FM high dosage group(4 mg/kg) also displayed significantly stronger antipyretic effects on fever in rabbits induced by peptone than those of 0.2 g/kg analgin-treated group(P<0.05) and 0.2 g/kg aminopyrine-treated group(P<0.01),respectively.
Result:The antipyretic action of the 18 kinds of amino acids at the dosages of 1.5% and 4% were generally equal between 1.5 and 4.5 hours (P<0.01), but the 4% group effected more quickly and the duration was longer;
Result:The antipyretic action of the 18 kinds of amino acids at the dosages of 1.5% and 4% were generally equal between 1.5 and 4.5 hours (P<0.01), but the 4% group effected more quickly and the duration was longer;
Within 30 minutes after intramuscular injection,antipyretic action of compound preparation was worse than that of simplex preparation and antondin injection (P<0.01),but no difference among three products after one hour(P>0.05).
Comparative studies were described on central nervous system effects of New Artif ical Calculus Bovis. The results were observed. New Artifical Calcalus Bovis have inhibitory action on central nervous system of mice and have antipyretic action to fevered rat. It is as pharmacological actions as Natrual Calculus Bovis.
Some researcheres reports that the pathway of lipoxygenases does not affect normal body temperature and the pathway of cytochrome P450 - dependent monooxygenases is involved in antipyresis and in controlling the upper limit of fever.
The largest percentage of total number (21.95%) is from 21 to 30. The main causative drugs include penicillins (32.28%)、antifebrile and antalgic (13.39%) 、cephalosporins (10.24%) 、Chinese traditional medicines (9.45%) and antiepileptics (9.45%) .
Methods: To made the rabbit model of virosis fever using Sendai virus,and treat them with niuhuang chengqi tang by filling stomach. Then observe its antifebrile effects and influences to substance P(SP),neurotensin (NT) in brain,intestine and peripheral blood,to CD4+ and CD8+ T cell in thymus,to interferon-γ(IFN-γ) in peripheral blood.
Objective To explore the antifebrile effects and changes of toxicity after compatibility of both compound isatis leaf injection and compound amidopyrine injection.
Antipyretic drugs such as acetylsalicylic acid, dexamethasone, and lipocortin 5-(204-212) peptide counteract IL-1β-induced fever and abolish changes in Ca2+ and PGE2 concentrations in CSF.
The study was designed to verify the adequate, prolonged antipyretic action of DCF infusion, to quantify its haemodynamic and cerebral impact and to assess any negative effect on renal and liver function.
The site of antipyretic action of AD-1590 in the sequential process involved in the development of fever caused by bacterial pyrogen (LPS) was investigated in rabbits.
There was a delayed onset of antipyresis (yeast-induced hyperthermia in rats), analgesia (acetylcholine-induced abdominal constriction in mice) and inhibition of caster oil-induced diarrhea in rats.
Antipyresis occurred 3 hours after administration of AHR-10037, 4 mg/kg, PO, vs 1 hour after administration of acetylsalicylic acid, 100 mg/kg, PO; maximum analgesic activity (ED50-4.1 mg/kg) occurred at 4 hours.
This suggests that dipyrone, probably through its active metabolites, inhibits prostaglandin synthesis to induce antipyresis and, by analogy, analgesia as well.