Patients were divided into three groups according to the pathogen burden: group A, n≤3,group B, n=4-5 and group C, n≥6. Results The pathogen burden was independent of the C-reactive protein level.
Increasing pathogen burden was significantly associated with increasing atherosclerosis risk, the prevalence of atherosclerosis was 44.4%,70.6% and 76.7% in group A, B and C.
It was impossible by statistical testing to determine the additional infection burden on the body that might be caused by poor oro-dental health.
Objective To evaluate the relationship between infection burden and coronary atherosclerosis and the plaque feature. Methods One hundred and eighty two patients underwent coronary angiography in Zhongshan Hospital from 2002-2003. Atherosclerosis and vulnerable plaque were determined by intravascular ultrasound (IVUS). Seropositivity of cytomegalovirus, helicobacter pylori, chlamydia pneumonia, hepatitis B virus, EB virus, CoxB virus, influenza A virus, influenza B virus and mycobacterium tuberculosis were...
Objective To evaluate the relationship between infection burden and coronary atherosclerosis and the plaque feature. Methods One hundred and eighty two patients underwent coronary angiography in Zhongshan Hospital from 2002-2003. Atherosclerosis and vulnerable plaque were determined by intravascular ultrasound (IVUS). Seropositivity of cytomegalovirus, helicobacter pylori, chlamydia pneumonia, hepatitis B virus, EB virus, CoxB virus, influenza A virus, influenza B virus and mycobacterium tuberculosis were determined by ELISA. The serum hs-CRP was detected by Dade Behring prospect ( Immuno-nehelomitery). Patients were divided into three groups according to the pathogen burden: group A, n≤3,group B, n=4-5 and group C, n≥6. Results The pathogen burden was independent of the C-reactive protein level. Increasing pathogen burden was significantly associated with increasing atherosclerosis risk, the prevalence of atherosclerosis was 44.4%,70.6% and 76.7% in group A, B and C. The risk associated with elevated pathogen burden was much higher when CRP was also elevated(>5.0 mg/L) (43.8%, 70.0%, 70.8%)vs(45.5%, 63.7%, 96.8%). The positively of vulnerable plaque increased significantly when the pathogen burden was high(n>5)(33.3%, 32.4% and 51.7% P<0.05). Conclusion Our data suggested that infection burden was associated with prevalence of coronary atherosclerosis,and it was particularly important when C-reactive protein was elevated. The high level infection burden could predict vulnerable plaque.
Objective:To establish a real-time fluorescent quantitative PCR method for determining the BK virus(BKV) level in renal transplant recipients,and to evaluate its clinical application.Methods: Plasmids containing part of BKV VP1 gene conservative region were constructed as external standards,and a TaqMan probe technique was used to establish a quantitative method for determination of BKV.Urine and peripheral blood(PB) samples from 112 renal transplant recipients were assayed for BK virus levels,and the results...
Objective:To establish a real-time fluorescent quantitative PCR method for determining the BK virus(BKV) level in renal transplant recipients,and to evaluate its clinical application.Methods: Plasmids containing part of BKV VP1 gene conservative region were constructed as external standards,and a TaqMan probe technique was used to establish a quantitative method for determination of BKV.Urine and peripheral blood(PB) samples from 112 renal transplant recipients were assayed for BK virus levels,and the results were compared with those of 40 healthy controls.Results: The real-time fluorescent quantitative PCR assay established in this study had good sensitivity,specificity,and reproducibility.The minimal detectable level was 8×10~(2)copy/ml,intro-experiment variation was 0.54%-3.78%,and intra-experiment variation was 0.62%-4.58%.BKV was detected in 27.7% urine samples and 11.6% PB samples from patients.The median level of BKV in urine and PB were(8.2×)10~(4)copy/ml and 2.4×10~(3)copy/ml,respectively.BKV positive rate of 40 healthy population in urine and PB samples were 2.5% and 0%,respectively.The positive rate and level of BKV in renal transplant recipients were both significantly higher than those in normal cohort(both P<0.01).The positive rate of BKV in urine samples were significantly higher than that in PB samples(P=(0.02),)but the BKV load in urine samples was not related to that in PB samples.Conclusion: The real-time fluorescent quantitative PCR assay in this study is simple,reliable,and precise,which lays a foundation for future study of the relationship between BKV infection and renal graft loss.
感染负荷
infection burden
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