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兔坐骨神经
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  rabbit sciatic nerve
     Objective To observe the influence of the NOS expression on the spinal cord half transection injury of adult rat after transplantation of the microencapsulated rabbit sciatic nerve tissue, Study the mechanism that the transplantation with microencapsulated different race nervous tissue/cells treats the spinal cord injury(SCI).
     目的:观察大鼠脊髓半横断损伤后植入微囊化兔坐骨神经组织对NOS表达的影响,进一步探讨微囊化异种神经组织细胞移植治疗脊髓损伤(spinal cord injury,SCI)的机制。
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     Objective: To study the difference of expression of Kv1.5 mRNA of Schwann cell in rabbit sciatic nerve injured with different methods.
     目的:观察不同方式损伤兔坐骨神经电后受损区域神经许旺细胞Kv1.5钾通道基因的表达水平。
短句来源
     Morphology Analysis to the Injury of Rabbit Sciatic Nerve after Stereotactic Radiation.
     立体定向照射后兔坐骨神经放射性损伤的形态学分析
短句来源
     Influence of transplanting microencapsulated rabbit sciatic nerve tissue on spinal cord injured neurons in adult rats
     微囊化兔坐骨神经组织移植对大鼠脊髓损伤神经元的影响
短句来源
     Isolation,Purification and Cultivation of Schwann Cells from Adult Rabbit Sciatic Nerve in Vitro
     成年兔坐骨神经雪旺细胞的分离纯化培养
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  rabbit sciatic nerves
     MethodsEAN models were established on mice by subcutaneous injection of homogenate prepared from rabbit sciatic nerves. The expression of CD28,CTLA 4,B7 1 and B7 2 proteins in lymphocytes of peripheral blood was examined with immunohistochemistry,and that of B7 1 and B7 2 mRNA with RT PCR dynamically on day 14(incubation period),day 18(primary period)and day 22(peak of disease)after mice immunization.
     方法于小鼠双后肢足垫皮下注射兔坐骨神经匀浆 ,建立EAN模型 ,用免疫组化观察外周淋巴细胞CD2 8,CTLA 4,B7 1和B7 2蛋白的表达 ; 用RT PCR检测外周淋巴细胞B7 1和B7 2mRNA的表达。
短句来源
     OBJECTIVE:To observe the pathological changes of rabbit sciatic nerves after exposure to HIU and determine the correlation of HIU dosage with its prognosis.
     目的:观察HIU作用于兔坐骨神经干后的病理变化及其剂量与预后的相关性。
短句来源
     Methods:Acute,graded,nerve compression was applied to 35 rabbit sciatic nerves in whom on flatable mimiature plexiglass compression device had been implanted in the thigh.
     方法:用特制的气囊压迫装置,对35条兔坐骨神经进行急性压迫实验。
短句来源
     Methods EAN models were induced in Wistar rats by immunization with rabbit sciatic nerves homogenate and complete Freund's adjuvant(CFA). Expressions of MCP-1,RANTES in the sciatic nerves of experimental rats were detected by immunohistochemistry technology at different time.
     方法给W istar大鼠足垫皮下注射兔坐骨神经匀浆建立EAN模型,用免疫组化技术检测EAN大鼠发病不同时间坐骨神经MCP-1和RANTES的表达。
短句来源
     Objective: To determine the changes of the action potential peak value and maximal nerve conductive velocity of the rabbit sciatic nerves after the exposure of high intensity ultrasound(HIU) (7.1MHz,45.86W/cm2)and to establish the experimental base for treating refractory pain with HIU. Methods: The rabbit sciatic nerves were exposed to high intensity ultrasound of different doses;
     目的:观察高强度超声(High Intensity Ultrasound,HIU)作用于兔坐骨神经干后,胫神经、腓浅神经动作电位幅度、神经传导速度的变化,为高强度超声用于顽固性疼痛的治疗提供实验基础。
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  rabbit sn
     ②SCI rats models establishment: Totally 90 healthy SD rats were randomly divided into 3 groups with 30 rats in each: Microencapsulated rabbit SN cells suspension group (Microencapsulated group);
     ②脊髓损伤大鼠模型制作:取健康SD大鼠90只,随机分为3组,微囊化兔坐骨神经组织细胞悬液组(微囊化组);
短句来源
     The gelatin sponges with the size of 2 mm×2 mm×2 mm were grafted as filling cage, and adsorpted 10 μL microencapsulated rabbit SN cells (Microencapsulated group) and 10 μL rabbit SN cells (Only suspension group) respectively;
     立即在损伤腔内植入约2mm×2mm×2mm的明胶海绵作为填充支架,微囊化组在明胶海绵上吸附10μL微囊化兔坐骨神经组织细胞悬液; 单纯悬液组在明胶海绵上吸附10μL单纯兔坐骨神经组织细胞悬液;
短句来源
     AIM: To observe and compare the impacts on nerve growth factor (NGF) expression in rats of three groups: microencapsulated rabbit sciatic nerve (SN) cells transplantations on rats with spinal cord injury (SCI), rabbit SN cells transplantations on rats with SCI and rats only with SCI groups.
     目的:观察并比较兔坐骨神经组织细胞微囊化处理与单纯兔坐骨神经组织细胞移植至大鼠损伤脊髓及大鼠单纯脊髓损伤3组神经生长因子表达的变化。
短句来源
     Rabbit SN cells suspension group (Only suspension group); Only injured group.
     单纯兔坐骨神经组织细胞悬液组(单纯悬液组)和单纯损伤组,每组30只。
短句来源
     CONCLUSION: The SCI recovery in rats can be significantly accelerated by transplanting microencapsulated rabbit SN cell suspension. Compared with only suspension group and only injured group, the NGF can express highly after microencapsulation, which can improve the repair and regeneration of injured spinal cord.
     结论:兔坐骨神经组织细胞悬液移植对大鼠脊髓损伤修复有明显的促进作用,微囊化处理后大鼠损伤脊髓神经生长因子表达高于单纯细胞悬液移植和单纯损伤组,更有利于损伤脊髓的再生和修复。
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  “兔坐骨神经”译为未确定词的双语例句
     With the adjusted cell concentration of (2.0-2.5) ×106 L-1, the microencapsulated suspension was mixed with the alginate saline solution, and ejaculated to 20 mmol/L barium chloride saline solution by double-cavity ejaculator, then rinsed twice by saline.
     兔坐骨神经组织细胞悬液微囊化处理,将细胞浓度调整为(2.0~2.5)×106L-1后与15g/L海藻酸钠生理盐水溶液混合,经双腔喷头将海藻酸钠-坐骨神经组织细胞悬液混合液喷入20mmol/L的氯化钡生理盐水溶液中,加入生理盐水洗涤2次。
短句来源
     The Expression of C-ret mRNA in Rabbit Sacral Sympathetic Ganglia After Sciatic Nerve Repaired
     兔坐骨神经损伤修复后骶交感神经节内c-ret mRNA表达的变化
短句来源
     AIM:To observe the changes of Schwann's cells of injured sciatic nerve due to 75 V voltages in adult rabbits.
     目的:观察成年兔坐骨神经受到75V电压损伤后受损区域许旺细胞的变化。
短句来源
     Objective To study the efficiency of artificial nerves made of vein (V), basement membrane (BM), Schwann cells (SC) and nerve growth factor (NGF) in bridging 1.5 mm sciatic nerve defects.
     目的 研究静脉 (V)、基底膜 (BM)、雪旺细胞 (SC)和神经生长因子 (NGF)制备人工神经桥接 15mm兔坐骨神经缺损的作用。
短句来源
     Establishment and Evaluation of the Model of the Sciatic Nerve Firearm Injury in Rabbit
     兔坐骨神经火器伤模型的建立与选择
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  rabbit sciatic nerve
The effect of exogenous nerve growth factor(NGF) examined on the neural repair of adult rabbit sciatic nerve was evaluated in the present study.
      
We investigated the morphological changes in peripheral nerve following slow nerve elongation by laser Doppler flowmetry controlled expansion in a rabbit sciatic nerve model.
      
On a rabbit sciatic nerve, a combination of adjacent longitudinal tripoles of the 12 electrode array generally yields a stimulation performance similar to that which would be expected if a 24 electrode array is used.
      
Ultrastructural study of rabbit sciatic nerve regeneration following experimental excisional transection and autograft reconstru
      
Tonic sympathetic activity in the rabbit sciatic nerve
      
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  rabbit sciatic nerves
Twenty-four hours after nerve crush, the Schwann cell plasma membrane and subjacent outer layer of Schwann cell cytoplasm were examined by freeze-fracture in myelinated fibres from the rat and rabbit sciatic nerves.
      
In acute experiments on rabbit sciatic nerves, we have found that tripolar stimulation with this implant system is in general highly selective.
      
Analysis of rabbit sciatic nerves revealed that concentration of peripheral nervous system (PNS) myelin proteins is normal in Plp-pt myelin.
      
The localization of voltage-sensitive sodium channels was investigated in mouse, rat and rabbit sciatic nerves using iodinated α- and β-Scorpion toxins (ScTx) as specific probes.
      
In the sciatic nerve, which is widely considered as a model 'myelinated nerve', the nodal membrane represented only a small fraction of the total axonal membranes (0.2% and 0.05% for mouse and rabbit sciatic nerves respectively).
      
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  rabbit sn
Control coronary vascular resistance was 1.12±0.11 mm Hg/ml/min in hearts from normal rabbits and 1.53±0.16 mm Hg/ml/min in hearts from cholesterol-fed rabbits (n=9 each,
      
To assess the physiological importance of this impairment, we compared vasodilator effects of acetylcholine and nitroprusside, an endothelium-independent agent, in control rabbits (n=12) and rabbits fed a 1% cholesterol diet for 10 weeks (n=8).
      
New Zealand white rabbits prepared as uninephrectomized (sham) controls (n=7), or one kidney/one clip (1K1C) hypertensive rabbits (n=7) were examined four weeks after surgery.
      
The hearts were obtained from rabbits (n=4) anesthetized with intravenous pentobarbital sodium.
      
Four groups of anesthetized open-chest New Zealand white rabbits (N=26) were utilized.
      
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The post-ganglionic discharges from the cervical sympathetic and the splanchnic nerves were recorded in 68 rabbits and 3 cats anaesthized with urethane or urethane and chloralose. Arterial blood pressure was also recorded in some experiments. The patterns of efferent discharge were similar among the various sympathetic nerves. A rise of blood pressure followed an increase of frequency of discharges of the sympathetic, and a fall followed a decrease, with a lag of about 1-3 seconds. A single stimulus applied...

The post-ganglionic discharges from the cervical sympathetic and the splanchnic nerves were recorded in 68 rabbits and 3 cats anaesthized with urethane or urethane and chloralose. Arterial blood pressure was also recorded in some experiments. The patterns of efferent discharge were similar among the various sympathetic nerves. A rise of blood pressure followed an increase of frequency of discharges of the sympathetic, and a fall followed a decrease, with a lag of about 1-3 seconds. A single stimulus applied to the central stump of the cervical or abdominal vagus or of the carotid sinus nerve induced, after a short latency, a phase of augmentation of discharges lasting for 0.07-0.15 second, and then followed by a diminution of discharge. But the stimulation of the sciatic nerve and of the depressor nerve of the rabbit usually only induced an inhibition of the efferent sympathetic discharge. When the afferent fibres of peripheral nerves were stimulated with low frequency repetitive shocks, grouping of the efferent sympathetic discharges synchronous with the rhythm of the stimulus could be observed. In the rabbit, during vagus and sinus nerve stimulation the highest frequency was 10 to 13 per second, but when the somatio and the depressor nerves were stimulated, the highest frequency was only 3 to 5 per second. Repetitive stimulation of the aortic nerve of the cat only induced continuous sympathetic activity, but when the aortic nerve and the sciatic nerve were stimulated simultaneously, synchronization of the efferent bursts with the rhythm of the stimuli could be obtained. Low frequency stimulation of the pressor area in the medulla also induced bursts of the sympathetic discharge synchronized with the frequency of stimulation. Efferent sympathetic discharges were first inhibited by stimulating the depressor area at the obex, but discharges synchronous with stimulus gradually appeared later in spite of the stimulation.

颈上交感神经与内脏神经的传出冲动表现同相变化,冲动群互相同步,冲动的幅度与频率变化和动脉血压的变化相呼应,但内脏神经对传入刺激的反应较之颈上交感神经更为明显。以单个电刺激作用于迷走或颈动脉窦神经向中端,可诱发交感传出冲动呈兴奋——抑制双相反应。如给予重复电刺激,交感冲动群发放的频率变成与刺激的频率同步,其最高频率可达每秒10—3次。更高频率时,不再表现规律性,转为连续的发放。停止刺激后,有后抑制现象。重复电刺激家兔减压神经或猫和兔的坐骨神经,能完全抑制交感神经干的冲动发放。同样,重复电刺激猫主动脉弓附近神经小枝时,引起交感干持续、强烈的冲动发放。如同时刺激猫的主动脉弓处神经小枝及坐骨神经,则在一定的刺激频率下,交感冲动亦与刺激同步,最高可达7—8次/秒。以重复电刺激直接作用于延髓加压区,可得到良好的交感传出冲动节律同步的反应。刺激闩都附近可完全抑制交感传出冲动,但长期刺激下,能在抑制下释放出来,表现与刺激节律同步的冲动发放,以上两种同步的最高频率亦可达10—13次/秒。在延髓以上水平切断脑干,不影响上述机能;在闩部前方切断脑干,交感冲动大部分消失,也不能再产生反射性变化。以上结果说明,在刺激迷走和窦神经时所引...

颈上交感神经与内脏神经的传出冲动表现同相变化,冲动群互相同步,冲动的幅度与频率变化和动脉血压的变化相呼应,但内脏神经对传入刺激的反应较之颈上交感神经更为明显。以单个电刺激作用于迷走或颈动脉窦神经向中端,可诱发交感传出冲动呈兴奋——抑制双相反应。如给予重复电刺激,交感冲动群发放的频率变成与刺激的频率同步,其最高频率可达每秒10—3次。更高频率时,不再表现规律性,转为连续的发放。停止刺激后,有后抑制现象。重复电刺激家兔减压神经或猫和兔的坐骨神经,能完全抑制交感神经干的冲动发放。同样,重复电刺激猫主动脉弓附近神经小枝时,引起交感干持续、强烈的冲动发放。如同时刺激猫的主动脉弓处神经小枝及坐骨神经,则在一定的刺激频率下,交感冲动亦与刺激同步,最高可达7—8次/秒。以重复电刺激直接作用于延髓加压区,可得到良好的交感传出冲动节律同步的反应。刺激闩都附近可完全抑制交感传出冲动,但长期刺激下,能在抑制下释放出来,表现与刺激节律同步的冲动发放,以上两种同步的最高频率亦可达10—13次/秒。在延髓以上水平切断脑干,不影响上述机能;在闩部前方切断脑干,交感冲动大部分消失,也不能再产生反射性变化。以上结果说明,在刺激迷走和窦神经时所引起的交感传出冲动群的节律性,乃由于此两种传入神经中含有抑制性和兴奋性两种纤维。在其影响下,中枢交替发生兴奋与抑制,从而反映于传出冲动。

The repair process of the iibial fascicle of the rabbit sciatic nerve which had been transected and sutured or simply crushed was studied by means of light and . electron microscopy.It was found that the perineurium was able to heal after the nerve had been transected and sutured through the formation of a new epineurium-perineurium tube which contained many minute fascicles of regenerated nerve fibers. The newlyformed epineurium-perineurium tubs rejoined ths two stumps of the transected epineurium theath perineurium...

The repair process of the iibial fascicle of the rabbit sciatic nerve which had been transected and sutured or simply crushed was studied by means of light and . electron microscopy.It was found that the perineurium was able to heal after the nerve had been transected and sutured through the formation of a new epineurium-perineurium tube which contained many minute fascicles of regenerated nerve fibers. The newlyformed epineurium-perineurium tubs rejoined ths two stumps of the transected epineurium theath perineurium tube. The healing process of the nerve fascicle after crushing was similar to that after transection and suturing.From the transection and suturing of the nerve to the formation of the new epineurium-perineurium tubs the sequence of pathological events occurring in the epineurium and perineurium could be divided into 3 stages, the first stage of trau-matic inflammation, degeneration and necrosis of the perineurium, the second stage of perineurial cell proliferation, and the regeneration nerve fiber growth into the pre-perineurium mass and the third stage of the formation of new small nerve fascicles.The formation of the new epineurium-perineurium tube is of vital importance to nerve regeneration, it can prevent the nerve fibers from growing astray and guide them to the distal perineurium tube. The pro-perineurial cells might originate from the proliferation of the perineurial cells, themselves.The normal histological and ultrastructural morphology of the rab bit sciatic nerve was described. The nuclei of the perineurial cells have the tendency to form palisades. It seems that this may explain the palisading of the nuclei of neurofibr-oma cells.

兔坐骨神经胫神经束横断吻合和单纯挤压损伤后光、电镜对照观察,发现束膜损伤后能够修复,其方式是形成一含有许多神经小束的新外膜-束膜管,从而实现两断端束膜的再连接。神经切断缝合后至新外膜-束膜管的形成,外膜、束膜的变化可分为三期,即创伤性炎性反应,束膜变性坏死期,前束膜细胞增殖、神经纤维长入期与再生神经小束形成期。新外膜-束膜管的形成对神经的再生具有重要意义,能阻止新生的神经纤维向外生长并诱导其长入远端束膜管。作者考虑,再生束膜细胞可能来自束膜细胞本身的增殖。本文还描述了兔坐骨神经束膜的正常组织学和超微结构态形,束膜细胞核有作栅状排列的倾向,似可解释神经纤维瘤细胞每作栅状排列的现象。

The present experimental study was carried out to investigate the effect of indogenous prostaglandeins produced in the peripheral nerves after injury and the action of indomethacin ( a prostaglandin synthesis inhibitor) on their regeneration on the animal models with sciatic nerve crushed. The main results were: 1 , Radioimmunoassay demonstrated a stepladder-like increase in PGF 2 alpha in the sciatic nerve after crushing injury ; 2 , light microsocpy showed the number, diameter and area of the cross section...

The present experimental study was carried out to investigate the effect of indogenous prostaglandeins produced in the peripheral nerves after injury and the action of indomethacin ( a prostaglandin synthesis inhibitor) on their regeneration on the animal models with sciatic nerve crushed. The main results were: 1 , Radioimmunoassay demonstrated a stepladder-like increase in PGF 2 alpha in the sciatic nerve after crushing injury ; 2 , light microsocpy showed the number, diameter and area of the cross section of regenerated, myelinated nerve fibers passing through the crushed segment of the tibial fascicle of sciatic nerve of the rabbits being more than those injected with normal saline ; 3 , Culture of dissociated dorsal ganglia root cells from newborn rabbits revealed that nerve cells grown in media containing PGF 2 alpha showed significantly smaller size, less number of regenerated processes and lower content of RNA than those grown in media containing indomethacin. Scanning electronmicroscopy demomstrated different surface morphological features. These results indicated that an excess prostaglandin was produced in the rcushed nerve and inhibited nerve regeneration. Indomethacin as a prostaglandin synthesis inhibitor prevented excessive prostaglandin formation to promote nerve regeneration.

本研究以兔坐骨神经挤压损伤为模型,通过光、电镜观察以及对前列腺素(PG)F_(2a)的放免测定,并结合乳兔背根神经节细胞体外培养等方法来研究PG对周围神经损伤后再生的影响及其合成抑制剂消炎痛的作用。放免测定结果显示,挤压伤后发生华勒氏变性的坐骨神经,PGF_(2a)含量随伤后时间延长呈梯度升高,而注射消炎痛的动物,PGF_(2a)则不升高或者降低。形态学观察结果显示,穿过神经挤压区再生的有髓神经纤维数目、直径、面积等,注射消炎痛的动物均大于注射生理盐水对照的动物。背根神经节分离细胞培养结果显示,在培养基中加入PGF_(2a),培养的神经细胞体积小,突起再生的数目少,RNA含量低;相反,在培养基中加入PG合成抑制剂消炎痛,培养神经细胞钵积大,突起再生的数目多,RNA含量高。同时扫描电镜观察到,各组培养神经细胞有不同的表面形态改变。 以上实验结果表明:(1)周围神经挤压损伤后华勒氏变性过程中产生了过量PG,抑制神经纤维的再生。(2)PG合成抑制剂消炎痛因能阻止神经损伤后PG的产生,故具有促进神经再生的作用。 文中讨论了神经损伤后过量PG产生的原因以及本实验结果的意义等问题。作者考虑:(1)周围神经损伤...

本研究以兔坐骨神经挤压损伤为模型,通过光、电镜观察以及对前列腺素(PG)F_(2a)的放免测定,并结合乳兔背根神经节细胞体外培养等方法来研究PG对周围神经损伤后再生的影响及其合成抑制剂消炎痛的作用。放免测定结果显示,挤压伤后发生华勒氏变性的坐骨神经,PGF_(2a)含量随伤后时间延长呈梯度升高,而注射消炎痛的动物,PGF_(2a)则不升高或者降低。形态学观察结果显示,穿过神经挤压区再生的有髓神经纤维数目、直径、面积等,注射消炎痛的动物均大于注射生理盐水对照的动物。背根神经节分离细胞培养结果显示,在培养基中加入PGF_(2a),培养的神经细胞体积小,突起再生的数目少,RNA含量低;相反,在培养基中加入PG合成抑制剂消炎痛,培养神经细胞钵积大,突起再生的数目多,RNA含量高。同时扫描电镜观察到,各组培养神经细胞有不同的表面形态改变。 以上实验结果表明:(1)周围神经挤压损伤后华勒氏变性过程中产生了过量PG,抑制神经纤维的再生。(2)PG合成抑制剂消炎痛因能阻止神经损伤后PG的产生,故具有促进神经再生的作用。 文中讨论了神经损伤后过量PG产生的原因以及本实验结果的意义等问题。作者考虑:(1)周围神经损伤后,过量PG的产生为其修复和功能恢复缓慢的重要原因;(2)本实验研究在神经营养因素之外,找到一促进神经损

 
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