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   逆转活性 的翻译结果: 查询用时:0.02秒
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逆转活性
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  reversal activity
     RESULTS: DRO significantly reversed MDR in K562/A02 (P < 0.01). After treatment of DRO 20, 10, and 5 μmol/L, the chemosensitivity to ADR was increased to 14, 13, and 4 folds, respectively. The reversal activity of DRO was similar to that of verapamil (VRP).
     结果:DRO显著逆转K562/A02的MDR,在20、10和5μmol/L浓度时,对ADR的化学敏感性分别增加到14、13和4倍,逆转活性与维拉帕米相当。
短句来源
     This study was to explore MDR reversal activity of a novel compound FG020327, and its mechanism.
     本研究对一种新的多芳基取代咪唑化合物FG020327的体外逆转活性及其逆转机制进行了探讨。
短句来源
     METHODS: MTT assay was used to evaluate MDR reversal activity of FG020327 in 2 P-gp expressing tumor cell lines, KBv200 and MCF-7/ADR. Adriamycin (ADM) accumulation in MCF-7/ADR cells was detected by fluorescence spectrophotometry.
     方法以MTT法检测FG020327对多药耐药肿瘤细胞MCF-7/ADR及KBv200的耐药逆转活性;
短句来源
     Five μmol/L of FG020327 enhanced sensitivity of KBv200 cells to vincristine (VCR) by 44.9 folds, the reversal activity of which was 3 times that of verapamil (VRP). However, FG020327 had little effect on drug-sensitive MCF-7 cells and KB cells.
     结果FG020327在体外具有较强的逆转活性,在5μmol/L浓度下使多药耐药细胞KBv200对长春新碱的敏感性增加44.9倍,逆转活性是公认的强逆转剂维拉帕米的3倍熏但它对敏感株对抗癌药物的敏感性基本无影响。
短句来源
     Most of these analogues have shown a potent multidrug resistant reversal activities in MTT assay against KB/V200 and K562/A02 cells. Three compounds among these taxoids showed better reversal activity than Verapamil.
     对KB/V200和K562/A02耐药癌细胞的实验表明:大部分该类化合物具有较好的多药耐药逆转作用,其中三个化合物逆转活性显著强于已知对照药Verapamil。
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  “逆转活性”译为未确定词的双语例句
     Bepridil had more potent reversal action on MDR cells than verapamil under equimolar concentration (10 μmol/L).
     在相同的浓度下(10μmol/L),其逆转活性较维拉帕米强。
短句来源
     However, DRO did not markedly increase ADR accumulation in K562. CONCLUSION: DRO had strong reversal effect on MDR in K562/A02, which was comparable to that of VRP, but the reversal effect was viadifferent pathways.
     但DRO不能明显增加K562细胞内的ADR的浓度。 结论:DRO对K562/A02的MDR有较强的逆转活性,逆转强度与维拉帕米相当,其逆转机制有多种不同的途径。
短句来源
     Conclusion PSC 833 is at least 3~10 fold more potent than CsA or Ver with respect to MDR reversing activity, and it may function by inhibiting the function of P gp and not reducing the levels of mdr1 mRNA and P gp directly.
     结论 PSC 833较CsA、Ver逆转活性至少高 3~10倍 ,其逆转K5 6 2 /A0 2多药耐药的机制可能是通过抑制P gp功能 ,而非直接下调mdr1mRNA及P gp水平
短句来源
     Conclusion Rb1 combined with VRE can reverse multi drug resistance of K562/HHT in vitro increasely.
     结论 Rb1联合异博定可以显著增强Rb1逆转活性
短句来源
     It had more potent reversal action on SGC7901/VCR cells than Verapamil at the concentration of 10 μmol/L(P<0.01).
     在浓度为10μmol/L时,逆转活性较VRP为高(P<0.01);
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  相似匹配句对
     Synthesis of taxoids against multidrug resistant tumor cells
     MDR逆转活性紫杉烷类化合物的合成
短句来源
     Activated Carbon Fibers
     活性碳纤维
短句来源
     Active Packaging Materials
     活性包装材料
短句来源
     ④ down-regulate P glucoprotein activity and reverse tumor cells multidrug resistance.
     ④下调P糖蛋白活性 ,逆转多药耐药 ;
短句来源
     The Household Registering System Reform Reverse
     户籍改革逆转
短句来源
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  reversal activity
The multidrug-resistance (MDR)-reversal activity of 232 phenothiazines and structurally related compounds was tested in MDR P388 cells.
      
The contribution of these residues to the MDR-reversal activity was particularly evident among compounds containing a cyclic tertiary amine.
      
Studies of the resistance reversal potential of related compounds suggest that the complex amine portion of tirilazad is important for its reversal activity, while the steroid portion is less important.
      
We have previously reported that multidrug (MDR)-reversal activity can be exerted by compounds in which two ring structures of certain types are connected by one alkyl bridge to a secondary or tertiary amine group.
      
In the present investigation we studied the MDR-reversal activity of compounds in which the two ring structures were connected by separate alkyl bridges to the amine group.
      
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Aim: To explore the reversal of multidrug resistance (MDR) and its mechanisms by bepridil which is a new calcium channel blocker. Methods: The cellular accumulation of Fura-2 and fold-reversal were studied with Fura-2/AM and MTT assay, respectively. Cellular doxorubicin (Dox) accumulation was measured by fluorescence spectrophotometry. Cellular free calcium ion concentration was determined with Fura 2-AM. Results: Bepridil significantly increased the celluar accumulation of Fura-2 in MCF-7/ADR cells and increased...

Aim: To explore the reversal of multidrug resistance (MDR) and its mechanisms by bepridil which is a new calcium channel blocker. Methods: The cellular accumulation of Fura-2 and fold-reversal were studied with Fura-2/AM and MTT assay, respectively. Cellular doxorubicin (Dox) accumulation was measured by fluorescence spectrophotometry. Cellular free calcium ion concentration was determined with Fura 2-AM. Results: Bepridil significantly increased the celluar accumulation of Fura-2 in MCF-7/ADR cells and increased cytotoxicity in MCF-7/ADR cells to adriamycin and KBv200 cells to vincristine, but not increase in the actions on their parental sensitive cells. Bepridil had more potent reversal action on MDR cells than verapamil under equimolar concentration (10 μmol/L). The cellular Dox accumulation was markedly increased in the presence of bepridil in MDR cells. No effect was observed for ADR accumulation in the high or concentration. And cellular free calcium ion was not changed by bepridil in MDR cells. Conclusions: Bepridil was potental MDR reverser in vitro. Its reversal mechanism was associated with the increase of the cellular accumulation of anticancer drug and without relation to calcium ion concentration.

目的:为了探讨新的钙阻断剂苄丙洛逆转肿瘤多药抗药性(MDR)的作用及其机理。方法:以Fura-2/AM法测定P-糖蛋白功能,MTT法测定细胞毒作用,细胞内阿霉素(Dox,ADR)测定以荧光分光光度计法,细胞内钙离子测定用Fura-2-AM法。结果:苄丙洛能显著增加DNR细胞内Fura-2的积累和降低MCF-7/ADR细胞对ADR的IC50,对相应的敏感细胞株MCF-7无此作用。在相同的浓度下(10μmol/L),其逆转活性较维拉帕米强。苄丙洛能显著地增加MDR细胞内Dox的积累。高钙或低钙离子浓度不能改变MDR细胞内Dox积累,苄丙洛也不能改变MDR细胞内游离钙离子浓度。结论:苄丙洛能在体外逆转MDR,且较维拉帕米强。其逆转机理与增加细胞内抗癌药物的积累有关,与钙离子浓度无关。

Objective:To study modulation of mdr1 by nomegestrol acetate(NOM) in K562 cell line, as compared with megestrol acetate(MG).Methods:Adriamycin(ADM) resistant K562(K562/ADM) and parental K562(K562/S) were treated with NOM or MG.The alterations of chemosensitivity to ADM were evaluated by MTT assays,mRNA and protein of mdr1 gene depression by RT PCR and immunohistochemistry,and accumulation of ADM by flow cytometry(FCM).Results:Both NOM and MG markedly enhance chemosensitivity to ADM in K562/ADM.After 20 μmol,10...

Objective:To study modulation of mdr1 by nomegestrol acetate(NOM) in K562 cell line, as compared with megestrol acetate(MG).Methods:Adriamycin(ADM) resistant K562(K562/ADM) and parental K562(K562/S) were treated with NOM or MG.The alterations of chemosensitivity to ADM were evaluated by MTT assays,mRNA and protein of mdr1 gene depression by RT PCR and immunohistochemistry,and accumulation of ADM by flow cytometry(FCM).Results:Both NOM and MG markedly enhance chemosensitivity to ADM in K562/ADM.After 20 μmol,10 μmol and 5μmol of reversal drugs treatment,the chemosenstivity to ADM increased 18.6,14.1 and 5.3 times respectively in NOM treated cells, and 16,14.5 and 5 times respectively in MG treated cells.FCM assays showed that both drugs treated cells increased accumulation of ADM by 3~4 times.The reversal activity of NOM was similar to that of MG,both NOM and MG were found to inhibit mdr1 expression at the level of mRNA and protein.This modulation on gene expression was time dependent and the maximal effects appeared after 5 days of drug treatment.Conclusion:NOM markedly reverses P glycoprotein induced MDR of K562/ADM.NOM was effective as MG.Both drugs can modulate mdr1 expression in a time dependent manner.Since NOM have low toxicity,they might be used as good reversal agents.

目的比较甲诺孕酮(NOM)与甲地孕酮(MG)对K562耐阿霉素(ADM)细胞株(K562/ADM)mdr1基因的调节。方法应用细胞培养、MTT比色、免疫组织化学、RT┐PCR和流式细胞技术进行分析。结果NOM确有逆转作用,逆转活性与MG相似,并可下调mdr1表达,调节呈时间依赖性。结论NOM可明显逆转P糖蛋白介导的K562/ADM的MDR,因其毒性作用轻微,有可能成为较好的新型逆转剂。

The authors investigated the cytotoxicity of ingredients of Chinese herbs, such as osides, rhiem an-thraquinone and alkaloids, and studied the reversal activity of drug-resistance by these ingredients on mul-tidrug-resistance cell lines-MCF-7/ADR and HL60/ADR with different mechanisms. The results showed that in vitro, using the routine dose, osides had no cytotoxicity on drug-resistant or drug-sensitive cell lines, and had no effect on the drug - resistance; rhiem anthraquinone had more strong cytotoxicity...

The authors investigated the cytotoxicity of ingredients of Chinese herbs, such as osides, rhiem an-thraquinone and alkaloids, and studied the reversal activity of drug-resistance by these ingredients on mul-tidrug-resistance cell lines-MCF-7/ADR and HL60/ADR with different mechanisms. The results showed that in vitro, using the routine dose, osides had no cytotoxicity on drug-resistant or drug-sensitive cell lines, and had no effect on the drug - resistance; rhiem anthraquinone had more strong cytotoxicity on drug - resistant cell lines than on drug sensitive cell lines, but had no reversal activity of drug-resistance. Whereas, alkaloids had light cytotoxicity on drug-resistant cell lines than steroidal alkaloids PM1 and PM2 could significantly reverse multidrug-resistance of MCF-7/ADR and HL60/ADR cell lines, and markedly intensify effect of anti-cancer agents.

我们以两种耐药机制不同的多药耐药瘤株MCF-7/ADR和HL60/ADR为研究对象,对多种中药皂甙,大黄蒽醌和部分生物碱等成分进行了细胞杀伤实验和耐药逆转研究。结果表明,常现剂量下,皂甙体外对耐药和敏感细胞均没有杀伤作用,其中大多数不具备耐药逆转活性,少部分具有很低的耐药逆转活性;大黄蒽醌类对耐药和敏感细胞均有很强的杀伤作用,而且对耐药细胞的杀伤作用似乎更强,但也不具备逆转耐药活性;生物碱类普遍对耐药细胞生长有轻度抑制作用,并首次发现甾类生物碱PM1或PM2对上述两种不同耐药细胞的耐药性有明显逆转作用。

 
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