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心脏特异
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  heart-specific
     Advances of Heart-Specific Transcription Factors: NKX2-5,TBX5 and GATA4 in Congenital Heart Disease
     心脏特异转录因子NKX2-5、TBX5、GATA4与先天性心脏病的研究进展
短句来源
     Molecular Cloning, Characterization and Expression of Lrrc10:a Novel Mouse Heart-specific Member of Leucine-rich Repeat Superfamily
     心脏特异新基因Lrrc10的分子克隆与特性分析
短句来源
     Lrrc10, a novel mouse heart-specific gene, was cloned from mouse embryo heart by application of EST assembly. The cDNA of Lrrc10 is 1410bp and intronless. The gene is mapped to mouse chromosome 10D2. The longest ORF of the cDNA encodes a putative protein of 274 amino acids.
     Lrrc10基因是采用EST介导的基因克隆和表达谱分析,成功克隆的一个在小鼠心脏特异表达的新基因,该基因cDNA全长为1410bp,定位于小鼠染色体10D2,无内含子,其最大开放阅读框编码的假定蛋白有274氨基酸组成,含有7个亮氨酸重复继续基序。
短句来源
     A novel mouse heart-specific gene, Lrrc10(GenBank Acc No. AF527781), was cloned from mouse embryo heart by application of EST assembly and RT-PCR.
     采用表达序列标签 (EST)介导的基因克隆和表达谱分析 ,从小鼠心脏克隆了一个心脏特异新基因Lrrc10(GenBankAccNo .AF5 2 7781) .
短句来源
  cardiac-specific
     Objective: p93 and Nelin ,two cardiac-specific expression genes, were isolated based on large-scale ESTs(expressed sequence tags) sequencing from adult heart cDNA library recently.
     目的p93和Nelin是近年来在构建成人心脏cDNA文库并进行新ESTs(expressed sequence tags)分离的基础上,克隆出的心脏特异表达的基因。
短句来源
     Objective To highly level express and purify the fragment of kinase and serine domain of cardiac-specific gene p93 in Escherichia coli.
     目的 在大肠杆菌中高水平表达并分离纯化心脏特异表达基因p93的激酶与丝氨酸结构域片段。
短句来源
  “心脏特异”译为未确定词的双语例句
     Prediction of Cardiac Specifically Expressed Genes by Using Cis-Regulatory Modules
     用心脏顺式调控模块预测心脏特异表达基因
短句来源
     The cardiac atria and ventricle diversification were monitored by whole-mount in situ hybridization with specific markers,amhc,vmhc,nkx2.5 and nppa genes.
     应用胚胎整体原位杂交观察视黄酸对心脏特异基因vmhc,amhc,nkx2.5和nppa表达的影响。
短句来源
     Inhibition of dHAND expression by atRA in H9c2 cells and its mechanism
     全反视黄酸调节心脏特异转录因子蛋白表达及其机制
短句来源
     Conclusion:Bedside tests for cardiac specific troponin Ⅰ are highly sensitive for the early detection of myocardial cell injury in acute coronary syndrome. Negative test results are associated with low risk and allow rapid and safe discharge of patients with an episode of acute chest pain from the emergency room.
     结论 :床边心脏特异 c Tn I定性检测对急性冠脉综合征的早期心肌损害具有高度的敏感性 ,阴性结果心性事件发生率非常低 ,可以允许急诊胸痛病人早期出院。
短句来源
     Objective To address the mechanism whereby d HA ND and MEF2C transcription regulate cardiac gene.
     目的探讨碱性螺旋-环-螺旋转录因子(dHAND)和肌肉增强因子(MEF2C)调控心脏特异基因心钠素(ANP)表达及其分子机制。
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  heart-specific
Autoimmune myocarditis develops after the presentation of heart-specific antigens to autoaggressive CD4+ T cells and after inflammation has infiltrated the tissues.
      
Transgenic mice exhibiting dilated cardiomyopathy were developed via the introduction of a mutated, heart-specific gene (myosin light chain).
      
In normoxic and hypoxic animals, endurance training enhanced the ratio of the heart-specific lactate dehydrogenase isozyme LDH1 to total LDH activity (+59%, P>amp;lt;0.01; +92%, P>amp;lt;0.05 respectively).
      
To this end, we have constructed a bilateral heart-specific fate map of the left and right contributions to the developing heart in the Xenopus embryo.
      
Left-side injection caused heart-specific left-right reversal, and this phenotype was rescued by co-injection of mature Nodal protein.
      
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  cardiac-specific
AOP-1 interacts with cardiac-specific protein kinase TNNI3K and down-regulates its kinase activity
      
Since the first biomarker of myocardial necrosis was described in 1954, cardiac-specific biomarkers have been increasingly identified.
      
Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I
      
A possible dual consequence of increased myocardin and decreased HOP expression levels on serum response factor-dependent cardiac-specific expression in the normal heart and at heart failure is discussed.
      
Genetic analysis of cardiac-specific transcription factors reveals insights into congenital heart disease
      
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  heart specific
The mitochondrial damage in late-onset doxorubicin cardiomyopathy is heart specific and not found in skeletal muscle.
      
Competitive running caused a rise in the serum concentration of the heart specific fraction of creatine kinase in seven of the nine (healthy) elite runners.
      
Fatal infantile hypertrophic cardiomyopathy secondary to deficiency of heart specific phosphorylase b kinase
      
We describe here a male infant with a rare form of glycogenosis caused by deficiency of heart specific phosphorylase b kinase.
      
This structural difference necessitates establishment of heart specific parameters for cardiac gene therapy.
      


Objective:To prospectively investigate the usefulness of bedside tests for the detection of cardiac troponin Ⅰ in the evaluation of patients with acute chest pain.Methods:In 125 consecutive patients who had had acute chest pain without ST segment elevation on their electrocardiograms,troponin I status(positive or negative) was determined at least twice by sensitive, qualitative bedside tests based on the use of specific monoclonal antibodies.Testing was performed on arrival and four or more hours later so...

Objective:To prospectively investigate the usefulness of bedside tests for the detection of cardiac troponin Ⅰ in the evaluation of patients with acute chest pain.Methods:In 125 consecutive patients who had had acute chest pain without ST segment elevation on their electrocardiograms,troponin I status(positive or negative) was determined at least twice by sensitive, qualitative bedside tests based on the use of specific monoclonal antibodies.Testing was performed on arrival and four or more hours later so that one sample was taken at least six hours after the onset of pain. The troponin I results were made available to the treating physicians.Results:Troponin Ⅰ tests were positive in 40 patients(32%). Among 22 patients with evolving myocardial infarction,troponin Ⅰ tests were positive in all. Among 48 patients with unstable angina,troponin Ⅰ tests were positive in 13 patients(27%). During 30 days of follow up, there were 4 deaths and 4 nonfatal myocardial infarctions. Troponin Ⅰ proved to be strong, independent predictors of cardiac events. The event rates in patients with negative tests were only 1.2 percent for troponin Ⅰ.Conclusion:Bedside tests for cardiac specific troponin Ⅰ are highly sensitive for the early detection of myocardial cell injury in acute coronary syndrome. Negative test results are associated with low risk and allow rapid and safe discharge of patients with an episode of acute chest pain from the emergency room.[FK(WB80011。6]

目的 :研究床边肌钙蛋白 I(c Tn I)定性检测对急诊胸痛病人诊治的价值。方法 :12 5例无 ST段提高的急性胸痛病人 ,采用单克隆抗体感光技术行床边 c Tn I定性检测。受诊时及 4小时后各测一次 c Tn I,胸痛不足 2小时者在入院后 6小时复测第三次 ,保证胸痛 6小时内有一次血标本。且能将检测结果及时提供给值班医生。结果 :c Tn I阳性 40例 (32 % ) ,其中有 2 2例临床确诊急性心肌梗死。 48例不稳定心绞痛病人 ,c T-n I阳性 13例。随访 30天 ,发现 4例死亡 ,4例非致命性心肌梗死。提示 c Tn I是心性事件独立的有力预测因素。c Tn I阴性者心性事件率 1.2 %。结论 :床边心脏特异 c Tn I定性检测对急性冠脉综合征的早期心肌损害具有高度的敏感性 ,阴性结果心性事件发生率非常低 ,可以允许急诊胸痛病人早期出院。阳性结果应收住院进一步观察诊治

A novel mouse heart-specific gene, Lrrc10(GenBank Acc No. AF527781), was cloned from mouse embryo heart by application of EST assembly and RT-PCR. The cDNA of Lrrc10 was 1 410 bp and intronless. This gene was mapped to mouse chromosome 10D2 by BLAST search to mouse genome. The longest ORF of the cDNA encoded a putative proteins of 274 amino acids. Seven leucine rich repeat motifs were present between 53 amino acid to 212 amino acid. No known gene or protein was significantly homologous to Lrrc10 or its deduced...

A novel mouse heart-specific gene, Lrrc10(GenBank Acc No. AF527781), was cloned from mouse embryo heart by application of EST assembly and RT-PCR. The cDNA of Lrrc10 was 1 410 bp and intronless. This gene was mapped to mouse chromosome 10D2 by BLAST search to mouse genome. The longest ORF of the cDNA encoded a putative proteins of 274 amino acids. Seven leucine rich repeat motifs were present between 53 amino acid to 212 amino acid. No known gene or protein was significantly homologous to Lrrc10 or its deduced protein. However, XM-137268, a predicted human gene submitted by NCBI genome annotation project,shared high identity to Lrrc10. It may be concluded that XM-137268 was the uncloned human orthologue of Lrrc10. BLAST to EST database showed that cDNA of Lrrc10 was supported by 18 ESTs, all of them were from mouse heart. RT-PCR performed on a panel of different mouse tissues demonstrated that expression of Lrrc10 was strongly in heart, low in lung, not or very weakly in other tissues. These results suggest that Lrrc10 is a novel heart specific member of leucine rich repeat superfamily. As far as, no heart-specific member of this family was reported before.

采用表达序列标签 (EST)介导的基因克隆和表达谱分析 ,从小鼠心脏克隆了一个心脏特异新基因Lrrc10(GenBankAccNo .AF5 2 7781) .该基因cDNA全长为 14 10bp ,定位于小鼠染色体 10D2 ,在基因组中无内含子 .Lrrc10的最大开放阅读框编码的假想蛋白由 2 74个氨基酸组成 ,含有 7个亮氨酸重复基序 .同源性检索未发现有整体同源性的已知基因 .EST数据库中支持该基因cDNA序列的全部 18条EST均来自小鼠心脏组织 .对小鼠的不同组织cDNA的RT PCR检测证实该基因主要在心脏中强表达 ,在肺低表达 ,而在其他组织中不表达或表达很弱 .因此该基因是心脏特异的富亮氨酸重复超家族新成员

To investigate the function of ALK3 gene, the gene regulation and the signaling pathway related to ventricular septum defect during heart development. The model mice with ALK3 gene knock out via α MHC Cre/lox P system were bred. The mRNA expression level of control group was compared with that of experiment group and ALK3 downstream genes were screened using PCR select cDNA subtraction microarray. The mRNA of control group was extracted from E11.5 normal mouse hearts, and that of experiment group, from E11.5...

To investigate the function of ALK3 gene, the gene regulation and the signaling pathway related to ventricular septum defect during heart development. The model mice with ALK3 gene knock out via α MHC Cre/lox P system were bred. The mRNA expression level of control group was compared with that of experiment group and ALK3 downstream genes were screened using PCR select cDNA subtraction microarray. The mRNA of control group was extracted from E11.5 normal mouse hearts, and that of experiment group, from E11.5 hearts of mice with α MHC Cre +/- ALK3 F/+ genotype. It was found that the mice with ALK3 gene knock out produced heart defects involving the interventricular septum. The platelet activating factors acetylhydrolase and the transcription factor Pax 8 and so on, were down regulated. However, the Protein Tyrosine Kinase (PTK) of Focal Adhesion Kinase (FAK) subfamily and beta subtype protein 14 3 3 were up regulated in the α MHC Cre +/- ALK3 F/- mice. These data provide support that ALK3 gene played an important role during heart development. The platelet activating factors acetylhydrolase and Pax 8 genes could be important ALK3 downstream genes in the BMP signaling pathway during interventricular septum development. PTK and beta subtype protein 14 3 3 might be regulatory factors in this pathway.

了解ALK3在心脏发育中的作用 ,探索室间隔缺损的特异相关基因及其信号传导途径。应用α MHC Cre loxP系统 ,建立了心脏ALK3基因敲除小鼠模型 ,利用PCR选择性cDNA差异显示法和基因芯片扫描 (RNAmicroar ray)的方法 ,比较对照组和试验组mRNA表达水平 ,筛选ALK3下游基因。对照组的mRNA来自α MHC Cre+ -ALK3F + 的 11.5d小鼠胚胎心脏 ,试验组的mRNA来自α MHCCre+ - ALK3F - 的 11.5d小鼠胚胎心脏。心脏特异的ALK3基因敲除后 ,血小板激活因子乙酰水解酶及转录因子Pax 8等基因的表达水平下降 ,β亚类 14 3 3蛋白及蛋白酪氨酸激酶等基因的表达水平上调。血小板激活因子乙酰水解酶及转录因子Pax 8等基因可能是ALK3重要的下游基因 ,与室间隔缺损的形成有关 ;β亚类 14 3 3蛋白及蛋白酪氨酸激酶等基因是骨形态形成蛋白信号传导途径的调控因子

 
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