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   多样性合成 的翻译结果: 查询用时:0.311秒
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多样性合成
相关语句
  diversity-oriented synthesis
     Diversity-oriented synthesis in drug discovery
     药物发现中的定向多样性合成
短句来源
     Application of Diversity-oriented Synthesis and Forward-synthesis Analysis in Drug Discovery
     多样性合成与向前合成分析在药物发现中的应用
短句来源
     The characteristics of diversity-oriented synthesis and forward-synthesis analysis and their application in drug discovery were reviewed using practical examples.
     结合实例,综述多样性合成与向前合成分析的特点及其在药物发现中的应用。
短句来源
  相似匹配句对
     Coumarin fluorescent dyes such as C.
     合成了C.
短句来源
     N,N,N?
     合成了 N,N,N?
短句来源
     Diversity-oriented synthesis in drug discovery
     药物发现中的定向多样性合成
短句来源
     The Diversity of Children's Literature
     儿童文学的多样性
短句来源
     Genetic Diversity
     基因多样性
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  diversity-oriented synthesis
In this report, we review two approaches to design and synthesize compound libraries for biological screenings, i.e., diversity-oriented synthesis (DOS) and biology-oriented synthesis (BIOS).
      
Naturally occurring macrocycles often exhibit remarkable biological activities and, therefore, constitute an attractive starting point for diversity-oriented synthesis for lead discovery in drug development.
      
This pathway illustrates a key element in a planning algorithm for diversity-oriented synthesis.
      


Modern drug discovery not only involves screening small molecules for their ability to bind to a preselected protein target,but also their ability to modulate a biological pathway in cells or organisms,without regard for any particular protein target.This process is likely to benefit in the future from an evolving forward analysis,used in diversity-oriented synthesis,which leads to structurally complex and diverse small molecules.Several strategies for producing structurally molecular complexity and diversity...

Modern drug discovery not only involves screening small molecules for their ability to bind to a preselected protein target,but also their ability to modulate a biological pathway in cells or organisms,without regard for any particular protein target.This process is likely to benefit in the future from an evolving forward analysis,used in diversity-oriented synthesis,which leads to structurally complex and diverse small molecules.Several strategies for producing structurally molecular complexity and diversity are presented in this review.

本文介绍了定向多样性合成的概念、在药物发现中的作用及实现分子复杂性和多样性的方法。

The characteristics of diversity-oriented synthesis and forward-synthesis analysis and their application in drug discovery were reviewed using practical examples. To solve the issue of lacking in structural complexity and diversity of molecules in compound database, the strategy for diversity-oriented synthesis was developed, in which simple components, fewer reaction steps and combinatorial chemistry were used to synthesize structurally complex and diverse small molecules.

结合实例,综述多样性合成与向前合成分析的特点及其在药物发现中的应用。设计以简单的构件为起点,用组合化学技术合成结构复杂多样的小分子化合物,即应用多样性合成策略是解决各种化合物库中分子结构缺乏多样性和复杂性的有效方法,并将在药物发现中发挥巨大作用。

 
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