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效应细胞
相关语句
  effector cell
    T lymphocyte is the main effector cell of cellular immunity.
    T淋巴细胞是细胞免疫的主要效应细胞
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  “效应细胞”译为未确定词的双语例句
    Conclusions As a new type of killer cells, PHA CD3AK cells have some advantages over the control group CD3AK cells in proliferation, cytotoxicity against BT325, and the utilizing amount of IL 2, indicating the synergistic enhancing role of PHA, CD3 and IL 2. The application of PHA CD3AK cells might open a new prospect to clinical therapeutic approach for maligant gliomas.
    结论 PHA、CD3和IL 2具有协同增强作用 ,使PHA CD3AK细胞成为较CD3AK细胞增殖能力、杀伤活性更强的免疫效应细胞 ,且IL 2用量减少 ,为胶质瘤的过继免疫治疗打下了理论基础
短句来源
    Methods A new type of killer cells,named CD3AK cells was induced by means of costimulating the peripheral blood mononuclear cells with CD3 and IL-2.Some biological characteristics of CD3AK cells were compared with control group LAK cells.
    方法 用CD3和rIL - 2共同诱导人外周血单个核细胞 ,诱导、扩增新型抗胶质瘤效应细胞CD3AK细胞 ,并与LAK细胞在某些生物学方面进行了比较。 结果 两组效应细胞增殖曲线均于第 6天达高峰 ,峰值可见 ,CD3AK细胞 >LAK细胞 (P <0 0 5 ) ;
短句来源
    Conclusion There are the limitary shared of T-cell receptor(TCR) gene Vα7 and Vβ14 in TIL of glioma. The TCR subtypes of Vα7 and Vβ14 may be the major immune cell in local antitumor respone.
    结论 人脑胶质瘤 TIL 存在着抗原受体基因 Vα7、Vβ14的优势取用 ,表达这一 TCR亚型的 TIL 可能是局部抗肿瘤反应的主要效应细胞
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    Proliferation of oligodendrocyte precursor and the dosage-dependent inhibition of lead,mercury and the effect of cytotoxicity: changes of cellular quantity,cellular morphology,superficial markers during the developmental course
    少突胶质前体细胞的增殖与铅、汞、镉剂量依赖性抑制作用及其细胞毒性效应:细胞数量、细胞形态、表面标志物在发育过程中的变化
短句来源
    TNF α/GIL have various inhibitory efficiencies to the growth of tumor in nude mice. Human glioma infiltrating lymphocytes transduced by TNF α gene may be a useful antitumor effector to human glioma.
    因此,TNF-α基因转染的人脑胶质瘤浸润淋巴细胞(TNF-α/GIL)是脑胶质瘤免疫基因治疗的一种有效的效应细胞
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  effector cell
These therapeutic strategies are designed to stimulate dendritic cell proliferation, promote antigen uptake and processing, stimulate an effector cell response via direct antigen presentation, or target tumor cells via antibody therapy.
      
Results indicate that schistosomes restrict effector cell adhesion through developmental, sexual, and regional differences in adhesive properties.
      
The structural rigidity of the effector cell is an important determinant of these functions.
      
The human lung mast cell is known to be a critical effector cell in the mediation of asthma.
      
Acute graft-versus-host disease (GVHD) conceptually may be divided into three evolutionary stages: allostimulation, effector cell homing to specific tissues, and cellular targeting and injury.
      
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We report the changes of phenotype and antitumor cytolytic activity of glioma-infiltrating lymphocytes(GIL)before and after recombinant interleukin-2(rIL-2)and thymic factor D(TFD).The results indicated that(a)GIL could be isolated from the human gliomas and proliferate after initiated in vitro;(b)most of fresh GIL were T lymphocytes,in which CD8 cells were more than CD4 cells, while the former became declining and the latter growing with time prolonged in culture;(c)killing activity of fresh GIL was weak,but...

We report the changes of phenotype and antitumor cytolytic activity of glioma-infiltrating lymphocytes(GIL)before and after recombinant interleukin-2(rIL-2)and thymic factor D(TFD).The results indicated that(a)GIL could be isolated from the human gliomas and proliferate after initiated in vitro;(b)most of fresh GIL were T lymphocytes,in which CD8 cells were more than CD4 cells, while the former became declining and the latter growing with time prolonged in culture;(c)killing activity of fresh GIL was weak,but that of initiat ed GIL was strong;(d)TFD could potentiate the initiated roles of rIL-2.Therefroe,it is reasonable to believe that GIL will be used as an ideal effector cells in the treatment of human brain gliomas.

经重组白细胞介素2(rIL-2)和胸腺因子D(TFD)培养前后的人脑胶质瘤浸润淋巴细胞(GIL)的表型及抗自体瘤细胞活性变化。(1)GIL可被分离,培养后可增值;(2)新鲜GIL主要为T淋巴细胞,其中CD+8细胞多于CD4细胞,随培养时间延长呈相反变化;(3)新鲜GIL活性很弱,培养后很强;(4)TFD可能只有增强rIL-2的激活作用。提示GIL可望作为理想的效应细胞用于脑胶质瘤的治疗。

Objective To investigate the role of T lymphocyte subsets and the adhesion molecules in the pathogenesis of the experimental allergic neuritis (EAN). Methods The animal model was induced in rats by immunization with myelin emulsion of rabbit′s sciatic nerve. The Antibody to intercellular adhesion molecule 1 (ICAM 1) was injected to the rats before inducing of EAN. The manifestations of the animals and the pathological changes were observed and compared with the group which was not injected with the antibody...

Objective To investigate the role of T lymphocyte subsets and the adhesion molecules in the pathogenesis of the experimental allergic neuritis (EAN). Methods The animal model was induced in rats by immunization with myelin emulsion of rabbit′s sciatic nerve. The Antibody to intercellular adhesion molecule 1 (ICAM 1) was injected to the rats before inducing of EAN. The manifestations of the animals and the pathological changes were observed and compared with the group which was not injected with the antibody and with the control group. The distributions of CD4 positive T cells and CD8 positive T cells and the expressions of adhesion molecules on the infiltrating T cells in blood and peripheral nerve tissue.Results (1) The treatment with monoclonal antibody to ICAM 1 suppressed the active EAN. The histological sections of the peripheral nerve tissue showed a pronounced reduction of the inflaminatory infiltrates treated with the antibody to ICAM 1. The semi thin sections also confirmed the same finding. (2) The animals treated with antibody to ICAM 1 showed lower expressions of adhesion molecules on CD4 + cells in the impaired tissue but not in the peripheral blood than the naturally attacked group. (3) There are prevalently higher expressions of CD54 and CD11a on CD4 + cells but not CD8 + cells in the impaired tissue than peripheral blood. (4) The impaired tissue showed higher CD4 +/CD8 + in the naturally attacked animals than in those pretreated with the antibody to ICAM 1, though the peripheral blood showed differeat results. Conclusions (1) CD4 positive T cells acted primarily in the immune response of EAN. (2) The espressions of ICAM in CD4 positive T cells might be remarkably involved in the pathogenesis of EAN. (3) The ICAM 1 antibody to adhesion molecules might be of use in the approach to the autoimmune disease such as EAN.

目的探讨T细胞亚群及粘附分子在实验性变态反应性神经炎(EAN)中的作用。方法用兔坐骨神经匀浆免疫Wistar大鼠,建立EAN模型;同时用抗细胞间粘附分子-1(ICAM-1)单抗注入大鼠后再诱导EAN。观察自然病程组、抗体注射组及对照组动物的临床病理。用双重酶标免疫组化技术检测CD4+、CD8+T细胞分布以及粘附分子CD54、CD11a、CD62在CD4+及CD8+细胞上的表达。结果抗体注射组发病率及发病程度明显低于自然病程组;组织中粘附分子在CD4+细胞上的表达及CD4+/CD8+自然病程组高于抗体注射组;CD54、CD11a在CD4+细胞上的表达高于CD8+细胞。结论CD4+细胞是主要的效应细胞,CD4+细胞上粘附分子的表达对效应T细胞进入病变组织起主导作用;抗ICAM-1抗体能够预防EAN发生。

In order to study the antitumor activity of human glioma infiltrating lymphocytes (GIL) transduced by TNF α gene, retroviral vector PLTSN with Neo r gene driven by SV 40 early promoter, TNF α gene driven by LTR and packaging cell line PA 317 were used to clone cell line LTSN/PA317 producing LTSN at high titer. The recombinant glioma, to have a king of GIL (TNF/GIL) for production of TNF α at certain level. Inject TNF α/GIL into the body for nude mice through abdominal cavity or in the site of the tumor...

In order to study the antitumor activity of human glioma infiltrating lymphocytes (GIL) transduced by TNF α gene, retroviral vector PLTSN with Neo r gene driven by SV 40 early promoter, TNF α gene driven by LTR and packaging cell line PA 317 were used to clone cell line LTSN/PA317 producing LTSN at high titer. The recombinant glioma, to have a king of GIL (TNF/GIL) for production of TNF α at certain level. Inject TNF α/GIL into the body for nude mice through abdominal cavity or in the site of the tumor respectively. In vitro, before later transduction, the growth and expression of GILs surface markers showed no significant difference from TNF α/GIL, while the transduced GIL/(tnf/GIL) grows successfully in high concentration of G 418, suggesting TNF α/GIL contain Neo r cDNA; TNF α/GIL has two to five folds of cytotoxicity to SHG 44 or autoglioma cells compared with GIL+IL 2; TNF α/GIL have various inhibitory efficiencies to the growth of tumor in nude mice. Human glioma infiltrating lymphocytes transduced by TNF α gene may be a useful antitumor effector to human glioma.

应用脂质体转染技术构建能表达肿瘤坏死因子-α(TNF-α)基因的重组逆转录病毒。采用鱼精蛋白促进法,将重组病毒介导TNF-α基因转染人脑胶质瘤浸润淋巴细胞(GIL)。在体外,转染后的GIL(TNF-α/GIL)的抗肿瘤活性比GIL+IL-2强2~5倍。在荷瘤裸鼠体内,TNF-α/GIL能显著抑制肿瘤生长。因此,TNF-α基因转染的人脑胶质瘤浸润淋巴细胞(TNF-α/GIL)是脑胶质瘤免疫基因治疗的一种有效的效应细胞

 
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