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干扰rna
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  interfering rna
     Objective To assess the effect of small interfering RNA(siRNA) specific to protein kinase CK2αon proliferation and apoptosis of Hep-2 cell line.
     目的探讨蛋白激酶CK2α特异性小干扰RNA(small interfering RNA,siRNA)对人喉癌细胞系Hep-2增殖和凋亡的影响。
短句来源
     Short Interfering RNA Suppressed Expression of Ku80 Gene in HeLa Cells
     短干扰RNA抑制人宫颈癌HeLa细胞Ku80基因表达
短句来源
     Dicer,including Dicer-1 and Dicer-2,was first discovered in Drosophila. Two complexes,Dicer-1/R3D1-L and Dicer-2/R2D2 can produce microRNA(miRNA)and small interfering RNA(siRNA)respectively.
     Dicer酶最早在果蝇中发现,包括Dicer-1和Dicer-2,分别以Dicer-1/R3D1-L、Dicer-2/R2D2复合物的形式作用于微小RNA(microRNA,miRNA)和小干扰RNA(smallinterferingRNA,siRNA)的产生。
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     Effects of small interfering RNA on CXCR4 expression in LNcap cells
     小干扰RNA对LNcap细胞CXCR4基因表达的影响
短句来源
     This study was designed to investigate the effect of small interfering RNA (siRNA) on expression of mdr1 gene and drug-resistance in multidrug-resistant human leukemia K562/ADM cell.
     本文研究小干扰RNA分子(siRNA)对白血病多药耐药K562/ADM细胞mdr1基因表达和耐药性的影响。
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  interference rna
     Effect of small interference RNA on E6, E7 mRNA of human papillomavirus type-18 in cervical cancer cells
     小分子干扰RNA对子宫颈癌细胞中人乳头状瘤病毒18型E6、E7mRNA表达的影响
短句来源
     Construction of recombinant retroviral vector expressing E2F1 short interference RNA
     表达E2F1小干扰RNA的逆转录病毒载体的构建
短句来源
     Inhibition of Cell Proliferation by Small Interference RNA Against LRP16 Gene in Human Breast Cancer MCF-7 Cells
     小干扰RNA抑制LRP16基因表达限制了MCF-7乳腺癌细胞增殖
短句来源
     One is microRNA (miRNA),the other is small interference RNA (siRNA).
     一类为微小RNA(microRNA ,miRNA) ,另一为小干扰RNA(siRNA)。
短句来源
     Objective To study the effect of small interference RNA on E6, E7 mRNA of human papillomavirus type-18(HPV18) in cervical cancer cells.
     目的探讨小分子干扰RNA(siRNA)对宫颈癌细胞系HeLa细胞中人乳头状瘤病毒(HPV)18型E6、E7mRNA表达的干扰作用。
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  “干扰rna”译为未确定词的双语例句
     Effects of TSG101 siRNA on the growth and drug sensitivity of SH-SY5Y cells
     TSG101小干扰RNA对SH-SY5Y细胞生长和药物敏感性的作用
短句来源
     (2) 3×ERE-Luc was cotransfected with ERα and either LRP16 specific siRNAs(LRP16-siRNA374 and LRP16-siRNA668) or Control-(siRNA) into MCF-7 cells,then the relative luciferase activity was measured;
     (2)将3×ERE-Luc,ERα真核表达载体、针对LRP16的小干扰RNA(LRP16-siRNA374,LRP16-siRNA668)或对照小干扰RNA(control-siRNA)共转染MCF-7细胞,测定3×ERE-Luc的相对荧光素酶活性;
短句来源
     The effect of siRNA-Her2/neu on the drug sensitivity of Her2/neu-overexpressing lung adenocarcinoma cell line
     靶向Her2/neu基因小干扰RNA对肺腺癌Calu-3细胞株药物敏感性的影响
短句来源
     Inhibition of HBs-GFP fusion gene expression by RNA interference
     小干扰RNA体外抑制HBs-GFP融合基因的表达
短句来源
     Methods: Three pairs of DNA template coding siRNA were synthesized against STAT3 to reconstruct pSilencer 1.0-U6-STAT3-siRNA, which was transfected into PC3 and LNCaP cells.
     方法: 针对STAT3mRNA序列设计合成 3对编码小干扰RNA(siRNA)的DNA模板,构建pSilencer1. 0 U6 siRNA STAT3重组质粒,转染PC3及LNCaP细胞;
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  interfering rna
Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested.
      
Structural features suggested that this RNA is a defective interfering RNA (diRNA).
      
Plasmid expressing small interfering RNA (siRNA) against HIF-1a (pSilence-2.1-U6-siRNA) was constructed and transfected into LS174T cells in hypoxia condition.
      
Objective: To construct the small interfering RNA(siRNA) expression cassettes (SECs) targeting activated K-ras gene sequence and investigate the effects of SECs on K-ras gene in human pancreatic cancer cell line MIAPaCa-2.
      
RNA interference using small-interfering RNA (siRNA) has been demonstrated to be an effective method for inhibiting the expression of a given gene in human cells.
      
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  interference rna
Inhibition of proliferation of human breast cancer MCF-7 cells by small interference RNA against LRP16 gene
      
Methods: Hairpin small interference RNA (siRNA) strategy, by which hairpin siRNA was released by U6 promoter and was mediated by pLPC-based retroviral vector, was adopted to knockdown endogenous LRP16 level in MCF-7 cells.
      
Inhibition of proliferation of human Hela cells by small interference RNA against Pokemon gene
      
OBJECTIVE To determine the effect of short interference RNA (siRNA) against STAT3 induced inhibition of STAT3 gene expression and on the growth and apoptosis of Lewsis lung cancer cells.
      
A cell-based assay was developed to screen small interference RNA (siRNA) to block the expression of two genes of the severe acute respiratory syndrome (SARS) virus.
      
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The conditions for detecting tobacco mosaic virus (TMV) RNA in tobacco leave extract by RNA dot hybridization using a radioactive probe containing the cDNA of 3' terminal RNA of TMV strain OM have been studied. These conditions include the homology between the TMV strains isolated from Yunnan and Shanghai and the strain OM, the method for extracting viral RNA from tobacco leave and for adsorbing the extracted viral RNA onto nitrocellulose filter efficiently, the material interrupting the adsorption of viral...

The conditions for detecting tobacco mosaic virus (TMV) RNA in tobacco leave extract by RNA dot hybridization using a radioactive probe containing the cDNA of 3' terminal RNA of TMV strain OM have been studied. These conditions include the homology between the TMV strains isolated from Yunnan and Shanghai and the strain OM, the method for extracting viral RNA from tobacco leave and for adsorbing the extracted viral RNA onto nitrocellulose filter efficiently, the material interrupting the adsorption of viral RNA onto nitrocellulose filter and the hybridization of viral RNA with probe, and the speciality, sensitivity of the RNA dot hybridization method for detecting TMV-RNA in tobacco leave.

用普通烟草花叶病毒OM株3′-端约2kb的cDNA为探针,探索了用RNA斑点杂交法对烟草组织中烟草花叶病毒RNA进行检测的条件。这些条件包括用分子杂交法观察云南烟区和上海烟草上分到的烟草花叶病毒与OM株的同源性,从烟草组织中提取烟草花叶病毒的几种方法的比较,使RNA有效地固定在硝酸纤维素滤膜上的方法,烟草组织中是否有干扰RNA固定和杂交的物质,斑点杂交方法检测烟草花叶病毒的特异性、灵敏度等。

RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is homologous in sequence to the silenced gene. In mammal cells, small interfering RNA (siRNA) duplexes can induce RNAi potently, which may provide a new approach to the therapeutics of certain diseases. Focusing on the five genes which coding five crucial proteins of SARS coronavirus(SARS-CoV) respectively, 348 siRNA candidate targets were obtained...

RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is homologous in sequence to the silenced gene. In mammal cells, small interfering RNA (siRNA) duplexes can induce RNAi potently, which may provide a new approach to the therapeutics of certain diseases. Focusing on the five genes which coding five crucial proteins of SARS coronavirus(SARS-CoV) respectively, 348 siRNA candidate targets were obtained following bioinformatic methods. In theory, potent siRNA duplexes specifically suppress expression of their corresponding SARS-CoV target gene, while have no influence on the normal expression of human gene. It would lay a foundation for the further experimental researches on the siRNA-like drug design for the SARS-CoV.

NA干涉 (RNAinterference ,RNAi)是一种特异性地导致转录后基因沉默的现象 ,在哺乳动物细胞中小分子干扰RNA双链体 (smallinterferingRNAduplexes ,siRNAduplexes)可以有效地诱导RNAi现象 ,为一些疾病的治疗开辟了新的途径 .针对SARS冠状病毒 (SARScoronavirus ,SARS CoV)中编码 5个主要蛋白质的基因 ,用生物信息学的方法设计了3 48条候选siRNA靶标 .在理论上 ,相应的siRNA双链体能特异地抑制SARS CoV靶基因的表达 ,同时不会影响人体细胞基因的正常表达 ,这为进一步siRNA类药物的实验研究提供了理论基础

RNA interference (RNAi) is a biological process in which the introduction of double-stranded RNA (dsRNA) into a cell leads to targeted post-transcriptional gene silencing. Historically, RNAi has been used as a tool for functional genomics research in C.elegans and Drosophila. Initial attempts to activate the RNAi pathway in mammalian cells were unsuccessful, since the introduction of dsRNA>30 nucleotides in length results in non-specific suppression of gene expression. Much of this response is due to activation...

RNA interference (RNAi) is a biological process in which the introduction of double-stranded RNA (dsRNA) into a cell leads to targeted post-transcriptional gene silencing. Historically, RNAi has been used as a tool for functional genomics research in C.elegans and Drosophila. Initial attempts to activate the RNAi pathway in mammalian cells were unsuccessful, since the introduction of dsRNA>30 nucleotides in length results in non-specific suppression of gene expression. Much of this response is due to activation of the dsRNA-dependent protein kinase PKR, and the subsequent phosphorylation and inactivation of the translation factor elF2a. As RNAi mechanism being extensively studied, researchers discovered that double stranded short interfering RNA (siRNA) oligotides of 21~23 nucleotides could be used to mediate a gene silencing effect in mammalian cells. The application of RNAi to mammalian cells has the potential to revolutionize the field of functional genomics. The ability to simply, effectively, and specifically down-regulate the expression of genes in mammalian cells holds enormous scientific, commercial, and therapeutic potential.

RNA干扰 (RNAi)是生物界普遍存在的一种抵御外来基因和病毒感染的进化保守机制 .RNAi是由双链RNA触发的转录后基因沉默机制 ,具有序列特异性 ,在哺乳动物细胞中 ,RNAi由 2 1~ 2 3个核苷酸组成的双链RNA引发 .小干扰RNA (siRNA)可以在体外合成或通过表达载体在哺乳动物细胞内合成 .由于RNAi技术具有快速、简单和特异性强等特点 ,在基因功能研究、抗病毒治疗和抗肿瘤治疗等方面有广泛的应用前景

 
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