the ADCC effect. There are no avident relationship between ADCC and HI, NT. The ADCC activity is another immunological property of the JEV-McAb. After the infction of JEV the ADCC activity of mice spleen cells gradully gose down. This perpase is related to JEV's pathogenicity. In the course of JEV infection, ADCC effect has some protective functions, but it lies in the second position compared with the neutralization.

以日本乙型脑炎病毒(JEV)感染的BHK_2,细胞为靶细胞,小鼠脾细胞为效应细胞,测定了6株日本乙型脑炎病毒单克隆抗体(JEV-McAb)介导ADCC效应的活性。结果表明,2H_4、2F_2、nG_2、mG_9等种特异性及属特异性McAb无介导~(51)Cr释放的活性,而mC_3及2D_2两株亚组特异性McAb可介导ADCC效应;但mC_3和2D_2介导ADCC效应的活性也不相同。JEV-McAb的ADCC活性与血凝抑制(HI)、中和(NT)等功能之间无明显的关系,它是JEV-McAb的又一免疫学特征。小鼠感染JEV后,其脾细胞的ADCC活性下降,这可能与JEV的致病性有关。在JEV感染中,ADCC效应具有一定的保护功能。

 
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