Objective:It is to investigate the effect of rhIL-13(recombinant human interleukine-13) on the differentiation of Dami cells,a megakaryocytic leukemia cell line, and the expression of IL-13Rα1(interleukine-13 receptor alpha 1)on Dami cells, and to elucidate the mechanism of IL-13-induced differentiation of Dami cells.
目的:研究重组人白细胞介素13(recombinant human interleukine-13,rhIL-13)对巨核细胞白血病细胞株Dami细胞分化的影响,以及Dami细胞白细胞介素13受体α1(Interleukine-13receptor alpha1,IL-13Rα1)的表达,探讨IL-13诱导Dami细胞分化的机制。
After the treatment of leukemia cell line K562 and its multidrug-resistant cell line K562/A02 by thapsigargin, intracellular calcium concentrations ([Ca~ 2+]i) in K562 and K562/A02 were measured by fluorescence spectrophotometer with calcium sensitive fluorescence indicator Fura-2/AM;
The data Showed that when LAK: BMMNC: leukemic cell was 20 : 10 : 1, the colony formation of U937, HL60 and K562 were 1.21% ±2.10% , 1.56% ±1.65% and 0.26 ±0.19% of control resectively after 12 hours preincubation.
To investigate the expression of JWA after hemin and (or) thermal stress exposure, we treated K562 (chronic myelogenous leukemia cells) cells with different doses of hemin and thermal stress using different exposure times.
The seven-day leukemia cells feature lower proliferative potential and higher sensitivity to oxidative stress and platidiam.
Apoptosis in P388 Leukemia Cells Induced by Specific Inhibitors of 5- and 12-Lipoxygenase and the Product of Cyclooxygenase, Pro
We studied the effect of specific inhibitors of 5- and 12-lipoxygenases as well as the product of cyclooxygenase activity, prostaglandin E2?, on proliferation and death of P388 leukemia cells.
The cytotoxins were considerably different in cytotoxicity and cooperativity of the effect on human promyelocytic leukemia cells HL60, mouse myelomonocytic cells WEHI-3, and human erythroleukemic cells K562.
HLDF has been isolated from the culture medium of human promyelocytic leukemia cell line HL-60.
It was shown that the full-size neurotrophic factor from pigment epithelium (PEDF) induces the cell differentiation of the human promyelocyte leukemia cell line HL-60.
Liposomal formulation of a methotrexate diglyceride conjugate: Activity toward a culture of methotrexate-resistant leukemia cell
The results of the biologic tests of the complexes of arsenic show that the biologic effect of these complexes of arsenic to leukemia cell (HL-60) is higher than arsenic only by MTT colorimetric assay.
In autodigestion assays, endonucleaw activity in non-apoptotic HL-60 promydocytic leukemia cell nuclei cleaved the chromatin of he autologous cells to an oligonucleosomal length pattern.
Effects of mycelial fungus (Pleurotes ostreatus) extracts used separately and in combination with the cytostatic drugs doxorubicine and cyclophosphamide on cultured transformed human cells (HeLa and myeloid leukemic cells) were investigated.
Effects of inhibition of ubiquitin-proteasome pathway on human primary leukemic cells
Though there were a lot of reports about the totally different responses to the inhibition of ubiquitin-proteasome pathway in different kinds of cell lines, much less has been known about the responses in primary human leukemic cells.
Various tolerances to arsenic trioxide between human cortical neurons and leukemic cells
Homoharringtonine (HHT) has currently been used successfully in the treatment of acute and chronic myeloid leukemias and has been shown to induce apoptosis of different types of leukemic cells in vitro.