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i型前胶原
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  type i procollagen
     Results rhTGF β 1 up regulated the gene expression of TGF β 1 and type I procollagen.
     结果  rh TGF-β1 能上调TGF-β1 和 I型前胶原的基因表达。
短句来源
     Type I procollagen mRNA level at the power density of 150 mW/cm 2 was lower than that at 100 mW/cm 2 ( P < 0.05) .
     以 15 0mW /cm2 重复照射 ,细胞胶原合成与I型前胶原基因表达水平亦显著低于对照组 (P <0 .0 5 ) ,且 15 0mW /cm2 照射后的I型前胶原基因表达水平低于 10 0mW /cm2 照射 (P <0 .0 5 )。
短句来源
     Methods Cultured HSC-T6 cells treated with H 2O 2 served as control group,the effects of SF on type I procollagen and CTGF mRNA level were determined by reverse transcription polymerase chain reaction(RT-PCR).
     方法 以 5 0 μmol·L-1H2 O2 处理的HSC -T6细胞为氧化应激模型组 ,采用RT -PCR方法检测并分析 12 5 μmol·L-1和 5 0 0 μmol·L-1SF对细胞中I型前胶原及其相关调控因子CTGF表达的影响。
短句来源
     Results Collagen synthesis and type I procollagen mRNA level remained unchanged when the laser was irradiated at the power density of 10 mW/cm 2 or 50 mW/cm 2. Compared with control, collagen synthesis and type I procollagen mRNA level were significantly decreased at the power density of 100 mW/cm 2 or 150 mW/cm 2 ( P <0.05).
     结果 培养增生性瘢痕成纤维细胞的胶原合成、I型前胶原基因表达水平在 10、5 0mW /cm2 照射后无变化 ,10 0mW /cm2 重复照射后降低 ,与对照组相比有显著性差异 (P <0 .0 5 ) ;
短句来源
     Methods Cultured fibroblasts derived from hypertrophic scars (HS) were irradiated with He Ne laser for 30 min at various power densities (10 mW/cm 2, 50 mW/cm 2, 100 mW/cm 2 and 150 mW/cm 2), once a day for 3 consecutive days. In 24 h after repeated irradiation collagen production and type I procollagen mRNA level of fibroblasts were measured with the incorporation of [ 3H] proline and blot hybridization techniques respectively.
     方法 以不同功率密度 (10、5 0、10 0和 15 0mW /cm2 )He Ne激光照射培养增生性瘢痕成纤维细胞 30min ,1/d ,连续照射 3d ,在 3d重复照射后 2 4h用3H 脯氨酸掺入法和斑点杂交法分别检测成纤维细胞胶原合成和I型前胶原基因表达。
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  procollagen type i
     Objectives To evaluate the clinical significance of serum procollagen type I carboxy terminal peptide (PIP) in patients with essential hypertension (EH).
     目的测定高血压病(EH)患者血清I型前胶原羧基端肽(PIP)水平,探讨其临床意义。
短句来源
     [Objective] To investigate the clinical value of quantitative assessment of MF in essential hypertension(EH) patients by serum concentrations of carboxyterminal propeptide of procollagen type I(PICP) and procollagen type Ⅲ(PCⅢ).
     目的探讨血清I型前胶原羧基端肽(P ICP)、Ⅲ型前胶原(PCⅢ)水平作为高血压病(EH)心肌纤维化(M F)血清标志物的临床价值。
短句来源
     Methods Molecular markers-serum procollagen type I c-terminal propeptide (PICP),serum osteocalin (BGP) and totoal alkaline phosphatase (AKP) were taken as the markers, and bone formation was observed before prednison-pretreatment and during prednison-pretreatment 3-4 weeks in children with nephrotic syndrome.
     方法 以I型前胶原羧基端前肽 (PICP)、骨钙蛋白 (BGP)及碱性磷酸酶 (AKP)为参数 ,对单纯性NS患儿泼尼松治疗前及治疗 3~4周后骨合成状况进行探讨。
短句来源
     [Objective] To study the changes of diastolic function of left ventricle by Tissue Doppler Imaging (TDI) and analyse the relations between the diastolic function of left ventricle and the serum level of procollagen type I C-terminal peptide (PIP) in patients with essential hypertension.
     目的应用组织多普勒成像(TDI)技术评价高血压病患者左心室舒张功能变化,并探讨其与胶原代谢的血清标志物I型前胶原羧基端肽(PIP)水平之间关系。
短句来源
     To observe osteocalcin(OC), bone alkaline phosphatase(BALP), and procollagen type I carboxyterminal propeptide(PCPI) the status the phenotypic markers of osteoblasts tor vitamin D deficiency rickets(VDDR) in infancy.
     【目的】 通过成骨细胞的表型标志物骨钙蛋白、骨碱性磷酸酶、I型前胶原羧基端伸展肽 ,探讨小儿维生素D缺乏性佝偻病时成骨细胞的功能状况。
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  procollagen i
     Gene transfection using lipid mediated TGFβ1 sense and antisense gene expression vectors and its effects on TGFβ1 and procollagen I mRNA expression in~(60) Co-irradiated human embryo lung fibroblasts
     TGFβ1正、反义基因转染~(60)Co照射HELF对TGFβ1及I型前胶原mRNA表达调控影响
短句来源
     After 6 weeks of treatment, the rats were killed and liver samples were obtained for observing the histopathological changes and investigating content of hydroxyproline(HYP) , the mRNA levels of procollagen I (procol-I) and tissue inhibitor of metalloproteinase-1(TIMP-1).
     6周后,处死大鼠,取肝组织进行病理学观察并测定肝组织匀浆中的羟脯氨酸(HYP)含量,检测I型前胶原mRNA(procol-ImRNA)和组织金属蛋白酶抑制因子1mRNA(TIMP-1mRNA)的表达水平。
短句来源
     Objective To study the molecular mechanism of fibrosis in the patients with severe viral hepatitis by detecting the expressions of procollagen I mRNA and platelet-derived growth factor-1 (PDGF-1) mRNA and type Ⅰ ,Ⅳ collagen.
     目的 了解重症病毒性肝炎患者肝组织I型前胶原mRNA、血小板衍生生长因子-1(PDGF-1)mRNA及Ⅰ、Ⅳ型胶原蛋白的表达情况,探讨重症病毒性肝炎纤维化发生的分子机制。
短句来源
     RESULTS: This polypeptide could significantly inhibit the TGFβ1 induced collagen synthesis and down regulate the expression of procollagen I mRNA in the fibroblasts from scar.
     结果该短肽可以明显抑制TGFβ1所诱导的增生性瘢痕成纤维细胞的胶原合成量及细胞内I型前胶原mRNA的表达。
短句来源
     Methods Serum procollagen I(PCⅠ) and procollagenⅢ(PCⅢ)were measured by radioimmuoassay in 42 EH patients and 20 normal volumteers.
     方法 采用放免法测定 2 0例正常人和 4 2例 EH患者 (伴心肌肥厚者2 0例和不伴心肌肥厚者 2 2例 )的血清 I型前胶原 (PC )和 型前胶原 (PC )的浓度。
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  “i型前胶原”译为未确定词的双语例句
     The corresponding fluence level for significant down-regulation of mRNA expression of procollage III α_1 was 6 J/cm~2 and 7 J/cm~2(P<0.05).
     在能量密度为6,7 J/cm2时能抑制III型前胶原基因α1mRNA的表达(P<0.05),而对I型前胶原基因1α,2α的表达与对照无显著性差异.
短句来源
     The expression of I procollagen mRNA was highest at 42 day, and there is a significant difference between Q1 and H1 group Q2 and H2 group at 28 day(P<0.05), but there is no significant difference between Q2 and H2 at 42 day.
     I型前胶原mRNA的表达在28天时芪丹1组和氢可1组及芪丹2组和氢可2组组间均有显著性差异,但在42天时,芪丹2组与氢化可的松2组其表达无显著差异(P<0.05)。
短句来源
     No significantly difference of mRNA expression of SMAD2, SMAD3, SMAD7 and type I procollagea were found between controls and fibroblasts treated with pulsed dye laser in the fluence 4 J/cm2 (p>0.05).
     然而,能量密度为4J/cm2的脉冲染料激光对转化生长因子1、I型前胶原基因α1,α2以及SMAD2,3,7mRNA的表达与对照组无明显差异。
     764-3 at a final concentration of 15μg/ml for 24 hours conld stimulate type I collagen mR-NA expression,but exerted no effect on type Ⅲ collagen expression.
     加入764-3(终浓度为15μg/ml)24h对Ⅲ型前胶原mRNA表达无明显作用,对I型前胶原mR-NA表达非但不抑制反而有明显促进作用。
短句来源
     Results Human (α 1) Ⅲ procollagen mRNA expression in portal hypertensive patients were higher than control group(P<0.01), however, Human (α 1) I procollagen mRNA expression in portal hypertensive patients shows a non-significant difference pattern with control group(P>0.05).
     结果门脉高压症时脾静脉壁 (α1)Ⅲ型前胶原mRNA表达明显增高 (P <0 .0 1) ,但门脉高压症病人脾静脉壁 (α1)I型前胶原mRNA表达与非门脉高压症病人相比差异无显著性意义 (P >0 .0 5 )。
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  type i procollagen
Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides
      
Antisense DNA oligonucleotides directed against specific sequences within α1(I) and α2(I) mRNA of type I procollagen were complexed to a cell-specific carrier, and screened for their effectiveness in reducing α1(I) and α2(I) mRNA levels.
      
Osteocalcin, a biochemical marker for osteoblast activity, and the carboxy-terminal propeptide of type I procollagen (PICP), a marker of collagen formation, were slightly but not significantly higher in gastrectomy-treated patients.
      
Simultaneously, circulating carboxyterminal propeptide of type I procollagen (PICP) was released in the perfusion medium (threefold versus C).
      
Gene expression of type I procollagen was significantly greater in Group MH than in Group MC at 7?days postoperatively and was also significantly greater in Group AH than in Group AC at 28?days (P?>amp;lt;?0.05).
      
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  procollagen type i
In the course of CVB3 myocarditis, CTGF upregulation coincided with increased cardiac TGF-β and procollagen type I mRNA expression, preceding the formation of fibrotic lesions.
      
The significantly enhanced transcript levels of TGF-β, CTGF, and procollagen type I in cultivated CVB3-infected primary cardiac fibroblasts substantiate the role of fibroblasts as a relevant cell population in cardiac remodeling processes.
      
Immunohistochemistry was performed using antibody of the amino-terminal end of the procollagen type I propeptide (M-57).
      
Serum concentration of procollagen type I carboxyterminal propeptide in systemic sclerosis
      
A 50% decrease in the amount of procollagen type I and type III mRNAs was observed after 2 and 4 days of coculture while collagenase gene expression was upregulated by 300% when compared with control lattices.
      
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  procollagen i
Procollagen Iα2 (COL1A2) mRNA levels were quantitated by (a) northern blot analysis and (b) reverse transcriptase polymerase chain reaction.
      
Active transforming growth factor-β1 activates the procollagen I promoter in patients with acute lung injury
      
Experimental tissue expansion induces changes in expression of procollagen I and III messenger RNA
      
Dermal procollagen I and procollagen III gene expression in response to tissue expansion was investigated by dot-blot analysis using digoxigenin-labeled RNA probes complementary to either human procollagen-al (I) mRNA or procollagen-a1 (III) mRNA.
      
In response to the trauma of surgery, procollagen I and III mRNA transcriptions were found to be decreased significantly within the first few days after implantation.
      
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Two stable clones of hybridoma cell lines which secret monoclonal antibodlles against amino-terminal propeptide of type Ⅲ procollagen (P Ⅲ P )have been developed. the monoclonal antibodies did not crossreact with type Iprocollagen and type Ⅱcollagen by inhibition ELISA. Dot-ELISA revealed that the antibodies recognize the conforma-tional antigenic determinants. The antibodies were also used for immunolocalizatlon of type Ⅲ procollagen in human hep-atocellular carcinoma tissues. cultured mouse fibroblasts and...

Two stable clones of hybridoma cell lines which secret monoclonal antibodlles against amino-terminal propeptide of type Ⅲ procollagen (P Ⅲ P )have been developed. the monoclonal antibodies did not crossreact with type Iprocollagen and type Ⅱcollagen by inhibition ELISA. Dot-ELISA revealed that the antibodies recognize the conforma-tional antigenic determinants. The antibodies were also used for immunolocalizatlon of type Ⅲ procollagen in human hep-atocellular carcinoma tissues. cultured mouse fibroblasts and rat fibroblasts. Results indicated that the membrane ot these two kinds of fibroblasts were obviously stained. the cytoplasm of the hepatic neoplastic cells were also clearly stained. The finding demonstrated that the hepatic neoplastic cells have the ability of synthesiziny type Ⅲ procollagen.

制备出两株分泌抗PⅢP(Ⅲ型前胶原肽)单克隆抗体的杂交瘤细胞株。竞争抑制ELISA试验表明:两株单抗与PCI(I型前胶原)及CⅢ(Ⅲ型胶原)无交叉反应。Dot-ELISA示两株单抗均针对PⅢP构象决定簇。应用所制备的单抗对人肝细胞癌组织及大鼠、小鼠成纤维母细胞进行免疫定位。结果显示两种成纤维母细胞均呈明显膜阳性;肝癌细胞浆内呈粗颗粒状染色,提示肝癌细胞具有合成Ⅲ型前胶原的能力。

he ratio of type I and type Ⅲ soluble collagen (I/Ⅲ)was quantified in main pulmonary artery.Type Iand type Ⅲ cdlagen were extracted by double acetic acid-pepsin digestion and analysed by 2-mercaptoethanol in-terrupted SD5PAGE. The gel was then scanned on Shimadzu CS-910 densitometer. The results showed that I/Ⅲ was increased at the end of 21 days after hypoxia,but no obvious change of I/Ⅲ on 7 days was found. Onthe other hand,there was an increase in pro(1) mRNA on 7 days after hypoxia。The possible mechanism...

he ratio of type I and type Ⅲ soluble collagen (I/Ⅲ)was quantified in main pulmonary artery.Type Iand type Ⅲ cdlagen were extracted by double acetic acid-pepsin digestion and analysed by 2-mercaptoethanol in-terrupted SD5PAGE. The gel was then scanned on Shimadzu CS-910 densitometer. The results showed that I/Ⅲ was increased at the end of 21 days after hypoxia,but no obvious change of I/Ⅲ on 7 days was found. Onthe other hand,there was an increase in pro(1) mRNA on 7 days after hypoxia。The possible mechanism ofthese changes was disscussed.

用双醋酸-胃蛋白消化法提取可溶性1、Ⅲ型胶原混合物,用β-巯基乙醇阻断-SDS-PAGE分出Ⅲ型胶原之单-α_1(Ⅲ)条带测定常压低氧大鼠肺外肺动脉壁中1、Ⅲ胶原比值的变化。结果表明,吸入低氧气体1周I/Ⅲ型胶原比值未见有统计学意义的变化;吸入低氧气体3周I/Ⅲ型胶原比值明显升高。而在吸入低氧气体1周时I型前胶原[Proα_1(I)]mRNA已呈有统计学意义之升高。

The effect of ligustrazine and 764-3 on type I and type Ⅲ collagen mRNA expression incuitured fibroblasts was sttidied.The results showed that ligustrazine at a final concentra-tion of 30μg/ml for 24 hours could inhibit type I and type Ⅲ collagen mRNA expression;764-3 at a final concentration of 15μg/ml for 24 hours conld stimulate type I collagen mR-NA expression,but exerted no effect on type Ⅲ collagen expression.The possible mecha-nism of 764-3 action was discussed.

川芎嗪和764-3均有抑制纤维化的作用。本工作观察了川芎嗪和764-3对体外培养的成纤维细胞Ⅰ、Ⅲ型前胶原mRNA表达的影响结果表明,加入川芎嗪(终浓度30μg/ml)24h对I、Ⅲ型前胶原mRNA表达均有明显抑制作用;加入764-3(终浓度为15μg/ml)24h对Ⅲ型前胶原mRNA表达无明显作用,对I型前胶原mR-NA表达非但不抑制反而有明显促进作用。作者对764-3这种作用的可能原因做了初步讨论。

 
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