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碘解磷定
相关语句
  pralidoxime iodide
     Except that 2 patients were given pralidoxime iodide 0.5~1.5 g,others were treated with 0.5~30.0 g of pralidoxime chloride.
     肟类药物除 2例用碘解磷定外 ,其余均给予氯解磷定治疗 ,用量 0 .5~ 3 0 .0g。
短句来源
     The initial and total atrpine dose was1~10mg or10~176mg,respectively,according to the severity of intoxication. 7patients were given2~4g of pralidoxime iodide,5other patients treated with3~10g of pralidoxime chloride.
     根据病情轻重 ,At首剂用量1~10mg,总量10~176mg ,7例用肟类药物碘解磷定2~4g,5例用氯解磷定3~10g。
短句来源
     Determination of pralidoxime iodide in human plasma and urine by reversed-phase high performance liquid chromatography
     人血、尿中碘解磷定的高效液相色谱分析
短句来源
     The detection limit was 0.02 mg·L -1 .CONCLUSION This method is rapid,simple and accurate and is suitable for the determination of serum concentration of pralidoxime iodide.
     检测限为 0 .0 2mg·L-1。 结论 :方法快速、准确、灵敏度高 ,可用于碘解磷定的血药浓度监测及药动学研究。
短句来源
     OBJECTIVE To determine the concentration of pralidoxime iodide in human serum.
     目的 :测定人血清中碘解磷定的浓度。
短句来源
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  “碘解磷定”译为未确定词的双语例句
     Results The linear range were 0.5~8.0 μg/ml with r=0.9988 in plasma and r=0.9968 in urine.
     结果血、尿中碘解磷定浓度的线性范围是0.5~8.0μg/m l;
短句来源
     Determination of Pralidoximi Iodidum by ICP-AES
     碘解磷定的ICP-AES测定
短句来源
     RESULTS There was a good linear relationship within the range of 0.1 ~50 mg·L -1 .The average absolute recovery was 94.40% ,RSD= 4.5% and the method recovery was 100.40% ,RSD= 3.2% .
     结果 :碘解磷定的平均绝对回收率为 94 .4 0 % ,RSD为 4 .5 % ; 平均方法回收率为 10 0 .4 % ,RSD为 3.2 % ;
短句来源
     A new method for the determination of succinylcholine chloride, neostigmine bromide and pyraloxime iodide formulations by oscillopolarographic titration with sodium tetraphenylborate(Na _ TPB) has been established.
     以四苯硼钠 (Na_TPB)为沉淀剂、四乙基氯化铵为滴定剂 ,采用示波极谱滴定法测定氯化琥珀胆碱、溴化新斯的明、碘解磷定3种氢卤酸季铵盐类药物制剂的含量。
短句来源
     RESULTS High concentrations of PAM (>1 0 mmol·L -1 ) could inhibit normal mouse ChE activity in vitro, in a concentration dependent manner.
     结果 离体实验 1 0mmol·L-1以上浓度的碘解磷定对小鼠胆碱酯酶有抑制作用 ,且呈量效关系 ;
短句来源
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  相似匹配句对
     STABILITY OF PYRALOXIME IODIDE INJECTION
     注射液的稳
短句来源
     INDIRECT ICP-AES DETERMINATION OF PRALIDOXIMI IODIDUM CONTENT IN INJECTION
     间接原子发射光谱法测
短句来源
     Indirect determination of pralidoximi iodidum by atomic absorption spectroscopy
     原子吸收光谱法间接测
短句来源
     Determination of Pralidoximi Iodidum by ICP-AES
     的ICP-AES测
短句来源
     Determination of Pyraloxide Iodine by the Oscillopolarographic Titration
     示波极谱滴法测
短句来源
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  pralidoxime iodide
Pralidoxime Iodide (2-PAM) Penetrates Across the Blood-Brain Barrier
      
The in vivo rat brain microdialysis technique with HPLC/UV was used to determine the blood-brain barrier (BBB) penetration of pralidoxime iodide (2-PAM), which is a component of the current nerve agent antidote therapy.
      


A quaternary ammonium ion-selective electrode prepared by using, di-(2-ethyl hexyl) phthalate as an active substance and a plasticizer has been studied. This electrode exhibited a Nernstian response to quaternary ammonium salt drugs, such as berberine, benzalkonium bromide and pyraloxine iodide

用邻苯二甲酸二(2-乙基)己酯作为活性物质和增塑剂制作PVC膜电极。该电极对季铵盐类药物黄连素、新洁尔灭和碘解磷定具有能斯特响应,用于成品药的分析取得满意的结果。

The relationship between toxicokinetics and toxicodynamics on cholinesterase(ChE) inhibition of dichlorvos (DDVP),and the influence of pralidoxime iodide (PAM) on this relationship were investigated. Blood concentration of DDVP was determined with 4-(4-nitrobenzyl)-pyridine colorimetric method and blood ChE activity aws analyzed by Ellman's method. The principal toxicokinetic parameters are as follows:when iv 3.23mg·kg -1 ,first-order elimination kinetics,three compartment model,t 1/2 β=172min,V c=0.61L·kg...

The relationship between toxicokinetics and toxicodynamics on cholinesterase(ChE) inhibition of dichlorvos (DDVP),and the influence of pralidoxime iodide (PAM) on this relationship were investigated. Blood concentration of DDVP was determined with 4-(4-nitrobenzyl)-pyridine colorimetric method and blood ChE activity aws analyzed by Ellman's method. The principal toxicokinetic parameters are as follows:when iv 3.23mg·kg -1 ,first-order elimination kinetics,three compartment model,t 1/2 β=172min,V c=0.61L·kg -1 ;when ig 12.9mg·kg -1 ,also first order kinetics ,two compartment model,t 1/2 β=126min,k a=0.49min -1 ,F=0.390. The curves are same shaped in toxicokinetics and toxicodynamics,but the slop of the former curve is larger than the latter one,e.g. when ig administration,the regression analysis of the points at the distribution and elimination phaes of toxicokinetics with the corresponding points of toxicodynamics shows b=0.434,r=.0.996.PAM(50mg·kg -1 iv at 11th min)does not affect the toxicokinetis of DDVP(12.9mg·kg -1 ,ig),but it changes the ChE inhibition toxicodynamics of DDVP with about 2-3 folds increase of the slop of the curve(b increased from 0.434 to 1.427). The concentration-effect relationship of DDVP inhibiton on ChE activity in vitro is basically identical with in vivo. Therefore it is concluded that the time-concentration relation ship in vivo can be estimated by using the time-effect relationship in vivo and the concentration-effect relationship in vitro of DDVP.

用比色法测定全血中敌敌畏浓度求得其iv及ig的房室模型及系列毒代动力学参数.iv时呈三房室分布,t1/2β=172min,Vc=0.61Lkg-1;ig时呈二房室分布,t1/2β=126min,ka=0.49min-1,F=0.390.用Elman氏法测定全血胆碱酯酶活性求得敌敌畏的毒效动力学参数.证明两种动力学的曲线型基本一致且同步变化,但毒效动力学曲线的斜率较小.敌敌畏ig中毒时iv碘解磷定,对敌敌畏毒代动力学没有影响,但对毒效动力学有明显影响,使斜率增加约3倍.离体实验敌敌畏抑制全血胆碱脂酶活性的浓度-效应关系与在体者基本一致,故离体的浓度-效应关系配合以在体的时间-效应关系,可推测出在体的时间-浓度关系.

Trace I- can make a slot on oscillogram of mercury-membrane and wolfram electrodes. Using AgNO3 standard solution to titrate,a little surfeit of Ag+ can make a mutation onoscillogram,that is the slot disappearing. It can be used to indicate end point sensitively.

本文报道了以硝酸银作滴定剂,醋酸钠与醋酸为示波极谱底液,采用交流示波极谱滴定法测定了碘解磷定,该法快速、简便,终点直观,获得满意结果.

 
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