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急性肾毒性
相关语句
  acute nephrotoxicity
    The experimental study of L - arginine preventing HD - PDD - induced acute nephrotoxicity in rabbits
    L-精氨酸预防大剂量顺铂所致家兔急性肾毒性的实验研究
短句来源
    Conclusion; L-arginine can significantly prevent the HD? FDD induced acute nephrotoxicity in rabbits and 1.3g/kg group is superior.
    结论:L-精氨酸可有效预防顺铂所致的家兔急性肾毒性,且以高剂量(1.3g/kg)为优。
短句来源
    Objective To observe the preventive effect of L arginine on the HD DDP induced acute nephrotoxicity.
    目的 :观察L 精氨酸预防大剂量顺铂急性肾毒性的临床疗效。
短句来源
    Conclusion L arginine can significantly prevent the HD DDP induced acute nephrotoxicity without reducing the antitumor activity of cisplatin.
    结论 :L 精氨酸可显著预防大剂量顺铂的急性肾毒性 ,而不影响顺铂的抗癌活性
短句来源
  acute nephrotoxicity
    The experimental study of L - arginine preventing HD - PDD - induced acute nephrotoxicity in rabbits
    L-精氨酸预防大剂量顺铂所致家兔急性肾毒性的实验研究
短句来源
    Conclusion; L-arginine can significantly prevent the HD? FDD induced acute nephrotoxicity in rabbits and 1.3g/kg group is superior.
    结论:L-精氨酸可有效预防顺铂所致的家兔急性肾毒性,且以高剂量(1.3g/kg)为优。
短句来源
    Objective To observe the preventive effect of L arginine on the HD DDP induced acute nephrotoxicity.
    目的 :观察L 精氨酸预防大剂量顺铂急性肾毒性的临床疗效。
短句来源
    Conclusion L arginine can significantly prevent the HD DDP induced acute nephrotoxicity without reducing the antitumor activity of cisplatin.
    结论 :L 精氨酸可显著预防大剂量顺铂的急性肾毒性 ,而不影响顺铂的抗癌活性
短句来源
  “急性肾毒性”译为未确定词的双语例句
    The Effective Obseruation of L-arginine to Prevent Aute Nephrotonicity Induced by High Dose Cisplatin(HD Dop)
    L-精氨酸预防大剂量顺铂所致急性肾毒性的临床研究
短句来源
    Dosage of L-arginine Preventing Acute High-dose PDD Nephrotoxicity
    左旋精氨酸预防大剂量顺铂急性肾毒性的剂量探讨(英文)
短句来源
    Objective: To observe the preventive effect of L-arginine on the HD-PDD induced acute phrotoxicity in rabbits.
    目的:观察L-精氨酸预防大剂量顺铂所致的家兔急性肾毒性的疗效。
短句来源
    Objective: To explore the optimal dose of L-arginine to prevent acute high-dose (HD)-PDD nephrotoxicity.
    目的探讨左旋精氨酸预防大剂量顺铂急性肾毒性的最佳剂量。
短句来源
    Conclusion: The optimal dose of L- arginine to prevent acute HD-PDD nephrotoxicity is 10 g/(m2·d). Increased dosage can't improve the effect accordingly.
    结论左旋精氨酸有效预防大剂量顺铂急性肾毒性的最佳剂量为每天10g/m2,增加剂量并不增加疗效。
短句来源
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  acute nephrotoxicity
One serious side effect of Cyclosporine A therapy is its acute nephrotoxicity characterized by a marked decrease in the glomerular filtration rate.
      
By way of lowered ultrafiltration coefficient this effect of Cyclosporine A may be partly responsible for its acute nephrotoxicity.
      
Urinary gamma-glutamyl transferase as an indicator of acute nephrotoxicity in rats
      
It is concluded that the measurement of urinary GGT can be used as an indicator of acute nephrotoxicity.
      
The role of glutathione in the acute nephrotoxicity of sodium dichromate
      
更多          
  acute nephrotoxicity
One serious side effect of Cyclosporine A therapy is its acute nephrotoxicity characterized by a marked decrease in the glomerular filtration rate.
      
By way of lowered ultrafiltration coefficient this effect of Cyclosporine A may be partly responsible for its acute nephrotoxicity.
      
Urinary gamma-glutamyl transferase as an indicator of acute nephrotoxicity in rats
      
It is concluded that the measurement of urinary GGT can be used as an indicator of acute nephrotoxicity.
      
The role of glutathione in the acute nephrotoxicity of sodium dichromate
      
更多          


Objective: To observe the preventive effect of L-arginine on the HD-PDD induced acute phrotoxicity in rabbits. Methods: Each of 16 rabbits weight 2-3kg, female:8, male:8, All rabbits were divided into four groups randomly, each group included two males and two females, group A was the control group, group B was FDD - alone group, group C was FDD combined high -does L-arginine (1. 3g/kg), group D was FDD combined low-dose arginine(0. 5g/kg) . The dose of FDD was 6mg/kg. One of each group rabbits was killed and...

Objective: To observe the preventive effect of L-arginine on the HD-PDD induced acute phrotoxicity in rabbits. Methods: Each of 16 rabbits weight 2-3kg, female:8, male:8, All rabbits were divided into four groups randomly, each group included two males and two females, group A was the control group, group B was FDD - alone group, group C was FDD combined high -does L-arginine (1. 3g/kg), group D was FDD combined low-dose arginine(0. 5g/kg) . The dose of FDD was 6mg/kg. One of each group rabbits was killed and kidneys were cut after injecting drugs 72 hours later; then pathologic changes was observed. Results: Group A: normal; group B: proximal tubule epithelial cells necrosis and falling were observed in large amount of cells, necrosis matters and tube-shape protein were filled in the proximal tubule of necrosis; group C: there were no proximal tubule epithelial cells necrosis and falling, tube - shape protein were observed occasionally; group D: proximal tubule epithelial cells necrosis and tube-shape protein were observed. Conclusion; L-arginine can significantly prevent the HD?FDD induced acute nephrotoxicity in rabbits and 1.3g/kg group is superior.

目的:观察L-精氨酸预防大剂量顺铂所致的家兔急性肾毒性的疗效。方法:2~3kg的家兔16只,雌、雄各半,随机分为4组(亦雌、雄各半):A组为对照组;B组为单用顺铂组,C组为顺铂联合高剂量L-精氨酸组(1.3g/kg),D组为顺铂联合低剂量L-精氨酸组(0.5g/kg),顺铂用量均为6mg/kg,用药后72小时处死家兔取其肾脏观察病理变化。结果:A组正常;B组区域性肾小管上皮细胞坏死、脱落,坏死的肾小管内充满大量的坏死物及蛋白管型;C组未见肾小管上皮细胞坏死、脱落,管腔内偶见蛋白管型,D组零星区域肾小管上皮细胞坏死、脱落,管腔内见多量坏死物及蛋白管型。结论:L-精氨酸可有效预防顺铂所致的家兔急性肾毒性,且以高剂量(1.3g/kg)为优。

Objective To observe the preventive effect of L arginine on the HD DDP induced acute nephrotoxicity.Methods A randomized, study was used in patients who received HD DDP(100 mg/m 2)treatment.All patients were randomized into the test group(used HD DDP and arginine)and the control group(used HD DDP along).L arginine was used simultaneously with DDP and the dosage was 10 g/(m 2·d).β 2 MG in urine before and 24 hours after using HD DDP were measured respectively.The varity of β 2 MG were examined...

Objective To observe the preventive effect of L arginine on the HD DDP induced acute nephrotoxicity.Methods A randomized, study was used in patients who received HD DDP(100 mg/m 2)treatment.All patients were randomized into the test group(used HD DDP and arginine)and the control group(used HD DDP along).L arginine was used simultaneously with DDP and the dosage was 10 g/(m 2·d).β 2 MG in urine before and 24 hours after using HD DDP were measured respectively.The varity of β 2 MG were examined and analysed.Results 38 cases were eligible for a nalysis of clinical efficancy.The response rate(RR)was 92 1%.There was significantly statistic difference between the two groups in varity of β 2 MG in urine( P <0 005).the overall response rate was 50% after chemotherapy in 30 patients of non small cell lung cancer.Conclusion L arginine can significantly prevent the HD DDP induced acute nephrotoxicity without reducing the antitumor activity of cisplatin.

目的 :观察L 精氨酸预防大剂量顺铂急性肾毒性的临床疗效。方法 :对适合用大剂量顺铂( 10 0mg/m2 )化疗的患者随机分为研究组 (顺铂加精氨酸周期 )和对照组 (单用顺铂周期 ) ,两组形成自身对照 (即 1例患者的 2个周期进行自身对照 )。L 精氨酸的用法为 10g/ (m2 ·d) ,在用顺铂的当天给予 ,比较研究组与对照组化疗后 2 4h尿 β2 微球蛋白 ( β2 MG)的变化。结果 :38例对可评价疗效的患者中 ,显效 2 3例对 ( 60 5% ) ,有效 12例对 ,总有效率 92 1% ( 35/ 38)。加L 精氨酸周期化疗后的尿β2 MG值( x±s)明显低于不加精氨酸周期的尿 β2 MG值 ( x±s) ,两者相比 ,,差异具有非常显著性P <0 0 0 5。30例非小细胞肺癌患者化疗后CR 3例 ,PR 12例 ,总有效率 50 % ,疗效较好。结论 :L 精氨酸可显著预防大剂量顺铂的急性肾毒性 ,而不影响顺铂的抗癌活性

Objective: To explore the optimal dose of L-arginine to prevent acute high-dose (HD)-PDD nephrotoxicity. Methods: 128 cases using PDD with the dosage of 100 mg/m2 within two days (D1, 2) in combination with L-arginine were randomly divided into 3 groups of A, B and C. The dosages of L- arginine in the 3 groups were 5 g/(m2·d), 10 g/(m2·d) and 15 g/(m2·d), respectively. Each patient received 2 cycles chemotherapy to form self control: 1 cycle combined with L-arginine, while 1 cycle chemotherapy alone. β2-MG in...

Objective: To explore the optimal dose of L-arginine to prevent acute high-dose (HD)-PDD nephrotoxicity. Methods: 128 cases using PDD with the dosage of 100 mg/m2 within two days (D1, 2) in combination with L-arginine were randomly divided into 3 groups of A, B and C. The dosages of L- arginine in the 3 groups were 5 g/(m2·d), 10 g/(m2·d) and 15 g/(m2·d), respectively. Each patient received 2 cycles chemotherapy to form self control: 1 cycle combined with L-arginine, while 1 cycle chemotherapy alone. β2-MG in urine, BUN, Cr and uric acid in blood were detected just 24 h before and after using PDD. The changes of each index in the three groups were observed in the presence or absence, and the therapeutic effects were compared among the three groups. Results: There was no significant difference in BUN, Cr and uric acid in blood before and after chemotherapy in the presence or absence, showing these indexes could not be used as markers of early acute nephrotoxicity. Urine β2-MG values in the presence and absence were 0.9120±0.6618 vs 1.5167±0.7908 (P<0.05), 0.5404±0.5810 vs 1.4616±0.8120 (F<0.01), 0.4998±0.6210 vs 1.5210±0.7710 (P<0.01) in the groups A, B and C respectively. The excellent effective rate and total effective rate in groups A, B and C were 40.9% and 59.1%, 68.2% and 90.9%, and 77.5% and 97.5%, respectively. There was significant difference in the excellent effective rate and total effective rate between groups A and B, but not between groups B and C. Conclusion: The optimal dose of L- arginine to prevent acute HD-PDD nephrotoxicity is 10 g/(m2·d). Increased dosage can't improve the effect accordingly.

目的探讨左旋精氨酸预防大剂量顺铂急性肾毒性的最佳剂量。方法选择128例肿瘤病人,随机分为A、B、C3组,3组病人顺铂的剂量及用法相同,均为100mg/m2,分两天(第1、2天)给药。3组病人左旋精氨酸的用量分别为每天5g/m2、10g/m2和15g/m2,于化疗的当天在顺铂后应用,每例病人加与不加精氨酸周期的两周期化疗形成自身对照,每例病人化疗前及化疗后24h均检测尿β2-MG、血尿素氮(BUN)、血肌酐(Cr)及血尿酸,观察3组病人加与不加精氨酸周期化疗前后各观察指标的变化,并比较3组的疗效。结果血BUN、Cr及尿酸无论在加精氨酸周期还是在不加精氨酸周期,化疗前后检测值均无明显变化,该3项指标不宜作为早期急性肾功能损害的检测指标。而A、B、C3组病人化疗后的尿β2-MG值在加与不加精氨酸周期分别为0.9120±0.6618与1.5167±0.7908(P<0.05)、0.5404±0.5810与1.4616±0.8120(P<0.01)及0.4998±0.6210与1.5210±0.7710(P<0.01),均有明显差别,B组的结果差别极其显著,C组的结果差别也极其显著。A、B、C3组的显效率及...

目的探讨左旋精氨酸预防大剂量顺铂急性肾毒性的最佳剂量。方法选择128例肿瘤病人,随机分为A、B、C3组,3组病人顺铂的剂量及用法相同,均为100mg/m2,分两天(第1、2天)给药。3组病人左旋精氨酸的用量分别为每天5g/m2、10g/m2和15g/m2,于化疗的当天在顺铂后应用,每例病人加与不加精氨酸周期的两周期化疗形成自身对照,每例病人化疗前及化疗后24h均检测尿β2-MG、血尿素氮(BUN)、血肌酐(Cr)及血尿酸,观察3组病人加与不加精氨酸周期化疗前后各观察指标的变化,并比较3组的疗效。结果血BUN、Cr及尿酸无论在加精氨酸周期还是在不加精氨酸周期,化疗前后检测值均无明显变化,该3项指标不宜作为早期急性肾功能损害的检测指标。而A、B、C3组病人化疗后的尿β2-MG值在加与不加精氨酸周期分别为0.9120±0.6618与1.5167±0.7908(P<0.05)、0.5404±0.5810与1.4616±0.8120(P<0.01)及0.4998±0.6210与1.5210±0.7710(P<0.01),均有明显差别,B组的结果差别极其显著,C组的结果差别也极其显著。A、B、C3组的显效率及总有效率分别为40.9%及59.1%、68.2%及90.9%、77.5%及97.5%,经X2检验,A、B两组的显效率及总有效率均差别显著,B、C两组的显效率及总有效率均无显著性差别。结论左旋精氨酸有效预防大剂量顺铂急性肾毒性的最佳剂量为每天10g/m2,增加剂量并不增加疗效。

 
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