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糖尿病微血管并发症
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  diabetic microangiopathy
     Obejective The aim of this study was to investigate the changes of serum soluble CD40L (sCD40L) and soluble E-selectin(sE-selectin)and their roles in the pathogenesis of diabetic microangiopathy, and to provide evidence for early diagnosis and treatment of diabetic microangiopathy.
     目的:观察糖尿病患者血清中可溶性CD40配体(sCD40L)和可溶性E-选择素(sE—selectin)的变化,探讨其在糖尿病微血管并发症发病中的作用,为糖尿病微血管并发症的早期诊断、治疗提供依据。
短句来源
     Study on the Association between Diabetic Microangiopathy and Polymorphisms of the Aldose Reductase Gene in Type 2 Diabetes Mellitus
     醛糖还原酶基因多态性与2型糖尿病微血管并发症关系的研究
短句来源
     Objective To evaluate the role of BglⅡ restriction fragment length polymorphism within intron 7 of the α sununit of platelet α 2β 1 integrin in Chinese type 2 diabetes mellitus(DM) with diabetic microangiopathy(DMAP).
     目的 探讨血小板粘合素α2 β1分子α亚单位第 7内含子BglⅡ限制性片段多态性与2型糖尿病微血管并发症 (DMAP)的关系。
短句来源
     A study for RAGE Gly82Ser polymorphism in Chinese type 2 diabetic microangiopathy
     中国人2型糖尿病微血管并发症与AGE受体基因Gly82Ser多态性相关研究
短句来源
     A study of association between polymorphism of aldose reductase gene and diabetic microangiopathy
     醛糖还原酶基因多态性与糖尿病微血管并发症的相关性研究
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  “糖尿病微血管并发症”译为未确定词的双语例句
     Expression and Clinical Significance of Platelet Membrane Protein CD62P and CD63P on Type II Diabetes Mellitus Combined with Micro-vascular Lesion
     血小板膜糖蛋白CD62P CD63在2型糖尿病微血管并发症患者的表达及临床意义
短句来源
     ⑥ The serum collagen Ⅳ had significant positive correlation with laminin (r=0.58, P < 0.001=. CONCLUSION: The levels of serum collagen Ⅳ and laminin are closely related to the occurrence and development of microvessel complication in type 2 diabetes and change of glucose.
     ⑥血清Ⅳ型胶原和层粘连蛋白水平呈显著正相关(r=0.58,P<0.001)。 结论:血清Ⅳ型胶原和层粘连蛋白水平与2型糖尿病微血管并发症的发生、发展及血糖的变化密切相关。
短句来源
     The evaluation of glycemic control and microvascular complications in adolescents with type 1 diabetes
     1型糖尿病青少年患者血糖控制和糖尿病微血管并发症
短句来源
     Study on the Relationship between Polymorphism of Manganese Superoide Dismutase Gene and Diabetic Microvascular Complications in Type 2 Diabetes Mellitus
     锰超氧化物歧化酶基因多态性与2型糖尿病微血管并发症相关性研究
短句来源
     Relationship between plasma homocysteine and microangiopathy in type 2 diabetes mellitus
     血浆同型半胱氨酸浓度与2型糖尿病微血管并发症关系探讨
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  相似匹配句对
     Analysis of risk factors related to diabetic vascular complications
     糖尿病大血管和微血管并发症危险因素分析
短句来源
     Complication of Diabetes
     探询糖尿病并发症
短句来源
     Development of Drugs for Treatment of Diabetic Complication
     糖尿病并发症的药物治疗
短句来源
     Early onset of severe diabetes mellitus-related microvascular complications
     早期发生的严重糖尿病相关性微血管并发症
短句来源
     The Relationship Between Microvascular Complications and Hypertension in Type I Diabetes Mellitus
     Ⅱ型糖尿病微血管并发症与高血压的关系
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  diabetic microangiopathy
Pulmonary dysfunctions, associated with diabetic microangiopathy, could be unmasked by atelectasis, capillary leak and other pathophysiological conditions developing after the use of extracorporeal circulation.
      
Metabolic abnormalities due to hyperglycaemia, lack of insulin and their consequences and ischaemic phenomena secondary to diabetic microangiopathy account for nerve lesions.
      
Despite the clinical importance of diabetic microangiopathy, the mechanisms of pathogenesis remain elusive.
      
The histobioptic results show that "diabetic microangiopathy" is also manifest in the vascular system of the bone marrow.
      
Skin oxygen pressure was increased to a large extent only in patients assumed to suffer from diabetic microangiopathy.
      
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  diabetic microvascular complication
Nephropathy is a major diabetic microvascular complication; both metabolic and hemodynamic perturbations play critical roles in its occurrence and progression toward end-stage renal disease.
      
The role of hyperglycaemia in the development of diabetic microvascular complication is now proved beyond doubt.
      


he activities of Na+-K+-ATPase and Mg2+-ATPase and lipid peroxidation of erythrocytemembrane in 40 non-insulin-dependant diabetes mellitus(NIDDM) patients were inves-tigated, The results showed that the activities of Na+-K+-ATPase and Mg2+-ATPase oferythrocyte membrane were significantly decreased in diabetics while the level of lipidperoxide(LPO)of erythrocyte membrane was significantly increased.Sunultaneously,the activities ofsuperoxide di smutase and glutathine peroxidase of erythrocrte were significantly...

he activities of Na+-K+-ATPase and Mg2+-ATPase and lipid peroxidation of erythrocytemembrane in 40 non-insulin-dependant diabetes mellitus(NIDDM) patients were inves-tigated, The results showed that the activities of Na+-K+-ATPase and Mg2+-ATPase oferythrocyte membrane were significantly decreased in diabetics while the level of lipidperoxide(LPO)of erythrocyte membrane was significantly increased.Sunultaneously,the activities ofsuperoxide di smutase and glutathine peroxidase of erythrocrte were significantly lowered indiabetics as compared with normal controls.The above abnormal changes were more markwt indiabetics with retinopatliy than in those without retinopathy. The changes of the activity of Na+-K+-ATPase and Mg2+-ATPase were inversely correlated with errythrocyte membraneLPO and index of errythrocyte filtrati on (IF).These suggested that the signi ficant enhancement oflipid peroxidation of erythrocyte membrane may be respousible for the decrease of the activify ofNa+-K+-ATPase and Mg2+-ATPase which may be involved in the pathogenesis of diabcticretinopathy.

本文探讨了NIDDM患者红细胞膜Na ̄+—K ̄+—ATP酶及Mg ̄(2+)—ATP酶活性改变与脂质过氧化的关系,以及这两者在糖尿病微血管并发症发生中所起的作用。结查显示,NIDDM患者红细胞膜Na ̄+—K ̄+—ATP酶与Mg ̄(2+)—ATP酶活性显著降低。而红细胞膜LPO则显著增高。红细胞SOD及GSHpx活性显著降低,伴有糖尿病视网膜病变者以上变化更为显著。红细胞膜Na ̄+—K ̄+—ATP酶和Mg ̄(2+)—ATP酶活性与红细胞膜LPO、红细胞IF呈显著负相关,红细胞膜LPO与红细胞IF呈显著正相关,表明红细胞膜脂质过化增强是导致膜Na ̄+—K ̄+—ATP酶和Mg ̄(2+)—ATP酶活性降低的重要因素,并且它们都参与糖尿病视网膜病变的发生。

Objective To investigate the association between dinucleotide repeat polymorphism at 5' end of aldose reductase (AR) gene and diabetic microangiopathy in Chinese. Methods A case control study for 362 Chinese subjects (including 217 type 2 diabetes mellitus with or without nephropathy or retinopathy and 145 non diabetes control) was performed. The number of (AC) n dinucleotide of AR gene was determined by PCR denaturing polyacrylamide gel electrophoresis. Results Tandem (AC) repeats of the AR gene were...

Objective To investigate the association between dinucleotide repeat polymorphism at 5' end of aldose reductase (AR) gene and diabetic microangiopathy in Chinese. Methods A case control study for 362 Chinese subjects (including 217 type 2 diabetes mellitus with or without nephropathy or retinopathy and 145 non diabetes control) was performed. The number of (AC) n dinucleotide of AR gene was determined by PCR denaturing polyacrylamide gel electrophoresis. Results Tandem (AC) repeats of the AR gene were highly polymorphic and 7 alleles were observed in type 2 diabetes mellitus and control. The most prevalent allele was 24 times in (AC) repeat and was designated as Z allele. In type 2 diabetes mellitus with both nephropathy and retinopathy, a decreased frequency of Z+6 allele was found in comparison with type 2 diabetes mellitus without microangiopathy (Fisher's exact, P=0.038). In addition, an elevated frequency of Z-2 allele was observed in type 2 diabetes mellitus with severe nephropathy (renal insufficiency) as compared with type 2 diabetes mellitus without nephropathy (Fisher's exact, P=0.039). Conclusion AR gene alleles are associated with the development of diabetic microangiopathy. The Z-2 allele of the AR gene may be a risk factor for developing severe nephropathy in type 2 diabetes mellitus.Whereas,the Z+6 allele may protect against the development and progression of diabetic nephropathy and retinopathy in Chinese subjects.

目的 探讨醛糖还原酶(AR)基因多态标记(AC)n 与中国人2 型糖尿病微血管并发症之间的关系。方法 用32P引物末端标记法,经聚合酶链反应变性聚丙烯酰胺凝胶电泳,检测362 例中国人(217 人为2 型糖尿病,其中156 人合并肾病或视网膜病变,145 人为非糖尿病对照)AR 基因的二核苷酸(AC)n 串联重复序列多态标记,比较各组间的等位基因频率和基因型频率。结果 (1)在非糖尿病对照者和2 型糖尿病患者中,见到七种AR 基因的等位基因,其中以(AC)24(138bp) 等位基因(Z)最常见。(2)同时合并肾病和视网膜病变的2 型糖尿病组与无并发症的2 型糖尿病组相比,Z+ 6等位基因频率显著减少(Fisher 确切, P=0 .038), 含Z+ 6 等位基因的基因型频率也显著减少(P=0.004)。(3) 无并发症的2 型糖尿病组与对照组比较其Z+ 6 等位基因频率显著增加( P= 0.044) 。(4)2 型糖尿病合并肾病伴肾功能不全者与不伴有肾病的2 型糖尿病者相比,Z- 2 等位基因频率显著增加( P= 0 .039),同时含Z- 2 等位基因的基因型频率也呈增加趋势。结论 AR...

目的 探讨醛糖还原酶(AR)基因多态标记(AC)n 与中国人2 型糖尿病微血管并发症之间的关系。方法 用32P引物末端标记法,经聚合酶链反应变性聚丙烯酰胺凝胶电泳,检测362 例中国人(217 人为2 型糖尿病,其中156 人合并肾病或视网膜病变,145 人为非糖尿病对照)AR 基因的二核苷酸(AC)n 串联重复序列多态标记,比较各组间的等位基因频率和基因型频率。结果 (1)在非糖尿病对照者和2 型糖尿病患者中,见到七种AR 基因的等位基因,其中以(AC)24(138bp) 等位基因(Z)最常见。(2)同时合并肾病和视网膜病变的2 型糖尿病组与无并发症的2 型糖尿病组相比,Z+ 6等位基因频率显著减少(Fisher 确切, P=0 .038), 含Z+ 6 等位基因的基因型频率也显著减少(P=0.004)。(3) 无并发症的2 型糖尿病组与对照组比较其Z+ 6 等位基因频率显著增加( P= 0.044) 。(4)2 型糖尿病合并肾病伴肾功能不全者与不伴有肾病的2 型糖尿病者相比,Z- 2 等位基因频率显著增加( P= 0 .039),同时含Z- 2 等位基因的基因型频率也呈增加趋势。结论 AR 的Z- 2 等位基因是促进中国人2 型糖尿病并发严

Objective: To invesigate the feature of microcirculation of diabetes.Methods: We use type of WX-9A black-αnd-white television and microscope made in Xuzhou to determin nail fold microcirculation of Left-hand ring finger for 200 diabetes and 200 nondiabtes patients.Results: Found that single integral and total integral in the diabetes group was higher than that of the nondiabetes group ( P <0.05),and figure's change had certain specificity in the diabete group.Conclusion: It's show that check in nail fold microcirculation...

Objective: To invesigate the feature of microcirculation of diabetes.Methods: We use type of WX-9A black-αnd-white television and microscope made in Xuzhou to determin nail fold microcirculation of Left-hand ring finger for 200 diabetes and 200 nondiabtes patients.Results: Found that single integral and total integral in the diabetes group was higher than that of the nondiabetes group ( P <0.05),and figure's change had certain specificity in the diabete group.Conclusion: It's show that check in nail fold microcirculation contributed to diabetic microangiopathy diagnosis.

目的 :探讨糖尿病患者甲襞微循环的特点。方法 :应用徐州产WX -9A型黑白电脑微循环测定仪及显微镜 ,观察糖尿病患者及非糖尿病患者的左手无名指甲襞微血管襻的状态。结果 :糖尿病组形态积分 ,流态积分 ,襻周积分和总积分均高于非糖尿病组 (P <0 0 5 ) ,且形态改变有其特异性。结论 :甲襞微循环检查有助于糖尿病微血管并发症的诊断。

 
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