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子宫内膜癌细胞系
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  endometrial carcinoma cell line
     Conclusion Ishikawa is still an ER-positive endometrial carcinoma cell line while HEC-1A is a cell line with low-expression ER.
     结论Ishikawa细胞是ER阳性子宫内膜癌细胞系,而HEC-1A细胞则为ER低表达细胞系。
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     Methods Human endometrial carcinoma cell line HHUA cells were cultured in vitro and treated with different concentrations of NaB.The growth suppressing effect of NaB on HHUA cells was observed by drawing growth curves.
     方法 :不同浓度的NaB作用于体外培养的人子宫内膜癌细胞系HHUA ,通过绘制细胞生长曲线观察NaB对细胞生长的抑制作用 ;
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     Objective To study the phosphorylation and activation of ERK1/2 and Akt by stromal cell derived factor-1α(SDF-1α) in endometrial carcinoma cell line Ishikawa and Hea-1A.
     目的 探讨基质细胞衍生因子1α(SDF - 1α)对子宫内膜癌细胞系HEC - 1A和Ishikawa磷脂酰肌醇3激酶/蛋白激酶B (PI- 3K/Akt)及丝裂原活化蛋白激酶(MAPK)信号传导通路的激活作用。
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     Objective To study the effect of sodium butyrate(NaB) on proliferation of human endometrial carcinoma cell line HHUA cells and its mechanism.
     目的 :探讨丁酸钠 (NaB)对人子宫内膜癌细胞系HHUA细胞体外增殖的影响及机制。
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     The growth-inhibitory effect of endometrial carcinoma cell line HEC-1A induced by somatostatin receptor family
     生长抑素受体家族介导的子宫内膜癌细胞系HEC-1A的生长抑制作用
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  “子宫内膜癌细胞系”译为未确定词的双语例句
     (2) The proliferation of endometrial cancer cell line HEC-1B could be increased by both E 2 and TAM.
     (2)E2 和TAM可以促进子宫内膜癌细胞系HEC 1B的生长。
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     Conclusion:17β-estradiol can down-regulate the expression of ERRα mRNA and this regulation is mediated by estrogen receptor.
     结论: 17βE2 可减少子宫内膜癌细胞系Ishikawa细胞ERRαmRNA的表达,此减少作用是通过ER介导完成的。
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     Objective To examine the effect of Hycamtin on two kinds of endometrial carcinoma cell lines, Ishikawa 3H12 and HEC 1A.
     目的 观察盐酸拓扑替康 (Hycamtin)对子宫内膜癌细胞系Ishikawa 3H12和HEC 1A体外生长的影响。
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     Expressions of estrogen receptor α and β in endometrialcarcinoma cell lines, Ishikawa and HEC-1A
     子宫内膜癌细胞系Ishikawa和HEC-1A细胞雌激素受体表达
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     As compared with normal endometrium ,these were significantly low levels expression of SDF-1 and CXCR4 in endometrial carcinoma tissues.
     结论:CXCR4和SDF-1在子宫内膜癌细胞系、子宫内膜组织及内膜癌组织中的表达存在差异,在内膜癌组织中其表达均显著弱于正常及良性病变者。
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     [Purpose] To observe the ectopic autocrine phenomenon of HCG in endometrial carcinoma cell lines.
     [目的]观察子宫内膜癌细胞异位HCG自分泌现象。
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     Objective To establish a cell line of human endometrial adenocarcinoma and study its characteristics.
     目的 :建立人子宫内膜癌细胞 ,并研究其生物学特性。
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     Progesterone-modulated proteins in human endometrial cancer cell line Ishikawa
     孕激素对人子宫内膜癌细胞Ishikawa影响的蛋白质组学研究
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     Study on Human Telomerase Reverse Transcriptase(hTERT) Promoter Activity in Cervical Carcinoma Cell Line and Endometrial Carcinoma Cell Line
     宫颈癌及子宫内膜癌细胞中hTERT启动子活性的研究
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     The Establishment of a Cell Line from Human Endometrial Adenocarcinoma and the Observation of its Biological Characteristics
     人子宫内膜癌细胞HECCL-1的建立及其生物学特性的初步观察
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  endometrial carcinoma cell line
Genistein-induced proteome changes in the human endometrial carcinoma cell line, ishikawa
      
Effect of estrogen and antiestrogen on chemotherapeutic sensitivity of endometrial carcinoma cell line
      
Growth, morphologic, and invasive characteristics of early and late passages of a human endometrial carcinoma cell line (RL95-2)
      
Estrogenicity of bisphenol A in a human endometrial carcinoma cell line.
      
The Hec1A endometrial carcinoma cell line was resistant toward all tubulin inhibitors as tested.
      


Objective To study the roles of estrogen (E2) to the regulation of progestrone receptor isofonns in uterine endometrial carcimoma .Methods The uterine endometrial adehocarcinoma cell line HEC - IB was cultured in vitro and the breast cancer cell line MCF- 7 was used as control. Different concentrations of 5 nm, 10 nm and 20 nm estrogen were used to stimulate the cell line respectively for 24, 48 and 72 h. The changes of the two isoforms hPRA and hPRB by different concemtra-tions of estrogen under different periods...

Objective To study the roles of estrogen (E2) to the regulation of progestrone receptor isofonns in uterine endometrial carcimoma .Methods The uterine endometrial adehocarcinoma cell line HEC - IB was cultured in vitro and the breast cancer cell line MCF- 7 was used as control. Different concentrations of 5 nm, 10 nm and 20 nm estrogen were used to stimulate the cell line respectively for 24, 48 and 72 h. The changes of the two isoforms hPRA and hPRB by different concemtra-tions of estrogen under different periods were examined by Western blot respectively.Results ①For HEC - IB cell line, under all kinds of concemtration and time period , estrogen showed no significant influence on hPRB. But hPRA had down - regulation under 5 nm estrogen and this down - regulation became more significant, as concemtration was larger and time longer. ②For MCF - 7 cell line, under all kinds of concentration and time period, estrogen could up - regulated the two isoforms, especially The 10nm estrogen influenced significantly. In different concemtrations, up- regulation was more obvious after 48 h. Conclusions The regulation of estrogen to hPR isoforms showed cell speciality, dose - dependency and time - dependency. HEC - IB cell line, under all kinds of concemtration and time, estrogen gave no significant influence on hPRB, while hPRA was down - regulated.

目的 研究不同剂量雌激素(雌二醇,E_2)对子宫内膜癌细胞系中孕激素受体亚型在蛋白水平的调控,探讨雌激素、孕激素受体亚型与子宫内膜癌的关系。方法 体外培养子宫内膜癌细胞系HEC-IB,分别用含5nm、10nm、20nm雌二醇的培养液分别作用于细胞24、48、72h,以不含雌二醇的培养液培养细胞为自身对照。通过Western blot方法观察不同剂量雌激素对孕激素受体亚型A、B的蛋白水平调控的动态变化,并以乳腺癌细胞系MCF-7为对照。结果 ①HEC-IB细胞分别经5nm、10nm、20nm的E_2作用24、48、72h后,与未加药的细胞相比,不同浓度、时间下E_2对hPRB调控作用均不明显;而对hPRA的作用在E_2 5um时下调,且随时间延长,下调作用越加明显;在10nm的第24、48h下降,其后渐上升,而在E_2 20nm作用72h时基本恢复加药前的水平。②MCF-7细胞分别经E_2 5nm、10nm、20nm作用24、48、72h后,与未加药的细胞相比较,各种浓度及时间下,E_2对hPRA、B有上调作用的趋势;其中10nm的E_2上调作用较为明显,各种浓度的E_2在第48h的上调...

目的 研究不同剂量雌激素(雌二醇,E_2)对子宫内膜癌细胞系中孕激素受体亚型在蛋白水平的调控,探讨雌激素、孕激素受体亚型与子宫内膜癌的关系。方法 体外培养子宫内膜癌细胞系HEC-IB,分别用含5nm、10nm、20nm雌二醇的培养液分别作用于细胞24、48、72h,以不含雌二醇的培养液培养细胞为自身对照。通过Western blot方法观察不同剂量雌激素对孕激素受体亚型A、B的蛋白水平调控的动态变化,并以乳腺癌细胞系MCF-7为对照。结果 ①HEC-IB细胞分别经5nm、10nm、20nm的E_2作用24、48、72h后,与未加药的细胞相比,不同浓度、时间下E_2对hPRB调控作用均不明显;而对hPRA的作用在E_2 5um时下调,且随时间延长,下调作用越加明显;在10nm的第24、48h下降,其后渐上升,而在E_2 20nm作用72h时基本恢复加药前的水平。②MCF-7细胞分别经E_2 5nm、10nm、20nm作用24、48、72h后,与未加药的细胞相比较,各种浓度及时间下,E_2对hPRA、B有上调作用的趋势;其中10nm的E_2上调作用较为明显,各种浓度的E_2在第48h的上调作用更为显著。结论 E_2对hPR亚型的调控具有细胞特异性、时间及剂量的依赖性。HEC-IB细胞中,各种浓度、时间下E_2对hPRB调控作用均不明显;而对hPRA的调控作用具有下调的趋势。

Objective We study the regulation of human progestrone receptor isoforms A and B in uterine endometrial carcinoma cell line by different concentration of human insulin like growth factor Ⅰ (IGF Ⅰ) for different time,to investigate the roles of IGF Ⅰ and progestrone receptor isoforms in uterine endometrial carcimoma Methods The uterine endometrial adenocarcinoma cell line HEC IB was cultured in vitro and the breast cancer cell line MCF 7 was used as control Western blot was applied to examine the...

Objective We study the regulation of human progestrone receptor isoforms A and B in uterine endometrial carcinoma cell line by different concentration of human insulin like growth factor Ⅰ (IGF Ⅰ) for different time,to investigate the roles of IGF Ⅰ and progestrone receptor isoforms in uterine endometrial carcimoma Methods The uterine endometrial adenocarcinoma cell line HEC IB was cultured in vitro and the breast cancer cell line MCF 7 was used as control Western blot was applied to examine the changes of the two isoforms by different concerntration IGF Ⅰ for different time Results (1) In HEC IB cell line, 10 ng/ml IGF Ⅰ made hPRB up regulated in the first 24 h But according to lager concerntration and longer time, human progesterone receptor (hPR) B became down regulated, which were significant at 20 ng/ml IGF Ⅰ for 72 h and 40 ng/ml IGF Ⅰ for 48-72 h The change of hPRA was like hPRB (2) In MCF 7 cell line, 10 ng/ml and 40 ng/ml IGF Ⅰ made hPRA and hPRB significantly up regulated in 24, 48, 72 h Twenty ng/ml IGF Ⅰ made hPRB up regulated also in the first 24 h But in 48 h and 72 h, down regulation of hPRB was detected Twenty ng/ml IGF Ⅰ made hPRA down regulated in 24, 48, 72 h Conclusions (1) The regulation of IGF Ⅰ to hPR isoforms has cell type specific and dose dependenct and time dependenct (2) In HEC IB cell line, 10 ng/ml IGF Ⅰ made hPRB significantly up regulated in 24 h But following exposure to IGF Ⅰ at larger concentration and longer time, hPRB became down regulated The change of hPRA is like hPRB

目的 探讨不同剂量人类胰岛素样生长因子 Ⅰ (IGF Ⅰ )对子宫内膜癌细胞系中孕激素受体亚型表达的动态变化的调控。方法 体外培养子宫内膜癌细胞系HEC IB ,以乳腺癌细胞系MCF 7为对照 ,采用蛋白印迹 (Westernblot)法观察不同剂量IGF Ⅰ对两种孕激素受体亚型表达的动态变化的调控。结果  (1)HEC IB细胞中 ,IGF Ⅰ 10ng/ml作用 2 4h ,人孕激素受体B亚型 (hPRB)表达有明显上调作用 ,随着剂量的增加、作用时间的延长 ,hPRB表达逐渐下调 ,IGF Ⅰ 2 0ng/ml作用 72h及 4 0ng/ml作用 4 8h时 ,下调最明显。人孕激素受体A亚型 (hPRA)表达的变化趋势与hPRB大致相同 ,IGF Ⅰ为 2 0ng/ml作用 4 8h时下调至最低。 (2 )MCF 7细胞中 ,IGF Ⅰ 10、4 0ng/ml对hPRA、hPRB表达均有上调的作用 ,在第 2 4、4 8、72h时较为明显。IGF Ⅰ 2 0ng/ml作用 2 4h对hPRB表达有上调的作用 ,但在 4 8、72h出现明显的下调 ;而对hPRA表达均为下调作用。结...

目的 探讨不同剂量人类胰岛素样生长因子 Ⅰ (IGF Ⅰ )对子宫内膜癌细胞系中孕激素受体亚型表达的动态变化的调控。方法 体外培养子宫内膜癌细胞系HEC IB ,以乳腺癌细胞系MCF 7为对照 ,采用蛋白印迹 (Westernblot)法观察不同剂量IGF Ⅰ对两种孕激素受体亚型表达的动态变化的调控。结果  (1)HEC IB细胞中 ,IGF Ⅰ 10ng/ml作用 2 4h ,人孕激素受体B亚型 (hPRB)表达有明显上调作用 ,随着剂量的增加、作用时间的延长 ,hPRB表达逐渐下调 ,IGF Ⅰ 2 0ng/ml作用 72h及 4 0ng/ml作用 4 8h时 ,下调最明显。人孕激素受体A亚型 (hPRA)表达的变化趋势与hPRB大致相同 ,IGF Ⅰ为 2 0ng/ml作用 4 8h时下调至最低。 (2 )MCF 7细胞中 ,IGF Ⅰ 10、4 0ng/ml对hPRA、hPRB表达均有上调的作用 ,在第 2 4、4 8、72h时较为明显。IGF Ⅰ 2 0ng/ml作用 2 4h对hPRB表达有上调的作用 ,但在 4 8、72h出现明显的下调 ;而对hPRA表达均为下调作用。结论  (1)IGF Ⅰ对人孕激素受体亚型的调控具有细胞特异性、以及时间和剂量的依赖性。 (2 )HEC IB细胞中 ,IGF Ⅰ 10ng/ml作用2 4h对hPRA、hPRB表达有上调作用 ,随着剂量的增加、作用时间的延长 ,hPRA、hPRB表达渐下调

Objective To investigate the regulation of human progestrone receptor isoforms A and B in uterine endometrial carcinoma by estrogen and insulin like growth factor 1 (IGF I) so as to provide theoretical basis for clinical hormone treatment of uterine endothelium cancer. Methods The uterine endometrial adenocarcinoma cell line HEC IB and the breast cancer cell line MCF 7 were cultured in vitro. The HEC IB cells were stimulated by 10 nmol/L estrogen and 20 ng/ml IGF I respectively for 72 h. The MCF 7...

Objective To investigate the regulation of human progestrone receptor isoforms A and B in uterine endometrial carcinoma by estrogen and insulin like growth factor 1 (IGF I) so as to provide theoretical basis for clinical hormone treatment of uterine endothelium cancer. Methods The uterine endometrial adenocarcinoma cell line HEC IB and the breast cancer cell line MCF 7 were cultured in vitro. The HEC IB cells were stimulated by 10 nmol/L estrogen and 20 ng/ml IGF I respectively for 72 h. The MCF 7 cells were stimulated by 10 nmol/L estrogen for 72 h. Western blotting was used to examine the protien levels of the two isoforms of receptors of progesterone. RNA was extracted from the cells. Reverse transcription polymerse chain reaction (RT PCR) was used to detect the mRNA levels of the isoform B. Results (1) Western blotting showed that the photodensity values of hPRA and hPRB did not change significantly after the HEC IB cells were stimulated by estrogen for 72 hours ( P =0.716, and 0.391 respectively), however, the hPRA and hPRB were significantly down reguated after IGF I had been given for 72h( P =0.008 and 0.002 respectively). After MCF 7 cell was given estrogen for 72 h,hPR A tended to be up regulated,but this change had no significant difference( P =0.074);however, hPRB was significantly up regulated( P =0.044). (2) RT PCR showed that hPRB mRNA was not expressed in HEC IB cells originally, and became positive after stimulation by estrogen and IGF 1 for 72 hours respectively, howecer, the expression level being higher in the HEC IB cells stimulated by estrogen than in those stimulated by IGF 1. hPRB was not expressed in MCF 7 cells originally too, and became positive after simulation by estrogen and IGF 1 for 72 hours respectively, however, the expression level being higher in the MCF 7 cells stimulated by estrogen than in those stimulated by IGF 1. Conclusion (1) Estrogen and IGF I regulate hPR isoforms and have cell speciality. (2) Estrogen and IGF I up regulate hPRB mRNA at gene level or transcription level, but there are some inhibitory factors which make the protein production become less after transcription.

目的 通过研究雌激素、胰岛素样生长因子 (IGF) I对子宫内膜癌孕激素受体亚型A和B的调控作用 ,探讨孕激素对子宫内膜癌的作用机制及影响因素 ,为临床孕激素治疗子宫内膜癌提供理论依据。方法 对体外培养子宫内膜癌细胞系HEC IB和乳腺癌细胞系MCF 7,分别给予雌二醇(E2 ) 10nmol/L和IGF I 2 0ng/ml作用 3d ,用Western印迹方法观察两种孕激素受体亚型的蛋白质含量变化 ;从细胞中提取RNA ,通过逆转录 多聚酶链反应 (RT PCR) ,观察孕激素受体B亚型的mRNA水平的调控。结果  (1)Western印迹试验显示 ,HEC IB细胞给予E2 作用 72h后 ,人孕激素受体 (hPR) A、hPR B光密度值用药前后差异无显著意义 ,P =0 716 ,P =0 391。给予IGF I作用 72h ,hPR A、hPR B明显下调 (P =0 0 0 8,P =0 0 0 2 )。 (2 )RT PCR显示 ,HEC IB细胞中hPRBmRNA未见表达 ,给予 10nmol/L雌激素刺激 72h后 ,hPRBmRNA阳性 ,呈上调作用 ;经IGF...

目的 通过研究雌激素、胰岛素样生长因子 (IGF) I对子宫内膜癌孕激素受体亚型A和B的调控作用 ,探讨孕激素对子宫内膜癌的作用机制及影响因素 ,为临床孕激素治疗子宫内膜癌提供理论依据。方法 对体外培养子宫内膜癌细胞系HEC IB和乳腺癌细胞系MCF 7,分别给予雌二醇(E2 ) 10nmol/L和IGF I 2 0ng/ml作用 3d ,用Western印迹方法观察两种孕激素受体亚型的蛋白质含量变化 ;从细胞中提取RNA ,通过逆转录 多聚酶链反应 (RT PCR) ,观察孕激素受体B亚型的mRNA水平的调控。结果  (1)Western印迹试验显示 ,HEC IB细胞给予E2 作用 72h后 ,人孕激素受体 (hPR) A、hPR B光密度值用药前后差异无显著意义 ,P =0 716 ,P =0 391。给予IGF I作用 72h ,hPR A、hPR B明显下调 (P =0 0 0 8,P =0 0 0 2 )。 (2 )RT PCR显示 ,HEC IB细胞中hPRBmRNA未见表达 ,给予 10nmol/L雌激素刺激 72h后 ,hPRBmRNA阳性 ,呈上调作用 ;经IGF I 2 0ng/ml作用后 ,hPRBmRNA阳性 ,IGF I对其有上调作用 ,但IGF I的上调作用弱于雌激素。MCF 7细胞中hPRBmRNA未见表达 ,经10nmol/L雌激素刺激 72h后 ,hPRBmRNA阳性 ,呈上调作用 ,但雌激素对hPRBmRNA的上调作用在MCF 7细胞中弱于HEC IB细胞。结论  (1)E2 和IGF I对hPR亚型均有调控作用 ,且具有不

 
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