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   胰岛素基因 的翻译结果: 查询用时:0.016秒
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胰岛素基因
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  insulin gene
     The order of insulin gene expression level form strong to weak was:blank control group(1.98± 1.22),STZ lipectomy group(1.52± 0.68),STZ insulin group(1.37± 0.55),STZ glyburide group(1.08± 0.24) and STZ control group(0.79± 0.31).
     胰岛素基因表达强度,由强到弱顺序为空白对照组(1.98±1.22)、STZ手术组(1.52±0.68)、STZ胰岛素组(1.37±0.55)、STZ格列本脲组(1.08±0.24)、STZ对照组(0.79±0.31)。
短句来源
     Compared with DN group, TG and FFA in blood and pancreas of DH group were futherly increased (P<0.01,P<0.01;P<0.01,P<0.05), and insulin gene expression,insulin content were futherly decreased(P<0.05,P<0.01);
     在两个糖尿病组之间,上述指标亦存在着差异,DH组血浆及胰腺内TG和FFA含量比DN组进一步增多(分别为P<0·01、P<0·01、P<0·01、P<0·05),且胰岛素基因表达水平和胰岛素含量进一步下降(P<0·05、P<0·01)。
短句来源
     Results Compared with NC group, TG and FFA content in the blood and pancreas of DN group were significantly higher(P<0.05~P<0.01); and insulin gene expression、insulin content were decreased (P<0.01,P<0.01).
     结果与NC组相比,DN组血浆及胰腺内TG和FFA含量明显增多(P<0·05~P<0·01),而胰岛素基因表达水平和胰岛素含量则明显降低(P<0·01、P<0·01);
短句来源
     The Difference between the Promoter CMV and EF1αto the Expression of Human Insulin Gene in BHK Cell
     启动子CMV和EF1α对人胰岛素基因在BHK细胞中表达的影响
短句来源
     After the treat- ment of insulin, compared with DH group, though plasma lipid did not been ameliorated obviously(P>0.05); TG and FFA content in pancreas were markedly reduced (P<0.01,P<0.01), furthermore, insulin gene expression and insulin content also increased simultaneously (P<0.01,P<0.01).
     胰岛素治疗后,与DH组相比,血循环中的TG和FFA水平虽然没有改善(P>0·05),但胰腺内TG和FFA含量明显下降(P<0·01、P<0·01),同时胰岛素基因表达水平和胰岛素含量亦升高(P<0·01、P<0·01)。
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  “胰岛素基因”译为未确定词的双语例句
     Conclusion: Intravenous injection of GLP-1(7-36)NH_2 can promote proinsulin gene transcripts,(increase) pancreas′s proinsulin mRNA level,stimulate insulin biosynthesis and secretion and quickly decrease blood(glucose.)
     结论:静脉注射GLP-1(7-36)NH2能促进糖尿病鼠胰岛素基因转录、升高胰腺胰岛素原mRNA水平、促进胰岛素的合成与分泌,迅速升高血胰岛素水平以降低血糖。
短句来源
     Methods The human insulin (INS) gene digested with EcoRⅠ and BamHⅠwas inserted into MCS sites of eukaryotic expression vector pIRES2-EGFP to construct pIRES2-EGFP-INS.
     方法将人胰岛素基因插入到真核表达载体pIRES2-EGFP的EcoRⅠ和BamHⅠ位点中,构建重组质粒pIRES2-EGFP-INS。
短句来源
     Digest the recombinant plasmid with BamHⅠ and SacⅠ,and clone the obtained fusion gene into expression vector pBI121.Identify the recombinant plasmid by digestion with BamHⅠ and SacⅠ.
     将霍乱毒素B亚单位(CTB)基因与这种不带C肽的人胰岛素基因融合后,插入克隆载体,然后用BamHⅠ和SacⅠ进行酶切,并将酶切的融合基因片段连接在植物表达载体pBI121上,最后用BamHⅠ和SacⅠ进行酶切鉴定。
短句来源
     Methods GLP-1 was added at final concentrations of 1,10,10~2 and 10~3nmol/L to media containing 2.2mmol/L(low),5.5mmol/L(normal),11.1mmol/L(high) glucose. All islets samples were harvested after 24h,and total RNA was extracted in a single series for RT-PCR.
     方法不同刺激浓度的GLP-1(0 nmol/L、1 nmol/L、10 nmol/L、102nmol/L、103nmol/L)与葡萄糖浓度分别为2.2 mmol/L、5.5 mmol/L、11.1 mmol/L的RPMI1640营养液共培养24 h后,提取细胞总RNA,运用半定量RT-PCR技术检测胰岛素基因表达的变化。
短句来源
     Conclusion The promoter EF1α was more effective than CMV in BHK cells.
     结论 在BHK细胞中启动子EF1α启动胰岛素基因表达的活性比启动子CMV高。
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  相似匹配句对
     The gene therapy of insulin for diabetes
     糖尿病的胰岛素基因治疗
短句来源
     4 new genes were obtained.
     U基因
短句来源
     Expression of Designed Human Insulin Gene in Ganoderma lucidium
     表达人胰岛素基因的转基因灵芝
     Genetic Information Carrier Gene
     基因简史
短句来源
     Insulin can inhibit the apoptosis of VSMCs.
     同时胰岛素
短句来源
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  insulin gene
In addition, genetic defects in the glucokinase gene, the glucose sensor of the pancreatic β cells, and the insulin gene also lead to impaired glucose tolerance.
      
On the other hand, ERK1/2 activity is required for maximal glucose-dependent activation of the insulin gene promoter.
      
These kinases most likely act directly and indirectly on multiple pathways that regulate β-cell function and, in particular, to transduce an elevated glucose signal into insulin gene transcription.
      
Antioxidant treatment in vitro prevents disappearance of these two transcription factors and normalizes insulin gene expression.
      
Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, the follistatin gene, and a region near the insulin receptor, the evidence supporting linkage is not overwhelming.
      
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A recently devised protocol was used to obtain macrophage (M) lines with a variety of derived DNA to see if different oncogenes would lead to generation of M lines with different phenotypes. SV 40 DNA, cellular myc genes, U 937 DNA and Insulin gene have been used and 7 cell lines obtained. All these lines show heterogeneity in the cell phenotype and in each case there are Macrophage-like cells. They all secrete collagenase and lysozyme. 30-40% of these lines have Fc receptor and Fc receptor mediated phagocytosis...

A recently devised protocol was used to obtain macrophage (M) lines with a variety of derived DNA to see if different oncogenes would lead to generation of M lines with different phenotypes. SV 40 DNA, cellular myc genes, U 937 DNA and Insulin gene have been used and 7 cell lines obtained. All these lines show heterogeneity in the cell phenotype and in each case there are Macrophage-like cells. They all secrete collagenase and lysozyme. 30-40% of these lines have Fc receptor and Fc receptor mediated phagocytosis and also complement receptor and phagocytosis. Heterogeneity within the lines is probably due to the fact that the lines are not cloned yet, It is supposed that this protocol can be used not only to derive M lines but also T and B cell lines.

本文报告应用转染技术建立巨噬细胞传代株,探讨应用不同来源的DNA获得具有不同功能特性的巨噬细胞株,应用SV40DNA、C-myc基因,U937DNA和胰岛素基因已获得7株细胞,经鉴定它们均有巨噬细胞的特性,即可分泌胶元酶、溶菌酶,其中有30—40%的细胞带有Fc受体,并有经Fc受体介导的吞噬功能。细胞株内细胞功能各异是因为细胞株尚未克隆化。从本试验结果看不仅经转染方法可获得巨噬细胞株,而且有可能经此法获得B或T淋巴细胞传代株。

The polymorphic characteristics of DNA region adjacent to the 5' end of the insulin gene in 83 Han subjects in China including 26 normal people and 57 diabetics were analysed by restriction endonuclease Bgl 1 gene mapping of chromosomal DNA. DNA fragments obtained by Bgl 1 digestion mainly contained 2.8 ± 0.3 kb (5%), 3.5±0.3kb (10%), 4.2 ± 0.3kb (46%) and 5±0.4kb (36%). In contrast with western white and black people, the above region is homozy-gous in 86% of the Han subjects analysed. This difference may be...

The polymorphic characteristics of DNA region adjacent to the 5' end of the insulin gene in 83 Han subjects in China including 26 normal people and 57 diabetics were analysed by restriction endonuclease Bgl 1 gene mapping of chromosomal DNA. DNA fragments obtained by Bgl 1 digestion mainly contained 2.8 ± 0.3 kb (5%), 3.5±0.3kb (10%), 4.2 ± 0.3kb (46%) and 5±0.4kb (36%). In contrast with western white and black people, the above region is homozy-gous in 86% of the Han subjects analysed. This difference may be associated with the racial characteristics. No definite correlation between such polymorphism and the type of diabetes has been found.

本文应用Bgl 1限制性内切酶图谱及墨迹杂交分析了83人的染色体DNA。其中正常人26名,糖尿病患者57名,为国内首次对中国汉族人胰岛素基因5'-端邻近的多态性特征的研究分析。酶解的DNA片段的长度主要是2.8±0.3Kb(5%),3.5±0.3Kb(10%),4.2±0.3Kb(46%)以及5±0.4Kb(36%)。有86%的人的多态区的等位基因是纯合子,与西方白人及黑人的有所不同。这可能反映了该多态性具有某些种族特征。我们尚未发现多态性与糖尿病类型之间有明显的关系。

By the polymsrase chain reaction (PGR), we have amplified the selected segments of DNA of insulin gene. Then the point mutation could be detected by dot-blot hybridization of the segments of DNA with sequence-specific oligonucleotide inprobes. We have applied this method for the analysis of insulin gene mutation in a Chinese diabetic patient with hyper-in sulineraia. The result has indicated that this is a case With insulin gene mutation B25 (TTC-TTG). This point mutation resulted, in the substitution of a leucine...

By the polymsrase chain reaction (PGR), we have amplified the selected segments of DNA of insulin gene. Then the point mutation could be detected by dot-blot hybridization of the segments of DNA with sequence-specific oligonucleotide inprobes. We have applied this method for the analysis of insulin gene mutation in a Chinese diabetic patient with hyper-in sulineraia. The result has indicated that this is a case With insulin gene mutation B25 (TTC-TTG). This point mutation resulted, in the substitution of a leucine for phenylalanine. This is the first identification of Insulin Chicago in Chinese diabetic patients.

本文应用聚合酶链反应(PGR)扩增了1例糖尿病伴有高胰岛素血症患者以及正常对照的胰岛素基因片段,随后用合成的顺序特异性寡核苷酸探针对上述患者及正常对照的胰岛素基因片段进行点杂交(dot-blot)分析。结果发现该患者是1例胰岛素基因B链25位突变患者(芝加哥胰岛素型),基因突变为B_(25)(TTC-TTG),蛋白质水平为亮氨酸在B_(25)位上替代苯丙氨酸,从而在中国糖尿病患者中首次发现了此类突变病例。

 
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