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   i型前胶原 在 心血管系统疾病 分类中 的翻译结果: 查询用时:1.696秒
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i型前胶原
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  type i procollagen
    Methods 54 elder essential hypertensive patients with left atrial myocardial fibrosis and 20 normotensive subjects were enrolled. The former was divided by carboxyterminal propeptide of type I procollagen(PICP) into essential hypertensive patients with PICP>127 μg/L and essential hypertensive patients with PICP<127 μg/L.
    方法老年高血压病患者54例分为高血压I型前胶原羧基端前肽(PICP)<127μg/L组和高血压PICP>127μg/L组,健康对照20例。
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  procollagen i
    Methods Serum procollagen I(PCⅠ) and procollagenⅢ(PCⅢ)were measured by radioimmuoassay in 42 EH patients and 20 normal volumteers.
    方法 采用放免法测定 2 0例正常人和 4 2例 EH患者 (伴心肌肥厚者2 0例和不伴心肌肥厚者 2 2例 )的血清 I型前胶原 (PC )和 型前胶原 (PC )的浓度。
短句来源
  procollagen type i
    Objectives To evaluate the clinical significance of serum procollagen type I carboxy terminal peptide (PIP) in patients with essential hypertension (EH).
    目的测定高血压病(EH)患者血清I型前胶原羧基端肽(PIP)水平,探讨其临床意义。
短句来源
    [Objective] To investigate the clinical value of quantitative assessment of MF in essential hypertension(EH) patients by serum concentrations of carboxyterminal propeptide of procollagen type I(PICP) and procollagen type Ⅲ(PCⅢ).
    目的探讨血清I型前胶原羧基端肽(P ICP)、Ⅲ型前胶原(PCⅢ)水平作为高血压病(EH)心肌纤维化(M F)血清标志物的临床价值。
短句来源
    [Objective] To study the changes of diastolic function of left ventricle by Tissue Doppler Imaging (TDI) and analyse the relations between the diastolic function of left ventricle and the serum level of procollagen type I C-terminal peptide (PIP) in patients with essential hypertension.
    目的应用组织多普勒成像(TDI)技术评价高血压病患者左心室舒张功能变化,并探讨其与胶原代谢的血清标志物I型前胶原羧基端肽(PIP)水平之间关系。
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  “i型前胶原”译为未确定词的双语例句
    Methods The serum concentrations of carboxyterminal propeptide of type Ⅰprocollagen(PICP)and aminoterminal propeptide of type Ⅲ procollagen(PIIINP)were measured by radioimmunoassay on the 5th,15th,30th and 90th days after AMI.
    方法 应用放射免疫法测定 32例AMI患者发病后第 5天、1 5天、30天、90天血清I型前胶原羧基端肽 (PICP)和Ⅲ型前胶原氨基端肽(PⅢNP)含量。
短句来源
    The serum concentration of procollagen Ⅰ(PCI), procollagen Ⅲ(PCⅢ),laminin(LN) and hyaluronic acid(HA) in patient group(n=37) and in control group(n=20) were measured. The correlation analysis was made with the area of fibrosis.
    测定患者组(n=37)与正常对照组(n=20)血清I型前胶原(procollagenI,PCI)、III型前胶原(procollagenⅢ,PCⅢ)、纤联蛋白、透明质酸的含量,并和纤维化面积作相关分析。
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  type i procollagen
Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides
      
Antisense DNA oligonucleotides directed against specific sequences within α1(I) and α2(I) mRNA of type I procollagen were complexed to a cell-specific carrier, and screened for their effectiveness in reducing α1(I) and α2(I) mRNA levels.
      
Osteocalcin, a biochemical marker for osteoblast activity, and the carboxy-terminal propeptide of type I procollagen (PICP), a marker of collagen formation, were slightly but not significantly higher in gastrectomy-treated patients.
      
Simultaneously, circulating carboxyterminal propeptide of type I procollagen (PICP) was released in the perfusion medium (threefold versus C).
      
Gene expression of type I procollagen was significantly greater in Group MH than in Group MC at 7?days postoperatively and was also significantly greater in Group AH than in Group AC at 28?days (P?>amp;lt;?0.05).
      
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  procollagen i
Procollagen Iα2 (COL1A2) mRNA levels were quantitated by (a) northern blot analysis and (b) reverse transcriptase polymerase chain reaction.
      
Active transforming growth factor-β1 activates the procollagen I promoter in patients with acute lung injury
      
Experimental tissue expansion induces changes in expression of procollagen I and III messenger RNA
      
Dermal procollagen I and procollagen III gene expression in response to tissue expansion was investigated by dot-blot analysis using digoxigenin-labeled RNA probes complementary to either human procollagen-al (I) mRNA or procollagen-a1 (III) mRNA.
      
In response to the trauma of surgery, procollagen I and III mRNA transcriptions were found to be decreased significantly within the first few days after implantation.
      
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  procollagen type i
In the course of CVB3 myocarditis, CTGF upregulation coincided with increased cardiac TGF-β and procollagen type I mRNA expression, preceding the formation of fibrotic lesions.
      
The significantly enhanced transcript levels of TGF-β, CTGF, and procollagen type I in cultivated CVB3-infected primary cardiac fibroblasts substantiate the role of fibroblasts as a relevant cell population in cardiac remodeling processes.
      
Immunohistochemistry was performed using antibody of the amino-terminal end of the procollagen type I propeptide (M-57).
      
Serum concentration of procollagen type I carboxyterminal propeptide in systemic sclerosis
      
A 50% decrease in the amount of procollagen type I and type III mRNAs was observed after 2 and 4 days of coculture while collagenase gene expression was upregulated by 300% when compared with control lattices.
      
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Objectives To evaluate the clinical significance of serum procollagen type I carboxy terminal peptide (PIP) in patients with essential hypertension (EH). Methods The serum concentratin of PIP was measured by specific radioimmunoassay in EH patients ( n =48) and in normotensive control subjects (NH, n =30). Two diamensional, M mode and Doppler ultrasound recordings were obtained in every subject to determine serveral parameters of left ventricular anatomy and function. Ambulatory ECG monitoring was performed...

Objectives To evaluate the clinical significance of serum procollagen type I carboxy terminal peptide (PIP) in patients with essential hypertension (EH). Methods The serum concentratin of PIP was measured by specific radioimmunoassay in EH patients ( n =48) and in normotensive control subjects (NH, n =30). Two diamensional, M mode and Doppler ultrasound recordings were obtained in every subject to determine serveral parameters of left ventricular anatomy and function. Ambulatory ECG monitoring was performed in EH patients to record the ventricular arrhythmias which were categorized according to Lown Wolf classification. Results Serum concentration of PIP was markedly higher in EH patients (6.91±0.62μg/L vs 4.8±0.38μg/L, P < 0.01 ) than in normal subjects (6.91±0.62μg/L vs 4.8±0.38μg/L, P < 0.01) and it was correlated positively with the left ventricular mass index (LVMI, r =0.5163, P <0.05) and negatively with the left ventricular diastolic function ( P <0.05) in EH patients with LV hypertrophy. The serum concentration of PIP was significantly higher ( r =-0.5734, P <0.05)in ventricular arrhythmic patients of>grade Ⅲ than that in those of grade 0~Ⅱ (7.25±0.37μg/l vs 6.11±0.54 μg/L, P <0.05).Conclusion The finding suggests that the synthesis of myocardial collagen type I may be abnormally increased in patient with EH, and thus serum PIP might be an indirect index of hypertensive myocardial fibrosis.

目的测定高血压病(EH)患者血清I型前胶原羧基端肽(PIP)水平,探讨其临床意义。方法采用放射免疫分析方法测定48例EH患者和30例正常血压(NH)的健康人血清PIP的水平,并用超声心动图测量左室解剖、舒缩功能参数。动态心电图(DCG)记录EH组室性心律失常程度,并以Lownwolf法分级。结果EH组血清PIP浓度较对照组显著升高(6.91±0.62μg/Lvs4.8±0.38μg/L,P<0.01)。在EH并左室肥厚者,血清PIP浓度与左室质量指数正相关(LVMI)(r=0.5163,P<0.05),与左室舒张功能呈负相关(r=-0.5734,P<0.05)。EH组Lownwolf分级3级以上室性心律失常者血清PIP水平较0~2级明显升高(7.25±0.37μg/Lvs6.11±0.54μg/L,P<0.05)。结论EH患者可能有心肌局部I型胶原合成增加,测定血清PIP浓度可作为了解心肌纤维化程度的间接指标

Objective To investigate the changes of myocardial collagen synthesis and heart function in patients with acute myocardial infarction(AMI)without thrombolytic therapy or in failure to thrombolytic therapy within 3 months after infarction.Methods The serum concentrations of carboxyterminal propeptide of type Ⅰprocollagen(PICP)and aminoterminal propeptide of type Ⅲ procollagen(PIIINP)were measured by radioimmunoassay on the 5th,15th,30th and 90th days after AMI.Before discharge and on the 90th day all patients...

Objective To investigate the changes of myocardial collagen synthesis and heart function in patients with acute myocardial infarction(AMI)without thrombolytic therapy or in failure to thrombolytic therapy within 3 months after infarction.Methods The serum concentrations of carboxyterminal propeptide of type Ⅰprocollagen(PICP)and aminoterminal propeptide of type Ⅲ procollagen(PIIINP)were measured by radioimmunoassay on the 5th,15th,30th and 90th days after AMI.Before discharge and on the 90th day all patients underwent echocardiography to determine the left ventricular end- diastolic diameter(LVEDd),the left ventricular ejection fraction(LVEF)and the E/A ratio.Correlation analyses were made between the E/A ratio and the serum concentrations of PICP and PIIINP on the 90th day.30 healthy people served as control group.Results Compared to the control group,the serum concentrations of PICP and PIIINP in AMI group were significantly increased on the 5th,15th,30th and 90th days,and the LVEDd was significantly larger while the LVEF and E/A ratio were significantly lower before discharge and on the 90th day after infarction.Conclusions The serum concentrations of PICP and PIIINP increase significantly and elevate until the 90th day after AMI in patients without thrombolytic therapy or in failure to thrombolytic therapy.There is a close relation between the dysfunction of left ventricle and myocardial fibrosis.

目的 研究未进行溶栓治疗或溶栓治疗未成功的急性心肌梗死 (AMI)患者发病后 3个月内的心肌胶原纤维合成指标以及左室收缩、舒张功能指标的变化规律。方法 应用放射免疫法测定 32例AMI患者发病后第 5天、1 5天、30天、90天血清I型前胶原羧基端肽 (PICP)和Ⅲ型前胶原氨基端肽(PⅢNP)含量。超声测定AMI患者出院前、第 90天的左室舒张末期内径 (LVEDd)、左室射血分数(LVEF)、二尖瓣舒张早期血流速度峰值 (A)的比值。将第 90天的E/A比值与血清PICP和PⅢNP水平作相关分析。 30例健康人作为正常对照组。结果 AMI发病后第 5天、1 5天、30天、90天的血清PICP和PⅢNP水平分别与对照组比较均明显升高 (P <0 .0 1 )。AMI组出院前和第 90天的LVEDd均明显大于对照组 ,LVEF和E/A比值均明显低于对照组 (P <0 .0 1 )。第 90天的E/A比值与血清PICP和PⅢNP水平均呈明显负相关 (P <0 .0 0 1 )。结论 未进行溶栓治疗或溶栓治疗未获成功的AMI患者血清PICP和PⅢNP含量明显增高并持续 3个月以上。左室舒张功能障碍与心...

目的 研究未进行溶栓治疗或溶栓治疗未成功的急性心肌梗死 (AMI)患者发病后 3个月内的心肌胶原纤维合成指标以及左室收缩、舒张功能指标的变化规律。方法 应用放射免疫法测定 32例AMI患者发病后第 5天、1 5天、30天、90天血清I型前胶原羧基端肽 (PICP)和Ⅲ型前胶原氨基端肽(PⅢNP)含量。超声测定AMI患者出院前、第 90天的左室舒张末期内径 (LVEDd)、左室射血分数(LVEF)、二尖瓣舒张早期血流速度峰值 (A)的比值。将第 90天的E/A比值与血清PICP和PⅢNP水平作相关分析。 30例健康人作为正常对照组。结果 AMI发病后第 5天、1 5天、30天、90天的血清PICP和PⅢNP水平分别与对照组比较均明显升高 (P <0 .0 1 )。AMI组出院前和第 90天的LVEDd均明显大于对照组 ,LVEF和E/A比值均明显低于对照组 (P <0 .0 1 )。第 90天的E/A比值与血清PICP和PⅢNP水平均呈明显负相关 (P <0 .0 0 1 )。结论 未进行溶栓治疗或溶栓治疗未获成功的AMI患者血清PICP和PⅢNP含量明显增高并持续 3个月以上。左室舒张功能障碍与心肌纤维化密切相关

Objective To evaluate left ventricular diastolic function(LVDF)by Doppler tissue imaging(DTI) in patients with essential hypertension(EH). Methods Serum procollagen I(PCⅠ) and procollagenⅢ(PCⅢ)were measured by radioimmuoassay in 42 EH patients and 20 normal volumteers. Ea, Aa, Ea/Aa were measured by DTI in EH patients and normal group. The diastolic flow velocity E.A. E/A were measured by transmitral valve Doppler flow. Results Mitral valve flow parameters and mitral anulus parameters by DTI were decreased...

Objective To evaluate left ventricular diastolic function(LVDF)by Doppler tissue imaging(DTI) in patients with essential hypertension(EH). Methods Serum procollagen I(PCⅠ) and procollagenⅢ(PCⅢ)were measured by radioimmuoassay in 42 EH patients and 20 normal volumteers. Ea, Aa, Ea/Aa were measured by DTI in EH patients and normal group. The diastolic flow velocity E.A. E/A were measured by transmitral valve Doppler flow. Results Mitral valve flow parameters and mitral anulus parameters by DTI were decreased significantly (P<0.01)in hypertensive patients with non-left ventricular hypertrophy (LVH) and LVH. E. E/A.were no significant difference(P>0.05) in EH patients between non-LVH and LVH,A negative correlations were found betweenPCⅠ or PCⅢ and E/A. Ea/Aa in EH patients with non-LVH group.Conclution The alteration of DTI was closely related to serum concentration of PCⅠ and PCⅢ for asses myocardial fibrosis in EH patients. DTI can be used as objective parameter for diagnosis of LVDF in EH patients.

目的 探讨多普勒组织成像 (DTI)技术评价高血压病 (EH)患者左心室舒张功能的价值 ,以寻求一种可靠、客观的评价高血压左心室舒张功能的新方法。方法 采用放免法测定 2 0例正常人和 4 2例 EH患者 (伴心肌肥厚者2 0例和不伴心肌肥厚者 2 2例 )的血清 I型前胶原 (PC )和 型前胶原 (PC )的浓度。用 DTI法检测正常人及 EH患者二尖瓣环舒张早期运动速度 (Ea)、舒张晚期运动速度 (Aa)及 Ea/Aa,并用二尖瓣血流多普勒法检测舒张期血流速度 E、A及 E/A,比较两种方法测值与血清 PC 、PC 型前胶原的相关性。结果  1.EH患者非左心室肥厚(non- L VH )组及左心室肥厚 (L VH )组二尖瓣口血流参数、二尖瓣环 DTI参数均明显低于正常对照组 (P<0 .0 1) ;2 .EH患者 non- L VH组与 L VH组间 E、E/A无明显差异 (P>0 .0 5 ) ,但 L VH组 Ea、Ea/Aa明显低于 non- L VH组(P<0 .0 5 ) ;3.EH患者 non- L VH组血清 PC 、PC 与 E/A及 Ea/Aa均呈负相关 ;而 L ...

目的 探讨多普勒组织成像 (DTI)技术评价高血压病 (EH)患者左心室舒张功能的价值 ,以寻求一种可靠、客观的评价高血压左心室舒张功能的新方法。方法 采用放免法测定 2 0例正常人和 4 2例 EH患者 (伴心肌肥厚者2 0例和不伴心肌肥厚者 2 2例 )的血清 I型前胶原 (PC )和 型前胶原 (PC )的浓度。用 DTI法检测正常人及 EH患者二尖瓣环舒张早期运动速度 (Ea)、舒张晚期运动速度 (Aa)及 Ea/Aa,并用二尖瓣血流多普勒法检测舒张期血流速度 E、A及 E/A,比较两种方法测值与血清 PC 、PC 型前胶原的相关性。结果  1.EH患者非左心室肥厚(non- L VH )组及左心室肥厚 (L VH )组二尖瓣口血流参数、二尖瓣环 DTI参数均明显低于正常对照组 (P<0 .0 1) ;2 .EH患者 non- L VH组与 L VH组间 E、E/A无明显差异 (P>0 .0 5 ) ,但 L VH组 Ea、Ea/Aa明显低于 non- L VH组(P<0 .0 5 ) ;3.EH患者 non- L VH组血清 PC 、PC 与 E/A及 Ea/Aa均呈负相关 ;而 L VH组血清 PC 、PC 与Ea/Aa亦呈负相关 ,与 E/A无明显相关。结论  DTI能更准确定量高血压患者二尖瓣环舒张期运动速度的改变 ,DTI法检测二尖瓣环运动速度之比与反应心肌纤维化程度的血清 PC 、PC 浓度相关良好 ,有利于舒张功能受损程度的判断 ,优于传统的二尖瓣口血流法。

 
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