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i型受体     
相关语句
  type i receptor
     DISTRIBUTION OF NEURONS EXPRESSING INTERLEUKIN-1 TYPE I RECEPTOR mRNA IN RAT BRAIN
     大鼠脑内白细胞介素1I型受体mRNA的分布
短句来源
     INFLUENCE OF CEREBRAL ISCHEMIA AND INTRAPERITONEALINJECTION OF MK801 ON THE EXPRESSION OF IL-1 TYPE I RECEPTOR mRNA IN GERBIL HIPPOCAMPUS
     脑缺血及腹腔注射MK801后对海马IL-1I型受体mRNA表达的影响
短句来源
     ② The detection with reverse transcription polymerase chain reaction and immunofluorescence method showed that after serum deprivation culture in the differentiated smooth muscle cells,the expression of transforming growth factor beta type I receptor was increased,the expressions of smad2 and smad3 had unobvious changes,the expression of smad4 was increased,and that of smad7 was decreased;
     ②反转录聚合酶链反应和细胞免疫荧光方法检测发现,去血清培养后的分化表型平滑肌细胞中,转化生长因子βI型受体表达增加,smad2和smad3表达无明显变化,smad4表达增加,smad7表达下降。
短句来源
     During differentiation,vascular smooth muscle cells may regulate the differentiating function through transforming growth factor beta type I receptor/smad4;
     血管平滑肌细胞分化时,可能通过转化生长因子βI型受体/smad4调控细胞分化功能;
短句来源
     After culture in high serum, the smooth muscle cells were induced to transform to proliferation phenotype,the expression of transforming growth factor beta type I receptor was decreased,the expression of smad4 was decreased,that of inhibitory smad7 was increased,and there were no obvious changes in the expressions of smad2 and smad3.CONCLUSION:The expression of transforming growth factor beta/smads is closely correlated with the phenotype state of vascular smooth muscle cells.
     而高血清培养诱导平滑肌细胞转化为增殖表型后,转化生长因子βI型受体表达下降,smad4表达下降,抑制型smad7表达增加,smad2和smad3表达无明显变化。 结论:转化生长因子β/smads表达与血管平滑肌细胞表型状态密切相关。
短句来源
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  i receptor
     Expression of TGF-β1 and TGF-βI receptor in cultured normal human melanocytes
     体外培养正常人黑素细胞TGF-β1及其I型受体的表达
短句来源
     DISTRIBUTION OF NEURONS EXPRESSING INTERLEUKIN-1 TYPE I RECEPTOR mRNA IN RAT BRAIN
     大鼠脑内白细胞介素1I型受体mRNA的分布
短句来源
     INFLUENCE OF CEREBRAL ISCHEMIA AND INTRAPERITONEALINJECTION OF MK801 ON THE EXPRESSION OF IL-1 TYPE I RECEPTOR mRNA IN GERBIL HIPPOCAMPUS
     脑缺血及腹腔注射MK801后对海马IL-1I型受体mRNA表达的影响
短句来源
     ② The detection with reverse transcription polymerase chain reaction and immunofluorescence method showed that after serum deprivation culture in the differentiated smooth muscle cells,the expression of transforming growth factor beta type I receptor was increased,the expressions of smad2 and smad3 had unobvious changes,the expression of smad4 was increased,and that of smad7 was decreased;
     ②反转录聚合酶链反应和细胞免疫荧光方法检测发现,去血清培养后的分化表型平滑肌细胞中,转化生长因子βI型受体表达增加,smad2和smad3表达无明显变化,smad4表达增加,smad7表达下降。
短句来源
     Pathogenesis of mammary cancer: correlation of the expression of insulin like growth factor I receptor with Her 2/c erbB 2 and p53
     乳腺癌发病机制的研究:胰岛素样生长因子I型受体表达与Her-2/c-erbB-2及p53的相关性
短句来源
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  type i receptors
     Expression of TGFβ1 and its type I receptors ALK1 and ALK5 mRNA in brain arteriovenous malformation
     TGFβ1及I型受体ALK1/ALK5mRNA在脑动静脉畸形中的表达及意义
短句来源
     Objective To explore the expression of transforming growth factor beta1(TGFβ1)and its type I receptors activin-like kinase 1(ALK1)and ALK5 mRNA in the development of brain arteriovenous malformation(BAVM).
     目的探讨转化生长因子β1(TGFβ1)及其I型受体ALK1、ALK5在脑动静脉畸形中的表达,并探讨其在脑动静脉畸形发生、发展中的作用。
短句来源
  type ⅰ receptor
     Collagen network remodeling in rats with dilated cardiomyopathy and the changes of angiotensin Ⅱ and it's type Ⅰreceptor
     扩张型心肌病大鼠胶原重塑与血管紧张素II及其I型受体变化
短句来源
     Effect of Liver-aid Tablets on Expression of Transforming Growth Factor Beta-1 ’s TypeⅠReceptor in Rats with Hepatic Fibrosis
     护肝片对纤维化肝组织TGFβ_1I型受体表达的抑制作用
短句来源
     Aim:To investigate the angiotensin ⅡtypeⅠ receptor gene A1166C polymorphism in essential hypertensive Chinese Han population.
     研究中国汉族人血管紧张素 I I的 I型受体( A T1 R) A1166 C 基因多态性与原发性高血压的关系。
短句来源
     Objective: To study the effect of Liver aid Tablets on protein and mRNA expression of transforming growth factor beta 1’ s typeⅠreceptor(Tβ 1RⅠ)in rat hepatic fibrosis.
     目的:观察护肝片对中、晚期纤维化肝组织转化生长因子β1I型受体(Tβ1RⅠ)蛋白及其mRNA表达的影响。
短句来源
     Conclusion: Exogenous PACAP may act as a protective effect in brain edema induced by ischemia in rats,which is mediated by type Ⅰ receptor.
     结论 :外源性PACAP对缺血性脑水肿具有保护作用 ,该作用是由I型受体介导的。
短句来源

 

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      type i receptor
    Moreover, angiotensin II type I receptor blockade (ARB) produces clinical and hemodynamic benefits in patients with CHF who are already receiving ACE inhibitors.
          
    We focus on our own research, which targets the use of antisense of the angiotensin type I receptor in various models of hypertension.
          
    If persons are unable to tolerate ACE inhibitors because of cough, angioneurotic edema, rash, or altered taste sensation, angiotensin II type I receptor antagonists (ARBs) should be given.
          
    Mutation of phenylalanine-34 of parathyroid hormone disrupts NHERF1 regulation of PTH type I receptor signaling
          
    Internalization of the PTH type I receptor (PTH1R) is regulated in a cell- and ligand-specific manner.
          
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      i receptor
    Expression and regulation of mRNAs for insulin-like growth factor-I receptor and LH receptor in corpora lutea
          
    Relationship between insulin-like growth factor-I receptor (IGF-IR) and luteinizing hormone receptor (LHR) mRNA expression as well as their regulation was determined in rat corpora lutea (CL).
          
    In the quadriceps muscle, the expression of IGF-I, IGF-I receptor, IL-1β and TNFα were assessed by RT-PCR and quantitative immunohistochemistry.
          
    Moreover, angiotensin II type I receptor blockade (ARB) produces clinical and hemodynamic benefits in patients with CHF who are already receiving ACE inhibitors.
          
    We focus on our own research, which targets the use of antisense of the angiotensin type I receptor in various models of hypertension.
          
    更多          
      type i receptors
    Oxidative stress in blood vessels and the kidney in hypertension can be induced by diverse vasoconstrictor mechanisms, including blockade of nitric oxide synthase and activation of angiotensin II type I receptors and thromboxane receptors.
          
    Additionally, the relatively high affinity for CL 218,872 suggests that even NM contains Type I receptors.
          
    Vasoactive intestinal polypeptide (VIP) (1-100 nM) was without appreciable effect on either enkephalin secretion or biosynthesis, implicating PACAP type I receptors in PACAP-stimulated enkephalin secretion and synthesis.
          
    Since CL 218,872 has a selective affinity for Type I benzodiazepine receptors, these results suggest that stimulation of Type I receptors is not sufficient to decrease 5-HT or CA turnover rates in midbrain-hindbrain.
          
    The type I receptors (chordotonal, campaniform and hair sensilla) were inactivated within 5-15 min following phentolamine application.
          
    更多          


    By using dot blot and in situ

    利用分子杂交原理,我们采用斑点杂交和原位杂交实验,证明了在正常大鼠肾脏有白细胞介素-1I型受体特异mRNA表达,分布于肾脏皮质和髓质。用兔抗大鼠肾皮质血清诱导产生的大鼠肾炎模型肾组织,其白细胞介素-1I型受体特异mRNA表达量明显高于正常肾组织,尤其髓质部分较为显著。肾脏固有细胞如上皮细胞及肾小球中某些细胞(可能为系膜细胞)在正常情况下有少量介素-1I型受体mRNA表达,随着炎症的产生表达量明显增高。我们的实验结果为白细胞介素-1在肾脏中的功能通过结合白细胞介素-1特异受体的作用机制,白细胞介素-1在肾脏中的自泌与旁泌作用方式,在分子水平上提供了实验依据。

    Red blood cell CR1 (RBC-CR1) activity was determined with the yeast rosette rate after red blood cells of chinckens were incubated in vitro with 20% ' 10% and 5% epimedium-propolis mixture. The rosette rates of RBC-MR1 were 38. 9%, 22. 0% and 9. 0% respectively. RBC-CR1 rosette rates of chinckens in control group were 9. 3%. It was indicated that RBC-R1 activity was significately increased and related to the dose of epimediumpropolis mixture.

    用不同浓度的淫羊藿-蜂胶合剂与鸡红细胞在体外进行孵育,然后测其红细胞补体I型受体(CR1)的活性,以判定淫羊霍-蜂胶合剂对红细胞免疫功能的增强作用。结果显示:经20%、10%和5%的淫羊藿-蜂胶合剂处理后的鸡红细胞CR1花环率(CR1-R)分别为:38.9%、22.0%和9.0%,面对照组鸡红细胞CR1-R是9.3%。此结果表明:淫羊藿-蜂胶合剂具有明显的增高红细胞CR1活性作用,并与剂量有关。

    We demonstrated the changes of the expression of IL- 1Rt I mRNA in gerbil hippocmpus after cerebral ischemia and intraperitoneal injection of MK801 by in situ hybridization histochemistry. The results showed that the expression of IL-Rt I mRNA in the pyramidal cells of gerbil hippocampus greatly increased after cerebral ischemia and the effect could be decreased to the normal level by intraperitoneal injection MK801. The result suggests that IL-1 and IL- IR might take part in the mechanism of ischemia damage...

    We demonstrated the changes of the expression of IL- 1Rt I mRNA in gerbil hippocmpus after cerebral ischemia and intraperitoneal injection of MK801 by in situ hybridization histochemistry. The results showed that the expression of IL-Rt I mRNA in the pyramidal cells of gerbil hippocampus greatly increased after cerebral ischemia and the effect could be decreased to the normal level by intraperitoneal injection MK801. The result suggests that IL-1 and IL- IR might take part in the mechanism of ischemia damage in brain.

    本实验采用原位杂交技术,检测沙土鼠脑缺血及使用MK801后海马内IL-1I型受体mRNA表达变化。结果表明:脑缺血后海马锥体细胞层IL-1I型受体mRNA表达明显增强,而脑缺血同时腹腔注射MK801后,海马锥体细胞层IL-1I型受体mRNA表达显著降低。结果提示:IL-1及其受体可能参与缺血性脑损伤的致病机制。

     
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