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分子药物
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  molecular drug
     Ribozyme and Its Design as Molecular Drug and Application
     核酶及其分子药物设计与应用
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     Conclusions: The results demonstrated that JIP inhibit the growth of nasopharyngeal carcinoma through arresting the cell cycle at G1/S checkpoint and triggering the apoptosis of cells. Data suggest that JIP is a potent molecular drug for the treatmeat of the patients with nasopharyngeal carcinoma.
     结论:JIP能够有效抑制鼻咽癌细胞生长增殖,引起鼻咽癌细胞周期G1/S期延长,并明显促进鼻咽癌细胞凋亡,提示JIP是治疗鼻咽癌潜在的分子药物
短句来源
     Finally, the drug release kinetics of alginate/ poly-L-arginine-chitosan complex microcapsules were investigated by using bovine hemoglobin (Hb) as a macromolecular drug model and 5-Flucrouracil (5-Fu) as a low molecular drug model.
     最后,以牛血红蛋白作为大分子药物模型,以5-氟尿嘧啶为小分子药物模型,考察了海藻酸钠/几丁聚糖—聚精氨酸复合微胶囊的药物释放动力学。
短句来源
     the extracts of Chinese herb: triterpenes and polysaccharides; small molecular drug: aspirin, sodium salicylate and a new compound ZXS 1; vitamin C and recombinant protein: rhTFAR19 on apoptosis in XS 200. XS 200 was pre incubated with drugs for 30 min and added with cytochrome C of threshold (0.0625 μmol·L -1 ) and mouse liver nuclei.
     方法 药物 (激素 :雌激素及其部分拮抗剂 ,中药提取物 :灵芝三萜和多糖 ,小分子药物 :阿司匹林、水杨酸钠和乙酰唑胺 ,维生素C及重组蛋白rhTFAR19)预先与XS 2 0 0共孵育 ,然后加入阈剂量 (0 .0 6 2 5 μmol·L- 1)的细胞色素C和小鼠肝细胞核 ,提取总DNA进行电泳鉴定。
短句来源
     Conclusion TPT can inhibit the growth and induce the apoptosis of human hepatocarcinoma cell in vitro. It suggests that TPT is a potent molecular drug for the treatment of patients with hepatocarcinoma.
     结论 TPT对肝癌细胞具有显著的体外生长抑制及凋亡诱导作用 ,提示TPT是治疗肝癌潜在的分子药物
短句来源
  molecular drugs
     Conclusion The results demonstrated that the N-terminal 24 amino acids of the p55(N24 p55) gamma inhibit the growth and proliferation of gastric carcinoma through arresting the cell cycle at G1/S checkpoint. It suggests that N24p55 gamma may be potential molecular drugs for the treatment of gastric carcinoma.
     结论 p55γN末端24个氨基酸能够抑制胃癌细胞的生长和增殖,引起细胞周期G1 /S期延长,提示N24p55γ可能成为治疗胃癌的潜在的分子药物
短句来源
     Studies have shown that nearly 100% of large molecular drugs and 98% of small molecular drugs can not penetrate across the blood-brain barrier (BBB).
     研究表明100%的大分子药物和98%的小分子药物不能透过血脑屏障(Blood-Brain Barrier, BBB)。
短句来源
     (2) ALG microcapsule is a hydrophilic gel, as a drug carrier, it is easily leaked out encapsulated hydrophilic small molecular drugs, and cause a low encapsulate rate and a short releasing time.
     (2)ALG微胶囊为亲水性凝胶,其作为药物载体,包裹水溶性小分子药物,常发生泄漏,造成药物包封率较低,释放时间过短。
短句来源
     Objective To explore the drug against SARS coronavirus and study the anti-SARS virus activities of 13 different synthetic small molecular drugs on the cell culture system.
     目的 为探索SARS的治疗药物 ,实验观察合成的 13种小分子药物抑制SARS冠状病毒的效果。
短句来源
     Eperimental study on screening of small molecular drugs in vitro for inhibiting SARS coronavirus.
     小分子药物抑制SARS病毒的体外实验研究
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  “分子药物”译为未确定词的双语例句
     the effect of CID voltage on APCI/MS was observed with 5 kinds of drugs as the model compounds.
     以其中 5种小分子药物为模型化合物 ,观察碰撞诱导解离电压 (CID电压 )对APCI/MS的影响。
短句来源
     The yeast three-hybrid system makes the detection of interaction of protein- protein, protein-RNA and protein-small molecule possible.
     在酵母双杂交基础上发展起来的酵母三杂交系统,其应用范围已扩大到蛋白质-蛋白质、蛋白质-RNA、蛋白质-小分子药物间的相互作用等更加广泛的研究领域。
短句来源
     Objective To screen for the inhibitor of vascular endothelial growth factor (VEGF)165 from random peptide library.
     目的 从随机噬菌体肽库中筛选血管内皮生长因子 (VEGF1 6 5)的抑制剂 ,研究治疗实体瘤生长的小分子药物
短句来源
     Objective:To find small molecular leads for inhibition on early stage of HIV infection by identification and characterization of the HIV-1 gp41 C-helix mimotopes.
     目的 :筛选可作为小分子先导化合物的HIV 1gp4 1C螺旋模拟位 ,为开发抗HIV 1早期感染的小分子药物奠定基础。
短句来源
     Objective To find small molecular that can lead to inhibition of HIV-1 infection in early stage by screening the cyclic peptide that can bind to HIV-1 gp41 NHR from phage display peptide library.
     目的筛选可与HIV-1 gp41 NHR结合的环肽,为研制抗HIV-1早期感染的小分子药物奠定基础。
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  molecular drug
This system was originally developed to predict the activities of low-molecular "drug-like" organic compounds.
      
falciparum isolates, mainly imported from different countries of sub-Saharan Africa to assess their molecular drug-resistance profiles.
      
In this review, we summarize the important roles of LXRs in metabolism and vascular biology and discuss their implications as potential molecular drug targets for the treatment of cardiovascular diseases.
      
Cerivastatin: a cellular and molecular drug for the future
      
The development of one of these molecular drug categories, e.
      
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  molecular drugs
Although cerivastatin is no longer on the market because of some problematic side effects, it could be one of the most potent cellular and molecular drugs for the future.
      


In the present study, the conjugate of mitomycin C with murine monoclonal antibody was prepared and its cytotoxicity against gastric cancer cell line was studied. Mitomycin C was modified by glutaric anhydride to introduce carboxylic group in N-1α position. The mitomycin C derivative was then treated with N-hy-droxysuccinimide and dicyclohexylcarbodiimide to form active ester of mitomycin C. The conjugate was prepared by reacting of antibody with mitomycin C active ester. The conjugate showed highly selective...

In the present study, the conjugate of mitomycin C with murine monoclonal antibody was prepared and its cytotoxicity against gastric cancer cell line was studied. Mitomycin C was modified by glutaric anhydride to introduce carboxylic group in N-1α position. The mitomycin C derivative was then treated with N-hy-droxysuccinimide and dicyclohexylcarbodiimide to form active ester of mitomycin C. The conjugate was prepared by reacting of antibody with mitomycin C active ester. The conjugate showed highly selective cytotoxicity against target cells. In a chronic 48 h test, the cytoxicity of MGII-MMC against human gastric cancer cell line KATO I was similar to that of free MMC, but greater than that of irrevalent conjugate. While the MGII-MMC showed only a little cytotoxic effects upon non-target cell SL7 (human embryonic lung cell line), compared with free MMC. The results suggest that the selective cytotoxicity of MGII-MMC is mediated by antibody.

作者报道胃癌单克隆抗体MG11-丝裂霉素C(MMC)结合物的制备及其对肿瘤细胞的杀伤作用。首先用戊二酐处理MMC,于MMC上引入羧基,MMC衍生物与N羟基琥珀酰亚胺及2,2′-二环已基碳二亚胺反应,得到MMC活性酯,后者与抗体反应将MMC引入抗体中。经测定,每克分子抗体中引入约6~7克分子药物,结合物对人胃癌细胞KATⅢ具有较强的选择性杀伤作用,在0.56μg/ml水平(药物浓度)对肿瘤细胞杀伤牢达60%,优于游离药物(51%)及无关抗体结合物(9.3%),提示选用的胃癌单抗对MMC具有较好的导向作用。

Adriamycin, an anthracycline anticancer drug, was linked covalently to monoclonal antibody (McAb), MGb 2, against human gastric cancer with the use of dextran as a multivalent carrier. ELISA and immunofluorescent staining revealed that the immune reactivity of McAb MGb2 was well retained after conjugation. In vitro, the cytotoxicity of ADM-DEX-MGb2 conjugate against human gastric cancer cell lines(SGC-7901 and BGC-823) was similar to that of free ADM, but stronger than that of conjugate of ADM with normal mouse...

Adriamycin, an anthracycline anticancer drug, was linked covalently to monoclonal antibody (McAb), MGb 2, against human gastric cancer with the use of dextran as a multivalent carrier. ELISA and immunofluorescent staining revealed that the immune reactivity of McAb MGb2 was well retained after conjugation. In vitro, the cytotoxicity of ADM-DEX-MGb2 conjugate against human gastric cancer cell lines(SGC-7901 and BGC-823) was similar to that of free ADM, but stronger than that of conjugate of ADM with normal mouse IgG. While the conjugate showed very low cytotoxicity to normal human embryonic lung cell line(SL7). Our result suggested that the immunoconjugation exhibited highly selective cytotoxicity to gastric cancer cells, so it may have potential use in human gastric carcinoma therapy.

本文报道蒽环类抗癌药阿霉素通过中间载体葡聚糖与胃癌单抗MG b_2交联组成阿霉素—葡聚糖—MGb_2结合物;每克分子抗体可携带35克分子的药物,结合物在偶联过程中抗体活性无明显丧失,稀释度达10~(-9)M抗体水平,结合物仍保留较好的与靶细胞结合活力;体外细胞毒试验证实结合物对胃癌细胞S GC—7901及BGC—823具有选择性杀伤作用,但对正常人胚肺细胞SL_7的毒性很弱。结果提示所选择单抗MGb_2具有良好的导向作用,可携带结合的阿霉素特异地杀伤胃癌靶细胞。

In the present study,pingyangmycin (PYM) was linked covalently to the murine monoclonal antibody MGb_2 for human gastric cancer via a dextran (DEX)bridge. The molar ratio of MGb_2: DEX: PYM was 1: 3: 65±5 in the conjugate. It was confirmed by indirect immunofluorescent staining that the immunological activity of MGb_2 in the conjugate was well preserved. The conjugate can well bind to tumor target cells when the concentration of MGb_2 in the conjugate was 1×10~(-10)mol/L. In vitro study indicated that the conjugate...

In the present study,pingyangmycin (PYM) was linked covalently to the murine monoclonal antibody MGb_2 for human gastric cancer via a dextran (DEX)bridge. The molar ratio of MGb_2: DEX: PYM was 1: 3: 65±5 in the conjugate. It was confirmed by indirect immunofluorescent staining that the immunological activity of MGb_2 in the conjugate was well preserved. The conjugate can well bind to tumor target cells when the concentration of MGb_2 in the conjugate was 1×10~(-10)mol/L. In vitro study indicated that the conjugate showed stronger selective cytotoxicity against tumor target cell lines (ECA-109) than free PYM and the normal mouse IgG-DEX-PYM conjugate (P<0. 01) and less cytotoxicity against nontarget cell lines (HEP-2) than free PYM(P<0. 05) in the same study. The results suggested that MGb_2-DEX-PYM conjugate is a better antibody-guided agent.

本文报道用葡聚糖为中介体制备抗胃癌单抗MGb_2与平阳霉素的结合物,经测算每克分子抗体可携带60~70克分子的药物。在结合物制备过程中抗体活性无明显丧失,结合物能与靶细胞特异结合。体外细胞毒试验证实,结合物对靶细胞(食管癌细胞ECA—109)具有较强的选择性杀伤作用,优于游离平阳霉素及无关抗体结合物;对非靶细胞则毒性明显减弱。提示该免疫结合物可能会成为一种较好的抗体导向化疗药物。

 
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