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实验性哮喘
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  experimental asthma
     The maximal binding volume (Bmax) of β-adrenoreceptor in the lung tissues of guinea-pigs in health group, experimental asthma group and ear acupuncture treatment group was determined with radiological ligand binding analysis.
     本文采用放射配基结合分析法分别测定健康组、实验性哮喘组和哮喘耳针治疗组豚鼠肺组织中β-受体最大结合量(Bmax)。
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     AIM:To explore the regulatory mechanism of nerve growth factor (NGF) on calcitonin gene related peptide(CGRP) in experimental asthma.
     目的探讨实验性哮喘时神经生长因子(nervegrowthfactor,NGF)对降钙素基因相关肽(calcitoningenerelatedpeptide,CGRP)的调节机制。
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     CONCLUSION: Levels of PMN counting and expression of MPO and NE are significantly increased in experimental asthma rats. PMN may be involved in inflammation in asthma via increasing the levels of NE and MPO.
     结论:PMN计数、NE和MPO的表达水平在此实验性哮喘中增加,PMN可能通过分泌NE、MPO参与哮喘炎症过程。
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     CONCLUSION: BCG can upregulate the number of Th1 cells and lighten the airway inflammatory reaction of experimental asthma mice.
     BALF中炎性细胞数减少。 结论 :BCG可在体上调Th1细胞 ,减轻实验性哮喘动物气道的炎症反应
短句来源
     Effects of Ear Acupunctrue on β-Adrenoreceptor in Lung Tissues of Guinea-pigs with Experimental Asthma
     耳针对实验性哮喘豚鼠肺组织β-受体的影响
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  experimental asthmatic
     AIM:To evaluate the role of inhaling N 6-phenyl-2R-isopropyl-adenosine (R-PIA) on the airway resistance and pulmonary compliance of experimental asthmatic guinea-pigs.
     目的 :研究腺苷受体激动剂R -苯异丙基腺苷 (N6-phenyl- 2R -isopropyl-adenosine ,R -PIA)对实验性哮喘豚鼠气道阻力、肺顺应性的影响。
短句来源
     Determinations of IL-5 Contents in the Supernatants of Spleen Cell Cultures of Experimental Asthmatic Mice and its Significance
     实验性哮喘小鼠脾细胞培养上清液IL-5的测定及其意义
短句来源
     Regulation of calcitonin gene related peptide levels by nerve growth factor in experimental asthmatic guinea pig
     神经生长因子对实验性哮喘豚鼠降钙素基因相关肽的调节作用
短句来源
     Regulation of T lymphocytes on antigen-specific IgG from Blymphocytes in experimental asthmatic mice
     实验性哮喘小鼠T淋巴细胞对B淋巴细胞产生特异性IgG的调节作用
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     AIM: To explore the regulatory mechanism of nerve growth factor (NGF) on substance P in the experimental asthmatic guinea pig.
     目的:探讨实验性哮喘时神经生长因子(NGF)对P物质(SP)的调节机制。
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  “实验性哮喘”译为未确定词的双语例句
     GATA-3 expression in asthmatic mice and its significance
     实验性哮喘小鼠肺组织中转录因子GATA-3的表达及意义
短句来源
     CONCLUSION: MIP-1α and RANTES are high expression in the bronchus epithelial cells in experimental murine asthma.
     结论 :本研究证明MIP - 1α和RANTES等在实验性哮喘时支气管中的高表达 ,上皮细胞是主要表达细胞。
短句来源
     Regulatory effect of T lymphocyte on specific-IgE secreted by B lymphocyte in mouse with asthma
     实验性哮喘小鼠T淋巴细胞对B细胞分泌特异性IgE的调节作用
短句来源
     The calcitonin gene related peptide (CGRP) levels in the visceral afferent system of asthmatic guinea pigs were measured by means of radioimmunoassay.
     本文应用放射免疫分析方法研究了实验性哮喘豚鼠与下呼吸道有关的内脏传入系统内降钙素基因相关肽含量的变化 ,藉以探讨降钙素基因相关肽在哮喘发病时的作用机制。
短句来源
     ADCC Effect of Immunocytes in Experimental Mouse with Asthma
     实验性哮喘小鼠免疫细胞的ADCC作用
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  experimental asthma
Studies of experimental asthma, especially the use of murine models, have contributed significantly to the understanding of the genetics and immune-mediated pathophysiology of pulmonary airways during allergy.
      
However, controversies surrounding animal systems data and at the interface between animal and human studies raise questions regarding the true utility of experimental asthma research.
      
These results suggest that pUMVC3-hFLex treatment can prevent the development of airway remodeling and maintain airway protection in chronic experimental asthma model, and might provide a novel approach for treating chronic asthma.
      
In experimental asthma in dogs, the major component of the acute bronchoconstrictive response to antigen inhalation appears to involve a vagally mediated reflex.
      
Analysis on BALF Cyst LTs levels in mice with experimental asthma.
      
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Using radioligand binding assay(RLBA), the changes of beta-receptor in guinea pigs suffered from-allergic experimental asthma were screened. The results that were treated with Scatchard analysis showed that the maximal binding volume (Bmax)to beta-receptor in asthmatic animals is decreased significantly in comparison with those of normal animals. The changes of beta-receptor at different asthmatic times were observed. The percentage of ~3H-DHA Bmax decreased had statistical significance. By treating the animals...

Using radioligand binding assay(RLBA), the changes of beta-receptor in guinea pigs suffered from-allergic experimental asthma were screened. The results that were treated with Scatchard analysis showed that the maximal binding volume (Bmax)to beta-receptor in asthmatic animals is decreased significantly in comparison with those of normal animals. The changes of beta-receptor at different asthmatic times were observed. The percentage of ~3H-DHA Bmax decreased had statistical significance. By treating the animals with electrical acupuncture, the decreased number of beta-receptor in asthmatic animals was elevated to normal level, while the number of beta-receptor in normal animals exhibitedno changes. Thus, we suggest that one of the mechanisms of beneficial effect to asthma treated with electrical acupuncture is likely to elevate the decreased number of betarece-ptor.

本文采用放射配基结合法,观察了实验性哮喘豚鼠肺组织β-肾上腺素能受体的变化,并与正常动物作了比较。结果表明,哮喘豚鼠肺组织的β-受体结合~3H-DHA的最大结合量(BmAX)比对照组者低38%(P<0.01)。首次观察到随哮喘发作次数的增多,豚鼠肺组织β-受体的减少趋于明显;电针刺激可使哮喘豚鼠肺组织的β-受体数量恢复至对照动物水平。电针刺激对正常动物的β-受体数量未见有影响。

The measurement of pulmonary mechanics is a quite good method for the study of antiasthrngtics in animal experiments in vivo. In this paper, the measurement of pulmonary mechanics included pulmonary resistance (R_L) and pulmonary dynamic compliance (Cdyn). The former is an index which reflects large airway caliber and the latter is an index which reflects small airway caliber. α-Terpineol is one of the antiasthmatic principles of essential oil of Artemisia argyi. R_L was decreased and Cdyn was increased after...

The measurement of pulmonary mechanics is a quite good method for the study of antiasthrngtics in animal experiments in vivo. In this paper, the measurement of pulmonary mechanics included pulmonary resistance (R_L) and pulmonary dynamic compliance (Cdyn). The former is an index which reflects large airway caliber and the latter is an index which reflects small airway caliber. α-Terpineol is one of the antiasthmatic principles of essential oil of Artemisia argyi. R_L was decreased and Cdyn was increased after inhalation of a-Terpineol aerosol, i e, α-Terpineol aerosol could dilate both large and small airways of normal guinea pigs. When guinea pigs which had been exposed to histamine aerosol were challeged with specific antigen, R_L was increased and Cdyn was decreased. The same result was obtained in guinea pigs sensitized actively by ovalbumin or passively by antiserum containing IgE. After inhalation of \% a-Terprneol aerosol for 2 min the changes of R_L and Cdyn by the challenge were almost totally abolished. These findings showed clearly that α-Terpineol is an effective antiasthmatic in experimental asthma in guinea pigs. Effects of α-Terpineol on pulmonary mechanics in guinea pigs were not affected by propranolol (5mg/kg, i v) and reserpine (5 mg/kg, i p). These findings showed that the bronchodilative effect of a-Terpineol was not via β-adrenocepter and did not depend on the function of adrenergic nerve.

肺机械功能测定是整体动物实验中研究平喘药较好的方法。本文通过测定豚鼠的潮气量(V)、呼吸气流速度(F)和胸内压(P),描记压力—流速(P-F)曲线和压力—容量(P-V)曲线,计算肺阻力(R_L)和肺动态顺应性(Cdyn),研究艾叶油的有效平喘成分之一——α-萜品烯醇(α-Ter-pineol)对豚鼠气道的直接扩张作用,对豚鼠组胺引喘、卵白蛋白主动致敏和IgE抗血清被动致敏豚鼠实验性哮喘的保护作用,并且用心得安、利血平等工具药初步分析其作用机理,发现其作用并非通过兴奋β肾上腺素受体,亦不受肾上腺素能神经功能的影响。

The β-adrenoceptor functions, including the β-adrenoceptor maximal binding capacity (Bmax)and responsiveness, were studied both in vivo and vitro in asthmatic patients and compared with healthy subjects. Both in healthy subjects and asthmatics, blood pressure, heart rate, lung function, blood sugar content and Bmax, before and after adrenaline injection, showed a significant difference. The changes between the content of blood sugar and Bmax of β-adrenoceptors showed a linear positive relation (P<0.005).The...

The β-adrenoceptor functions, including the β-adrenoceptor maximal binding capacity (Bmax)and responsiveness, were studied both in vivo and vitro in asthmatic patients and compared with healthy subjects. Both in healthy subjects and asthmatics, blood pressure, heart rate, lung function, blood sugar content and Bmax, before and after adrenaline injection, showed a significant difference. The changes between the content of blood sugar and Bmax of β-adrenoceptors showed a linear positive relation (P<0.005).The heavier of the state of asthma and the more of the β-adrenergic agonists used recently, the lower Bmax of β-adrenoceptors appeared, but it had nothing to do with the course of illness. To apply Bmax or to observe blood surgar content before and after adrenalin injection, combining the state of illness and the count of drugs used, might be a method to understand β-adrenoceptor sensitation and how to use β-adrenoceptor agonists correctly in clinical work. It is a basic research for recovering the function of β-adrenoce-ptor.

本文目的在于通过体外及体内方法测定哮喘患者月—肾上腺素能受体数目及反应性,并与健康人做对照。正常人及病人注射肾上腺素前后在血压、心率、肺功能,血糖、Bmax各项间均有显著性差异;且病人及健康人血糖变化与Bmax变化呈线性明显相关(P<0.05)。病情发作严重、短期内应用月受体激动剂较多者,Bmax下降,Bmax与病程关系不大。应用Bmax或注射肾上腺素观察血糖变化,结合患者病情及用药情况,可以推测9—受体敏感性,从而指导临床恰当应用9—受体激动剂,并为今后如何恢复犀—受体功能研究打下基础。 支气管哮喘与喘息性支气管炎为常见病、多发病,是造成慢性呼吸衰竭的重要原因。由于归—肾上腺素能受体(下称"受体)激动剂广泛应用于治疗哮喘,因此哮喘患者月受体功能也受到重视。早在1968年Szentivanyi就提出哮喘与"受体功能阻滞有关。近年来,国内外学者对实验性哮喘动物肺组织"受体进行了大量研究,深化了人们对哮喘的认识。国外学者认为,外周血液淋巴细胞月受体变化与肺组织中的变化一致,国内吕氏在建立完整淋巴细胞9受体测定方法的基础上,动态观察了实验性过敏哮喘豚鼠血液淋巴细胞中9受体最大结合容量(下称Bmax)和...

本文目的在于通过体外及体内方法测定哮喘患者月—肾上腺素能受体数目及反应性,并与健康人做对照。正常人及病人注射肾上腺素前后在血压、心率、肺功能,血糖、Bmax各项间均有显著性差异;且病人及健康人血糖变化与Bmax变化呈线性明显相关(P<0.05)。病情发作严重、短期内应用月受体激动剂较多者,Bmax下降,Bmax与病程关系不大。应用Bmax或注射肾上腺素观察血糖变化,结合患者病情及用药情况,可以推测9—受体敏感性,从而指导临床恰当应用9—受体激动剂,并为今后如何恢复犀—受体功能研究打下基础。 支气管哮喘与喘息性支气管炎为常见病、多发病,是造成慢性呼吸衰竭的重要原因。由于归—肾上腺素能受体(下称"受体)激动剂广泛应用于治疗哮喘,因此哮喘患者月受体功能也受到重视。早在1968年Szentivanyi就提出哮喘与"受体功能阻滞有关。近年来,国内外学者对实验性哮喘动物肺组织"受体进行了大量研究,深化了人们对哮喘的认识。国外学者认为,外周血液淋巴细胞月受体变化与肺组织中的变化一致,国内吕氏在建立完整淋巴细胞9受体测定方法的基础上,动态观察了实验性过敏哮喘豚鼠血液淋巴细胞中9受体最大结合容量(下称Bmax)和CAMP含量,注意到哮喘后期血液夕受体的变化与肺组织的相一致。外周血液淋巴细胞是很容易获得的

 
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