(3) comparative study on Ox-LDL andmalondiddehyde-modified LDL (MDA-LDL) and the characteristics of scavenger receptor boundOx-LDL and MDA-LDL in macrophages;
Vasodilator responsesto acetylcholine were impaired in the presence of ox-LDL(protein content 0.4 g· L-1) or lysophosphatidylcholine(LPC, 4 mg· L-1), a major component of ox-LDL.
Conclusions Rabbit peritoneal exudate macrophages can express MCP 1mRNA and protein,and OX LDL and OX VLDL induce strong erMCP 1mRNA and protein expression in the cells.
Methods After exposure of the macrophages to 25μg/ml of LDL,VLDL,OX LDL and OX VLDL respectively,and a 24 hour incubation at 37℃,the total RNA was extracted from the cells by guanidinium isothiocyanate method,and the media conditioned by the cultured macrophages were collected.
(2) The amount of MDA and OX LDL in the serum and renal tissue in the treated group is much lowed than that of the control group, and the activity of SOD is much higher than that of the control group (P<0 05) .
The positive correlation was found between oxLDL and TXB 2,GMP 140( P <0 01). After one month of the combination of vitamin C,vitamin E oral administration,the serum levels of oxLDL,TXB 2 and the level of GMP 140 were significantly decreased.
Antioxidant VitE can significantly decrease the injury of OXLDL in cultured endothelial cells. NO is increased 21%￣60%, compared with that in OXLDL group(P<001).
The morning venous blood was collected to determine the malondiadehyde (MDA) and superoxide dismutase (SOD) before adminstration and 1, 3 months after.
Skin iron levels, glutathione redox ratios (GSSG/GSH), diene conjugate (DC) amounts, blood glutathione status, oxidized low-density lipoprotein (oxLDL), and total antioxidativity was measured at the baseline and after three months.
In the same group, blood levels of oxLDL decreased (p >amp;lt; 0.05), and GSH levels increased (P >amp;lt; 0.001) with concomitant improvement in the GSSG/GSH ratio.
Convincing experimental evidence for such an impaired relaxation of smooth muscle has been presented recently following exposure to elevated oxLDL levels.
They reduce oxidation of low density lipoproteins (oxLDL), thereby protecting human vascular arterial endothelial and smooth muscle cells from oxLDL induced damages.
We measured the oxidized LDL(oxLDL) of plasma and lipoprotein (a) [Lp(a)] levels of serum on 51 patients with cerebrovascular dissorders and 20 cases of control group. A-mong 51 patients with cerebrovascular disorders,three groups of patients were included: patients with cerebral hemorrhage (CH), cerebral infarction (CD,and subarachnoid hemorrhage (SAH). The results revealed a significant difference on oxLDL levels in plasma between all patients groups and control group,either way on Lp(a). More...
oxidized LDL(oxLDL)and Liporotein(a) LP(a) in plasma in 125 patients with cerebral in- faretion cerebral hemorrhage and coronary atherosclerotic heart disease as well as 28 normal subjects were evaluated.The results showed that the amount Of oxLDL and LP(a) in three groups was significantly increased in comparision with control group(P<0.01 ),the positive rates of oxLDL and LP a) in three groups was significantly increased incomparision with control group(P<0.01),the positlve rates of #...
Macrophages induced from THP-1 cells by PMA were used as the cell model. Mab C7B,the monoclonal antibody directed against LDL receptor binding domain on apolipoprotein B molecules was incubated with oxidized LDL at 4℃ overnight to inhibit the intake by THP-1 macrophages from LDL receptor pathway.It was found that 50μg/ml Mab C7B could reduce significantly the binding and degradation of (125)￣I-oxLDL by cells. When THP-1 macrophages were loaded with oxLDL+C7B for 72 h,the amount of cholesteryl es...
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