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华西医院
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  west china hospital
     Methods The clinical data of 103 case of liver transplantation admitted between 2000 and 2003 in West China Hospital of Sichuan University were analyzed retrospectively.
     方法回顾性分析四川大学华西医院2000~2003年施行的103例肝脏移植病人的临床资料。
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     Materials and methods: 1. Between 2002/03/01 and 2005/03/05, the consecutive cases of ischemic stroke, verified using CT and the WHO's clinical diagnostic criteria for stroke, were prospectively registered at the neurological wards of the West China Hospital, Sichuan University.
     对象与方法:1.前瞻性登记于2002/03/01-2005/03/05期间,在四川大学华西医院神经内科连续入院的缺血性卒中患者。
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     Methods The clinical data of 81 patients with primary malignant duodenal neoplasm from 1990 to 2002 were analyzed respectively in West China Hospital of Sichuan University.
     方法回顾性分析四川大学华西医院1990年8月至2002年7月收治的81例原发性十二指肠恶性肿瘤的临床资料。
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     Analysis of Inpatient with Chronic Heart Failure in West China Hospital in 1980,1990 and 2000
     华西医院1980、1990、2000年心衰住院患者调查报告
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     Analysis of Mortality and Death Causes for Diabetic Inpatients in West China Hospital, 1996-2004
     华西医院1996年~2004年住院糖尿病患者病死率及死因分析
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  “华西医院”译为未确定词的双语例句
     Methods We searched PubMed(1970~2005-10)and CBM(1992~2005-10)in Oct.2005 to identify system reviews(SR)and cross-sectional study(CSS)about the diagnosis of pulmonary embolism.
     方法于2005-10以华西医院的病人为例并应用计算机检索PubMed(1970~2005-10)和中国生物医学文献数据库(CBM,1992~2005-10)中关于肺栓塞诊断的系统评价(SR)和横断面研究(CSS)。
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     Comparison the Clinical Characteristic of the 846 First Operation Patients and the 412 Reoperation Patients for Urinary Calculi in HuaXi Hospital in Recent 5 Years
     华西医院泌尿外科近5年尿路结石住院病人846例首次手术和412例再次手术的临床特点对比分析
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     Methods We randomly selected 60 samples from 394 samples of pathologically confirmed meningiomas stored in our department from Jan 2001 to Dec 2003.The sections of paraffin-embedded specimens were subject to immunohistochemical stain(LSAB method) and test for expression of Mdm2,bcl2 and AR.
     方法从华西医院病理科获得2001~2003年间病理诊断明确的脑膜瘤病例共394例,计算机随机抽样60例,将60例蜡块每份切片3张,做免疫组化染色,检测Mdm2、bcl-2、AR的表达。
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     Methods Rats were on low salt diet and CsA was administered by gastric gavage at a dose of 20 mg/(kg·d)for 28 days,and tranilast was gave to these rats in a dose of 400 mg/(kg·d).
     方法选取四川大学华西医院于2005年9月至2006年2月给低盐饮食SD大鼠灌胃20mg/(kg.d)剂量的CsA,制作大鼠CsA慢性肾毒性模型,同时喂饲400mg/(kg.d)剂量的曲尼司特。
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     Materials and Methods Ten patients diagnosed as acute infarcts in Department of Neurology of Huaxi Hospital of Sichuan University underwent conventional MRI and diffusion tensor imaging examination in 3 days after the onset of illness by excite-signa 3.0T MRT manufactured by GE company.
     材料和方法 使用GE公司signa—excite 3.0T磁共振机器对10名在四川大学华西医院神经内科诊断为急性脑梗塞的患者于发病3天内行常规MRI和弥散张量成像检查,测量病灶和对侧相应正常脑组织的部分各向异性系数(Fractionalof Anistrophy,FA)值、梗塞灶体积,并运用弥散张量纤维束成像(Diffusion Tensor Tractography,DTT)显示通过病灶的纤维束特征。
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     SETTING:Huaxi Hospital of Sichuan University.
     单位:四川大学华西医院
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     Department of Neurosurgery,West China Hospital,SiChuan University
     四川大学华西医院神经外科
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     AI KE HOSPITAL
     艾克医院
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     South Shore Hospital
     南岸医院
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     WEST CHINA UNIVERSITY OF MEDICAL SCIENCES
     华西医科大学
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  west china hospital
From January 2002 to September 2006, 56 adult patients underwent LDLT using right lobe grafts at the West China Hospital, Sichuan University Medical School, China.
      


Objective:To investigate the effective therapy for recurrent fibrosarcoma.Methods:The authors analyzed the data of the 11 cases of recurrent fibrosarcoma from 1998 to 2000 treated in the institution were analyzed and the literatures concerned were reviewed.Results:All of the patients had underwent one or several regional lesion resections before admission.After thorough pre operative preparation,exleusive resection was performed and the wounds were covered with various types of flaps.Adjuvant local radiotherapy...

Objective:To investigate the effective therapy for recurrent fibrosarcoma.Methods:The authors analyzed the data of the 11 cases of recurrent fibrosarcoma from 1998 to 2000 treated in the institution were analyzed and the literatures concerned were reviewed.Results:All of the patients had underwent one or several regional lesion resections before admission.After thorough pre operative preparation,exleusive resection was performed and the wounds were covered with various types of flaps.Adjuvant local radiotherapy was delivered after surgery.Over one to three years of follow up no recurrence or metastasis was observed.Conclusion:Extensive excision and flap transfer with postoperative local radiotherapy might be a effective therapy for recurrent fibrosarcoma.

目的 :探讨复发纤维肉瘤的治疗方案。方法 :分析四川大学华西医院 1998~ 2 0 0 0年收治的复发纤维肉瘤病人 11例的治疗并复习有关文献。结果 :11例均于院外行单纯局部切除后复发 ,最多为复发 5次 ,入院后行广泛切除后皮瓣转移 ,并辅以术后放疗 ,愈后良好 ,随访无复发。结论 :复发纤维肉瘤病人行广泛切除后皮瓣转移并辅以术后放疗是较好的治疗方案。

Objective To investigate the activation of nuclear factor κB (NF κB) and its relationship with expression of cytokine mRNA in intestinal mucosal biopsy specimens from patients with ulcerative colitis(UC). Methods 31 cases with UC were included in the study. 17 cases received sulfasalazine (SASP) or SASP and glucocorticoid treatment.14 cases did not receive any medication related with UC. Normal mucosa from 11 colon cancer cases served as control. Ten pieces of intestinal mucosal biopsy specimens were obtained...

Objective To investigate the activation of nuclear factor κB (NF κB) and its relationship with expression of cytokine mRNA in intestinal mucosal biopsy specimens from patients with ulcerative colitis(UC). Methods 31 cases with UC were included in the study. 17 cases received sulfasalazine (SASP) or SASP and glucocorticoid treatment.14 cases did not receive any medication related with UC. Normal mucosa from 11 colon cancer cases served as control. Ten pieces of intestinal mucosal biopsy specimens were obtained from each patient. NF κB DNA binding activity was evaluated with electrophoretic mobility shift assay(EMSA). Expression of cytokine mRNA were studied with reversal tanscription polymerase chain reaction (RT PCR).Results (1)The expression of IL 1β mRNA and IL 8 mRNA was increased significantly in patients with UC, as compared with that in the control specimens ( P <0.05) and had a significant positive correlation with NF κB DNA binding activity ( r =0 8363, P <0.05; r =0.6024, P <0.05, respectively). (2) Glucocorticoids and SASP strongly inhibited NF κB activation and signficantly decreased the expression of IL 1β mRNA and IL 8 mRNA. Conclusions NF κB is a major and essential factor in regulating the expression of cytokine and plays a fundamental role in the pathogenesis of UC. SASP and glucocorticoids decrease cytokine expression via inhibition of NF κB activation.

目的 探讨溃疡性结肠炎 (UC)患者肠黏膜活检组织细胞因子mRNA的表达及其与NF κB活化的关系 ,以及抗炎药物 (柳氮磺吡啶和糖皮质激素 )对其的影响。方法  31例来自四川大学华西医院的UC患者 (符合 1993年太原会议制定的UC诊断标准 )被纳入本研究。其中 17例使用过药物 (柳氮磺吡啶或柳氮磺吡啶 +糖皮质激素 )治疗 ,14例未用过任何与UC治疗相关的药物 ,11例同期结肠癌患者 (取其癌旁正常组织 )作为对照。采用 :(1)凝胶电泳迁移率改变分析检测核因子 (NF) κBDNA结合活性 ;(2 )逆转录聚合酶链反应检测白细胞介素 (IL) 1βmRNA和IL 8mRNA的表达。 结果  (1)UC患者肠黏膜活检组织IL 1βmRNA和IL 8mRNA表达与对照组相比明显升高 (P <0 0 5 ) ,且与NF κBDNA结合活性呈显著正相关 (IL 1β :r=0 836 3,P <0 0 5 ;IL 8:r=0 6 0 2 4 ,P <0 0 5 )。 (2 )糖皮质激素和柳氮磺吡啶明显抑制NF κB的活性 ,降低IL 1βmRNA和IL 8mRNA的表达。结论 ...

目的 探讨溃疡性结肠炎 (UC)患者肠黏膜活检组织细胞因子mRNA的表达及其与NF κB活化的关系 ,以及抗炎药物 (柳氮磺吡啶和糖皮质激素 )对其的影响。方法  31例来自四川大学华西医院的UC患者 (符合 1993年太原会议制定的UC诊断标准 )被纳入本研究。其中 17例使用过药物 (柳氮磺吡啶或柳氮磺吡啶 +糖皮质激素 )治疗 ,14例未用过任何与UC治疗相关的药物 ,11例同期结肠癌患者 (取其癌旁正常组织 )作为对照。采用 :(1)凝胶电泳迁移率改变分析检测核因子 (NF) κBDNA结合活性 ;(2 )逆转录聚合酶链反应检测白细胞介素 (IL) 1βmRNA和IL 8mRNA的表达。 结果  (1)UC患者肠黏膜活检组织IL 1βmRNA和IL 8mRNA表达与对照组相比明显升高 (P <0 0 5 ) ,且与NF κBDNA结合活性呈显著正相关 (IL 1β :r=0 836 3,P <0 0 5 ;IL 8:r=0 6 0 2 4 ,P <0 0 5 )。 (2 )糖皮质激素和柳氮磺吡啶明显抑制NF κB的活性 ,降低IL 1βmRNA和IL 8mRNA的表达。结论  (1)NF κB是UC细胞因子释放的关键调控因素 ,在UC的发生和发展中起着十分重要的作用。 (2 )糖皮质激素和柳氮磺吡啶可能通过抑制NF κB的活性 ,减少细胞因子的表达而起到抗炎作用。

Objective: The resistance of clinical bacterial isolates to commonly used antimicrobial agents was assayed in order to guide the rational selection of antibacterial agents. Methods: The MIC values of 12 antimicrobial agents against 295 bacterial strains were tested by E test (AB BIODISK Solna, Sweden) method validated by concurrent use of authentic strains. Isolates from 12 species were selected for analysis. Results: The resistant rate of S.aureus to oxacillin was 32 8%, most of them...

Objective: The resistance of clinical bacterial isolates to commonly used antimicrobial agents was assayed in order to guide the rational selection of antibacterial agents. Methods: The MIC values of 12 antimicrobial agents against 295 bacterial strains were tested by E test (AB BIODISK Solna, Sweden) method validated by concurrent use of authentic strains. Isolates from 12 species were selected for analysis. Results: The resistant rate of S.aureus to oxacillin was 32 8%, most of them were multidrug resistance and that of Strep.pyogenes to macrolides was 37%~41%. All enterococci were resistant to cephalosporin. Strep.pneumoniae was 8% resistant to β lactam/β lactamase inhibitory agents. H.influenza was 85%~95% resistant to clarithromycin and roxithromycin, of which 9% to azithromycin. The extended spectrum β lactamase producing strains in E.coli and K.pneumoniae were 35% and 45% respectively. Indol positive Proteus spp. The resistant rate of to β lactams was 30%~50%, but all sensitive to fluoroquinolones. Enterobacter spp. was 25% resistant to fluoroquinolones, and 50% to β lactam except cefperazone/sulbactam. Acinetobacter spp. was 40% resistant to fluoroquinolones, 60%~75% to 2nd and 3nd generations of cephalosporines, 35%~55% to β lactam/β lactamase inhibitor. P.aeruginosa were totally resistant to cefaclor, cefuroxime, 75% to ceftriaxone, 25% to cefperazone/sulbactam, 5% to fluoroquinolones. M.catahalis ( n =4) was totally resistant to macrolides, one strains resistant to cefaclor and ciprofloxacin. Conclusions: Clinical isolates can become resistant to almost all the antibacterial agents. Close surveillance on pathogenic bacteria should be strengthen in order to make a rational usage regimen in bacterial infection therapy.

目的 监测 2 95株临床分离菌对常用抗菌药物的耐药性 ,为临床合理选用抗菌药物提供实验研究依据。方法 通过E试验方法测定四川大学华西医院、第二医院 6个月内部分临床分离菌 12种 2 95株对临床常用 β 内酰胺类、氟喹诺酮类及大环内酯类的耐药性。结果  32 .8%的金葡球菌耐苯唑西林 ,且为多重耐药株 ;37%~ 41%化脓性链球菌耐大环内酯类 ;肠球菌属 10 0 %耐头孢菌素 ;肺炎链球菌 8%耐酶抑制剂复合制剂 ;流感嗜血杆菌 85 %~ 94%耐克拉霉素、罗红霉素 ,仅 5 %耐阿奇霉素 ;肺炎克雷伯氏菌与大肠埃希氏菌产超广谱 β 内酰胺酶分别为 45 %与 35 % ;变形杆菌属对 β 内酰胺类耐药率为 30 %~ 5 0 % ,对氟喹诺酮类敏感 ;肠杆菌属细菌 2 5 %耐氟喹诺酮类、5 0 %耐 β 内酰胺类 ,但对头孢哌酮 /舒巴坦敏感 ;不动杆菌属细菌对氟喹诺酮类耐药率为 40 % ,对第二、三代头孢菌素类为 6 0 %~ 75 %、对 β 内酰胺酶抑制剂复合制剂的耐药率在35 %~ 5 5 % ;铜绿假单胞菌 10 0 %耐所试广谱青霉素、头孢呋辛 ,75 %耐头孢曲松、...

目的 监测 2 95株临床分离菌对常用抗菌药物的耐药性 ,为临床合理选用抗菌药物提供实验研究依据。方法 通过E试验方法测定四川大学华西医院、第二医院 6个月内部分临床分离菌 12种 2 95株对临床常用 β 内酰胺类、氟喹诺酮类及大环内酯类的耐药性。结果  32 .8%的金葡球菌耐苯唑西林 ,且为多重耐药株 ;37%~ 41%化脓性链球菌耐大环内酯类 ;肠球菌属 10 0 %耐头孢菌素 ;肺炎链球菌 8%耐酶抑制剂复合制剂 ;流感嗜血杆菌 85 %~ 94%耐克拉霉素、罗红霉素 ,仅 5 %耐阿奇霉素 ;肺炎克雷伯氏菌与大肠埃希氏菌产超广谱 β 内酰胺酶分别为 45 %与 35 % ;变形杆菌属对 β 内酰胺类耐药率为 30 %~ 5 0 % ,对氟喹诺酮类敏感 ;肠杆菌属细菌 2 5 %耐氟喹诺酮类、5 0 %耐 β 内酰胺类 ,但对头孢哌酮 /舒巴坦敏感 ;不动杆菌属细菌对氟喹诺酮类耐药率为 40 % ,对第二、三代头孢菌素类为 6 0 %~ 75 %、对 β 内酰胺酶抑制剂复合制剂的耐药率在35 %~ 5 5 % ;铜绿假单胞菌 10 0 %耐所试广谱青霉素、头孢呋辛 ,75 %耐头孢曲松、2 5 %耐头孢哌酮 /舒巴坦 ,5 %耐氟喹诺酮类 ;4株粘膜炎莫拉氏菌完全耐大环内酯类 ,耐环丙沙星与头孢克洛各 1株。结论 临床分离致病菌对常用抗菌药物均有不同程度的耐药性 ,密切监测细菌的耐

 
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