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基因簇     
相关语句
  gene cluster
     snR72~78 snoRNA Gene Cluster in Yeast
     酵母snR72~78snoRNA基因簇的研究
短句来源
     The α - globin gene cluster is located on the short arm of chromosome 16 and arranged in the order of 5' —ζ- ψζ- ψα1-α2-α1-θ-3' , spaning 30Kb;
     位于第16号染色体短臂上的α-珠蛋白基因簇以5′-ζ-ψζ-ψα1-α2-α1-θ-3′顺序排列,全长约30kb;
短句来源
     The expression of intact and mutant human apolipoprotein AⅠ/CⅢ/AⅣ/AⅤ gene cluster in transgenic mice
     完整与突变的人载脂蛋白ApoAⅠ/CⅢ/AⅣ/AⅤ基因簇转基因小鼠研究(英文)
     Screening of the gene cluster for milbemycin biosynthesis from Streptomyces griseochromogenes
     Streptomyces griseochromogenes菌株milbemycin生物合成基因簇的筛选
短句来源
     the β-globin gene cluster is on the short arm of chromosome 11 and in the order of 5'-ε-Gγ-Aγ-ψβ-δ-β-3',spanning about 75 kb.
     位于第11号染色体短臂上的β-珠蛋白基因簇以5′-ε-Gγ-Aγ-ψβ-δ-β-3′顺序排列,总长度约75kb;
短句来源
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  gene clusters
     Establishment of α and β globin gene clusters transgenic mice and the study of trans-acting factors of β globin gene clusters
     建立α与β珠蛋白基因簇转基因鼠模型及β基因簇反式因子的研究
短句来源
     Cloning of Nisin Biosynthesis Gene Clusters and Studied on Structure-Function Relationship of nisZ Promoter and Structural Gene
     Nisin生物合成基因簇的克隆及nisZ启动子和结构基因的结构与功能研究
短句来源
     It may be deduced that the car gene clusters in LSSE-H2, KA1 and GTIN11 have the same origin, and could laterally transfer between different bacteria.
     对比研究表明,LSSE-H2,KA1和GTIN11中car基因簇的起源可能相同,并能在不同的细菌之间水平转移.
短句来源
     RT-PCR experiments also proved these gene clusters to exist.
     RT-PCR实验进一步验证了这些snoRNA基因簇的存在。
短句来源
     The human globin gene family consists of α - and β -globin gene clusters.
     人类珠蛋白基因家族分为α和β两个基因簇
短句来源
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  genes cluster
     Arginine Biosynthetic Genes Cluster of Corynebacterium Crenatum
     钝齿棒杆菌精氨酸生物合成基因簇的研究
短句来源
     Several DNA amplification fingerprinting (DAF) products were generated under appropriate conditions after amplification of genomic DNA sequences in the PCR by using consensus sequence primers. The DAFs were mainly derived from the α-globin genes cluster and specific to deletions of α-globin genes. A total of 61 patients suffered from α-thalassemia were diagnosed by DAF typing using differences between these patients and the normal.
     应用计算机辅助设计,选择α-珠蛋白基因簇中断裂好发部位或其外侧一致DNA序列设计引物,在包含低温退火的条件下,扩增并分析α-珠蛋白基因缺失的DNA指纹图谱,并据此对61例α-地中海贫血病人进行了基因分型诊断.该方法稳定、可靠,可望用于临床诊断.
短句来源
     Regrouped bacteriophage λHJ-3 containing complete biosynthesized genes cluster of nisin is screened out from the gene files of Lactococcus lactis AL2 with high yield of nisin. The gene encoding the precursor of nisin is amplified by PCR using the λHJ-3 as the template and is cloned into pMG36e. The result of DNA sequence analysis indicates that NisinZ is produced by Lactococcus lactis AL2.
     从乳链菌肽高产菌株Lactococcus lactis AL2的基因库中筛选到一个含有完整乳链菌肽生物合成基因簇的重组噬菌体λHJ-3,并在乳酸乳球菌中克隆和表达了编码乳链菌肽前体结构基因(nisZ)。
短句来源
  “基因簇”译为未确定词的双语例句
     A Novel Gene in APOA1/C3/A4/A5 cluster : Apolipoprotein A5
     APOA1/C3/A4/A5基因簇的新载脂蛋白基因:APOA5及其研究进展
短句来源
     Nine homologous genes (HOXD1,-D3,-D4,-D8,-D9,-D10,-D11,-D12, -D13) of HoxD complex locate on chromosome 2 in the order o f HOXD1 to HOXD13,among which HOXD13 is closest to the centromere.
     HOXD基因簇中的 9个同源基因 (HOXD1, D3, D4 , D8, D9, D10 , D11, D12 , D13)根据其距着丝粒的远近 ,按由远到近的顺序在染色体上依次排列。
短句来源
     Near these loci, there were a few candidate genes including lipoprotein lipase (LPL) and a cluster of apolipoprotein (apoA1 C3 A4).
     两位点附近分别有脂蛋白脂酶 (LPL)基因和 (apoA1 C3 A4)基因簇
短句来源
     Sequence analysis of a rice BAC q3037(H0207F01) identified a cluster of five tandemly arranged peroxidase genes, osp1, osp2, osp3, osp4 and osp5 , within a 22.5 kb region.
     通过对定位BAC克隆 q30 37(H0 2 0 7F0 1)的序列测定和分析 ,在其中一个 2 2 .5kb的区域发现一个由 5个第三类过氧化物酶基因 (依次命名为osp1、osp2、osp3、osp4、osp5 )组成的基因簇
短句来源
     The human p-globin locus contains five functional genes in the order 5'-ε-Gγ-Aγ-δ-β-3'.
     人β-珠蛋白基因簇包含五个功能基因,按5′-ε-Gγ-Aγ-δ-β-3′顺序排列。
短句来源
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  gene cluster
Chicken α-Globin Gene Cluster Is Preceded by the Nonerythroid-Specific Gene, the Beginning of Which Is Colocated with the Replic
      
The proliferating-cell gene cluster included MET, VIM, MYC, TOP2A, PCNA.
      
The neoangiogenesis and blood-cell gene cluster included LCK, HCK, FGR, MMP9, CSFR1, VEGF, FLT1, and KDR.
      
The fragment contains one truncated and three complete open reading frames highly homologous to the starch/maltodextrin utilization gene cluster from T.
      
The aglB and aglA genes from the starch/maltodextrin utilization gene cluster of Thermotoga neapolitana were subcloned into pQE vectors for expression in Escherichia coli.
      
更多          
  gene clusters
Molecular Evolution of Tandemly Repeated Heterochromatic Gene Clusters Involving a Switch of Their Function in the Genome of Dro
      
Polymorphism in hsp70 gene clusters ofDrosophila and variation in the numbers of gene copies andhsp70 isoforms in group viriliswere found.
      
identify the specific nuclear scaffold-bound DNA sequence in rRNA gene clusters of silkwormAttacus ricini, the detergent-like salt lithium 3', 5' diiodosalicylate (LIS) was used for the preparation of nuclear scaffold.
      
miRNA gene clusters and possible functions of complement miRNA pairs are discussed.
      
However, the strain possesses chromosomally located gene clusters coding for F1C (foc) and type I fimbriae (fim).
      
更多          
  tandem genes
High-level expression of acidic partner-mediated antimicrobial peptide from tandem genes inEscherichia coli
      
Here, we report that the two identical tandem genes rbr3A and rbr3B, which encode the heat shock protein Hsp21, show the transcription pattern of general stress genes.
      
As judged from these data, three of the four PGA genes isolated appear to be nearly identical, but one of the tandem genes is clearly different from the other genes.
      
However, in the second exon of one of the tandem genes we found a nucleotide substitution giving rise to a Glu→Lys substitution of the 43rd amino acid residue of the activation peptide, leading to a charge difference of the corresponding isozymogens.
      
The human orosomucoid (ORM) is controlled by two closely linked loci, ORM1 and ORM2, and two tandem genes, AGP1 and AGP2, encoding the proteins produced by the two loci, have been cloned.
      
更多          
  genes cluster
The position of the novel heat-stable resistance of LA2157 was localized in the resistance genes' cluster close to the location of gene Mi-1.
      
Similarly to their human counterparts, all baboon IGHV genes cluster into three clans, with one clan including the IGHV1, IGHV5 and IGHV7 subgroups, one clan including the IGHV2, IGHV4 and IGHV6 subgroups, and one clan including the IGHV3 subgroup.
      
Cattle are useful models for γδ T cell biology because they have γδ T cells that respond to isopentenylpyrophosphate (IPP) antigens, while mice do not, and some bovine TRGV genes cluster closely with human genes.
      
AtTPS genes cluster into five phylogenetic subfamilies of the plant TPS superfamily.
      
GART, SON, IFNAR, and CRF2-4 genes cluster on human Chromosome 21 and mouse Chromosome 16
      
更多          


The incidence of β-thalassemia is relatively high in South China. Prenatal gene diagnosis, followed by artificial abortion of affected fetuses, is an effective means of preventing birth of affected babies. Consequently, we first studied 10 restriction site polymorphisms in the β-globin gene cluster with the aid of 6 probes in 17 probands and their parents from Guangdong province and determined haplotypes associated with βA (normal β-genc) and βT (β-thalassemia gene) chromosomes. The 15βA chromosomes studied...

The incidence of β-thalassemia is relatively high in South China. Prenatal gene diagnosis, followed by artificial abortion of affected fetuses, is an effective means of preventing birth of affected babies. Consequently, we first studied 10 restriction site polymorphisms in the β-globin gene cluster with the aid of 6 probes in 17 probands and their parents from Guangdong province and determined haplotypes associated with βA (normal β-genc) and βT (β-thalassemia gene) chromosomes. The 15βA chromosomes studied belong to 7 haplotypes, 3 of which having not been reported before. The 26 βT chromosomes studied belong to 7 haplotypes as well, 3 of which having not been reported before, indicating that the βT-genes they carry may be new mutations. According to the incomplete data available, prenatal gene diagnosis is possible in about 30% of the families studied. The results were brieflv discussed.

β地中海贫血在华南地区发病率较高。产前基因诊断,对患病胎儿进行人工流产,是预防患婴出生的有效措施。我们首先对广东地区17个家庭的患儿及其父母,用6种探针进行了β基因簇内10个限制酶切位点多态性的研究,并定出β~A(正常β基因)与β~T(β地贫基因)染色体的单体型。β~A染色体共15条,分属7种单体型,其中3种为新类型。26条β~T染色体也分属7种单体型,其中3种为新类型,提示其携带的β~T基因可能为新的突变类型。根据已掌握的不完整资料,这17个家庭中,约30%可以进行产前基因诊断。文中并对所得结果作了简要讨论。

Analysis of genotype and haplotype detemined by polymorphic restriction endonuclease site in β-globin gene cluster is the basis of prenatal diagnosis for β-thalassemias. By application of 3 gene probes in relation to β-globin gene cluster and Southern blotting, there are 5 restriction polymorphic sites in clusters of Chinese.Linking these polymorphic sites,we obtained 9 genotypes which were composed of 7 haplotypes. Among them, the frequency of thetwo types +----and + +---is 61%, so they are predominant in Chinese...

Analysis of genotype and haplotype detemined by polymorphic restriction endonuclease site in β-globin gene cluster is the basis of prenatal diagnosis for β-thalassemias. By application of 3 gene probes in relation to β-globin gene cluster and Southern blotting, there are 5 restriction polymorphic sites in clusters of Chinese.Linking these polymorphic sites,we obtained 9 genotypes which were composed of 7 haplotypes. Among them, the frequency of thetwo types +----and + +---is 61%, so they are predominant in Chinese β-globingene cluster.

β珠蛋白基因多态性限制酶位点所组成的基因型和单体型的分析,是进行β地中海贫血产前诊断的基础。本文用Southern印迹杂交法,借助于与β珠蛋白基因簇有关的3个基因探针,分析了β珠蛋白基因簇内5个多态性位点,根据对这些多态性位点的连锁分析获得了9个正常中国人的基因型。这18个单基因型是由7种单体型组成的。其中+----及++---两型占61%,是我国β珠蛋白基因簇单体型的主要形式。

A Chinese couple whose two children died of β-thalassemia major requestedprenatal diagnosis during the third pregnancy.On the basis of hematological andhemoglobin examinations,the clinical diagnosis of 21 relatives in this family weredone.Then,by the RFLP haplotype analyses of DNA from the 21 relatives and fromamniotic fluid cells,the haplotype chromosomes with β-thalassemia determinant wereidentified.The fetus was found to have both haplotype chromosomes with β-thalassemia determinant from the ancestors,i.e.one...

A Chinese couple whose two children died of β-thalassemia major requestedprenatal diagnosis during the third pregnancy.On the basis of hematological andhemoglobin examinations,the clinical diagnosis of 21 relatives in this family weredone.Then,by the RFLP haplotype analyses of DNA from the 21 relatives and fromamniotic fluid cells,the haplotype chromosomes with β-thalassemia determinant wereidentified.The fetus was found to have both haplotype chromosomes with β-thalassemia determinant from the ancestors,i.e.one chromosome carrying β-thalassemia determinant was transmitted via great-grandmother→father→fetus,and another one via grandmother→mother→fetus.The fetus was thus sufferedfrom β-thalassemia major.

广西柳州一名孕妇曾生育过2例重型β-地中海贫血患儿,已先后死亡,因此要求进行β-地中海贫血的产前诊断。本文应用 DNA 限制酶酶谱技术,通过对这个家系各成员的β-珠蛋白基因簇单体型分析,鉴定出携带β-地中海贫血基因的染色体的单体型,诊断出胎儿患重型β-地中海贫血,即胎儿细胞携带两个β-地中海贫血基因,其中一个是从曾外祖母,通过祖母、父亲传下来,另一个是从外祖母通过母亲传给胎儿。这是国内对β-地中海贫血产前诊断的首例报道。

 
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