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蟾蜍心脏
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  toad heart
     When M1 and M2 receptors in an isolated toad heart were blockade, the excitative effect obviously was produced by 10-3M Ach in which the contraction was enhanced and increased.
     离体蟾蜍心脏在阻断M_1和M_2受体条件下,10~(-3)M的Ach可产生收缩明显增强伴频率增快的兴奋作用。
短句来源
     Study on ion perfu- sion experiments showed that the effects of the toad heart in vitro suggested that YFM could inhibit the inflow of Ca~(2+)and Na~+ in myocardial cell.
     离体蟾蜍心脏离子灌注实验表明,YFM 可能对心肌细胞 Ca~(2+)和 Na~+内流有抑制作用。
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     Using magnetic field to the isolated toad heart for 20min.
     以磁场作用于改良斯氏灌流的离体蟾蜍心脏20min。
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     Under certain conditions the 10~(-3)mol / L CaCI_2, KCI, morphine chloride and 5-HT chloride can induce inhibition on the toad heart in vitro, and the inhibition may be restrained by a blocker of CI~- channels-Furosemide.
     本文结果发现,10~(-3)mol/L的CaCl_2、KCl、氯化吗啡和氯化5-HT,对离体蟾蜍心脏均可产生抑制作用。 该作用可被Cl~-通道阻断剂速尿所阻抑;
短句来源
     A Study on the Positive Inotropic Action of Phycocyanin on Isolated Toad Heart
     藻蓝蛋白对离体蟾蜍心脏正性肌力作用研究
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  “蟾蜍心脏”译为未确定词的双语例句
     THE EFFECT OF THE AGONIST OF 5-HT_1, 5-HT_2, 5-HT_3 RECEPTOR ON THE HEART ACTIVITES OF TOAD
     5-HT_1、5-HT_2、5-HT_3受体激动剂对离体蟾蜍心脏活动的影响
短句来源
     METHODS:By infusion of toad hearts in vitro with 0.01-100×10 -5 mol·L -1 Ac, dose response relationship is observed.
     方法 :用 0 .0 1~ 10 0× 10 -5mol·L-1 Ac灌流蟾蜍心脏 ,观察 Ac抑制蟾蜍心脏收缩和致心律失常的量 -效反应。
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     LDH-1 predominates in heart of Bombina oricntalis and Bufo gargarizans.
     东方铃蟾与中华大蟾蜍心脏LDH同工酶表达均以LDH-1为主;
短句来源
     Methods:Ringers solution was used to maintain the normal action of the heart,then the heart was perfused by Ringer's solution 1 ml containing pituitrin at concentration of 0.125 u/ml,0.25 u/ml,and 0.5 u/ml,and washed before adding the next dosage. The myocardiac contractile force and heart rate were recorded separately after adding each dosage.
     方法 :斯氏法游离蟾蜍心脏 ,用 1mlRinger液维持蟾蜍心脏的正常活动 ,分别加入含有垂体后叶素 0 .12 5u/ml、0 .2 5u/ml、0 .5u/ml的Ringer液 ,记录心肌收缩力和心率的变化 ;
短句来源
     The dose-response reaction of NE, ACh, CaCl2 & KC1 was observed in isolated toad hearts.
     在离体蟾蜍心脏上,研究生物活性物质(NE,ACh,CaCl_2,KCl)的量—效关系。
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  相似匹配句对
     A PRELIMINARY INVESTIGATION OF THE MECHANISM OF THE EPINEPHRINE-INDUCED INHIBITION ON TOAD HEARTS
     肾上腺素抑制蟾蜍心脏机理初步探讨
短句来源
     Study on the alcohol concentration influence on the Bufo heart activity
     探究酒精对蟾蜍心脏活动的影响
短句来源
     CARDIAC AMYLOID OSIS
     心脏淀粉样变性病
短句来源
     BLOOD APPEARANCE OF TOAD
     蟾蜍的血象
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     The Heart of a Family
     家之心脏
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  toad heart
Resistance of adrenergic neurotransmission in the toad heart to adrenoceptor blockade
      
Stimulation of sympathetic nerves to the toad heart produced increases in both the rate and force of cardiac beat.
      
Therefore, in addition to its action on β-receptors, adrenaline seems to be producing excitation of the toad heart by acting on adrenoceptors which cannot be classified as either α-or β-receptors.
      
Modification of vagal action on the toad heart by changes in flow
      
Isolated, spontaneously active pacemaker cells from the sinus venosus region of the toad heart were loaded with the calcium indicator fluo-3.
      
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By continuous perfusion with calcium free Ringer solution, the activity of the hypodynamic toad heart may be augmented with certain phosphatides or soaps. Among those lipids, crude soy-bean phosphatides are most powerful. Crude egg yolk phosphatides and its alcoholic insoluble fraction and sodium or ammonium oleates are also effective; whereas the alcohol soluble fraction of egg yolk phosphatides(i.e. lecithin) and potassium oleate are ineffective. The perfusion fluids, which revive the activities of the hearts...

By continuous perfusion with calcium free Ringer solution, the activity of the hypodynamic toad heart may be augmented with certain phosphatides or soaps. Among those lipids, crude soy-bean phosphatides are most powerful. Crude egg yolk phosphatides and its alcoholic insoluble fraction and sodium or ammonium oleates are also effective; whereas the alcohol soluble fraction of egg yolk phosphatides(i.e. lecithin) and potassium oleate are ineffective. The perfusion fluids, which revive the activities of the hearts and which are drained after experiments contain about 1/8 to 1/4 the quantity of calcium of normal Ringer. Such calcium is speculated to be liberated from the cardiac tissue. In conclusion, the presence of a minute quantity of calcium in the perfusing fluid is necessary to aid the action of phosphatides in maintaining the contractility of the hearts.

(一)在無鈣任氏液中,蟾蜍心臟搏動停止,某些磷脂和皂類可以使心臟搏動恢復,並維持幾小時。 (二)在上述情况中,有效的脂類為大豆磷脂、粗製雞卵璘脂及其不溶於酒精的部分、油脂酸鈉和油脂酸銨等;溶於酒精的雞卵磷脂和油脂酸鉀,並無作用。 (三)心搏在無鈣任氏液中經磷脂作用而恢復後,鈣自心肌向灌流液釋出。 (四)心肌鈣質或灌流液中存在的微量鈣質是磷脂對心肌的興奮作用所必需。

The value of pyridine-2-aldoxine methiodide (2-PAM) as an antidote for organo- phosphorus poisoning has been well established. Here we intend to get an insight into some of its pharmacological actions other than its cholinesterase reactivating activity. In urethane anaesthetized cats, it caused excitation of respiration, elevation of blood pres- sure, contraction of nictitating membrane, and inhibition of intestinal movement. These effects were gradually weakened on repeated administration of the drug at short...

The value of pyridine-2-aldoxine methiodide (2-PAM) as an antidote for organo- phosphorus poisoning has been well established. Here we intend to get an insight into some of its pharmacological actions other than its cholinesterase reactivating activity. In urethane anaesthetized cats, it caused excitation of respiration, elevation of blood pres- sure, contraction of nictitating membrane, and inhibition of intestinal movement. These effects were gradually weakened on repeated administration of the drug at short intervals and were much reduced or even abolished by bilateral adrenalectomy, pretreatment with tolazoline, reserpine, or large doses of atropine but not with C_6. Besides, it stimulated the toad-heart and excited isolated guinea-pig ileum. The mechanism of its action was briefly discussed.

2-吡啶甲醛肟碘甲烷盐(2-PAM)为有效的有机磷解毒剂,本文对其药理作用作了初步的观察.证明对乌拉坦麻醉猫在接近临床用量时已能产生拟肾上腺素作用.连续应用多次后出现快速耐受现象.在应用抗肾上腺素药、利血平或切除两侧肾上腺后,2-PAM作用即减弱.C_6即使用至50毫克/公斤,亦不能阻断其作用,而5毫克/公斤的阿托品几能完全取消之.对离体及在位蟾蜍心脏也表现兴奋,此作用可部分地被C_6所阻断.2-PAM对离体豚鼠肠的兴奋作用,亦可被阿托品所取消.文内对其作用机制作了初步分析.

B-7601,a new synthetic anticholinergic drug, exertes an inhibitory action on the isolated heart of toads, shows antagonistic action to acetylcholine and synergitic action with isoproterenol. The coronary blood flow of the isolated rabbits heart is increased after administration. Intravenous injection of B-7601 produced the negative chronotropic and dromotropic action in rats.B-7601 shows significant therapeutic effect on the arrhythmias induced by barium chloride and aconitine in rats, its action are stronger...

B-7601,a new synthetic anticholinergic drug, exertes an inhibitory action on the isolated heart of toads, shows antagonistic action to acetylcholine and synergitic action with isoproterenol. The coronary blood flow of the isolated rabbits heart is increased after administration. Intravenous injection of B-7601 produced the negative chronotropic and dromotropic action in rats.B-7601 shows significant therapeutic effect on the arrhythmias induced by barium chloride and aconitine in rats, its action are stronger than that of atropine and scopolamine, which can also preventes the arrhythmias induces by chloroform-adrenaline in rabbits and by chloroform in mice.B-7601 has a significant local anesthetic action, its efficacy is much higher than procaine, but similar to the Dicaine. The LD-50 and ED-50 of B-7601 in mice(ⅳ) are found to be 7.15(7.12—7.19) and 0.76 (0.74—0.78) mg/kg respectively, with therapeutic index of 9.35.

B-7601为人工合成的新抗胆硷药物。它对离体蟾蜍心脏呈现抑制作用,能明显对抗乙酰胆硷作用,而与异丙肾上腺素有协同作用。B-7601能增强离体兔心冠脉流量。静注B-7601大鼠心脏呈现负性频率作用和负性传导作用。 B-7601能对抗大鼠静注氯化钡和乌头硷引起的心律失常,并其作用强于阿托品和东莨菪硷。B-7601尚能明显抑制小鼠吸入氯仿诱发的室性纤颇和氯仿一肾上腺素引起的家兔心律失常。 B-7601具有明显的表面麻醉作用,其作用强于普鲁卡因,约相当于的卡因。 小鼠静注B-7601的ED_(50)为0.76(0.74-0.78)mg/kg,LD_(50)为7.15(7.12-7.19)mg/kg,其治疗指数为9.35。

 
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