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重组卡介苗
相关语句
  recombinant bcg
    Construction of Recombinant BCG Secreting IL-2 and IFN-α 2a and Immunotherapeutic Effect on Mice with Bladder Cancer
    分泌IL-2和IFN-α2a的基因重组卡介苗构建和抗膀胱肿瘤实验研究
短句来源
    Objective: To investigate the effect of recombinant BCG secreting IL-2 (rBCG-IL-2) on peritoneal macrophages of mouse and inquire into the effect of rBCG-IL-2 on immunity of host.
    目的:研究能分泌人白细胞介素2的重组卡介苗(rBCC-IL-2)对小鼠腹腔巨噬细胞体外杀伤活性功能的改变,探讨rBCG-IL-2对宿主免疫功能的影响。
短句来源
    Effects of recombinant BCG and PPS on levels of nitric oxide released from peritoneal macrophages in tumor-bearing mice
    重组卡介苗及猪苓多糖对荷瘤小鼠巨噬细胞NO释放量的影响
短句来源
    Methods Gene engineering and electric transformation technologies were adopted to construction recombinant BCG,one of which was rBCG-IL-2 strain and the other was rBCG strain. Observe the growth of tumor and determine tumoricidal effect of macrophage after the tumor cells and recombined BCG have been inoculated in mouse in a few weeks.
    方法 采用基因工程技术和电转化技术 ,构建重组卡介苗即rBCG IL 2和rBCG ,并用瘤株重组BCG接种荷瘤小鼠 ,几周后观察肿瘤生长情况和检测巨噬细胞的杀伤活性。
短句来源
  “重组卡介苗”译为未确定词的双语例句
    Aim To observe the effects of rBCG IL 2, rBCG IL 2+PPS and polyporus polysaccharide(PPS)on levels of nitric oxide (NO) released from peritoneal macrophages of mice bearing melanoma .
    目的 观察重组卡介苗 (rBCG)和中药猪苓多糖(PPS) ,对荷瘤小鼠腹腔巨噬细胞释放NO的影响。
短句来源
    Objective To construct a recombinant secretory BCG Ag85B fused human interleukin (IL) 2. Methods BCG Ag85B signal sequence and IL 2 gene were amplified from the genome of BCG and IL 2 by PCR, respectively.
    目的 构建分泌性表达白介素 (IL) 2的重组卡介苗 (BCG)。 方法 分别以BCG和IL 2cDNA为模板 ,通过PCR扩增得到约 117bp的BCG抗原 85B(BCG Ag85B)信号肽序列和 399bp的IL 2基因序列。
短句来源
    Objective To constructarecombinant Bacillus Calmette Gurin (BCG )secreting BCGAg 85 Bfused humantumornecrosis factor (TNF) α .
    目的 构建分泌性表达肿瘤坏死因子(TNF) α的重组卡介苗
短句来源
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  recombinant bcg
Therefore, current studies aim at developing recombinant BCG (rBCG) strains secreting Th1-like cytokines to improve the effectiveness of the therapy.
      
Peripheral blood monocytes (PBMC) were stimulated by recombinant BCG and transformed into bacilli Calmette-Guerin activated killer (BAK) cells, and the effect of anticancer BAK cells was studied.
      
The result of MTT showed that the proliferation of PBMC in the recombinant BCG group was more powerful than in the other two groups (P >amp;lt; 0.05).
      
The result of LDH release assay showed that the antitumor activity of BAK cells stimulated by Recombinant BCG was the highest in all groups.
      
We conclude that the recombinant BCG can activate more PBMCs to anti-bladder cancer in vitro than wild-type BCG does.
      
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Objective To inquire into the effect of rBCG-IL-2 on tumor growth and immunity after it has been inoculateded in animal.Methods Gene engineering and electric transformation technologies were adopted to construction recombinant BCG,one of which was rBCG-IL-2 strain and the other was rBCG strain.Observe the growth of tumor and determine tumoricidal effect of macrophage after the tumor cells and recombined BCG have been inoculated in mouse in a few weeks.Results rBCG-IL-2 expressed and secreted IL-2 and the count...

Objective To inquire into the effect of rBCG-IL-2 on tumor growth and immunity after it has been inoculateded in animal.Methods Gene engineering and electric transformation technologies were adopted to construction recombinant BCG,one of which was rBCG-IL-2 strain and the other was rBCG strain.Observe the growth of tumor and determine tumoricidal effect of macrophage after the tumor cells and recombined BCG have been inoculated in mouse in a few weeks.Results rBCG-IL-2 expressed and secreted IL-2 and the count of secreting was about 9.87ng/ml±4.56ng/ml.The anti-growth effects of tumor of rBCG-IL-2 and rBCG were obvious higher than the control.Conclusion rBCG-IL-2 can prevent tumor from growing effectually,active immunity of the host early and enhance cytotoxicity of macrophage obviously.

目的 将表达IL 2重组BCG用于动物实验 ,观察其对肿瘤生长和机体免疫功能的影响。方法 采用基因工程技术和电转化技术 ,构建重组卡介苗即rBCG IL 2和rBCG ,并用瘤株重组BCG接种荷瘤小鼠 ,几周后观察肿瘤生长情况和检测巨噬细胞的杀伤活性。结果 rBCG IL 2能表达分泌IL 2 ,其表达量为 9 87ng ml± 4 56ng ml,rBCG IL 2与rBCG抑制肿瘤生长的作用明显优于对照组 ,并能提高小鼠巨噬细胞杀瘤率。结论 rBCG IL 2能有效抑制肿瘤生长 ,较早刺激机体的免疫功能 ,提高巨噬细胞的杀瘤活性。

Objective: To investigate the effect of recombinant BCG secreting IL-2 (rBCG-IL-2) on peritoneal macrophages of mouse and inquire into the effect of rBCG-IL-2 on immunity of host. Methods: Gene engineering technology, electricity transfer- ence and inoculation tumor cell are adopted; MTT assay is used to determine tumoricidal effect of macrophages. Results: Tumo- ricidal effect of macrophages of rBCG-IL-2 groups was higher than those of the control coups and BCG groups, and the tumorici- dal effect...

Objective: To investigate the effect of recombinant BCG secreting IL-2 (rBCG-IL-2) on peritoneal macrophages of mouse and inquire into the effect of rBCG-IL-2 on immunity of host. Methods: Gene engineering technology, electricity transfer- ence and inoculation tumor cell are adopted; MTT assay is used to determine tumoricidal effect of macrophages. Results: Tumo- ricidal effect of macrophages of rBCG-IL-2 groups was higher than those of the control coups and BCG groups, and the tumorici- dal effect of macrophages could reach a high state in a week. Conclusion: rBCG-IL-2 can raise tumoricidal effect of macrophages, improve immunity of host and is a prospect biological preparation.

目的:研究能分泌人白细胞介素2的重组卡介苗(rBCC-IL-2)对小鼠腹腔巨噬细胞体外杀伤活性功能的改变,探讨rBCG-IL-2对宿主免疫功能的影响。方法:采用基因工程技术和电转化技术构建卡介苗,采用MTT法测定小鼠腹腔巨噬细胞体外的杀伤活性。结果:rBCG-IL-2组小鼠腹腔巨噬细胞杀伤活性明显大于rBCG组和对照组,且巨噬细胞的杀伤活性在一周内达到最大。结论:rBCG-IL-2能提高巨噬细胞的杀伤活性,是一种很有前景的生物制剂。

Aim To observe the effects of rBCG IL 2, rBCG IL 2+PPS and polyporus polysaccharide(PPS)on levels of nitric oxide (NO) released from peritoneal macrophages of mice bearing melanoma . Methods Melanoma cell line B16 was injected hypodermically into outside of mouse left thigh to establish a model of tumor bearing mice. Nitric oxide synthesis assay was used to detect the levels of NO released from macrophages after being treated with rBCG IL 2, rBCG IL 2+PPS and PPS respectively, and the size of tumor...

Aim To observe the effects of rBCG IL 2, rBCG IL 2+PPS and polyporus polysaccharide(PPS)on levels of nitric oxide (NO) released from peritoneal macrophages of mice bearing melanoma . Methods Melanoma cell line B16 was injected hypodermically into outside of mouse left thigh to establish a model of tumor bearing mice. Nitric oxide synthesis assay was used to detect the levels of NO released from macrophages after being treated with rBCG IL 2, rBCG IL 2+PPS and PPS respectively, and the size of tumor volume was observed in various weeks. Results The NO level of rBCG IL 2 group was the highest in all the groups. As compared with the control group, the NO level of PPS group increased in the first two weeks and then decreased. The tumorstatic effect of macrophages from rBCG IL 2 and PPS groups on tumor growth were higher than that from the control. Conclusion rBCG IL 2 and PPS can enhance the NO level released from the macrophages. rBCG IL 2 prevent obviously the growth of the tumor.

目的 观察重组卡介苗 (rBCG)和中药猪苓多糖(PPS) ,对荷瘤小鼠腹腔巨噬细胞释放NO的影响。方法将黑色素瘤细胞株B16接种于小鼠左大腿外侧皮下 ,建立荷瘤小鼠模型 ,分别用rBCG IL 2、rBCG IL 2 +PPS和PPS进行局部治疗。于给药后第 1、2、3和 5wk处死小鼠 ,用NO酶法测定小鼠腹腔巨噬细胞释放NO的水平 ,并观察不同实验组瘤体的变化。结果 rBCG IL 2组小鼠腹腔巨噬细胞释放NO的水平最高。与对照组相比较 ,PPS组小鼠腹腔巨噬细胞释放NO的水平在第 1wk与第 2wk增高 ,第 3wk起与对照组释放的NO水平没有差异。rBCG IL 2组小鼠随给药时间的延长 ,皮下瘤体逐渐缩小。PPS组小鼠瘤体在给药后第 1wk和第 2wk生长缓慢 ,第 3wk起瘤体生长速度明显增加。结论 rBCG IL 2与PPS能提高小鼠腹腔巨噬细胞释放NO的水平 ,rBCG IL 2能明显抑制肿瘤生长

 
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