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  catch up growth
    Objective Nutrition insulin like growth factors (IGFs) axis is important to body catch up growth and gastrointestinal development, while gastrointestinal development is closely related to the nutritional absorb and catch up growth in infants with intrauterine growth retardation (IUGR).
    目的 生后早期的生长主要受营养的调控 ,营养物质 胰岛素 胰岛素样生长因子 (IGF)轴在胎儿宫内发育迟缓 (IUGR)生长追赶及胃肠发育中起着重要的作用 ,而胃肠发育又与营养物质的吸收、生长追赶关系密切。
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    This research aims to study the effects of early postnatal diet with different levels of protein and caloric on serum IGF 1, IGFBP3, intestinal development and catch up growth in rats with IUGR.
    该研究探讨生后早期不同蛋白质和热卡水平的营养干预如何调控IGF系统及影响IUGR大鼠的小肠发育和体格生长追赶 ,并追踪至成年期。
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Objective To know the related factors affecting the growth catche up in the children with malnutrition growth retardation(MGR).Methods To measure the stimulating levels of serum GH and to observe the relationship among increment of height,weight,and inherited factor in 28 cases of refeeding children (aged3~8yr)with MGR for 4 months to 4 years.Results The height velocity of growth catche up (△HSDS)correlated with the increment weight for height (△HWSDS) (P<0 01)positively,with the basic weight for height...

Objective To know the related factors affecting the growth catche up in the children with malnutrition growth retardation(MGR).Methods To measure the stimulating levels of serum GH and to observe the relationship among increment of height,weight,and inherited factor in 28 cases of refeeding children (aged3~8yr)with MGR for 4 months to 4 years.Results The height velocity of growth catche up (△HSDS)correlated with the increment weight for height (△HWSDS) (P<0 01)positively,with the basic weight for height (HWSDS)negatively(P<0 01),but not with the SDS of target height.The catche up in height velocity could be over the growth ability depending on chronological age.Two thirds of patients had hypersomatotroinemia and part of them had still kept it after returning to normal growth,which showed a continuous reset situation of somatotropin axis by the metabolic compensates responding to undernourishment.Conclusion Higher energy and protein should be offered early in order to utilize the favorable reset status of somatotropin axis to get satisfied catch up for the children with MGR.

目的 了解营养不良性生长迟缓儿生长追赶的影响因素。方法 观察28 例营养不良性生长迟缓儿,在调整营养供应后至少4 个月的身高体重增长与基础体格指标、骨龄和遗传因素的关系。结果 身高Z评分增长与身高别体重Z评分增长正相关( P< 0-01) ,与基础身高别体重Z评分负相关( P< 0-01) ,与基础骨龄正相关( P< 0-05);与年龄及遗传身高Z评分不相关。体重Z评分增长与基础身高别体重Z评分负相关( P< 0-01) ,与骨龄正相关( P<0-01)。身高增长速度可超过其年龄应有生长能力。部分患儿恢复期仍有高生长激素血症( 营养不良所致促生长素轴代谢代偿重整状态的持续)。结论 对营养不良性生长迟缓应尽早供给足够热量和蛋白,以充分利用促生长素轴的代谢代偿转为促生长效应,获得最大追赶。

Objective Nutrition insulin like growth factors (IGFs) axis is important to body catch up growth and gastrointestinal development, while gastrointestinal development is closely related to the nutritional absorb and catch up growth in infants with intrauterine growth retardation (IUGR). Now there are few reports about the postnatal intestinal development of IUGR infants in our country, and the reports have mainly focused on the gastrointestinal morphology and structure of new born IUGR rats. This research...

Objective Nutrition insulin like growth factors (IGFs) axis is important to body catch up growth and gastrointestinal development, while gastrointestinal development is closely related to the nutritional absorb and catch up growth in infants with intrauterine growth retardation (IUGR). Now there are few reports about the postnatal intestinal development of IUGR infants in our country, and the reports have mainly focused on the gastrointestinal morphology and structure of new born IUGR rats. This research aims to study the effects of early postnatal diet with different levels of protein and caloric on serum IGF 1, IGFBP3, intestinal development and catch up growth in rats with IUGR. Methods The IUGR rat model was established by nutrition restriction. Sixty four IUGR pups were randomly assigned into four groups: the IUGR model group, the IUGR high protein diet group, the IUGR low protein diet group and the IUGR high caloric group. The rats in the four groups were fed with a normal protein, a 30% protein and a 10% protein diets, and a diet with caloric being higher by 20% than the other three groups respectively. Sixteen normal pups receiving normal diet were served as the control group. The serum concentrations of IGF 1 and IGFBP3, body weight, body length and intestinal weight and length were measured at the 4th and 12th weeks after birth respectively. Results The IUGR high protein diet and high caloric diet groups manifested quick intestinal development and catch up growth, as well as the increased IGFs level; the IGFs level of the IUGR high protein diet group at the 4th week after birth was significantly higher than the other groups (P< 0.05 ). The IUGR model group manifested a relatively slow intestinal development and catch up growth and a non increased IGFs level. The body weight, body length and intestinal weight and length in the IUGR low protein diet group at the 4th and 8th weeks after birth were lower than those of other groups and the IGFs level was lower at the 4th after birth compared with that of the other groups (P< 0.05 ). The IGFs level was positively correlated to body weight, body length and intestinal weight and length at the 4th after birth (r= 0.930 , 0.884 , 0.678 , 0.978 respectively, all P< 0.05 ). At the 12th week after birth, there was no correlation among them. Conclusions IGF 1 is a sensitive index reflecting catch up growth and is positively related to intestinal development and body catch up growth during childhood (4th week of life), while the correlation disappears at adulthood (12th week of life).

目的 生后早期的生长主要受营养的调控 ,营养物质 胰岛素 胰岛素样生长因子 (IGF)轴在胎儿宫内发育迟缓 (IUGR)生长追赶及胃肠发育中起着重要的作用 ,而胃肠发育又与营养物质的吸收、生长追赶关系密切。目前国内有关IUGR出生时小肠发育状况报道甚少 ,且仅限于IUGR出生时胃肠形态结构的观察。该研究探讨生后早期不同蛋白质和热卡水平的营养干预如何调控IGF系统及影响IUGR大鼠的小肠发育和体格生长追赶 ,并追踪至成年期。方法 采用孕母饥饿法建立IUGR模型。 6 4只IUGR新生鼠随机分为 4组 :IUGR正常饮食组(SC组 ) ,饮食中蛋白含量 2 0 % ;IUGR高蛋白组 (SH组 ) ,饮食中蛋白含量占 30 % ;IUGR低蛋白组 (SL组 ) ,饮食中蛋白含量为 1 0 % ;IUGR高热卡组 (SA组 ) ,饮食中热卡较其它组高 2 0 %。 1 6只正常新生鼠为正常对照组 (C组 )予以正常饮食。幼鼠 3周断乳后继续予原饮食模式 1周 ,第 4周起各组均予正常饮食喂养。分别于出生时及生后第4周、1 2周测定各组大鼠的血清IGF 1、胰岛素生长因子结合蛋白...

目的 生后早期的生长主要受营养的调控 ,营养物质 胰岛素 胰岛素样生长因子 (IGF)轴在胎儿宫内发育迟缓 (IUGR)生长追赶及胃肠发育中起着重要的作用 ,而胃肠发育又与营养物质的吸收、生长追赶关系密切。目前国内有关IUGR出生时小肠发育状况报道甚少 ,且仅限于IUGR出生时胃肠形态结构的观察。该研究探讨生后早期不同蛋白质和热卡水平的营养干预如何调控IGF系统及影响IUGR大鼠的小肠发育和体格生长追赶 ,并追踪至成年期。方法 采用孕母饥饿法建立IUGR模型。 6 4只IUGR新生鼠随机分为 4组 :IUGR正常饮食组(SC组 ) ,饮食中蛋白含量 2 0 % ;IUGR高蛋白组 (SH组 ) ,饮食中蛋白含量占 30 % ;IUGR低蛋白组 (SL组 ) ,饮食中蛋白含量为 1 0 % ;IUGR高热卡组 (SA组 ) ,饮食中热卡较其它组高 2 0 %。 1 6只正常新生鼠为正常对照组 (C组 )予以正常饮食。幼鼠 3周断乳后继续予原饮食模式 1周 ,第 4周起各组均予正常饮食喂养。分别于出生时及生后第4周、1 2周测定各组大鼠的血清IGF 1、胰岛素生长因子结合蛋白 3(IGFBP 3)浓度及体重、身长和小肠重量、长度。结果 IUGR大鼠虽然宫内营养不良 ,但SH组及SA组呈快速小肠发育和体格生长追赶伴IGFs水平明显升高 ,其中 4周时SH组IGFs水平显著高于其余各组 (P <0 .0 5 ) ;S

Objective:To research the related factors of growth in low birth weight( LBW) infant.Method:We observed 40 cases LBW in clinic and then detect the length, weigh and head and chest size in the mean while detect the intelligence and hearing. Result and Conclusion: The data of growth intelligence and hearing in LBW infant is supeyior to those in very low birth weight infant. while, half of the LBW infant are as same as the normal ones after correct breast in early period.

目的:探讨低出生体重儿的生长发育情况及其相关影响因素。方法:对本院儿科门诊系统管理的40例低出生体重儿进行系统观察,对其体格发育指标如身长、体重、头围、胸围等进行监测,同时进行智力和听力测定。结果:(包括体格发育、智力和听力发育的有关指标的数据。)结论:极低出生体重儿的生长追赶明显落后于低出生体重儿。经过合理喂养和早期有效干预,约半数低出生体重儿至1岁时可以赶上正常出生体重儿。

 
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