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局部晚期宫颈癌
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  locally advanced cervical cancer
     Methods Twenteen patients dignosed by pathology with locally advanced cervical cancer in stage Ib-IIIb were treated with paclitaxel 135-175 mg/m~2 over 3 hours and cisplatin50-75 mg/m~2 for 2 cycles and followed by operation.
     方法选择病理确诊的12例Ⅰb~IIIb期局部晚期宫颈癌患者,行紫杉醇+顺铂化疗,紫杉醇135~175mg/m2,顺铂50~75mg/m2,此方案化疗2个疗程后手术,观察近期的疗效。
短句来源
     Methods:The expression of Ki67 and Bax protein were evaluated in tumor samples by immunohistochemistry before and after NACT in 23 patients with locally advanced cervical cancer.
     方法:在新辅助化疗(neoad juvant chemotherapy,NACT)前后用免疫组化方法检测23例局部晚期宫颈癌组织K i67和Bax的表达。
短句来源
     To study the correlation of the expression of Bax protein before and after neoadjuvant chemotherapy with clinical effect, the expression of Bax protein was evaluated in tumor samples by immunohistochemistry in 23 patients with locally advanced cervical cancer before and after neoadjuvant intraarterial chemotherapy.
     探讨Bax蛋白与宫颈癌新辅助化疗疗效之间的关系,用免疫组化方法检测23例局部晚期宫颈癌组织新辅助化疗前后Bax蛋白的表达。
短句来源
     Background and Objective: Neoadjuvant chemotherapy (NACT) for stage I b bulky tumor and locally advanced cervical cancer can decrease clinical stage and improve the effectiveness of the surgery. Neoadjuvant chemotherapy is usually carried out by intravenous or intra-arterial methods. COX-2 is the necessary enzyme for the synthesis of prostaglandins.
     背景和目的:宫颈癌的新辅助化疗(neoadjuvant chemotherapy,NACT),即宫颈癌手术前或放疗前进行化疗,对于宫颈局部肿瘤巨大的ⅠB期和局部晚期宫颈癌患者,可降低临床分期,提高可手术率。
短句来源
     Methods: Twenty three patients with locally advanced cervical cancer accepted one cycle chemotherapy of "TP" for cervical cancer before operation.
     方法:23例局部晚期宫颈癌患者,术前采用“TP”方案化疗1疗程后行子宫颈癌根治术。
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  locally advanced carcinoma of the cervix
     Clinical observation of new adjuvant chemotherapy on locally advanced carcinoma of the cervix
     局部晚期宫颈癌新辅助化疗初步临床观察
短句来源
     COMBINATION OF HYPERTHERAPY WITH RADIOTHERAPY VERSUS RADIOTHERAPY ALONE FOR LOCALLY ADVANCED CARCINOMA OF THE CERVIX
     热疗加放射治疗局部晚期宫颈癌
短句来源
     Methods Sever patients with locally advanced carcinoma of the cervix were used PVB project for two courses and then the local change of the cervix were observed.
     方法7例局部晚期宫颈癌患者用PVB方案化疗2个疗程后,观察宫颈局部肿瘤体积变化。
短句来源
     Methods: 75 patients with locally advanced carcinoma of the cervix were randomly divided into two groups. All patients were received radical hysterectomy, 35 cases were received arterial chemoembolization two weeks before surgery.
     方法:将75例局部晚期宫颈癌患者随机分为两组,各例均行宫颈癌根治术,研究组35例于术前两周行髂内动脉栓塞化疗。
短句来源
  local advanced cervical cancer
     Full Dose Radiotherapy Followed by Hysterectomy in the Treatment of Local Advanced Cervical Cancer
     放疗后近期子宫切除治疗局部晚期宫颈癌
短句来源
     The value of paclitaxel combined cisplatin in patients with local advanced cervical cancer
     紫杉醇联合顺铂用于局部晚期宫颈癌新辅助化疗近期疗效观察
短句来源
     Purpose] To determine whether radiotherapy and adjuvent hysterectomy can improve local control rate of local advanced cervical cancer.
     [目的]探讨局部晚期宫颈癌能否通过全量或近全量放疗后补充子宫切除术,提高局部控制率。
短句来源
     To explore the effect of uterne artery intrevenional chemotherapy combined with radiotherapy and simple radiotherapy in the treatment of local advanced cervical. For comparison of the uterne artery intrevenional chemotherapy combined radiotherapy (A group) and the simple radiotherapy (B group) in the treatment of patients with local advanced cervical cancer and 74 cases were randomized into two groups.
     为了探讨子宫动脉灌注化疗联合放射治疗局部晚期宫颈癌的效果,应用子宫动脉灌注化疗联合放疗(A组)和单纯放疗(B组)随机对照治疗局部晚期宫颈癌患者74例,A、B组各37例,比较近期疗效和远期疗效。
短句来源
  “局部晚期宫颈癌”译为未确定词的双语例句
     Apoptosis and Expression of Apoptosis-associated Bax Protein during Synchronal Radiochemotherapy of Locally Advanced Uterine Cervix Cancer
     凋亡及凋亡相关蛋白Bax在局部晚期宫颈癌同步放化疗中的表达
短句来源
     The significance of Ki67 and Bax expressions before and after neoadjuvant chemotherapy in locally advanced cervical carcinoma.
     Ki67和Bax在局部晚期宫颈癌新辅助化疗前后表达的意义
短句来源
     Expression of Cell Apoptosis Protein-Bax in Locally Advanced Cervical Carcinoma after Neoadjuvant Chemotherapy as an Indicator of the Efficiency of the Therapy
     局部晚期宫颈癌新辅助化疗后Bax蛋白作为治疗有效性的指标
短句来源
     In countries and areas where screening programs with PAP smear are not widely available, patients usually present with bulky stage ⅠB/Ⅱ, or locally advanced disease.
     在尚未开展宫颈涂片普查的国家和地区,患者就诊时肿瘤通常已发展至大肿块ⅠB/Ⅱ期或局部晚期宫颈癌
短句来源
     Study on Neoadjuvant Chemotherapy for Locally Advanced Uterine Cervical Carcinoma
     局部晚期宫颈癌新辅助化疗的临床研究
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  locally advanced cervical cancer
In 1999, five randomized studies demonstrated that chemoradiation with cisplatin and low-dose rate (LDR) brachytherapy has a benefit in locally advanced cervical cancer and for surgically treated patients in high-risk situations.
      
Radiation therapy has been the most active agent for the treatment of patients with locally advanced cervical cancer for many years.
      
These results are compelling evidence for the inclusion of cisplatin with irradiation as a new standard of care for patients with locally advanced cervical cancer.
      
Concurrent platinum-based chemo- and radiotherapy for locally advanced cervical cancer: A new gold-standard treatment
      
This study was conducted to test the efficacy and tolerability of this enzyme combination in preventing or reducing the acute side effects of radiation therapy in patients with locally advanced cervical cancer.
      
更多          
  locally advanced carcinoma of the cervix
If and when The role of chemotherapy in locally advanced carcinoma of the cervix
      


To observe the effect of carcioma hypertherapy with radiotherapy in treating the petients with locally advanced cervix cancer, 60 patients with locally advanced carcinoma of the uterine cervix were treated from January 1994 to December 1996. It was divided into two groups: hypertherapy with radiotherapy group (H+Rt), on 30 patients external irradiation average doses of 50.3 Gy (pelvic cavity), intracavitary irradiation average doses of 39.4 Gy (point A), intracavitary hypertherapy 43~45℃/40~45 min, four times...

To observe the effect of carcioma hypertherapy with radiotherapy in treating the petients with locally advanced cervix cancer, 60 patients with locally advanced carcinoma of the uterine cervix were treated from January 1994 to December 1996. It was divided into two groups: hypertherapy with radiotherapy group (H+Rt), on 30 patients external irradiation average doses of 50.3 Gy (pelvic cavity), intracavitary irradiation average doses of 39.4 Gy (point A), intracavitary hypertherapy 43~45℃/40~45 min, four times weekly and radiotherapy group (Rt only) of 30 patients external irradiaton average doses of 49.5 Gy (pelvic cavity), intracavitary irradiation average doses of 39.4 Gy (point A). The complete response rate (CR) H+Rt and Rt only were 80% and 13.3% respectively (p<0.01). A higher complete respons rate in patients with locally advanced cervix cancer is observed with radiotherapy and combination hypertherapy.

观察热疗加放射在治疗局部晚期宫颈癌的作用。从1994年1月-1996年12月收治局部晚期宫颈癌60例,分为两组。热放组30例,外照射平均剂量50.3Gy(全盆腔),腔内放疗平均剂量39.4Gy/A点,腔内热疗43℃~45℃/40min~45min,每周一次,共4次。单放组30例,外照射平均剂量49.5Gy/全盆腔,腔内放疗平均剂量36.13Gy/A点。肿瘤Ⅲ期完全消退率,热放组和单放组各为80%和13.3%,P<0.01。热疗加放疗治疗局部晚期宫颈癌近期疗效好。

Purpose] To determine whether radiotherapy and adjuvent hysterectomy can improve local control rate of local advanced cervical cancer. [Method] Twenty - four patients with histologically confirmed cervical cancer were treated by a combination of full dose radiotherapy followed by hysterectomy. Patients' average age was 40 years old. Histological type included squamous cell carcinoma (17 cases), adenocarcinoma (7 cases). Patients staged according to FIGO system, there were 17 cases in Ⅱb and 7 cases in Ⅲb....

Purpose] To determine whether radiotherapy and adjuvent hysterectomy can improve local control rate of local advanced cervical cancer. [Method] Twenty - four patients with histologically confirmed cervical cancer were treated by a combination of full dose radiotherapy followed by hysterectomy. Patients' average age was 40 years old. Histological type included squamous cell carcinoma (17 cases), adenocarcinoma (7 cases). Patients staged according to FIGO system, there were 17 cases in Ⅱb and 7 cases in Ⅲb. Cervical appearance was either barrel - shaped or bulky mass, with diameter dose > 4cm. Radiation > 7000cGy in 19 cases, > 6000cGy in 3 cases, > 5000cGy in 2 cases. [Result] Average follow -up time was 16 months (10 - 40 months). Within this period, there were 6 cases with persistent disease or early recurrent, short term failure occurred in 25% (6/24). Complete remission rate for patients with pelvic or para - aortic lymph node metastasis after radiation was 20% (1/5), that for those with or without local persistent tumor was 75 % (8/12) and 83. 2% (10/12) respectively, for those with neither lymph node metastasis nor persistent tumor was 90.7% (10/11). [Conclusion] For the patients with bulky tumor, resistent to radiation, high - risk pathological type and poor vagina anatomy, radiotherapy followed by adjuvent hysterectomy can improve local control rate, but the dose of radiation should be conservative, and the interval from radiation to operation should not be too long. Hysterectomy dose not benefit the patient with lymph node metastasis after radiation.

[目的]探讨局部晚期宫颈癌能否通过全量或近全量放疗后补充子宫切除术,提高局部控制率。[方法]24例宫颈癌,平均年龄40岁,病理证实腺癌7例,鳞癌17例;按FIGO分期Ⅱb17例,Ⅲb7例;宫颈呈桶型或大块型,直径均大于4cm;术前行常规综合放疗,放射剂量(A点)大于7000cGy19例,大于6000cGy3例,大于5000cGy2例;放疗结束后1~6周内行筋膜外子宫切除术4例,次广泛切除18例,广泛切除加盆腔淋巴结清扫术2例。[结果]治疗完成至今5个月至40个月,平均16个月,期间6例未控或复发,近期治疗失败率为25%(6/24)。放疗后仍有可查到盆腔和(或)腹主动脉旁淋巴结转移者,治疗成功率为20%(1/5);放疗后局部持续性肿瘤者,治疗成功率为75%(8/12);放疗后局部无持续肿瘤者(包括宫颈间质中见变性癌细胞团者)治疗成功率为83.3%(10/12);而既无淋巴结转移,又无宫颈持续肿瘤者治疗成功率为90.97%(10/11)。有术后并发症者2例,经保守治疗治愈。[结论]对于局部大块型、放疗后反应不良、某些高危病理类型及局部解剖条件不良的宫颈癌,放疗后近期补充子宫切除术可作为一种治疗方法,能...

[目的]探讨局部晚期宫颈癌能否通过全量或近全量放疗后补充子宫切除术,提高局部控制率。[方法]24例宫颈癌,平均年龄40岁,病理证实腺癌7例,鳞癌17例;按FIGO分期Ⅱb17例,Ⅲb7例;宫颈呈桶型或大块型,直径均大于4cm;术前行常规综合放疗,放射剂量(A点)大于7000cGy19例,大于6000cGy3例,大于5000cGy2例;放疗结束后1~6周内行筋膜外子宫切除术4例,次广泛切除18例,广泛切除加盆腔淋巴结清扫术2例。[结果]治疗完成至今5个月至40个月,平均16个月,期间6例未控或复发,近期治疗失败率为25%(6/24)。放疗后仍有可查到盆腔和(或)腹主动脉旁淋巴结转移者,治疗成功率为20%(1/5);放疗后局部持续性肿瘤者,治疗成功率为75%(8/12);放疗后局部无持续肿瘤者(包括宫颈间质中见变性癌细胞团者)治疗成功率为83.3%(10/12);而既无淋巴结转移,又无宫颈持续肿瘤者治疗成功率为90.97%(10/11)。有术后并发症者2例,经保守治疗治愈。[结论]对于局部大块型、放疗后反应不良、某些高危病理类型及局部解剖条件不良的宫颈癌,放疗后近期补充子宫切除术可作为一种治疗方法,能提高治愈率?

Purpose To evaluate the curative effect and possibility of the intraarterial chemotherapy followed by radical hysterectomy for locally advanced cervical cancer. Methods 59 patients with FIGO stage lb lV cervical cancer were enrolled and the tumor size with stage lb and lla must be more than 4 cm.Treatment consisted of bilateral internal iliac artery infusion of cisplatin 80 mg,5 Fu 1 500 mg,and AT1258 60 mg for 1-3 courses separated by 3 weeks.The tumor size was measured by vagina ultrasonic and CT before...

Purpose To evaluate the curative effect and possibility of the intraarterial chemotherapy followed by radical hysterectomy for locally advanced cervical cancer. Methods 59 patients with FIGO stage lb lV cervical cancer were enrolled and the tumor size with stage lb and lla must be more than 4 cm.Treatment consisted of bilateral internal iliac artery infusion of cisplatin 80 mg,5 Fu 1 500 mg,and AT1258 60 mg for 1-3 courses separated by 3 weeks.The tumor size was measured by vagina ultrasonic and CT before and after chemotherapy to calculate the shrunk size percent.All patients underwent radical hysterectomy.Patients with disease in the vagina,parametrium,pelvic lymphnodes or microscopic tumor emboli were followed postoperative pelvic irradiation. Results 59 patients underwent 122 courses of intraarterial chemotherapy for 1-3 courses each.The total response rate was 95%.Complete response (CR) was achieved in 18 of 59 patients (31%),while a partial response (PR) was noted in 38 (64%) and stable disease (SD) in 3 (5%).No patient had progressive disease.14 patients with pelvic lymphnode metastasis were all found to have PR and SD.No patient had lymphnode metastasis in CR.Of 18 patients with CR,17 patients had not recurrence.Only one patient with stage lla recurred 20 months after operation.But he also cured.All 18 patients with CR were living free of disease.But 3 in 38 patients with PR died and 3 patients with SD were all died.There were no severe complications related to intraarterial chemotherapy and radical hysterectomy. Conclusions lntraarterial chemotherapy before operation can shrink tumor size,decrease the lymphnode metastasis.It is feasible in helping elevating cure rate of patients with locally advanced cervical cancer who are at high risk for failure with conventional treatment.

目的 评价术前介入化疗联合根治术治疗局部晚期宫颈癌的可行性和疗效。方法  5 9例确诊为局部晚期宫颈癌的患者 ,采用Seldinger′s法股动脉穿刺插管进行盆腔介入化疗 ,药物为DDP80mg、5 Fu15 0 0mg、AT12 5 86 0mg。阴道B超和CT测量化疗前后的肿瘤大小 ,计算肿瘤消退百分比。经 1~ 3个疗程后行根治性子宫切除和盆腔淋巴清扫术。术后根据病理检查 ,如有盆腔淋巴结转移、宫旁组织浸润、脉管内有瘤栓或阴道切缘 (+)者都给予术后补充外放射治疗。结果 化疗总疗程数 12 2次 (1~ 3次 /每个病人 ) ,化疗总有效率为95 % ,其中 18例完全缓解 (占 31% ) ,38例部分缓解 (占 6 4% ) ,3例无变化 ,没有病例发生疾病进展。 5 9例中共有 14例发现术后盆腔淋巴结转移 (占 2 4% ) ,且均为化疗部分缓解者和无变化者 ,临床完全缓解者中无一例发生淋巴结转移。 18例临床完全缓解者 17例无复发 ,仅 1例lla期于术后 2 0月阴道复发 ,后经综合治疗病灶也消失 ,18例均无瘤生存。 38例部分消退者中 3例死亡。 3例化疗无效...

目的 评价术前介入化疗联合根治术治疗局部晚期宫颈癌的可行性和疗效。方法  5 9例确诊为局部晚期宫颈癌的患者 ,采用Seldinger′s法股动脉穿刺插管进行盆腔介入化疗 ,药物为DDP80mg、5 Fu15 0 0mg、AT12 5 86 0mg。阴道B超和CT测量化疗前后的肿瘤大小 ,计算肿瘤消退百分比。经 1~ 3个疗程后行根治性子宫切除和盆腔淋巴清扫术。术后根据病理检查 ,如有盆腔淋巴结转移、宫旁组织浸润、脉管内有瘤栓或阴道切缘 (+)者都给予术后补充外放射治疗。结果 化疗总疗程数 12 2次 (1~ 3次 /每个病人 ) ,化疗总有效率为95 % ,其中 18例完全缓解 (占 31% ) ,38例部分缓解 (占 6 4% ) ,3例无变化 ,没有病例发生疾病进展。 5 9例中共有 14例发现术后盆腔淋巴结转移 (占 2 4% ) ,且均为化疗部分缓解者和无变化者 ,临床完全缓解者中无一例发生淋巴结转移。 18例临床完全缓解者 17例无复发 ,仅 1例lla期于术后 2 0月阴道复发 ,后经综合治疗病灶也消失 ,18例均无瘤生存。 38例部分消退者中 3例死亡。 3例化疗无效者均已死亡。 5 9例均未发生严重的与化疗和手术相关的并发症。结论 术前介入化疗可缩小肿瘤病灶 ,减少淋巴结转移和亚临床播散。不但方法可行 ,而且有望提高局部晚期宫颈癌的生存率。

 
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