The results showed that APNF(0134), had effects on scavenging O2 (the two systems), H2O2, OH. and inhibiting O2-induced platelet aggregation dose-dependently, IC(50), were 4. 39、 4. 89 13. 62' 7. 19 122. 48 mg/L respectively.
Synthesis and Platelet Aggregation Inhibitory Activities of Analogues of 6-〔4-(4-substituted-piperazine)phenyl〕-5-methyl-4,5-dihydro-3(2H)pyridazinones
CONCLUSION: The inhibition of ethyl ferulate on platelet congregation induced by ADP is much better than that of ferulic acid. Ethyl ferulate against the CCl 4 acute liver injury is better than that of ferulic acid in mice.
BACKGROUND: Apart from anticoagulation property and suppressing platelet congregation capability, tongxinluo preparation has been proved by traditional Chinese medicine to possess certain function for protecting endothelial cells.
Piperbetol, methyl piperbetol, piperol A and piperol B inhibited the aggregation of rabbit platelet induced by PAF and the IC_(50) values were 17.9, 9.2, 142.0 and 14.0 μmol·L ̄(-1), respectively.
The peptides have an inhibitory effect on platelet aggregation in platelet-enriched blood plasma, when the process is induced by ADP, they also diminish the activity of factor XIIIa in blood plasma.
Repeated intramuscular administration of low molecular weight heparin-collagen complex proved to increase fibrinolytic activity and to decrease platelet aggregation in the blood of rats (11 months) with depressed anticoagulant system.
The elimination of one of thrombotic risk factors (decreasing elevated platelet aggregation) points to possible antithrombotic activity of ATP under these experimental conditions.
The influence of acetyl salicylic acid (ASA) derivatives with platelet-activating factor (PAF) lipid analogs on PAF-induced human platelet aggregation has been studied.
Those studies demonstrated platelet aggregation effects with agonist concentrations equivalent to and higher than those used in the present study.
例句来源
The anticoagulant and fibrinolytic effects of the total glucosides of Chi-Shao(Paeonia Iactifora)in rats were studied. When the drug was added in vitro in rat plasma at concentrations of 10.8 and 21.6 tag/ml, the plasma recalcium time was prolonged by 73 and 249% respectively ( P<0.01 ) while the blood platelet aggregation in platelet rich plasma induced by ADP (Bern's turbidimetric method)were reduced from 67.2% (mean aggregation of the control ) to 24.2 and 7.25% respectively. When the drug was admin-iste...
Trimeresurus Mucrosquamatus venom (TMV) induced the concentration-dependent aggregation of platelets of different species. The threshold concentrations of TMV inducing the platelet aggregation of human, rabbit, dog and Guinea pig were 2.0, 12.5, 2.0 and 0.6ug/ml respectively. EDTA interfered with the platelet aggregation by TMV, but heparin did not prevent the action of TMV. The platelet aggregation induced by TMV was accompanied by the release of serotonin (5-HT) from the challenged platelets. The concentr...
A series of 7-substituted chrom-4-one-2,carboxylic acid derivatives Ⅰ_(1~10) and 11_(1~8) were prepared. Ⅰ_(1~10) and 11_(1~2) were. obtained from Ⅳ with appropriate chlorides. Ⅱ_(3~8) were obtained from the reactions of Ⅰ_5 with amines. Ⅰ_6 and 11_1 showed similar antiallergic activities against passive cutaneous anaphylaxis (PCA) in the rat as compared with DSCG. Ⅰ_9 exhibited a strong anticoagulative activity in vitro.