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i型前胶原
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  type i procollagen
    [Methods] Serums from rats fed with Astragalus and Angelica mixture were prepard and levels of insulin-like growth factor - I (IGF- I), insulin-like growth factor binding protein-3 (IGFBP-3), osteocalcin (OC) and aminoterminal propeptide of type I procollagen (PINP) were assayed by RIA and RIMA, respectively.
    [方法]制备芪归合剂含药血清,以放射免疫法和免疫放射法检测其胰岛素样生长因子-I(IGF-I)、胰岛素样生长因子结合蛋白-3(IGFBP-3)、I型前胶原氨基端伸展肽(PINP)和骨钙素(OC)水平。
短句来源
    To evaluate the expression of type I procollagen and type III procollagen mRNA by Qidan Granuless on Bleomycin induced pulmonary fibrosis in rats and to explore its pathogenesis, 160 SD rats in good conditions were randomly divided into six groups:normal control group, model group, Qidan Granules group(G1,G2) and hydrocortisonum group(H1,H2).
    观察芪丹颗粒对博莱霉素致肺纤维化鼠的I型前胶原和III型前胶原mRNA表达的影响,探讨其作用机制。 用160只SD大鼠按随机区组设计分为对照组(N)、模型组(M)、芪丹颗粒剂1组和2组(Q1、Q2)、氢化可的松1组和2组(H1、H2)共6组。
短句来源
    III procollagen mRNA expression was increased in the acute alveolitis phrase of pulmonary fibrosis induced by Bleomycin, the expression of type I procollagen mRNA was mainly increased in the chronic stage of pulmonary fibrosis.
    在肺间质纤维化形成中,I型和III型前胶原mRNA表达呈动态变化,早期肺泡炎以III型前胶原mRNA大量增生为主,晚期纤维化期以I型前胶原mRNA增生为主。
短句来源
    Aim To study the changes of serum type I procollagen carboxyl terminal peptide (PIP) and the expression of type I collagen after balloon injury in rabbit and the effects of musk pill (MP) on it.
    目的 探讨血管球囊损伤后血清I型前胶原羧基端肽浓度和Ⅰ型胶原基因表达的变化及麝香保心丸对其影响。
短句来源
    Serum osteocalcin(OC),aminoterminal propeptide of type I procollagen(PINP)and carboxyterminal telopeptide of type I collagen(ICTP)levels were assayed by radioimmunoassay technique.
    以放射免疫法测定血清骨钙素(OC)、I型前胶原氨基端伸展肽(PINP)、I型胶原羧基端关联肽原(ICTP)水平。 结果模型组股骨长度(3.35±0.09)cm,低于正常组(3.53±0.11)cm(P<0.05);
短句来源
  procollagen i
    Effects of Qidan Granules on the Expression of Procollagen I and Procollagen III mRNA in Pulmonary Fibrosis Rats Induced by Bleomycin
    芪丹颗粒剂对肺纤维化鼠I型前胶原和III型前胶原mRNA表达的影响(英文)
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  “i型前胶原”译为未确定词的双语例句
    Methods The normal rats were fed on cordyceps mycelium and salvia mitiorrnizae respectively, then the rat sera were collected and incubated with subcultured hepatic stellatecells (HSC). HSC α-SM actin (SMA) expression, [3H]TdR and [3H]Proline incorporation, mRNA and protein production of type I collagen, mRNA and protein production of Transforming Growth Factor β1(TGFβ1) were observed.
    方法虫草菌丝与丹参流浸膏分别给大鼠经口灌胃给药后分离药物血清,观察药物血清对体外传代活化的大鼠肝星状细胞α-平滑肌肌动蛋白(SMactin,SMA)表达、[3H]TdR及[3H]脯氨酸掺入,TGFβ1、I型前胶原mRNA表达及其蛋白生成量的影响。
短句来源
    The expression of I procollagen mRNA was highest at 42 day, and there is a significant difference between Q1 and H1 group Q2 and H2 group at 28 day(P<0.05), but there is no significant difference between Q2 and H2 at 42 day.
    I型前胶原mRNA的表达在28天时芪丹1组和氢可1组及芪丹2组和氢可2组组间均有显著性差异,但在42天时,芪丹2组与氢化可的松2组其表达无显著差异(P<0.05)。
短句来源
    The expression of TGF-P1 mRNA and (a 1) I mRNA were observed with semi-quantified in situ RT-PCR.
    (6)肝组织石蜡包埋切片原位反转录 PCR it检测 TGF-pl mRNA、I型前胶原(al)mRNA表达水平,结果以半定量计分法评定。
短句来源
    The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed . Histological examination was also done.
    实验结束后测定肝纤维化指标透明质酸、III型前胶原I型前胶原及细胞生长转化因子 (HA、PCI、PCIII及TGF β1 )并作肝病理检查。
短句来源
    Methods Forty adult SD r ats got fracture on right femurs in middle three months after ovariectomy and re ceive estrogen therapy. Above rats were sacrificed at 7, 15 and 30 days after fr acture. Bone metabolite indexes including bone gla protein (BGP), procollagen Ⅰ carbotyl peptid(PICP) and bone ALP(B-ALP) were measured.
    方法成年SD大鼠卵巢摘除后3个月开始制作左侧股骨中段闭合骨折内固定手术模型,并分为骨折组和骨折用药组,每组各20只骨折用药组注射金雀异黄酮,分别于大鼠折骨后15和30dX射线摄片、检测血清骨碱性磷酸酶(B鄄ALP)、I型前胶原羧基端肽(PICP)、骨钙素(BGP)等骨形成生化指标,并与骨折组比较。
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  type i procollagen
Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides
      
Antisense DNA oligonucleotides directed against specific sequences within α1(I) and α2(I) mRNA of type I procollagen were complexed to a cell-specific carrier, and screened for their effectiveness in reducing α1(I) and α2(I) mRNA levels.
      
Osteocalcin, a biochemical marker for osteoblast activity, and the carboxy-terminal propeptide of type I procollagen (PICP), a marker of collagen formation, were slightly but not significantly higher in gastrectomy-treated patients.
      
Simultaneously, circulating carboxyterminal propeptide of type I procollagen (PICP) was released in the perfusion medium (threefold versus C).
      
Gene expression of type I procollagen was significantly greater in Group MH than in Group MC at 7?days postoperatively and was also significantly greater in Group AH than in Group AC at 28?days (P?>amp;lt;?0.05).
      
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  procollagen i
Procollagen Iα2 (COL1A2) mRNA levels were quantitated by (a) northern blot analysis and (b) reverse transcriptase polymerase chain reaction.
      
Active transforming growth factor-β1 activates the procollagen I promoter in patients with acute lung injury
      
Experimental tissue expansion induces changes in expression of procollagen I and III messenger RNA
      
Dermal procollagen I and procollagen III gene expression in response to tissue expansion was investigated by dot-blot analysis using digoxigenin-labeled RNA probes complementary to either human procollagen-al (I) mRNA or procollagen-a1 (III) mRNA.
      
In response to the trauma of surgery, procollagen I and III mRNA transcriptions were found to be decreased significantly within the first few days after implantation.
      
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Objective To investigate the mechanisms of cordyceps mycelium and salvia mitiorrhizae actions for anti-liver fibrosis. Methods The normal rats were fed on cordyceps mycelium and salvia mitiorrnizae respectively, then the rat sera were collected and incubated with subcultured hepatic stellatecells (HSC). HSC α-SM actin (SMA) expression, [3H]TdR and [3H]Proline incorporation, mRNA and protein production of type I collagen, mRNA and protein production of Transforming Growth Factor β1(TGFβ1) were observed. The...

Objective To investigate the mechanisms of cordyceps mycelium and salvia mitiorrhizae actions for anti-liver fibrosis. Methods The normal rats were fed on cordyceps mycelium and salvia mitiorrnizae respectively, then the rat sera were collected and incubated with subcultured hepatic stellatecells (HSC). HSC α-SM actin (SMA) expression, [3H]TdR and [3H]Proline incorporation, mRNA and protein production of type I collagen, mRNA and protein production of Transforming Growth Factor β1(TGFβ1) were observed. The incoopration of [3H]TdR and [3H]Pro, procollagen type I mRNA expression, collagen production, and hepatocyte albumin production were observed. Results Salvia mitiorrhizae decreased HSC SMA expression, type I collagen production and intracellular [3H]TdR incorporation remarkably, the ratio of control were 39.8%, 42.7% and 38.9% (p<0.01 vs. control. The former 2 indexes were obviously lower than the ones of cordyceps mycelium, P<0.05), also inhibited mRNA and protein expression of type I collagen and TGFβ1 (P<0.05). Cordyceps mycelium had similar effects on the above indexes, but especially decreased HSC TGFβ1 mRNA and protein expression strongly, the ration of control were 47.7% and 21.1% respectively (p<0.01 vs. Control, P<0.05 vs. Salvia mitiorrhizae treated group).Conclusions Salvia mitiorrhizae had the stronger action on inhibition of HSC activation cellagen production, mainly on precollopn bine posttranscription levels. Cordyceps mycelium mainly inhibited HSC TGFβ1 mRNA expression and autocrine. [

目的探讨虫草菌丝、丹参抗肝纤维化的作用机理。方法虫草菌丝与丹参流浸膏分别给大鼠经口灌胃给药后分离药物血清,观察药物血清对体外传代活化的大鼠肝星状细胞α-平滑肌肌动蛋白(SMactin,SMA)表达、[3H]TdR及[3H]脯氨酸掺入,TGFβ1、I型前胶原mRNA表达及其蛋白生成量的影响。结果丹参抑制HSC的SMA表达、I型胶原生成量及细胞内[3H]脯氨酸掺入的作用显著,分别为对照组的39.8%,42.7%与38.9%(P<0.01;前2项显著低于虫草菌丝组,P<0.05),尚可抑制细胞1型前胶原<mRNA,TGFβ1<mRNA及其蛋白的表达(P<0.01);虫草菌丝对上述指标也均有抑制作用,以抑制TGFβ1<mRNA及其蛋白表达的作用尤著,分别为对照组的47.7%和21.1%(P<0.01);显著低于丹参组,P<0.05。结论丹参具有较强的抑制HSC活化与胶原合成的作用,抑制胶原合成主要作用于前胶原转录后的水平;虫草菌丝的主要作用点抑制HSC的TGFβ1mRNA表达与自分泌。

OBJECTIVE To investigate the anti fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats. METHODS Rat liver fibrotic model was created by carbon tetrachloride(CCl 4).The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed .Histological examination was also done. RESULTS The liver fibrosis induced by CCl 4 was ameliorated,meanwhile,HA,PCI,PC III and TGF β 1 were decreased. On the other hand, the anti fibrotic effect of zhijuzi was also demonstrated by the histological examination.CONCLUSIONS...

OBJECTIVE To investigate the anti fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats. METHODS Rat liver fibrotic model was created by carbon tetrachloride(CCl 4).The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed .Histological examination was also done. RESULTS The liver fibrosis induced by CCl 4 was ameliorated,meanwhile,HA,PCI,PC III and TGF β 1 were decreased. On the other hand, the anti fibrotic effect of zhijuzi was also demonstrated by the histological examination.CONCLUSIONS Zhijizi may be useful for the treatment of hepatic fibrosis.

目的 :研究枳栉具子提取物的体内抗肝纤维化作用。方法 :用四氯化碳 (CCl4 )建立大鼠肝纤维化模型 ,造模开始后即给予枳栉具子提取物。实验结束后测定肝纤维化指标透明质酸、III型前胶原、I型前胶原及细胞生长转化因子 (HA、PCI、PCIII及TGF β1 )并作肝病理检查。结果 :枳栉具子提取物能显著降低血清HA、PCI、PCIII及TGF β1 含量 ;减轻肝脏胶原纤维增生程度。结论 :说明枳栉具子具有抗早期肝纤维化作用。

[Objective] To probe into the effects of Astragalus and Angelica mixture on cultured os-teoblasts in vitro by seropharmacological method. [Methods] Serums from rats fed with Astragalus and Angelica mixture were prepard and levels of insulin-like growth factor - I (IGF- I), insulin-like growth factor binding protein-3 (IGFBP-3), osteocalcin (OC) and aminoterminal propeptide of type I procollagen (PINP) were assayed by RIA and RIMA, respectively. Osteoblasts were isolated from the skull of 3 ~7 day newly born...

[Objective] To probe into the effects of Astragalus and Angelica mixture on cultured os-teoblasts in vitro by seropharmacological method. [Methods] Serums from rats fed with Astragalus and Angelica mixture were prepard and levels of insulin-like growth factor - I (IGF- I), insulin-like growth factor binding protein-3 (IGFBP-3), osteocalcin (OC) and aminoterminal propeptide of type I procollagen (PINP) were assayed by RIA and RIMA, respectively. Osteoblasts were isolated from the skull of 3 ~7 day newly born rats and identified by image analysis, HE staining, ALP staining, Xisuhong staining, and V-G collagen staining. The effects of serums from rats fed with Astragalus and Angelica mixture on the proliferation of osteoblasts were observed by MTT method. The levels of IGF- I, OC and PINP in the supernatant of cultured osteoblasts were assayed by RIA. The number of calcium nodule formed by cultured osteoblasts was observed under microscope. [Results] The levels of IGF- I, IGFBP-3, PINP and OC in the serums from rats fed with Astragalus and Angelica mixture(A&A group) were similar to that in the control serums ( P > 0. 05). The serums from rats fed with Astragalus and Angelica mixture and the control serums could promote the proliferation of osteoblasts, and the effect was dose dependent. 200 mL/ L and 300 mL/L of the serums from rats fed with Astragalus and Angelica mixture had a better effect on promoting the proliferation of osteoblasts than the control serums (P<0.01 and P <0. 05, respectively) . The levels of IGF- I, OC and PINP in the supernatant of cultured osteoblasts in the serums from rats fed with Astragalus and Angelica mixture were higher than that of in the control serums . [(4. 9±1. 6) μg/L vs (2. 8±1.5) μg/L, P <0.05, (36. 7±3. 8) μg/L vs (27. 8±7. 2) μg/L , P < 0.05 and( 1 677 ±67) μg/L vs (1 28±34) μg/L , P < 0. 01 ]. The number of calcium nodule formed by osteoblasts cultured by the serum from rats fed with Astragalus and Angelica mixture was higher than that of osteoblasts cultured by the control serums (25. 8±7. 8 vs 13. 3±6. 2, P < 0. 05) . [Conclusion] The serums from rats fed with Astragalus and Angelica mixture can directly promote the proliferation, secretion and mimeralization of cultured osteoblasts in vitro.

[目的]通过血清药理学方法观察黄芪当归合剂(芪归合剂)对体外培养的大鼠成骨细胞生物学特性的影响。[方法]制备芪归合剂含药血清,以放射免疫法和免疫放射法检测其胰岛素样生长因子-I(IGF-I)、胰岛素样生长因子结合蛋白-3(IGFBP-3)、I型前胶原氨基端伸展肽(PINP)和骨钙素(OC)水平。分离、培养乳鼠颅骨成骨细胞,通过形态学观察、HE染色、碱性磷酸酶染色(ALP染色)、茜素红S法、V-G法胶原染色进行培养成骨细胞的鉴定,以四唑盐比色法(MTT法)测定含药血清对成骨细胞增殖功能的影响;以放射免疫法测定培养上清液PINP、OC和IGF-I浓度;用矿化结节计数法观察含药血清对成骨细胞矿化功能的影响。[结果]含药血清IGF—I、IGFBP-3、PINP和OC水平与对照血清相比,差别无统计学意义(P>0.05)。含药血清和对照血清均可促进成骨细胞增殖,且呈浓度依赖性,但200 mL/L、300 mL/L含药血清促进成骨细胞增殖的能力高于对照血清组(分别P<0.01和P<0.05);含药血清组培养上清液PINP[(4.9±1.6)μg/L]、OC[(36.7±3.8)μg/L和IGF—I[(1 677...

[目的]通过血清药理学方法观察黄芪当归合剂(芪归合剂)对体外培养的大鼠成骨细胞生物学特性的影响。[方法]制备芪归合剂含药血清,以放射免疫法和免疫放射法检测其胰岛素样生长因子-I(IGF-I)、胰岛素样生长因子结合蛋白-3(IGFBP-3)、I型前胶原氨基端伸展肽(PINP)和骨钙素(OC)水平。分离、培养乳鼠颅骨成骨细胞,通过形态学观察、HE染色、碱性磷酸酶染色(ALP染色)、茜素红S法、V-G法胶原染色进行培养成骨细胞的鉴定,以四唑盐比色法(MTT法)测定含药血清对成骨细胞增殖功能的影响;以放射免疫法测定培养上清液PINP、OC和IGF-I浓度;用矿化结节计数法观察含药血清对成骨细胞矿化功能的影响。[结果]含药血清IGF—I、IGFBP-3、PINP和OC水平与对照血清相比,差别无统计学意义(P>0.05)。含药血清和对照血清均可促进成骨细胞增殖,且呈浓度依赖性,但200 mL/L、300 mL/L含药血清促进成骨细胞增殖的能力高于对照血清组(分别P<0.01和P<0.05);含药血清组培养上清液PINP[(4.9±1.6)μg/L]、OC[(36.7±3.8)μg/L和IGF—I[(1 677±67)μg/L]含量高于对照血清组[分别(2.8±0.5)μg/L、(27.8±7.2)μg/L、(1 284±34)μg/L](分别P<0.05,P<0.05和P<0.01);以含药血清培养的成骨细胞形成的矿化结节数(25.8±7.8)多于对照血清组(13.3

 
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