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胃低分化腺癌
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  gastric poorly differentiated adenocarcinoma
     Expression and significance of nm23 prior to and after radiotherapy in gastric poorly differentiated adenocarcinoma
     胃低分化腺癌照射前后nm23蛋白的表达及其意义
短句来源
     Objective To investigate the expression of nm23 in gastric poorly differentiated adenocarcinoma following radiotherapy.
     目的探讨放疗对胃低分化腺癌nm23蛋白表达的影响及其意义。
短句来源
     Conclusion Radiotherapy may enhance the expression of nm23 and inhibit the metastasis of gastric poorly differentiated adenocarcinoma,nm23 positive cases before and after radiotherapy have a good prognosis and it may be served as a marker to evaluate the prognosis of patient.
     结论放疗可能促进nm23的表达,从而对胃低分化腺癌的转移可能起到一定抑制作用; 放疗前、后nm23蛋白表达者预后好,其表达水平可能成为预测患者预后的指标。
短句来源
     Histologically, GHAC and HCC were similar but immunohistochemistry was valuable for their differentiation, of which the tumor cells of GHAC were AFP positive and HepPar1 negative, whereas the tumor cells of gastric poorly differentiated adenocarcinoma were both AFP and HepPar1 negative, and those of HCC were both AFP and HepPar1 positive.
     组织学上,胃肝样腺癌与HCC相似,但癌细胞AFP阳性、HepPar1阴性可与胃低分化腺癌(AFP和HepPar1均阴性)和原发性HCC(HepPar1阳性)相鉴别。
短句来源
     Methods: Surgical specimens of 6 cases of GHAC were evaluated for histology, immunohistochemistry and clinical data from January 2001 to December 2003 in Ruijin Hospital. Thirty cases of gastric poorly differentiated adenocarcinoma and hepatocellular carcinoma (HCC) were also taken as controls.
     方法:2001年1月~2003年12月期间于上海交通大学医学院附属瑞金医院病理证实为胃肝样腺癌者6例,同期随机选取胃低分化腺癌和原发性肝细胞癌(HCC)30例作为对照,统一行组织学、免疫组织化学检查和临床特点分析。
短句来源
  poorly differentiated adenocarcinoma of stomach
     Expression of cyclin A,cyclin E in poorly differentiated adenocarcinoma of stomach
     周期蛋白A、E在胃低分化腺癌中表达的研究
短句来源
     Objective To study the relationship between the expression of cyclin A and cyclin E clinicopathologic factors in poorly differentiated adenocarcinoma of stomach.
     目的探讨胃低分化腺癌组织中细胞周期蛋白A(cyclin A)、周期蛋白E(cyclin E)的表达及其与胃癌临床病理因素的关系。
短句来源
     Results The positive rates of cyclin A and cyclin E protein expression in 40 cases of poorly differentiated adenocarcinoma of stomach were 37.5%(15/40) and 45%(18/40),respectively.
     结果40例胃低分化腺癌组织中cyclin A、cyclin E表达阳性率分别为37.5%(15/40)4、5%(18/40);
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  “胃低分化腺癌”译为未确定词的双语例句
     Objective To explore expression of connexin(Cx26,Cx32,Cx43,Cx45)in transferred human stomach cell line(GES-1),humanwell differentiated stomach cancer cell line(N87) and human poor differentiated stomach cancer cell line(BGC-823) and their relationship to the metastatic potential of stomach cancer.
     目的探讨间隙连接蛋白(Cx)Cx26、Cx32、Cx43、Cx45在转化的人胃细胞系(GES-1)、胃高分化腺癌细胞系(N87)和胃低分化腺癌细胞系(BGC-823)中的表达及其与胃癌发生、发展的关系。
短句来源
     Establishment of human stomach poor-differentiation adenocarcinoma(PdGC-81)cell line and its biological characters
     PdGC-81人体胃低分化腺癌细胞系的建立及其生物学特性的观察
短句来源
     Conclusion We have successfully constructed the recombinant PUC-hU_6-extra plasmid vector that can efficiently transcribe small RNA molecules directed by hU_6 snRNA promoter in the gastric carcinoma cells——SGC-7901.
     结论成功构建了以hU6snRNA启动子驱动的、能在人胃低分化腺癌SGC-7901细胞内高效转录小分子RNA的表达质粒PUC-hU6-extra。
短句来源
     ( X2=11.97 p<0.05) (2) The expression of p27Kip1 and cyclinE in different pathological type of gastric cancer: The positive expression of p27 Kip1 in high differentiation adenocarcinoma , low differentiation adenocarcinoma and stomach mucoid carcinoma was 68.42%(14 of 19), 37.5% (9 of 24), 31.25% (5 of 16) respectively.
     24例胃低分化腺癌中9例p27~(kip1)阳性表达,阳性率37.5%; 16例胃黏液癌中5例p27~(kip1)阳性表达,阳性率31.25%。
短句来源
     ③The relationship between expression of Fas and the clinical and pathologic character in gastric carcinoma: The positive expression rate of Fas in high differectiation adenocarcinoma,low differentiation adenocarcinoma and stomach mucoid carcinoma was 58.33%, 33.33%, 33.33%, respectively.
     21例胃粘液癌中7例表达阳性,阳性率为33.33%。 胃高中分化腺癌Fas阳性表达率明显高于胃低分化腺癌,二者比较有显著性差异(x2=5.840,P<0.05);
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  poorly differentiated adenocarcinoma of stomach
We describe a case of poorly differentiated adenocarcinoma of stomach, which did not present typical symptoms of gastrointestinal malignancy on first visit.
      
Histopathological examination of endoscopic biopsy revealed a poorly differentiated adenocarcinoma of stomach.
      


This experiment was carried out by using hematoporphyrin derivative (HPD) and red light to study the biological effect of HPD in cell cycle of human gastric low-differentiated mucous adenocarcinoma cells.We have obser-ved that the distribution and transport of HPD were dependent on cell cycle; the HPD was transported from membrane to cytoplasm in the G_1 phase and directly into various region of cytoplasm in the S and G_2 phase,while HPD was scattered in the nuclear region in the M phase.

本文探讨了HPD衍生物加红光对人胃低分化腺癌MGC 80-3细胞不同周期的生物学效应。我们观察到HPD的转运与分布决定于细胞周期。G_1期在30分至60分钟内HPD从膜转运至胞质;S、G_2期则直接进入胞质的不同部位;而M期在核部位弥散分布。同步化细胞经HPD加红光处理后,引起细胞大量光敏杀伤,S与G_1期较明显,而M期光敏性最小。我们还观察到:不同周期细胞HPD的分布和HPD的光敏损伤部位密切相关。核仁对HPD的选择性结合也很明显。

This paper reports the results of immunohistochemical localization in colorectal carcinoma and adenoma by anti-human gastric carcinoma monoclonal antibody MG7.One hundred and twelve cases of colorectal carcinoma, 96 cases of surround-ing mucosa, 46 cases of adenoma and 14 cases of normal colonic mucosa wereexamined. One hundred and six of 112 cases of colorectal carcinoma were positivelystained (94.64%) and strong staining could be observed in 102 of 106 cases(96.23%). One of 14 cases normal colonic mucosa was...

This paper reports the results of immunohistochemical localization in colorectal carcinoma and adenoma by anti-human gastric carcinoma monoclonal antibody MG7.One hundred and twelve cases of colorectal carcinoma, 96 cases of surround-ing mucosa, 46 cases of adenoma and 14 cases of normal colonic mucosa wereexamined. One hundred and six of 112 cases of colorectal carcinoma were positivelystained (94.64%) and strong staining could be observed in 102 of 106 cases(96.23%). One of 14 cases normal colonic mucosa was only weak positive. Seventeen of46 cases adenoma revealed positive staining which was often associated with dys-plasia.These results suggest that MG7-associated antigen in human colorectal car-cinoma is abundant and relative specific antigen.

应用抗人胃低分化腺癌细胞系MKN46-9的单克隆抗体MG7对112例手术切除的大肠癌标本进行免疫组化观察,阳性106例(94.64%),强阳性占阳性病例的96.23%;96例癌旁粘膜中弱阳性26例(27.08%);14例断端正常粘膜仅1例呈弱阳性。46例大肠腺瘤中管状腺瘤43例,14例阳性(32.56%),3例绒毛状腺瘤均阳性。结果表明,MG7的抗原在大肠癌组织中含量较丰富,并具有相对特异性,同时在癌旁粘膜及大肠腺瘤组织中也有不同程度的表达。

This study was carried out to investigate the effects of ATP on cultured human stomach carcinoma MGC-803 cells. After ATP(0.16—0.23 mg/ml, 24—120 hrs)treatment, inhibition of cell growth rate was observed. The inhibition rate reached 80% after 96 hr exposure to ATP. At the same time, anti-tubulin immunofluorescent staining showed increase of organized microtubules (MT) in ATP-treated MGC-803 cells, in contrast with the poor MT immunofluorescence in control MGC-803 cells. By using rhodamie phalloidin combined...

This study was carried out to investigate the effects of ATP on cultured human stomach carcinoma MGC-803 cells. After ATP(0.16—0.23 mg/ml, 24—120 hrs)treatment, inhibition of cell growth rate was observed. The inhibition rate reached 80% after 96 hr exposure to ATP. At the same time, anti-tubulin immunofluorescent staining showed increase of organized microtubules (MT) in ATP-treated MGC-803 cells, in contrast with the poor MT immunofluorescence in control MGC-803 cells. By using rhodamie phalloidin combined staining, increased number of actin bundles, took the place of actin dots and patches which were seen in control MGC-803 cells. Immunofluorescent staining of fibronectin in ATP-treated MGC-803 cells was also increased evidently as compared with the control MGC-803 cells. Concomitant with the improvement of MT and stress fiber organization, the cell Concohas become more flattened. It appeared that the increase of MT and stress fibers was closely related to the recovery of cell morphology in ATP treated tumor cells. It is therefore concluded that ATP not only may inhibit tumor cell proliferation, but also may induce differentiation of cell morphology of tumor cells through its action on cytoskeletal structures.

本文报道人胃低分化腺癌细胞(MGC-803)在外源性三磷酸腺苷(ATP)的连续作用下,细胞增殖受到明显的阻抑,4天以后细胞增殖的抑制率达80%以上,细胞内的骨架系统有较明显的改善。微管由中央区的微管组织中心一直伸展到细胞边缘附近,使细胞充分铺展并变扁平,近似于正常上皮细胞的形态。微丝束变粗壮,纵横交错,布满细胞周边的细胞质内。点状的肌动蛋白荧光明显减少。细胞内外的纤维粘连蛋白的荧光反应更加明显。本文并讨论了细胞增殖和细胞骨架系统之间的关系。

 
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