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孕烯醇酮硫酸盐
相关语句
  pregnenolone sulfate
     Progesterone (1 mg·kg -1,10 mg·kg -1,sc) and pregnenolone sulfate (1 mg·kg -1,sc) significantly decreased performance of animals in the passive-avoidance task.
     孕酮 (1,10mg·kg-1,sc)和孕烯醇酮硫酸盐 (1mg·kg-1,sc)均可以在被动避暗试验中减轻东莨菪碱引起的记忆损伤。
短句来源
     Effects of Pregnenolone and Pregnenolone Sulfate on 3 H GABA Bound with GABA B Receptor in Different Areas of Mice Brain
     孕烯醇酮和孕烯醇酮硫酸盐对小鼠不同脑区~3H-GABA与GABA_B 受体结合的影响
短句来源
     Effects of Pregnanolone and Pregnenolone Sulfate on the Uptake of ~3H-γ-Aminobutyric Acid in Slices of Mice Brain
     孕烯醇酮和孕烯醇酮硫酸盐对小鼠全脑切片摄取~3H-γ-氨基丁酸的影响
短句来源
     CONCLUSION: Progesterone and pregnenolone sulfate can ameliorate the memory deficit.
     结论 :孕酮和孕烯醇酮硫酸盐可改善记忆损伤。
短句来源
     By using radioactive ligand receptor binding assay, this paper reported the effects of pregnenolong (Pe) and pregnenolone sulfate (Pes) on 3H GABA bound with GABA B receptor in different areas of mice brain.
     采用放射配体受体结合分析法 ,研究了孕烯醇酮 (Pe)和孕烯醇酮硫酸盐 (Pes)对小鼠不同脑区3H GABA与GABAB 受体结合的影响 .
短句来源
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  pregnanolone sulfate
     By using brain slice cultvating and rad iois otope tracing,the effects of different concentration (0.01~100 μmol/L) pregna nolone(Pe)and pregnanolone sulfate(Pes)on the uptake of -3H-γ-Aminobu tyri c Acid ( -3H-GABA) was studied in slices of mice whole brain.
     用离体脑片培养和同位素示踪法 ,研究了不同浓度 ( 0 .0 1~ 10 0μmol/L )的孕烯醇酮 ( Pe)和孕烯醇酮硫酸盐( Pes)对小鼠全脑切片摄取 3 H-γ-氨基丁酸 ( 3 H-GABA)的影响 .
短句来源
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  pregnenolone sulfate
An autoradiographic study comparing the interactions of 3α-OH-5α-pregnan-20-one, pregnenolone sulfate and pentobarbital with [35
      
For all of these structures, the interactions of 3α-OH-5α-pregnan-20-one (3α5αP), pregnenolone sulfate (PS), and pentobarbital with [35S]-TBPS binding, in the presence or the absence of GABA were studied.
      
The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task
      
The neurosteroid pregnenolone sulfate (PS) has been recently shown to positively modulate NMDA receptors and to have memory enhancing properties in mice.
      
The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice perfor
      
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  pregnanolone sulfate
Inhibition of NMDA-induced neuronal death by pregnanolone sulfate isomers is stereospecific.
      


By using brain slice cultvating and rad iois otope tracing,the effects of different concentration (0.01~100 μmol/L) pregna nolone(Pe)and pregnanolone sulfate(Pes)on the uptake of -3H-γ-Aminobu tyri c Acid ( -3H-GABA) was studied in slices of mice whole brain.The result s howed that 0.01~0.05 μmol/L Pe increased the uptake of -3H-GABA and 10~100 μmo l/L Pe decreased the uptake of -3H-GABA.100 μmol/L Pes markedly increas ed t he uptake of -3H-GABA.The levels of the uptake of 0.01~10 μmol/L P es are...

By using brain slice cultvating and rad iois otope tracing,the effects of different concentration (0.01~100 μmol/L) pregna nolone(Pe)and pregnanolone sulfate(Pes)on the uptake of -3H-γ-Aminobu tyri c Acid ( -3H-GABA) was studied in slices of mice whole brain.The result s howed that 0.01~0.05 μmol/L Pe increased the uptake of -3H-GABA and 10~100 μmo l/L Pe decreased the uptake of -3H-GABA.100 μmol/L Pes markedly increas ed t he uptake of -3H-GABA.The levels of the uptake of 0.01~10 μmol/L P es are nomal.When picrotoxin,bicuculline,pentabarbiturate and baclofen were se parately added to Pe(0.01 μmol/L),the level of uptake of -3H-GABA in th e brain slices was in creased.These results suggested that Pe and Pes could modulate the action of GAB A-ergic system through the GABA uptake system in the mice brain,and the effect was related to the concentration of Pe and Pes.

用离体脑片培养和同位素示踪法 ,研究了不同浓度 ( 0 .0 1~ 10 0μmol/L )的孕烯醇酮 ( Pe)和孕烯醇酮硫酸盐( Pes)对小鼠全脑切片摄取 3 H-γ-氨基丁酸 ( 3 H-GABA)的影响 .结果表明 :0 .0 1~ 0 .0 5 μmol/L Pe使 3 H-GABA的摄取量增加 ,而 10~ 10 0μmol/L Pe使摄取量降低 ( P均 <0 .0 0 1) .0 .0 1~ 10μm ol/L Pes对 3 H -GABA的摄取无显著影响 ,而 10 0 μmol/L 的 Pes使摄取量显著增加 ( P<0 .0 0 1) .用印防己毒素、荷包牡丹碱、戊巴比妥钠和巴氯芬分别与 0 .0 1μm ol/L Pe共同使用 ,均能明显增加脑片对 3 H-GABA的摄取 ( P<0 .0 5或 P<0 .0 0 1) .以上结果提示 ,Pe、Pes均能通过影响 GABA的摄取而调节 GABA能系统的活动 ,其影响效应与 Pe、Pes的浓度密切相关 .

Recent investigation shows the regulation of GABA A receptor by neurosteroids in mammalian brain. Though progesterone can be used as psychotropic drug via its interaction with GABA A receptor,the role of pregnenolone (Pe) and pregnenolone sulfate (Pes) remains unclear. To further elucidated neurosteroids on the modulation of GABA A receptor, we investigated the effect of Pe and Pes on the 3H GABA binding to the GABA A receptors in hypothalamus,cerebral cortex, hippocampus and cerbellum in mice using...

Recent investigation shows the regulation of GABA A receptor by neurosteroids in mammalian brain. Though progesterone can be used as psychotropic drug via its interaction with GABA A receptor,the role of pregnenolone (Pe) and pregnenolone sulfate (Pes) remains unclear. To further elucidated neurosteroids on the modulation of GABA A receptor, we investigated the effect of Pe and Pes on the 3H GABA binding to the GABA A receptors in hypothalamus,cerebral cortex, hippocampus and cerbellum in mice using a convulsion model induced by kainic acid. The results showed that Pe increased the binding of 3H GABA to the GABA A receptors in the tested brain areas. The increase of binding in the hypothalamus, hippocampus and cerebellum was significant (P <0 05 or P <0 001), but the inerese of binding in cerebral cortex was not significant ( P> 0 05). The modulation effect of Pe on GABA A receptors was blocked by picrotoxin, and consequently the kainic acid induced convulsion was inhibited. On the other hand, Pes markedly decreased the binding of the 3H GABA to GABA A receptors( P <0 01 or P <0 001) in all of the tested brain areas and enhanced the potency of kainic acid induced convulsive. These results suggest that Pe had marked sedative and anti convulsion effects, which were probably mediated by the GABA A receptors.

在建立稳定的红藻氨酸 (KA)诱发小鼠惊厥模型的基础上 ,用放射配体受体结合分析法 ,研究孕烯醇酮 (Pe)及其拮抗剂孕烯醇酮硫酸盐 (Pes)对小鼠下丘脑、大脑皮层、海马和小脑四个脑区γ 氨基丁酸A(GABAA)受体的调制作用。结果显示 ,Pe能增加某些脑区3H GABA与GABAA 受体的结合量 ,下丘脑、海马和小脑差异显著 (P <0 0 5或P <0 0 0 1) ,而大脑皮层差异不显著 (P >0 0 5 )。Pe对GABAA 受体的调制作用能被印防己毒素 (Pic)阻断 ,对KA的致惊效应具有抑制作用。Pes能显著降低各脑区GABAA 受体的结合量 (P<0 0 1或P <0 0 0 1) ,对惊厥有促进作用。实验结果提示 :孕烯醇酮具有明显的镇静和抗惊厥效应 ,并且可能是通过GABAA 受体介导的

By using radioactive ligand receptor binding assay, this paper reported the effects of pregnenolong (Pe) and pregnenolone sulfate (Pes) on 3H GABA bound with GABA B receptor in different areas of mice brain. The result showed that Pe decreased the binding of 3H GABA with GABA B receptor, and it could be blocked and turned over by baclofen. Pes markedly decreased the binding of 3H GABA with GABA B receptor in cerebral cortex and hippocampus and increased the binding in hypothalamus of...

By using radioactive ligand receptor binding assay, this paper reported the effects of pregnenolong (Pe) and pregnenolone sulfate (Pes) on 3H GABA bound with GABA B receptor in different areas of mice brain. The result showed that Pe decreased the binding of 3H GABA with GABA B receptor, and it could be blocked and turned over by baclofen. Pes markedly decreased the binding of 3H GABA with GABA B receptor in cerebral cortex and hippocampus and increased the binding in hypothalamus of mice brain. Baclofen could blocked the inhibition effect, enhance the effects of increase. These results suggested that major effects of Pe and Pes on 3H GABA bound with GABA B receptor in different areas of mice brain were inhibition effects.

采用放射配体受体结合分析法 ,研究了孕烯醇酮 (Pe)和孕烯醇酮硫酸盐 (Pes)对小鼠不同脑区3H GABA与GABAB 受体结合的影响 .结果显示 ,Pe对小鼠下丘脑、大脑皮层、海马、小脑GABAB 受体的结合均有抑制效应 ,且能被GABAB 受体激动剂巴氯芬 (Bac)所阻断并翻转 .Pes对大脑皮层、海马、小脑GABAB 受体的结合有抑制作用 ,而对下丘脑则有促进作用 .Bac能阻断Pes的抑制作用 (海马除外 ) ,加强Pes的促进作用 .实验结果提示 ,Pe ,Pes对各脑区GABAB 受体的结合具有一定的影响作用 ,且多为抑制效应

 
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