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免疫效应细胞
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  immunologic effector cells
     Results The immunologic effector cells down-regulated the expression of P185 and P-gp in MCF7/ADR cells.
     结果免疫效应细胞使MCF7/ADR细胞P185和P gp表达明显下降,CIK细胞作用后,MCF7/ADR细胞P185标记荧光几何均数下降了91.9%。
短句来源
     Conclusion Immunologic effector cells can simultaneously down-regulate the expression of P185 and P-gp in MCF7/ADR cell line, and increase the apoptosis rate of MCF7/ADR cells in combination with ADR.
     结论免疫效应细胞可同时下调P185蛋白和P gp蛋白的表达,协同ADR可提高MCF7/ADR细胞的凋亡率。
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     The accumulation and subcellular distribution of ADR in MCF7/ADR cells were increased after co-culture with the immunologic effector cells.
     免疫效应细胞增加了ADR在MCF7/ADR细胞内的积累及其在细胞核的分布。
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     Objective To investigate the effects of immunologic effector cells to enhance apoptosis induced by adriamycin (ADR) in multi-drug resistant human breast cancer cell line MCF7/ADR.
     目的探讨免疫效应细胞促进阿霉素(ADR)诱导乳腺癌耐药细胞MCF7/ADR凋亡的作用机制。
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     After hyperthermia the cytotoxic activity of immunologic effector cells against MCF7 cells rose by 86.23%, and was higher than against MCF7/ADR cells (rose by 30.32%).
     热冲击后免疫效应细胞对MCF7的杀伤活性提高了 86. 23%,超过了对MCF7 /ADR的杀伤活性 (提高了 30. 32% )。
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  immune effector cells
     Anti-P185~(erbB2) scFv-Fc-IL-2 modulates tumor cell surface molecules and activates immune effector cells
     抗人P185~(erbB2) scFv-Fc-IL-2调变肿瘤细胞表面分子和激活免疫效应细胞
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     ② ICRF187 attenuates the increases of cardiac immune effector cells(interstitial dendritic cells,cytotoxic.Thelper lymphocytes and macrophages)associated with cardiotoxicity.
     ②ICRF187减弱心脏毒性免疫效应细胞(树突状细胞,TH,TC淋巴细胞及巨噬细胞)的作用;
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     Enhancement of Killer Activity of Immune Effector Cells Caused by HLA-G Antisense Oligodeoxynucleotides
     HLA-G反义基因增强免疫效应细胞杀伤活性的研究
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     However,the cancer cells may downregulate Fas expression by themselves to resist the death signals transduced by FasL expressed by the immune effector cells and cancer cells,forming the Fas resistance mechanism---the prerequisite of the Fas counterattack,and therefore inhibiting the apoptosis of the cancer cells.
     而且癌细胞可下调Fas表达 ,抵御免疫效应细胞及癌细胞自身表达FasL所传递的死亡信号 ,形成“Fas抵抗” ,并因此抑制癌细胞凋亡。
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     (2)adoptive cellular immunotherapy using cytokine-induced killer cell, alloreactive NK cells, allogeneic or au-tologous leukemic-specific CD8 + cytotoxic T lymphocytes, and other immune effector cells;
     ②过继性细胞免疫治疗,用细胞因子诱导的杀伤细胞、同种反应NK细胞、同种或 自身白血病特异的CD8+细胞毒T淋巴细胞和其他免疫效应细胞;
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  immunoeffector cells
     During the in vivo study, the nude mice were allocated into 3 groups: preventive group (Ⅱ), 1~2 days before inoculating BEL 7402, gave DC activated immunoeffector cells;
     体内实验时 ,裸鼠分为 3组 :预防组 (Ⅱ ) ,于接种BEL 740 2前 1~ 2d天给DC激活的免疫效应细胞 ;
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     5~6 days later, mixed the culture of DC and immunoeffector cells for 1~2 days.
     方法 体外分别用人GM CSF、IL 4、TNFα、BEL 740 2TAA和人IL 2刺激正常人DC和去DC的单个核细胞 (免疫效应细胞 ) ,5~ 6d后混合培养DC和免疫效应细胞 1~ 2d。
短句来源
     In vivo study, the nude mice were allocated into 3 groups: preventive group (Ⅱ), 2 days before inoculating BEL-7402, gave DC activated immunoeffector cells;
     体内实验时,裸鼠分为3组:预防组(Ⅱ),于接种BEL-7402前2天给DC激活的免疫效应细胞;
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     Immunoeffector cells induced by dendritic cells inhibiting growth of BEL-7402
     树突状细胞诱导免疫效应细胞对BEL-7402的生长抑制
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     Inhibitory effect of Immunoeffector cells on growth of PC3 induced by dendritic cell vaccines
     树突状细胞疫苗诱导免疫效应细胞对PC3生长的抑制作用
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  “免疫效应细胞”译为未确定词的双语例句
     CD3Ak cells, which is induced bv anti-CD3 monoclonalantibody and rIL-2, is attaching importance based on it's rapid expansion, long time of living, strong anti-tumor activity and low side -effect.
     CD3AK(anti-CD3 antibody induced activated killer cells)是抗CD3单克隆抗体(anti-CD3 antibody,CD3McAb)和重组人白细胞介素-2(rIL-2)诱导产生的免疫效应细胞,目前CD3AK细胞正因其快速扩增,长期存活,高抗肿瘤活性及低毒副作用的优点而倍受重视。
短句来源
     Inhibitory and apoptosis roles of immunoeffectcells induced by dendritic cells vaccine on PC3 cells
     树突状细胞疫苗诱导免疫效应细胞对PC3的凋亡和抑制
短句来源
     The maximal inhibitory rate of the immunoeffectcells induced by DC vaccine on the PC3 cells was 98.1%.
     体外实验中,DC疫苗诱导免疫效应细胞对PC3的最大抑制(杀伤)效率为98.1%;
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     Conclusion: Cytotoxic cells including major CD56+ lymphocytes could be expanded from CBMC using SCGM via the synergistic induction with monoclonal anti-CD3 antibodies and IL-2. This work provides a simple and efficient way of expanding and enriching CD56+ cytotoxic lymphocytes from CBMC for the adoptive immunotheraphy of tumor.
     结论:在抗CD3单抗和IL鄄2作用下可使用SCGM,获得以CD56+淋巴细胞为主的强细胞毒性免疫效应细胞,为进行肿瘤过继免疫治疗提供了一种简单的扩增脐血CD56+细胞毒性淋巴细胞的方法。
短句来源
     Results For the in vitro experiment,the maximal killing rate in BEL7402 group was 81% and that in PC2,group 62.4%.
     结果体外实验中,DC 诱导免疫效应细胞对 BEL7402的最大杀伤效率为81%,对 PC3的最大杀伤效率为62.4%。
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  immunologic effector cells
In contrast to solid metastases, isolated micrometastatic tumor cells are appropriate targets for intravenously applied anti-cancer therapeutics because they are easily accessible to macromolecules and immunologic effector cells.
      
Immunologic effector cells termed cytokine-induced killer (CIK) cells are generated in vitro from peripheral blood lymphocytes by addition of interferon-gamma, interleukin (IL)-2, IL-1 and an antibody against CD3.
      
Immunologic effector cells such as lymphokine-activated killer (LAK) cells, activated T cells such as tumor-infiltrating lymphocytes (TILs), and cytokine-induced killer (CIK) cells may be suitable to remove residual tumor cells.
      
This study may be beneficial for the development of new immunologic effector cells for using in adoptive immunotherapy for glioblastoma multiforme in the future.
      
Several lines of evidence indicate that immunologic effector cells may play a role in the pathogenesis of idiopathic repetitive abortions.
      
  immune effector cells
Also, activated immune effector cells can promote vascular obliterative damage through direct cytotoxic pathways targeting the endothelium or by inducing proinflammatory molecules.
      
They possess all the components required to educate immune effector cells that can then mediate tumor destruction.
      
While infecting a vertebrate host, blood flukes (Schistosoma mansoni) must continually resist adhesions by immune effector cells.
      
Estrogen influences the function of immune effector cells, primarily through alterations in cytokine expression.
      
pedrosoi are apparently involved in the fungal interaction with immune effector cells, since sialidase-treated conidia were less resistant to phagocytosis by human neutrophils from healthy individuals.
      
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Many studies documented that themonary inflammatory respondence processesmay play a important role in the pathogen-esis of silicosis and asbestosis. Bronchoalve-olar lavage (BAL) is the sampling of lowerrespiratory tract by bronchofiberscope techni-que. Therefor, utilizing BAL to evaluate thechanges of cytology and biochemistry of BALF will be valuble. 72 individuals with silicosisor asbestosis and 19 volunteers unexposed tosilica or asbestos dust were studied. Fromstatistical analysis results, it is clear thatthe...

Many studies documented that themonary inflammatory respondence processesmay play a important role in the pathogen-esis of silicosis and asbestosis. Bronchoalve-olar lavage (BAL) is the sampling of lowerrespiratory tract by bronchofiberscope techni-que. Therefor, utilizing BAL to evaluate thechanges of cytology and biochemistry of BALF will be valuble. 72 individuals with silicosisor asbestosis and 19 volunteers unexposed tosilica or asbestos dust were studied. Fromstatistical analysis results, it is clear thatthe inffammatory response of lung to mine-ral dust is a significant change in early sta-ge of pneumoconiosis. The authors suggestthat it is useful that the BAL for the studyof pathogenesis of pneumoconiosis, the earlydiagnosis and evaluation of therapeutic ofec-tive in pneumoconiosis.

对72例尘肺及19名健康志愿者的支气管肺泡灌洗液(BALF)进行了细胞学及生化成份的分析。结果提示矽肺早期阶段(Ⅰ期)细胞浓度明显高于正常对照组及其他各期矽肺;细胞分类表现为矽肺淋巴细胞(Lym)比率增加,石棉肺除Lym增加外,嗜中性细胞(Neut)亦明显增加;矽肺、石棉肺的肺泡巨噬细胞(PAM)比率相对减少。生化成份测定结果为矽肺BALF的总蛋白、白蛋白、乳酸脱氢酶(LDH)、β-葡萄糖醛酸酶(β-G)及IgG含量不同程度增高,石棉肺除了Ⅰ期LDH活力升高外,其余指标变化不明显。作者认为BALF的细胞学改变是免疫效应细胞对外来刺激的一种应答,并与随之出现的炎性介质及生化变化有密切关系,可能是肺纤维化形成的基础。

The methods and technology of immunopharmacology for Chinese Materia Medica have been progressing rapidly in recent years. The regulation of Chinese Materia Medica on the activity of cytokine and effector cells is reviewed in this article. Many clinical studies indicate that Chinese Materia Medica can regulate the production and activity of IFN, ILs, TNF, etc., and affect the cytotoxieity of NK. LAK, CTL, etc. The immunopharmcological research of Chinese Materia Medica in molecular and cellular levels is useful...

The methods and technology of immunopharmacology for Chinese Materia Medica have been progressing rapidly in recent years. The regulation of Chinese Materia Medica on the activity of cytokine and effector cells is reviewed in this article. Many clinical studies indicate that Chinese Materia Medica can regulate the production and activity of IFN, ILs, TNF, etc., and affect the cytotoxieity of NK. LAK, CTL, etc. The immunopharmcological research of Chinese Materia Medica in molecular and cellular levels is useful for explaining the mechanism of whole regulation and two-way regulation depending on the function of the body. In this article, the relations between quantity and effect, the study in vivo and in vitro, and the whole drug and its component are also reviewed.

综述了中药在调节细胞因子和免疫效应细胞活性方面的研究进展。大量临床观察和动物实验表明,中药可广泛调节白细胞介素(LK_s)、干扰素(IFN)等的生成和活性,可影响自然杀伤细胞(NK)等的细胞毒活性。在分子、细胞水平开展中药免疫调节机理的研究,有助于揭示中药对于机体整合的药理作用和与功能状态相关的调节效应。文章亦分析了中药免疫药理的量效关系,体内与体外研究的关系,中药与有效成分的关系。

he in vivo

观察了小鼠接种高分泌IL-4的黑色素瘤细胞后体内免疫效应细胞(包括CTL、NK细胞及LAK细胞)抗肿瘤活性及其分泌的细胞因子(包括IL-2、IFN-r、TNF及GM-CSF)水平的变化,荷瘤后第15天小鼠脾细胞NK活性及经诱导后的LAK活性有所降低,而经诱导后的CTL杀伤活性显著升高,荷瘤小鼠腹腔内巨噬细胞杀伤活性及其分泌的IL-1水平也明显升高;在荷瘤后第4天及第12天出现两个高峰,实验结果表明,高分泌IL-4的黑色素瘤细胞体内生长受抑制是因为IL-4基因的导入及IL-4的分泌使体内CTL及巨噬细胞杀伤活性提高,因而使机体抗肿瘤免疫功能得以增强。

 
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