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效应细胞
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  effect cells
    Biological characters of the cells were studied in comparison of TAK,CD 3 AK,LAK,the results showed that the effect cells,TAK,CD 3 AK and LAK proliferated to 40.2 folds,41.7 folds,32.4 folds,21.5 folds in number respectively;
    结果显示培养到第10d时,实验组效应细胞,TAK细胞,CD3AK细胞和LAK细胞的增殖活性分别为40.2倍,41.7倍,32.4倍和21.5倍;
短句来源
    RESULTS: The killing rate of the bispecific monoclonal antibody induced effect cells to target cells was 61.23%, which was higher than that of the anti-CD3 (42.15%)(P<0. 01). This killing rate enhanced along with the elevation of efect-target radio (78.96%).
    结果 :该双功能抗体介导效应细胞对靶细胞的杀伤率为 6 1.2 3% ,高于单抗CD3(4 2 .15 % )的介导作用 (P <0 .0 1) ,并随着效靶比的提高杀伤率也升高 (78.96 % ) .
短句来源
    h. Cytotoxic activity was evaluated by MTT assay. Results (1) Cytotoxicity activities of effect cells stimulated by a certain values of rIL-2, anti-CD3 McAb and anti-CD28 scFv (VH) were stronger than those stimulated with scBsAb alone.
    结果  (1)以重组白细胞介素 2 (rIL 2 )、抗CD3单克隆抗体、抗CD2 8重链单域抗体 (VH)预刺激Jurkat及PBMC细胞比单纯用scBsAb激活效应细胞杀伤活性高 ;
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  “效应细胞”译为未确定词的双语例句
    The response of PBMC treated with PHA-P to exogeneous IL-2 was significantly decreased in the presence of TDSF, suggesting that TDSF can inhibit the action of IL2.The effect of PBMC after being stimulated with PHA-P was significantly suppressed by TDSF in does-dependent manner.
    当TDSF存在时,经PHA-P驯化的PBMC效应细胞对外源性IL-2反应显著减弱,表明TDSF能抑制IL-2的作用。 PHA-P刺激PBMC增殖,但TDSF使其增殖抑制。
短句来源
    cytotoxicity of the cells,TAK,CD 3 AK and LAK against ovarian carcinoma cells were 81.2% ,82.5%,54.3%,56.7% respectively,cytotoxicity of the cells against ovarian carcinoma cells COC1,COC2,SKOV3 and A2780,were 83.1%,51.4%,37.6% and 49.7% respectively.
    对卵巢癌COC1细胞的细胞毒活性分别为81.2%,82.5%,54.3%和56.7%。 实验组效应细胞对4种卵巢癌细胞COC1,COC2,SKOV3和A2780的细胞毒活性分别为83.1%,51.4%,37.6%和49.7%。
短句来源
    In 4 cases,the toxicity effect of T cells in MINI-DC group,at effect-target ratio of 20∶1,on auto-tumor cells wa s 25%-100%,higher than those on SKOV3 cells (5%-51%),HLE cells (2%-38%) ,and K562 cells (2%-25%).
    在效靶比为20∶1时,各组不同的效应细胞对自体肿瘤细胞的杀伤率分别为:MINI-DC-T组25%~100%、F(ab)2-DC-T组18%~40%、unpulsed-DC-T组13%~43%、T细胞组9%~58%,MINI-DC-T组高于其它各组。
短句来源
    Results The interferon-γ enhanced the specific CTL lysis of the tumor cell in a dose-dependent manner and also increased the expressions of HLA-A2 and CD54 on the tumor cell.
    结果γ干扰素可剂量依赖性地增强宫颈癌细胞对特异性效应细胞杀伤作用敏感性,并能增加宫颈癌细胞HLA-A2分子和CD54的表达。
短句来源
    Conclusion Interferon-γ can enhance the susceptibility of the cervical tumor cell to CTL lysis, and the mechanisms are associated with the enhanced expression of HLA-A2 and CD54 on the tumor cell surface.
    结论γ干扰素可增强宫颈癌细胞对特异性效应细胞杀伤作用的敏感性,其作用机制与其上调宫颈癌细胞表面HLA-A2分子和CD54分子表达有关。
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The tumor infiltrating lymphocytes (TIL) in histologic slides from 94 patients with ovarian malignancies were observed quantitatively with a light microscope for their relationship to the prognosis of human ovarian malignancies. The degree of lymphocyte infiltration directly affected patient's survival and it was closely related to clinical staging, cell grading, and histologic classification. The T lymphocytes characterized by alpha naphthyl acetate (ANAE) staining were major cells in the stroma of ovarian...

The tumor infiltrating lymphocytes (TIL) in histologic slides from 94 patients with ovarian malignancies were observed quantitatively with a light microscope for their relationship to the prognosis of human ovarian malignancies. The degree of lymphocyte infiltration directly affected patient's survival and it was closely related to clinical staging, cell grading, and histologic classification. The T lymphocytes characterized by alpha naphthyl acetate (ANAE) staining were major cells in the stroma of ovarian malignancies. The ultrastructures of TIL and cancer cells were investigated under an electron microscope. It was thereby confirmed that tumor cell damage was associated with TIL.

本文观察94例卵巢恶性肿瘤组织切片中肿瘤浸润淋巴细胞(TIL)与卵巢恶性肿瘤预后的关系。结果表明淋巴细胞浸润程度直接影响患者的预后,并与肿瘤的临床分期,细胞分级和组织类型密切相关。α-醋酸萘酯酶染色显示T淋巴细胞是肿瘤间质中的主要效应细胞。在电镜水平上分析TIL与肿瘤细胞的超微结构,进一步证实肿瘤细胞退化溶解与TIL有关。

short time lymphocyte culture for lymphokineactivated killer (LAK) cells was presented , the lympho-cytes being collected from the tumor draining regionallymph nixles in seven patients with gynecologic malig-nant tumors. The results showed different cytotoxic ac-tivities of LAK cells against Lewis pulmonary cacercells ,CAOV_3 cells and the new separated ovarian cacercells. And the cytotoxic activity of the LAK cells in-creased with the rise of the effecter cell-target cell ratioand maintained at a certain level...

short time lymphocyte culture for lymphokineactivated killer (LAK) cells was presented , the lympho-cytes being collected from the tumor draining regionallymph nixles in seven patients with gynecologic malig-nant tumors. The results showed different cytotoxic ac-tivities of LAK cells against Lewis pulmonary cacercells ,CAOV_3 cells and the new separated ovarian cacercells. And the cytotoxic activity of the LAK cells in-creased with the rise of the effecter cell-target cell ratioand maintained at a certain level when the rise of thelatter's increase reached a certain extent. The cytotoxicactivity of the LAK cells against autologous tumor cells(as from ovarian cancer) were shown to be muchstronger than against the others. As the culture dayslengthened , the cytotoxicities of the LAK cells from interleukinZIOKT 3 culture bacame stronger than frominterloukin-2 alone. Large quantities of lymphocytescould be collected from tumordraining lymphe nixles.This is a preliminary investigation on the inducing ofLAK cells from lymphocytes of the draining regionallymph nedes of malignant gynecologic tumors. Thequantitative increase of LAK cells and the effect of theircytotoxic activities are to be further explored.

对7例妇科恶性肿瘤患者肿瘤引流区域淋巴结的淋巴细胞,在体外进行短期淋巴因子激活杀伤(LAK)细胞的诱导培养。结果表明,LAK细胞对肺癌细胞系、卵巢癌CAOV_3细胞系及新分离的卵巢癌细胞杀伤能力不同,且效应细胞与靶细胞比例在40:1以上时,LAK细胞活性维持在一定水平;该LAK细胞对同种分离卵巢癌细胞杀伤能力更强。白细胞介素。2(IL-2)和OKT_3联合应用诱导LAK细胞,随着培养时间的延长,其杀伤靶细胞的能力强于单独使用IL-2诱导的LAK细胞。肿瘤引流区域淋巴结经分离可获得大量的淋巴细胞。

serial observation was made by means of inverted microscopy on the mixtureof cultured TIL, K562 and tumor cells from patients with ovarian cancer. The authorshad observed the whole interaction between the effect cells and the target cells, andfound out same killing process of TIL on K562 and tumor cells from cancer patients,but the killing speed was different. The killing speed of TILs from serous cystadeno- carcinoma against autologous tumor cells was fast, that of TILs against all ogeneicovarian tumor cells...

serial observation was made by means of inverted microscopy on the mixtureof cultured TIL, K562 and tumor cells from patients with ovarian cancer. The authorshad observed the whole interaction between the effect cells and the target cells, andfound out same killing process of TIL on K562 and tumor cells from cancer patients,but the killing speed was different. The killing speed of TILs from serous cystadeno- carcinoma against autologous tumor cells was fast, that of TILs against all ogeneicovarian tumor cells was less fast, and that of TILs from mucinous adenocarcinomaagainst tumor cells from adenocarcimona was slow. this observation will be helpfulto clinical treatment

本实验以卵巢浆液性囊腺癌及粘液性腺腺癌TIL细胞作为效应细胞,卵巢浆液性细胞及K562细胞作为靶细胞,采用单个细胞毒实验法,连续观察了效应细胞和靶细胞的结合及杀伤过程,发现TIL杀伤K562细胞及新鲜分离的肿瘤细胞具有相似的形态变化过程,但是变化速度存在着差异,其中浆液性囊腺癌TIL细胞杀伤自体肿瘤细胞形态变化最快,其次是杀伤异体同一组织类型细胞,最差的粘液性囊腺癌的TIL细胞杀伤异体浆液性囊腺癌细胞,这有助于指导临床治疗。

 
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