Objective To observe the expression of calcium-dependent proline-rich tyrosine kinase-2(Pyk2) in myocardium of rheumatic heart disease,the relationship between its role and cardiac fibrosis and clinical significance.
Conclusion We establish a feasible, simple and sensitive approach to measure mRNA of rat TIMP-1, TIMP-2 by multiplex RT-PCR, which may contribute to the research on cardiac fibrosis associated with hypertension.
Based on the above possible mechanism,in this experiment ,we explore the the inhibiting effect of valsartan and spironolactone on cardiac fibrosis and the expression of integrin 1 and fibronectin in the heart of spontaneously hypertensive rats.
Objective To investigate the effects of simvastatin (Sim) on the proliferation of rat cardiac fibroblasts (CFs) induced by arginine vasopressin (AVP) for theoretical bases of preventing and treating cardiac myofibrosis due to hypertention.
Conclusion: This study supports the hypothesis that the cardiac chymase may increase collagen synthesis and participate the formation and degradation of extracellular matrix in myocardial tissue and accelerate cardiac myofibrosis in spontaneously hypertensive rats.
We found that noise stress significantly increased the microvessel wall area, the number of microvessels with an outer diameter >amp;gt;19 μm, the degree of cardiac fibrosis, and the extent of ischemic myocardial lesions in SHR, but not in NWR.
TNFα-antagonism attenuates the development of experimental diabetic cardiomyopathy associated with a reduction of intramyocardial inflammation and cardiac fibrosis.
Cardiac Fibrosis as a Cause of Diastolic Dysfunction
The interaction of coronary tone and cardiac fibrosis
Aldosterone has direct effects on the vasculature and has been associated with vascular smooth muscle cell hypertrophy, endothelial dysfunction, cardiac fibrosis, proteinuria, and renal vascular injury.