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分子构形
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  molecular conformation
     Molecular conformation and expression effciency in the hepatocyte targeting gene drug
     肝细胞靶向基因药物分子构形和表达效率的研究
短句来源
     Objective To modulate the molecular conformation of the hepatocyte targeting drug to increase exogenous gene expression efficiency in the targeted cell.
     目的 :用调整肝细胞靶向基因药物分子构形的方法 ,以期提高外源转入基因在目标细胞的表达效率。
短句来源
  molecular conformations
     Relationship between the expression quantity and molecular conformations of gene drugs targeted at hepatoma cells in vitro
     肝癌细胞靶向基因药物分子构形与表达量关系的体外研究
短句来源
     3. Target gene drugs showed different molecular conformations in various adjuvant concentrations and expressed different levels of hIL12 quantities, the best ones are granular and circle-like and the optimal diameters ranged from 25nm to 150nm.
     3.在不同辅料浓度中两种靶向基因药物分子构形不同,不同构形药物分子转染后表达水平不一,直径在25~150nm的颗粒状或圆环状表达量最高。
短句来源
     2. The molecular conformations of targeting gene drugs played an important role in exogenous gene expression;
     2.靶向基因药物分子构形对外源基因的表达有重要影响;
短句来源
     Objective To increase exogenous gene expression quantity by modulating molecular conformations of targeting gene drugs to solving the problem of their low expression efficiency in targeting cells.
     目的 通过调整靶向基因药物分子构形来提高外源基因的表达量 ,以解决外源基因在靶细胞中表达效率低的难题。
短句来源
     Conclusions The molecular conformations of targeting gene drugs play an important role in exogenous gene expression, among which the best structures are granular and circle like and diameters range from 25 nm to 150 nm. The sizes and link styles of exogenous genes also have some effects on their expression quantity.
     结论 靶向基因药物分子构形对外源基因的表达有重要影响 ,以直径 2 5~ 1 50nm的颗粒状或圆环状构形为最佳分子构形 ,外源基因的大小及连接方式对其表达也有一定影响
短句来源
  molecular configuration
     According to the analysis of molecular configuration obtained in the molecular dynamics simulation of liquid-vapor nucleation, a numerical method and the underlying physical picture are given to identify non-liquid space.
     本文通过对汽液成核过程分子动力学模拟所得到的分子构形的分析,给出利用空间局域势能判别非液相空间的 方法及其物理图象。
短句来源
     We also discuss the correlation between the valence of two Co ions in the planar binuclear Co-phthalocyanine and molecular configuration,coordination property,molecular recognition and molecular rectifying character.
     讨论了平面双核酞菁钴分子中Co离子的价态与分子构形、配位性质、分子识别和分子整流特性等之间的联系.
短句来源
     In the molecules of the planar binuclear Co-phthalocyanine,the valences of two Co ions are different. The molecular configuration,Co(Ⅰ)Po-PcCo(Ⅲ),make this molecule display some (unique) properties.
     在平面双核酞菁钴分子中,两个Co离子具有不同的价态,Co(Ⅰ)Pc-PcCo(Ⅲ)这种分子构形使得该分子表现出一些独特的性质.
短句来源
  “分子构形”译为未确定词的双语例句
     , the geometrical configuration of C60 molecule is destroyed.
     时,C60分子构形破坏。
短句来源
     Results suggested that the molecular length, orientation and amino acid mutation had significant influences on the binding affinities but not the reverse kinetic rates of the selectin/ligand bindings, indicating that selectins must project Lee domain well above the membrane in accessible positions to mediate optimal adhesion of HL-60 cell.
     结果显示,分子长度、取向、氨基酸变异主要影响选择素-配体的反应亲和性,而非逆反应速率,进而说明选择素分子必须保持足够的长度来将Lec功能片段伸出细胞膜表面、同时还要保持一定的分子构形才能介导HL-60细胞的粘附反应。
短句来源
     Pinene can be high-selectively Hydrogenated to cis-pinane under optimum conditions.
     在一定条件下,蒎烯可高选择地氢化成顺式蒎烷,选择性的大小与催化剂的特性及蒎烯的分子构形~([1][2])有关。
短句来源
     Methods Some specific auxiliary molecules were added to the gene drug its molecular liquid conformation was investigated under the electron microscope and they were transfected into human hepatoma cell line BEL 7402 in vitro.
     方法 :加入特定辅料分子至基因药物中 ,用电镜观察其液态分子构形
短句来源
     Conclusion The molecular drug conformation had much influence on targeted gene expression efficiency in gene therapy.
     结论 :用于基因治疗的药物分子构形对其转入靶细胞的表达效率有重要的影响。
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  molecular conformation
The molecule surface area accessible for a solvent is considered as a property apparently related to the molecular conformation.
      
Changing the solvent by a more polar changes the molecular conformation.
      
As the electron-donor power of the p-substituents decreases and their electron-acceptor power grows, the molecular conformation changes in the sequence orthogonal-free rotation-planar.
      
Density functional theory (DFT) calculations at the B3LYP/6-31G** level of theory lead to a C2 molecular conformation in the ground electronic state.
      
>amp;gt;A procedure was developed for the synthesis of bis(2,5-dimethyl-3-thienyl)ethenes with partially fixed molecular conformation, and their photochromic properties in solution were studied.
      
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  molecular conformations
The nature and positions of substituents attached to aromatic rings, as well as their electronegativities and sizes, seem to affect the preferred molecular conformations and, hence, the binding of the compounds to the corresponding cell receptors.
      
Quantumchemical calculations by the AM1 method show that the molecular conformations of N-(chlorodimethylsilylmethyl)imides containing an intramolecular O→Si bond are not energetically most favorable in the gas phase.
      
A microscopic model of informative biomacromolecules is proposed in which the potential energy relief for an electron responsible for the switching between molecular conformations has a two-well structure.
      
The results are discussed in terms of molecular conformations.
      
The molecular conformations of shortened molecular models of vitamin E (tocopherol and tocotrienol) and their sulfur and selenium congeners were studied computationally at the DFT level of theory [B3LYP/6-31G(d)].
      
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  molecular configuration
Moreover, our study also reveals that molecular configuration selection and structural relaxation would play an important role in the design of such devices.
      
It is noted that the DNA molecule offers the designer a set of current-voltage characteristics depending on the molecular configuration.
      
The photoluminescence spectra of 5CB are determined by the molecular configuration and the intramolecular charge transfer in the excited state.
      
This molecular configuration possesses stability and has been described by the authors as an "angular dilation."
      
The simulation revealed that the field type and field strength act on the population of the molecular configuration.
      
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Positron annihilation lifetime spectra were measured for the Hep2 cell cultures treated with the interferon (3.6×10~7 Iu/mg Pr.)and control cells. The positron lifetime spectra were resolved into 3 lifetime components. The clear difference of the long-lifetime components related to the pick-off annihilation of ortho positronium between the interferon affected cells and the control cells was observed. The result showed that τ_3 in the interferon treated cells was longer than that in control cells, and Ⅰ_3 in...

Positron annihilation lifetime spectra were measured for the Hep2 cell cultures treated with the interferon (3.6×10~7 Iu/mg Pr.)and control cells. The positron lifetime spectra were resolved into 3 lifetime components. The clear difference of the long-lifetime components related to the pick-off annihilation of ortho positronium between the interferon affected cells and the control cells was observed. The result showed that τ_3 in the interferon treated cells was longer than that in control cells, and Ⅰ_3 in the former was lower than that in the latter, but the product of τ_3Ⅰ_3 was augmented. As to free volume model, the above result suggested that biological maeromolesular conformation volume of the interferon affected cells was increased. The relations belween such change and the anti-virus condition of the cell call for more further studies.

本文报道部分纯化人脐血干扰素(Interferon IFN)作用细胞和对照细胞中正电子寿命测量的结果。在干扰素作用细胞和对照细胞中O-Ps拾取湮没寿命(τ_3)分别为1.986ns和1.889ns,相应的强度(Ⅰ_3)分别为18.9%和19.3%。根据自由体积模型,乘积τ_3Ⅰ_3是细胞生物分子总构形体积的量度,τ_3从对照细胞的1.889ns增加到干扰素作用细胞的1.986ns,Ⅰ_3从19.3%稍微下降到18.9%,而τ_3Ⅰ_3升高,结果表明IFN可使细胞生物分子的构形体积增大。

Phase transition temperatures of stationary liquid and molar solution entropy as wb as solution enthalpy of three dichloro -benzene isomers and three chlorochlorotoluene isomers in four polysiloxane liquid crystal stationary phases (PLC-1, PLC-2,PLC-3, PLC-4) are deternined by capillary gas-liquid chromatograhy.The results are interpreted and analysed in terms of the interaction and configuration of the solute molecule.

利用毛细管色谱法研究了二氯取代苯,氯甲基苯的六种异构体在4种高分子液晶固定液中的溶解熵和溶解焓以及溶液的相转变温度,并从各溶质分子的构形和分子间相互作用特征的角度对所得结果进行了分析和讨论.

Pinene can be high-selectively Hydrogenated to cis-pinane under optimum conditions. The degree of selectivity is re- lated to properties of catalysts and forms of pinene molecules. Using cis-(97. 84 % ) and trans- (1. 96% ) pinene as raw materials, hydrogenated in the presence of W-6 Raney nickel and MX as cocatalyst. the total yield of pinane gained is 99. 69 %. among those the content of cis-pinane is 96. 15 %.

在一定条件下,蒎烯可高选择地氢化成顺式蒎烷,选择性的大小与催化剂的特性及蒎烯的分子构形~([1][2])有关。采用含量高的顺式蒎烯为原料,在适宜的温度、氢压及搅拌条件下,改变催化剂的某些特性能提高加氢所得蒎烷的顺式含量。以顺式 97. 84%、反式 1. 96%的蒎烯为原料,采取 W-6型雷尼镍与 MX~*助催化剂联用的条件下氢化,所得蒎烷总含量 99. 69%,其中顺式蒎烷含量 96. 15%。

 
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