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唇鳞癌
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  lip squamous cell carcinomas
     Objective: To study the relation of protein expression of inducible nitric oxide synthase(iNOS), endothelial nitric oxide synthase(eNOS) and vascular endothelial growth factor (VECF) in lip squamous cell carcinomas and its relation to clinical pathology and angiogenesis.
     目的:研究血管内皮生长因子(VEGF)、诱导型一氧化氮合酶(iNOS)和内皮型一氧化氮合酶(eNOS)在唇鳞癌组织中表达的相关性,及该三者与唇鳞癌血管生成和临床病理特征的关系,探讨一氧化氮(NO)和VEGF对唇癌生长的作用机制。
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     Significance of VEGFexpression and microvessel density in lip squamous cell carcinomas
     唇鳞癌中VEGF表达和微血管密度的临床意义
短句来源
     Methods:Lip squamous cell carcinomas tissue specimens were obtained from 42 patients undergoing operation,and the expression of iNOS, eNOS and VEGF were studied by using the immunohistochemistry technique. Microvessel density(MVD) was evaluated by counting endothelial cells which were immunostained by anti-FⅧRAg antibodies.
     方法: 应用免疫组织化学方法检测42例唇鳞癌手术切除标本VEGF、iNOS和eNOS的表达,第Ⅷ因子相关抗原(FⅧRAg)血管内皮细胞特异性染色计数肿瘤微血管密度(MVD)。
短句来源
     Results: ①Positive VEGF and iNOS and eNOS immunostaining were detected in 26(61.90%), 28(66.67%) and 31(73.81%)patients with lip squamous cell carcinomas respectively.
     结果:(1)26例唇鳞癌组织表达VEGF,28例表达iNOS,31例表达eNOS;
短句来源
     INOS and VEGF have a corre lation in their favoring angiogenesis of lip squamous cell carcinomas.
     (2)MVD随着VEGF和iNOS表达的增强而增加,说明两者对唇鳞癌血管生成具有促进作用。
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  “唇鳞癌”译为未确定词的双语例句
     Clinic pathology prognostic factors in squamous cell carcinoma of lip
     影响唇鳞癌预后的临床病理因素分析
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     WT5”BZ]Objective To study clinic pathology prognostic factors in squamous cell carcinoma of lip.
     目的 研究影响唇鳞癌预后的临床病理因素。
短句来源
     Methods 80 squamous cell carcinoma of lip were analyzed by means of several clinic and pathology factors.
     方法 以各临床病理指标来研究与唇鳞癌预后有关的因素。
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     ④In the clinicopathologic factors, lymph node metastasis and differentiated degree and invasion were significantly correlated with VEGF expression, but there was no significantly correlation between the clinicopathologic stage and VEGF positive expression.
     (2)VEGF、iNOS的表达与唇鳞癌MVD呈正相关,eNOS的表达与唇鳞癌MVD的差异无显著性意义;
短句来源
     Expression of iNOS was significantly correlated with differentiated degree?
     (3)VEGF的表达与唇鳞癌淋巴结转移和肿瘤分化程度及肿瘤浸润深度正相关;
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  相似匹配句对
     and squamous cell carcinoma was negative.
     阴性。
短句来源
     Carcinoma of the lips developing in discoid lupus erythematosus
     盘状红斑狼疮和
短句来源
     Squamous Cell Carcinoma of Gastric Cardia
     贲门
短句来源
     Expression of Nitric Oxide Synthase and Vascular Endothelial Growth Factor in Lip Squamous Cell Carcinomas
     NOS和VEGF在组织中的表达
短句来源
     Clinic pathology prognostic factors in squamous cell carcinoma of lip
     影响预后的临床病理因素分析
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  lip squamous cell carcinoma
In a prospective non-randomized study 21 patients with lower lip squamous cell carcinoma were treated with human natural leukocyte interferon (HNLI).
      
The response rate of six lower lip squamous cell carcinoma cases treated with recombinant interferon alpha 2c was 67% and the complete response rate was 17%.
      
Induction of apoptosis correlates with an increase in tissue transglutaminase (type II) activity.In vivo, 9-cis RA induces complete tumor regression of an early passage human lip squamous cell carcinoma xenograft.
      


WT5”BZ]Objective To study clinic pathology prognostic factors in squamous cell carcinoma of lip. Methods 80 squamous cell carcinoma of lip were analyzed by means of several clinic and pathology factors. And the prognostic factors were showed. Results 1.There were 5.4%, 6.5%, 47.7% cases showed neck metastasis in T 1,T 2,T 3 tumors and 3.6%,6.7%,66.7% in well, middle, poor differentiation tumors respectively. The pathological karyokinesis number was 3.25 in the cases of neck metastasis, and the same time...

WT5”BZ]Objective To study clinic pathology prognostic factors in squamous cell carcinoma of lip. Methods 80 squamous cell carcinoma of lip were analyzed by means of several clinic and pathology factors. And the prognostic factors were showed. Results 1.There were 5.4%, 6.5%, 47.7% cases showed neck metastasis in T 1,T 2,T 3 tumors and 3.6%,6.7%,66.7% in well, middle, poor differentiation tumors respectively. The pathological karyokinesis number was 3.25 in the cases of neck metastasis, and the same time the number showed statistically significant ( P <0 01). 2.The mean thickness of recurrence cases was 5.07mm( P <0.05). There were 7.1%,13.3%,55.6% cases showed recurrence in well, middle, and poor differentiation respectively ( P <0.005). Conclusion Neck metastasis was significantly associated with large tumor size and poor differentiation. It was easy to occur cervical lymph node spreading when the number of pathological karyokinesis was more than three. Further more, Local recurrence was significantly associated with poor differentiation. It was easy to recur when the tumor thickness was more than 5mm and the number of pathological karyokinesis was more than two. Both the number of capillary and the invasion degree of lymph cell were not the related prognostic factors. [WT5”HZ]

目的 研究影响唇鳞癌预后的临床病理因素。方法 以各临床病理指标来研究与唇鳞癌预后有关的因素。结果  1.区域淋巴结转移 :T1 有 5 .4% ,T2 有 6 .5 % ,T3有 41.7%的病例出现区域淋巴结转移 (0 .0 1

Objective: To evaluate the clinical significance of microvessel density(MVD) and vascular endothelial growth factor(VEGF) expression in lip squamous cell carcinomas Methods Immunohistochemical staining(SABC) was used to quantify MVD and VEGF expression in specimens from 37 patients with lip squamous cell carcinomas SPSS statistical software was used Results: VEGF expression was observed in 23 of the patients(62 16%) There was a significantly higher microvessel count (P<0 05) in the lip squamous cell...

Objective: To evaluate the clinical significance of microvessel density(MVD) and vascular endothelial growth factor(VEGF) expression in lip squamous cell carcinomas Methods Immunohistochemical staining(SABC) was used to quantify MVD and VEGF expression in specimens from 37 patients with lip squamous cell carcinomas SPSS statistical software was used Results: VEGF expression was observed in 23 of the patients(62 16%) There was a significantly higher microvessel count (P<0 05) in the lip squamous cell carcinomas with VEGF expression than in the lip squamous cell carcinomas without In the clinicopathologic factors, lymph node metastasis(P<0 05) and differentiated degree (P<0 05) and depth of tumor invasion (P<0 05) were significantly correlated with VEGF expression, but there was no significant correlation between the clinicopathologic stage and VEGF positive expression There was significant correlation between the lymph node metastasis(P<0 05),differentiated degree (P<0 05), depth of tumor invasion, clinicopathologic stage and highter MVD count Conclusion: This study indicates that VEGF expression is associated with angiogenesis, and VEGF is one of the main angiogenic factors for lip squamous cell carcinomas Quantification of VEGF and MVD in lip squamous cell carcinomas may provide a valuable marker for a biologic study of lip squamous cell carcinomas

目的 研究微血管密度 (microvesseldensity ,MVD)和血管内皮生长因子 (vascularendothelialgrowthfac tor ,VEGF)在唇鳞癌中的表达 ,探讨其临床意义。方法 采用SABC免疫组织化学染色方法检测 37例唇鳞癌中MVD和VEGF的表达 ,采用SPSS软件行统计分析。结果  6 2 16 %唇癌组织呈VEGF阳性表达。VEGF表达阳性的唇癌组织MVD显著高于VEGF表达阴性者 (P <0 0 5 )。VEGF表达与肿瘤的分化程度、淋巴结转移及浸润深度密切相关 ,而与肿瘤的临床分期无关。MVD记数与肿瘤的分化程度、淋巴结转移、浸润深度及临床分期密切相关。结论 唇癌组织VEGF表达与微血管密度有明显的相关性 ,是唇癌主要的新生血管诱导因子之一 ,VEGF、MVD可做为反映唇癌生物学行为的一个有效指标

Objective: To study the relation of protein expression of inducible nitric oxide synthase(iNOS), endothelial nitric oxide synthase(eNOS) and vascular endothelial growth factor (VECF) in lip squamous cell carcinomas and its relation to clinical pathology and angiogenesis. Methods:Lip squamous cell carcinomas tissue specimens were obtained from 42 patients undergoing operation,and the expression of iNOS, eNOS and VEGF were studied by using the immunohistochemistry technique. Microvessel density(MVD) was...

Objective: To study the relation of protein expression of inducible nitric oxide synthase(iNOS), endothelial nitric oxide synthase(eNOS) and vascular endothelial growth factor (VECF) in lip squamous cell carcinomas and its relation to clinical pathology and angiogenesis. Methods:Lip squamous cell carcinomas tissue specimens were obtained from 42 patients undergoing operation,and the expression of iNOS, eNOS and VEGF were studied by using the immunohistochemistry technique. Microvessel density(MVD) was evaluated by counting endothelial cells which were immunostained by anti-FⅧRAg antibodies. Results: ①Positive VEGF and iNOS and eNOS immunostaining were detected in 26(61.90%), 28(66.67%) and 31(73.81%)patients with lip squamous cell carcinomas respectively. ②Expression of VEGF bore a significant positive relation to iNOS, but not eNOS.③Cancer MVD were positively correlated with expression of VEGF and iNOS,but not of eNOS. ④In the clinicopathologic factors, lymph node metastasis and differentiated degree and invasion were significantly correlated with VEGF expression, but there was no significantly correlation between the clinicopathologic stage and VEGF positive expression. Expression of iNOS was significantly correlated with differentiated degree?clinicopathologic stage?lymph node metastasis and invasion. There were no significantly correlation between the clinicopathologic stage?differentiated degree?lymph node metastasis?invasion and eNOS positive expression. Conclusion: INOS, rather than eNOS play a positive role in lip squamous cell carcinomas development.INOS and VEGF have a corre lation in their favoring angiogenesis of lip squamous cell carcinomas.

目的:研究血管内皮生长因子(VEGF)、诱导型一氧化氮合酶(iNOS)和内皮型一氧化氮合酶(eNOS)在唇鳞癌组织中表达的相关性,及该三者与唇鳞癌血管生成和临床病理特征的关系,探讨一氧化氮(NO)和VEGF对唇癌生长的作用机制。方法: 应用免疫组织化学方法检测42例唇鳞癌手术切除标本VEGF、iNOS和eNOS的表达,第Ⅷ因子相关抗原(FⅧRAg)血管内皮细胞特异性染色计数肿瘤微血管密度(MVD)。结果:(1)26例唇鳞癌组织表达VEGF,28例表达iNOS,31例表达eNOS;VEGF与iNOS的表达正相关,与eNOS的表达无相关;(2)VEGF、iNOS的表达与唇鳞癌MVD呈正相关,eNOS的表达与唇鳞癌MVD的差异无显著性意义;(3)VEGF的表达与唇鳞癌淋巴结转移和肿瘤分化程度及肿瘤浸润深度正相关;与临床分期无关。iNOS表达与唇鳞癌的分化程度、临床分期和有无淋巴结转移及肿瘤浸润深度正相关;eNOS表达与唇鳞癌临床分期、分化程度和有无淋巴结转移及肿瘤浸润深度均无关。结论: (1)iNOS对VEG...

目的:研究血管内皮生长因子(VEGF)、诱导型一氧化氮合酶(iNOS)和内皮型一氧化氮合酶(eNOS)在唇鳞癌组织中表达的相关性,及该三者与唇鳞癌血管生成和临床病理特征的关系,探讨一氧化氮(NO)和VEGF对唇癌生长的作用机制。方法: 应用免疫组织化学方法检测42例唇鳞癌手术切除标本VEGF、iNOS和eNOS的表达,第Ⅷ因子相关抗原(FⅧRAg)血管内皮细胞特异性染色计数肿瘤微血管密度(MVD)。结果:(1)26例唇鳞癌组织表达VEGF,28例表达iNOS,31例表达eNOS;VEGF与iNOS的表达正相关,与eNOS的表达无相关;(2)VEGF、iNOS的表达与唇鳞癌MVD呈正相关,eNOS的表达与唇鳞癌MVD的差异无显著性意义;(3)VEGF的表达与唇鳞癌淋巴结转移和肿瘤分化程度及肿瘤浸润深度正相关;与临床分期无关。iNOS表达与唇鳞癌的分化程度、临床分期和有无淋巴结转移及肿瘤浸润深度正相关;eNOS表达与唇鳞癌临床分期、分化程度和有无淋巴结转移及肿瘤浸润深度均无关。结论: (1)iNOS对VEGF的生成和发挥作用的过程可能有重要影响;(2)MVD随着VEGF和iNOS表达的增强而增加,说明两者对唇鳞癌血管生成具有促进作用。

 
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