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   肿瘤基因 的翻译结果: 查询用时:0.041秒
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肿瘤基因
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  tumor gene
     Studies on tumor gene therapy by the HSV-tk/ACV system
     运用HSV-tk/ACV系统进行肿瘤基因治疗研究
短句来源
     RNA interference and tumor gene therapy
     RNA干扰与肿瘤基因治疗
短句来源
     Research on a New Compound TPT-CuCl_2 and Tumor Gene Therapy Mediated by Adenovirus
     对一种全新的肿瘤化疗药物TPT-CuCl_2和腺病毒介导的肿瘤基因治疗的研究
短句来源
     Conclusion Eukaryotic expression vector pcDNA3.0/CYP2B1 containing CYP2B1 gene under the control of a CMV promoter is an novel effective expression vector for tumor gene therapy.
     结论 CMV启动子调控的CYP2B1真核基因表达载体是肿瘤基因治疗中一种新型、高效的治疗载体。
短句来源
     CONCLUSION: The pcDNA3.1/V5 HisAα1,3GT was successfully constructed and this has laid a solid foundation for tumor gene therapy.
     结论 :成功地构建α1,3GT真核表达载体 ,为进行肿瘤基因治疗奠定了基础
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  cancer gene
     ④Tumor vaccine and ⑤Cancer gene therapy.
     ④肿瘤疫苗以及⑤肿瘤基因治疗。
短句来源
     Conclusion Human TAP2 cDNA is obtained and the recombinant eukaryotic expression vector is constructed,which provide the possibility for further expression of TAP2 in vitro ,and lay the foundation for further studying the function of TAP2 protein in cancer gene therapy.
     结论 获得了人TAP2cDNA并构建了重组真核表达载体 ,对TAP2基因产物在体外表达、进一步研究TAP2分子在肿瘤基因治疗方面的作用具有重要的意义。
短句来源
     Virus-directed enzyme prodrug therapy (VDERT) has been popular in cancer gene therapy due to its potential foe tumor-specific cytotoxicity.
     病毒介导的酶解前体药疗法(virus-directed enzyme prodrug therapy,VDEPT)因其转染效率高,毒副作用小的特性近年来已成为肿瘤基因治疗研究中的一个热点。
短句来源
     It has been already confirmed that the activity of human telomerase reverse transcriptase (hTERT) rise in approximately 90% human tumors whereas most nomal cells do not express the activity and it becomes a hotspot in transcriptional target of cancer gene therapy.
     近年来人端粒酶逆转录酶(human telomerase reverse transcriptase,hTERT)基因的启动子已被证实在90%以上的人类肿瘤组织中活性上调,现成为肿瘤基因治疗中转录靶向的研究热点。
短句来源
     Adenovirus Vector and Cancer Gene Therapy
     腺病毒载体与肿瘤基因治疗
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  tumor genes
     Expression of Tumor Genes in the Exfoliative Cells of Ductal Lavage and Their Relationship with Breast Carcinoma
     乳管镜下乳腺导管冲洗液脱落细胞肿瘤基因蛋白表达与乳腺癌关系的研究
短句来源
  “肿瘤基因”译为未确定词的双语例句
     Studies of P53/MDM2/P21 and HBV Correlation in Hepatoma Cells
     肝癌细胞中肿瘤基因P53/MDM2/P21与HBV关系的研究
短句来源
     Results The genetic alteration rate was 68.8% for APC, 46.2% for DCC, 41.7% for OGG1, 37.5% for p53, 27.3% for Ki-ras-2, 22.2% for RB1, and 14.3% for MCC.
     结果  7种肿瘤基因的变异率为APC (6 8.8% )、DCC (4 6 .2 % )、OGG1(4 1.7% )、p5 3(37.5 % )、Ki ras 2(2 7 3% )、RB1(2 2 .2 % )和MCC (14.3% )。
短句来源
     The model for the role of Pokemon in oncogenesis is hypothesized as Pokemon↑↑→ARF↓→MDM2→p53↓→tumorigenesis.
     Pokemon基因的作用模式为:Pokemon↑↑→ARF↓→MDM2→p53↓→肿瘤发生。 因此,以Pokemon基因为靶标的肿瘤基因治疗具有十分重要的意义。
短句来源
     Methods DNA chip was used to detect the mRNA from 11 human transitional cell carcinoma tissues and to investigate the genes related to signal transduction.
     方法使用人肿瘤基因表达谱芯片检测11例膀胱移行细胞癌组织基因表达谱的变化,以寻找与细胞信号转导相关的差异表达基因。
短句来源
     Conclusion Molecular genetic abnormality of chromosome 7 may play an important role on the molecular pathogenesis in GBM. The chromosomal regions at locus D7S2465 on 7q36 and between loci D7S640 and D7S684 on 7q 31.3-32 may exist oncogenes associated with GBM.
     结论7号染色体的分子遗传学异常可能在原发性胶质母细胞瘤的分子发病机制中发挥重要作用,在7q31.3~32上的D7S640~D7S684区域和7q36上的D7S2465位点所在区域可能存在与原发性胶质母细胞瘤相关的肿瘤基因
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  tumor gene
To investigate the possibility of tumor gene therapy using Jpk, its effect was tested in B16F10 murine melanoma cells.
      
Tumor gene therapy is potentially very specific and efficacious.
      
Suicide genes are promising tools in the arsenal of tumor gene therapy.
      
Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1?) product
      
The Wilms' tumor gene WT1 is overexpressed in most types of leukemias and various kinds of solid tumors, including lung and breast cancer, and participates in leukemogenesis and tumorigenesis.
      
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  cancer gene
These results suggest that the RA538 recombinant adenovirus could be a promising drug in cancer gene therapy.
      
A novel receptor-targeted gene delivery system for cancer gene therapy
      
Human PCAN1 (prostate cancer gene 1) is a prostate-specific gene that is highly expressed in prostate epithelial tissue, and frequently mutated in prostate tumors.
      
These results suggest that the silencing of IGF-1R has the potential to be an effective cancer gene therapy strategy for human lung cancer.
      
A less well-know example is Fanconi anemia (FA) a multisystem disorder caused by biallelic mutations in one of at least 13 different genes which include the BRCA2 breast cancer gene.
      
更多          
  tumor genes
Loss-of-function mutations in the lethal giant larvae, discs large, or brain tumor genes cause neoplastic overgrowth of larval brains and imaginal discs.
      
In addition, single nucleotide repeat regions of the two tumor genes BAX and transforming growth factor receptor II (TGFBR2) were also included.
      
Ad-TIP30 carrying exogenous TIP30-anti-tumor genes may be regarded as a potential candidate for the treatment of hepatocellular carcinoma.
      
The putative tumor genes involved in these alterations remain to be identified.
      
We hypothesized that one or several tumor genes might influence the behavior and metastatic potential of PMCs.
      


Rb gene is a cancer suppressor gene. Its product, Rb protein has close relation with the regulation of cell transformation, cell cycle and transcription. A lot of carcinomas such as retionblastoma, brest cancer, small cell lung cancer, prostate cancer, bladder cancer, oesteosacoma, soft tissue sarcoma etc. are related to the deletion or inactivation of Rb gene. Stomach cancer is a very common carcinoma of the gastrointestinal system. Researchers have shown that the development of stomach cancer is due to the...

Rb gene is a cancer suppressor gene. Its product, Rb protein has close relation with the regulation of cell transformation, cell cycle and transcription. A lot of carcinomas such as retionblastoma, brest cancer, small cell lung cancer, prostate cancer, bladder cancer, oesteosacoma, soft tissue sarcoma etc. are related to the deletion or inactivation of Rb gene. Stomach cancer is a very common carcinoma of the gastrointestinal system. Researchers have shown that the development of stomach cancer is due to the activation of many oncogenes and the inactivation of antioncogenes. By Southern Blot hybridization, we have tested cancer tissues of nine stomach cancer patients and one cell line BGC-823 with Rb gene probe, finding that the Rb gene of all the tissues and the cell line are abnormal as compared with that of normal human blood tissues. Among the cancer tissues of the nine patients, five have partial deletion of Rb gene, three as well as the cell line have complete deletion of Rb gene. This indicates that the loss of Rb gene is the key link of cancer development. We believe that, with the more sensitive method of Polymerase Chain Reaction (PCR), we can test the fallen cells of stomach hoping that it would be helpful to the early diagnosis of stomach cancer. Meanwhile, this experiment provides target cells of gene therapy research of tumors.

Rb基因是一种抗癌基因,其产物Rb蛋白与细胞转化、细胞周期调节及转录调控有密切关系。许多肿瘤如视网膜母细胞瘤、乳腺癌、小细胞肺癌、前列腺癌、膀胱癌、骨肉瘤、软组织肉瘤等,都与Rb基因的失活或缺失有关。胃癌是消化道常见多发肿瘤,研究表明,其发生发展与多种癌基因的活化、抗癌基因的异常有关。我们用Southern印迹杂交法,以Rb基因为探针,检测了九例胃癌患者的癌组织和一个胃癌细胞株,发现它们与正常人血相比Rb基因全部呈现异常。其中5例发生Rb基因部分缺失,3例及人胃腺癌细胞株BGC-823全部缺失。这表明在胃癌发生过程中Rb基因的丢失是一个重要环节。我们相信用更灵敏的多聚酶链式反应(PCR)技术检测胃脱落细胞,对患癌危险性的早期预报会有很大帮助。同对,本实验也对肿瘤的基因治疗研究提供了靶细胞。

Antisense can be used to control the expres-sion of specific genes. When targeted to specif-ic messenger RNAs or specific sequences of theDNA double helix, antisense inhibit transla-tion or transcription. Both strategies can beapplied to control the expression of oncogenesand growth factors in tumor cells. Here, theapplication of antisense was reviewed in cancerresearch briefly. a. Inhibition of oncogene andgrowth factor expression to suggest their func-tion in tumor cells. b. Discrimination betweenproto-oncogene...

Antisense can be used to control the expres-sion of specific genes. When targeted to specif-ic messenger RNAs or specific sequences of theDNA double helix, antisense inhibit transla-tion or transcription. Both strategies can beapplied to control the expression of oncogenesand growth factors in tumor cells. Here, theapplication of antisense was reviewed in cancerresearch briefly. a. Inhibition of oncogene andgrowth factor expression to suggest their func-tion in tumor cells. b. Discrimination betweenproto-oncogene and activated oncogene. c.Problems and approaches in antisense genetherapy.

反义核酸研究已活跃于肿瘤研究及基因治疗领域,反义核酸通过碱基配对待异性地抑制基因表达,因此为研究肿瘤中癌基因和生长因子的功能及癌基因突变检测提供了更为有效的手段,并为肿瘤的基因治疗提供了可能途径。文章综述了反义核酸在基因治疗中所面临的问题及部分解决办法。

Different structure and component of non-histone chromosomal proteins( NHCP ) between SRS-lymphoma and normal mouse lymphocyte were observed bymeans of SDS-PAGE, ELISA immunoblot methods.It was found that the antigenic pro-teins released from limited DNase l digestion of SRS-lymphoma chromatin were not detectedin normal lymphocytic chromatin digests.The differences of antigenic proteins were dependedupon the time of digestion. The relation of antigenic nonhistone proteins to active chromatin were also studied.Using...

Different structure and component of non-histone chromosomal proteins( NHCP ) between SRS-lymphoma and normal mouse lymphocyte were observed bymeans of SDS-PAGE, ELISA immunoblot methods.It was found that the antigenic pro-teins released from limited DNase l digestion of SRS-lymphoma chromatin were not detectedin normal lymphocytic chromatin digests.The differences of antigenic proteins were dependedupon the time of digestion. The relation of antigenic nonhistone proteins to active chromatin were also studied.Using SDS- PAGE and immunoblot analysis of SRS-Lym- phoma and normal mouse lymphocytic chromatin indicated that SRS- Lymphoma chromatinpossessed some relative antigenic NHCP with apparant molecular weight of 13(Kd,120Kd,110 Kd, 94Kd,57Kd,These results suggested that the antigenic NHCP of SRS-Lymphomamay locate in the area of active chromatin.

本文用SDS-PAGE分离正常及SRS-淋巴瘤小鼠淋巴细胞染色质NHCP,发现SRS-淋巴瘤细胞染色质存在130Kd,120Kd,110Kd,94Kd,57Kd肿瘤相关性NHCP两种染色质经DNaseⅠ有限度消化,优先被消化的活性染色质部位释放的蛋白不同。SRS-淋巴瘤细胞消化后释放的NHCP多于正常淋巴细胞,并具时相性差异。经多种免疫学方法证实,SRS-淋巴瘤NHCP具有肿瘤相关性,它的FLISA结果远高于正常淋巴细胞,SRS-淋巴瘤染色质有限度消化时NHCP释放的时相性变化,在ELISA中得到证实。免疫印迹结果表明:经正常染色质重吸收后的抗SRS-淋巴瘤染色质NHCP的抗血清与正常淋巴细胞染色质不显带,而与SRS-淋巴瘤细胞染色质显出多条阳性带,这些肿瘤相关性NHCP存在于不同处理的样品中。以上结果提示:SRS-淋巴瘤相关性NHCP位于活性染色质部位,它们可能是参与肿瘤基因表达的调控蛋白一反式作用因子。

 
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