The threshold of LN, HA, PC III and CIV content for diagnosing stage 4 (early cirrhosis)of hepatic was 140ng/ml, 130ng/ml, 120ng/ml and 70ng/ml, respectively, the diagnosis sensibility was 93%, 79%, 79% and 86% respectively, the specificity for diagnosing liver cirrhosis was'82%, 66%, 72% and 61% respectively.
The levels of LN,HA,PCⅢ and CⅣ in serum of these patients diagnosing cut-off value in stage 4 liver fibrosis(early cirrhosis)were 130 ng/ml, 140 ng/ml,120 ng/ml and 70 ng/ml respectively. Their sensibility of diagnosing liver cirrhosis was 79%,93%,79% and 86% respectively. Their specificity of diagnosing liver cirrhosis was 66%,82%,72% and 61% respectively.
The patients' age, serum AST, total bilirubin and platelet count had significant relation to the stage of liver fibrosis, and the age, blood PT, total bilirubin and platelet count were significant relevant indices for early liver cirrhosis, and their sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 31.5%, 94.4%, 60.7%, 83.3% and 80.7%, respectively.
Objective To investigate the significance of serum CA_(125) and CA_(19-9) detection in early diagnosis of hepatocirrhosis in patients with chronic hepatitis B.Methods Experiment group consisted of 94 patients with chronic hepatitis B had been done liver biopsy,53 patients were with early hepatocirrhosis and 41 patients were without.