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转运动力学
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  transport kinetics
     The Establishment and Application of the Transport Kinetics Model of Xenobiotics Across Blood-Brain Barrier
     外源化合物跨血脑屏障转运动力学模型的建立与应用
短句来源
  transporting kinetics
     Study on relationship between transporting kinetics of doxorubicin and MDR reversal index in K562/A cells
     K562/A细胞阿霉素转运动力学参数与逆转倍数的相关性
短句来源
     OBJECTIVE To study the relationship between transporting kinetics of doxorubicin in K562/A cells and the reversal effect of multidrug resistance (MDR) modulators.
     目的研究K562/A细胞中阿霉素转运动力学参数与多药耐药逆转剂逆转能力之间的相关性。
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  “转运动力学”译为未确定词的双语例句
     Studies on the Kinetic Models of Drug Uptake and Efflux of Doxorubicin for MDR Cancer Cells
     肿瘤细胞阿霉素转运动力学模型研究
短句来源
     Objective To study the kinetics and mechanisms of transference across the membrane of human erythrocytes by nickel ions (Ni 2+) and effect of Ni 2+ with the membrane of human erythrocytes.
     目的 研究镍离子 (Ni2 + )跨人红细胞膜转运动力学和转运机制 ,以及Ni2 + 对红细胞膜的作用。
短句来源
     Methods The rate of transmembrane transport of Ni 2+ was determined by the method of kinetics, and the influence on uptake of nickel by human erythrocytes had been studied by the variety of the concentration of Ni 2+ and pH of solution system and the transport promoter and inhibitor. The influence of Ni 2+ on membrane of erythrocytes was studied by kinetics of fluorescence scan.
     方法 利用转运动力学方法测定Ni的跨人红细胞胞膜转运速率 ,改变Ni2 + 的浓度、溶液pH值、转运促进剂和特异抑制剂 ,研究这些因素对红细胞摄入Ni2 + 的影响 ,并利用荧光动力学扫描方法观察Ni2 + 对膜蛋白内源性荧光的影响。
短句来源
     To identify if there was the mechanism of active efflux in erythromycin resistant Streptococcus strains with mefA gene isolated from veterinary clinic,several erythromycin resistant strains with mefA gene,ermB gene and several susceptible strains were selected in this test.
     为证实国内临床分离的动物源链球菌菌株中是否存在与红霉素耐药性相关的主动外排机制,选取含有mefA基因、ermB基因、不含mefA/ermB基因的链球菌耐药菌株和青霉素、红霉素均敏感的菌株,采用完整细胞物质转运动力学方法研究了菌株对红霉素的主动外排功能。
短句来源
     THE KINETICS OF FLUID AND SOLUTE TRANSPORT DURING PERITONEAL DIALYSIS AND ITS CLINICAL GUIDING VALUE
     腹膜透析时液体和溶质转运动力学及临床意义
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  相似匹配句对
     Studies on the Kinetic Models of Drug Uptake and Efflux of Doxorubicin for MDR Cancer Cells
     肿瘤细胞阿霉素转运动力学模型研究
短句来源
     Dynamics of Enzyme Catalysis
     酶催化动力学
短句来源
     Dynamics of Rational Functions
     有理函数的动力学
短句来源
     Transport kinetics of monomethylhydrazine across blood-brain barrier in rats
     一甲基肼跨血脑屏障转运动力学
短句来源
     transport route;
     转运途径;
短句来源
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  transport kinetics
The transport kinetics of the triplet state of solid chrysene embedded in the channels of various porous matrices is studied by observing its delayed luminescence.
      
Transport kinetics of O2(a1δg) and O2(b1σg+) molecules and O(3P)
      
It is shown that the densities and transport kinetics of O2(a1δg), O2(b1σg+), and O(3P) appear similar for oxygen mixtures with argon and helium in the same conditions independent of discharge mode.
      
Uptake studies using different concentrations of PteGlu revealed dual transport kinetics in the presence of a pH gradient and linear uptake in its absence.
      
The aims of this study were to develop and validate an HPLC method for the determination of cryptotanshinone in the human intestinal cell line Caco-2 monolayers, and to investigate the transport kinetics of cryptotanshinone.
      
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10-Hydroxycamptothecin (OPT) is a new antineoplastic alkaloid isolated from Camptotheca acuminata Decne, which is indigenous to China. In the present paper the effects of OPT on transport of thymidine and uridine in murine hepatoma cells were investigated. Thirty minutes after adding OPT (25~200μM) to a hepatoma cell culture a reduction of the transport rate of thymidine and uridine was noticed and the dose for 50% transport inhibition was found to be about 100μM. When hepatoma cells were pretreated with OPT...

10-Hydroxycamptothecin (OPT) is a new antineoplastic alkaloid isolated from Camptotheca acuminata Decne, which is indigenous to China. In the present paper the effects of OPT on transport of thymidine and uridine in murine hepatoma cells were investigated. Thirty minutes after adding OPT (25~200μM) to a hepatoma cell culture a reduction of the transport rate of thymidine and uridine was noticed and the dose for 50% transport inhibition was found to be about 100μM. When hepatoma cells were pretreated with OPT for 0.5hr and then the drug was removed from the medium, the inhibitory action of OPT on nucleoside transport was shown to be reversible.Since OPT did not exert significant influence on the activities of thymidine kinase and uridine kinase in hepatema cells, it was suggested that the transport inhibition of nucleosides by OPT was unlikely to interfere with the phosphorylation process but rather with cell membrane carrier systems.The results of transport kinetic analysis showed that the apparent K_m values for thymidine and for uridine transport in hepatoma cells were 8.3μM and 13μM, respectively, and that the inhibitory effect of OPT on transport was competitive.

10-羟基喜树碱(羟喜)是从我国南方特有植物喜树中分得的新抗癌有效成份。体外实验表明,不同浓度的羟喜(25~200μM)能程度不等地抑制小鼠肝癌细胞对胸苷和尿苷的转运。并能明显抑制[~3H]TdR或[~3H]UR掺入到DNA和RNA。若先用羟喜与癌细胞作用0.5小时,然后洗去药液,再观察对核苷转运的影响,发现羟喜对核苷转运的抑制是可逆的。体外实验还表明,羟喜对肝癌细胞胸苷激酶和尿苷激酶活力无明显的影响,这提示它抑制核苷转运的机制可能与核苷的磷酸化受抑无关。转运动力学的分析表明,小鼠肝癌细胞转运胸苷和尿苷的K_m值分别为0.53μM和13βM,V_(max)值分别为8.6和500pmol/分/10~6细胞。羟喜是竞争性抑制肝癌细胞对嘧啶核苷的转运。

10-Hydroxycamptothecin (OPT) is a new antineoplastic alkaloid isolated from Camptotheca acuminata Decne, which is indigenous to China. In the present paper the effects of OPT on transport of thymidine and uridine in murine hepatoma cells were investigated. Thirty minutes after adding OPT (25~200μM)to a hepatoma cell culture a reduction of the transport rate of thymidine and uridine was noticed and the dose for 50% transport inhibition was found to be about 100μM. When hepatoma cells were pretreated with OPT...

10-Hydroxycamptothecin (OPT) is a new antineoplastic alkaloid isolated from Camptotheca acuminata Decne, which is indigenous to China. In the present paper the effects of OPT on transport of thymidine and uridine in murine hepatoma cells were investigated. Thirty minutes after adding OPT (25~200μM)to a hepatoma cell culture a reduction of the transport rate of thymidine and uridine was noticed and the dose for 50% transport inhibition was found to be about 100μM. When hepatoma cells were pretreated with OPT for 0.5 hr and then the drug was removed from the medium, the inhibitory action of OPT on nucleoside transport was shown to be reversible. Since OPT did not exert significant influence on the activities of thymidinekinase and uridine kinase in hepatoma cells, it was suggested that the transportinhibition of nucleosides by OPT was unlikely to interfere with the phosphorylationprocess but rather with cell membrane carrier systems. The results of transport kinetic analysis showed that the apparen K_m values for thymidine and for uridine transport in hepatoma cells were 8.3μM and 13μM,respectively, and that the inhibitory effect of OPT on transport was competitive.

10-羟基喜树碱(羟喜)是从我国南方特有植物喜树中分得的新抗癌有效成份。体外实验表明,不同浓度的羟喜(25~200μM)能程度不等地抑制小鼠肝癌细胞对胸苷和尿苷的转运。并能明显抑制[~3H]TdR或[~3H]UR掺入到DNA和RNA。若先用羟喜与癌细胞作用0.5小时,然后洗去药液,再观察对核苷转运的影响,发现羟喜对核苷转运的抑制是可逆的。体外实验还表明,羟喜对肝癌细胞胸苷激酶和尿苷激酶活力无明显的影响,这提示它抑制核苷转运的机制可能与核苷的磷酸化受抑无关。转运动力学的分析表明,小鼠肝癌细胞转运胸苷和尿苷的K_m值分别为0.53μM和13μM,V_(max)值分别为8.6和500pmol/分/10~6细胞。羟喜是竞争性抑制肝癌细胞对嘧啶核苷的转运。

Sprague-Dawley rats were chosen as an animal model of chronic renal failure (CRF) .The serum and cardiac muscular AVP changes were observed. The effects on mean arterial pressure, peak value of left ventricular pressure and ATP ase activities of cardiac muscle were measured after intravenous injection of AVP and its antiserum in CRF rats. The result showed that the content of serum and cardiac AVP in CRF rats rose parallel to serum creatinine levels. Intravenous injection of standard AVP could reduce the Na-K-ATP...

Sprague-Dawley rats were chosen as an animal model of chronic renal failure (CRF) .The serum and cardiac muscular AVP changes were observed. The effects on mean arterial pressure, peak value of left ventricular pressure and ATP ase activities of cardiac muscle were measured after intravenous injection of AVP and its antiserum in CRF rats. The result showed that the content of serum and cardiac AVP in CRF rats rose parallel to serum creatinine levels. Intravenous injection of standard AVP could reduce the Na-K-ATP ase activity and aggravate the abnormal changes of cardiac indices. But ATP antiserum could improve cardiac function and provide significant protection for cardiac muscle. It suggested that the decreasin of Na-K-ATP ase activities caused by abnormal rising of AVP might participate in the pathogenesis of cardiac Insufficiency in CRF.

用SD大鼠制作慢性肾衰(CRF)动物模型,观察其血浆与心肌精氨酸加压素(AVP)含量的变化;CRF大鼠静脉分别注射AVP及其抗血清,观察其对平均动脉压、左心室压峰值和心肌细胞钠-钾-ATP酶(Na~+,K~+-ATP酶)活力的影响。结果表明,CRF~+大鼠血浆及心肌AVP含量与血肌酐水平同步增高;静脉注射AVP标准品,可使心肌Na~+,K~+-ATP酶活力明显降低,并加重心功能指标的异常变化;而给予AVP抗血清,则可改善心功能,对心肌有明显的保护作用。提示ATP含量异常增高所引起的Na~+,K~+-ATP酶泵转运动力学损害,可能参与CRF时心功能不全的病理过程。

 
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