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i型前胶原
相关语句
  type i procollagen
    Effects of Sodium Ferulate on Type I Procollagen and Connective Tissue Growth Factor mRNA Expression in Rat Hepatic Stellate Cells
    阿魏酸钠对肝星状细胞中I型前胶原和CTGF mRNA表达的影响
短句来源
    Methods Cultured HSC-T6 cells treated with H 2O 2 served as control group,the effects of SF on type I procollagen and CTGF mRNA level were determined by reverse transcription polymerase chain reaction(RT-PCR).
    方法 以 5 0 μmol·L-1H2 O2 处理的HSC -T6细胞为氧化应激模型组 ,采用RT -PCR方法检测并分析 12 5 μmol·L-1和 5 0 0 μmol·L-1SF对细胞中I型前胶原及其相关调控因子CTGF表达的影响。
短句来源
    Results On the oxidative stress conditon,type I procollagen and CTGF mRNA level were remarkably increased compared with untreated group. However,the expression of both of them can be down-regulated by SF.
    结果 肝星状细胞在氧化应激条件下I型前胶原mRNA和CT GFmRNA表达水平都明显上调 ,而阿魏酸钠可以下调二者的表达水平。
短句来源
  type i procollagen
    Effects of Sodium Ferulate on Type I Procollagen and Connective Tissue Growth Factor mRNA Expression in Rat Hepatic Stellate Cells
    阿魏酸钠对肝星状细胞中I型前胶原和CTGF mRNA表达的影响
短句来源
    Methods Cultured HSC-T6 cells treated with H 2O 2 served as control group,the effects of SF on type I procollagen and CTGF mRNA level were determined by reverse transcription polymerase chain reaction(RT-PCR).
    方法 以 5 0 μmol·L-1H2 O2 处理的HSC -T6细胞为氧化应激模型组 ,采用RT -PCR方法检测并分析 12 5 μmol·L-1和 5 0 0 μmol·L-1SF对细胞中I型前胶原及其相关调控因子CTGF表达的影响。
短句来源
    Results On the oxidative stress conditon,type I procollagen and CTGF mRNA level were remarkably increased compared with untreated group. However,the expression of both of them can be down-regulated by SF.
    结果 肝星状细胞在氧化应激条件下I型前胶原mRNA和CT GFmRNA表达水平都明显上调 ,而阿魏酸钠可以下调二者的表达水平。
短句来源
  “i型前胶原”译为未确定词的双语例句
    764-3 at a final concentration of 15μg/ml for 24 hours conld stimulate type I collagen mR-NA expression,but exerted no effect on type Ⅲ collagen expression.
    加入764-3(终浓度为15μg/ml)24h对Ⅲ型前胶原mRNA表达无明显作用,对I型前胶原mR-NA表达非但不抑制反而有明显促进作用。
短句来源
    Methods In order to study the effect of suramin on KFb and the interaction with TGF-β1, KFb was seeded in human fibrin lattice and its biological characteristic was measured by the assay of cell growth curve, 3H-proline incorporation and expression of I type pro-collagen mRNA.
    方法建立以人纤维蛋白原为支架的KFb三维培养系统,分别通过测定细胞的生长曲线。 细胞的胶原合成量及I型前胶原mRNA的表达情况来观察苏拉明对KFb影响及其与转化生长因子(TGF-β1)的相互作用。
短句来源
    Results Eight hours after the action of danshensu on the culture fibroblasts, the NF-kB combining activity was almost inhibited completely and the NF-1 combining activity decreased by about 50%. In addition, ladder-like DNA fragments were revealed clearly by sepharose electrophoresis. The mRNA levels of type Ⅰprocollagen α1 and α2 decreased by 56% and 59%,respectively.
    结果 丹参素对培养成纤维细胞作用8 h后,NF-κB结合活性几乎被完全抑制,NF-1结合活性降低近50%,琼脂糖凝胶电泳显示出清晰的梯状 DNA片段,RT-PCR方法测定显示,I型前胶原αl和α2的mRNA水平分别降低了56%和59%。
短句来源
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  type i procollagen
Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides
      
Antisense DNA oligonucleotides directed against specific sequences within α1(I) and α2(I) mRNA of type I procollagen were complexed to a cell-specific carrier, and screened for their effectiveness in reducing α1(I) and α2(I) mRNA levels.
      
Osteocalcin, a biochemical marker for osteoblast activity, and the carboxy-terminal propeptide of type I procollagen (PICP), a marker of collagen formation, were slightly but not significantly higher in gastrectomy-treated patients.
      
Simultaneously, circulating carboxyterminal propeptide of type I procollagen (PICP) was released in the perfusion medium (threefold versus C).
      
Gene expression of type I procollagen was significantly greater in Group MH than in Group MC at 7?days postoperatively and was also significantly greater in Group AH than in Group AC at 28?days (P?>amp;lt;?0.05).
      
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  type i procollagen
Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides
      
Antisense DNA oligonucleotides directed against specific sequences within α1(I) and α2(I) mRNA of type I procollagen were complexed to a cell-specific carrier, and screened for their effectiveness in reducing α1(I) and α2(I) mRNA levels.
      
Osteocalcin, a biochemical marker for osteoblast activity, and the carboxy-terminal propeptide of type I procollagen (PICP), a marker of collagen formation, were slightly but not significantly higher in gastrectomy-treated patients.
      
Simultaneously, circulating carboxyterminal propeptide of type I procollagen (PICP) was released in the perfusion medium (threefold versus C).
      
Gene expression of type I procollagen was significantly greater in Group MH than in Group MC at 7?days postoperatively and was also significantly greater in Group AH than in Group AC at 28?days (P?>amp;lt;?0.05).
      
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The effect of ligustrazine and 764-3 on type I and type Ⅲ collagen mRNA expression incuitured fibroblasts was sttidied.The results showed that ligustrazine at a final concentra-tion of 30μg/ml for 24 hours could inhibit type I and type Ⅲ collagen mRNA expression;764-3 at a final concentration of 15μg/ml for 24 hours conld stimulate type I collagen mR-NA expression,but exerted no effect on type Ⅲ collagen expression.The possible mecha-nism of 764-3 action was discussed.

川芎嗪和764-3均有抑制纤维化的作用。本工作观察了川芎嗪和764-3对体外培养的成纤维细胞Ⅰ、Ⅲ型前胶原mRNA表达的影响结果表明,加入川芎嗪(终浓度30μg/ml)24h对I、Ⅲ型前胶原mRNA表达均有明显抑制作用;加入764-3(终浓度为15μg/ml)24h对Ⅲ型前胶原mRNA表达无明显作用,对I型前胶原mR-NA表达非但不抑制反而有明显促进作用。作者对764-3这种作用的可能原因做了初步讨论。

:Objective To investigate the biological effects of suramin on keloid fibroblasts(KFb)and the interaction with transforming growth factor-β1( TGF-β1).Methods In order to study the effect of suramin on KFb and the interaction with TGF-β1, KFb was seeded in human fibrin lattice and its biological characteristic was measured by the assay of cell growth curve, 3H-proline incorporation and expression of I type pro-collagen mRNA. Result Suramin is able to suppress the growth and collagen synthesis of keloid fibroblasts....

:Objective To investigate the biological effects of suramin on keloid fibroblasts(KFb)and the interaction with transforming growth factor-β1( TGF-β1).Methods In order to study the effect of suramin on KFb and the interaction with TGF-β1, KFb was seeded in human fibrin lattice and its biological characteristic was measured by the assay of cell growth curve, 3H-proline incorporation and expression of I type pro-collagen mRNA. Result Suramin is able to suppress the growth and collagen synthesis of keloid fibroblasts. Meanwhile, the collagen synthesis of keloid fibroblasts induced by TGF-β1 is obviously suppressed. Conclusion Suramin can suppress the function of KFb obviously and antagonize the effect of TGF-β1. Suramin may become a new drug to care the keloid.

目的探讨苏拉明(suramin)对立体培养条件下瘢痕疙瘩成纤维细胞(KFb)的药物学作用。方法建立以人纤维蛋白原为支架的KFb三维培养系统,分别通过测定细胞的生长曲线。细胞的胶原合成量及I型前胶原mRNA的表达情况来观察苏拉明对KFb影响及其与转化生长因子(TGF-β1)的相互作用。结果苏拉明对KFb的生长及胶原合成均有抑制作用,且能明显抑制TGF-β1对KFb胶原合成的诱导作用。结论苏拉明能明显抑制KFb的生物学功能且对TGF-β1有明显的拮抗作用,这可能使其成为治疗瘢痕疙瘩的有效药物之一。

Objective To explore the effects of danshensu on fibroblast apoptosis and the expression of procollagen gene. Methods Danshensu was added to in vitro culture of human cutaneous fibroblasts,and the nuclear proteins and total RNA were harvested from the cells. Electrophoretic mobility shift assay (EMSA) was adopted to determine the combining activity of nuclear transcription factors NF-kB and NF-1. Cell apoptosis was analyzed by DNA ladder fragmentation. The procollagen gene expression was analyzed by...

Objective To explore the effects of danshensu on fibroblast apoptosis and the expression of procollagen gene. Methods Danshensu was added to in vitro culture of human cutaneous fibroblasts,and the nuclear proteins and total RNA were harvested from the cells. Electrophoretic mobility shift assay (EMSA) was adopted to determine the combining activity of nuclear transcription factors NF-kB and NF-1. Cell apoptosis was analyzed by DNA ladder fragmentation. The procollagen gene expression was analyzed by RT-PCR. Results Eight hours after the action of danshensu on the culture fibroblasts, the NF-kB combining activity was almost inhibited completely and the NF-1 combining activity decreased by about 50%. In addition, ladder-like DNA fragments were revealed clearly by sepharose electrophoresis. The mRNA levels of type Ⅰprocollagen α1 and α2 decreased by 56% and 59%,respectively. Conclusion Danshensu could inhibit the nuclear transcription factor NF-kB activity of fibroblast and induce the occurrence of its apoptosis. Furthermore, danshensu could also inhibit the nuclear transcription factor NF-1 activity of fibroblast and modulate the synthesis and secretion of collagen.

目的 探讨丹参素对成纤维细胞凋亡和前胶原基因表达的影响。 方法 于培养的人皮肤成纤维细胞(2×106)中加入丹参素(0.025 mg/ml),培养8 h后,从细胞中分离核蛋白及总RNA;采用 EMSA法测定NF-κB及 NF-l核转录因子结合活性;凋亡用 DNA梯度片段法分析;RT-PCR用于分析前胶原基因表达。 结果 丹参素对培养成纤维细胞作用8 h后,NF-κB结合活性几乎被完全抑制,NF-1结合活性降低近50%,琼脂糖凝胶电泳显示出清晰的梯状 DNA片段,RT-PCR方法测定显示,I型前胶原αl和α2的mRNA水平分别降低了56%和59%。 结论 丹参素抑制成纤维细胞核转录因子NF-kB的活性并诱导其发生凋亡,抑制成纤维细胞核转录因子NF-l的活性而调控胶原的合成与分泌,这可能是其抑制增生性瘢痕的细胞分子生物学机制。

 
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