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增殖细胞
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  proliferative cells
    Proliferation increased obviously in ipsilateral and contralateral SVZ and reached the peak at 7d in adult and aged rats after ischemia, but the proliferative cells of aged rats were strikingly less than those of adult rats.
    脑缺血后,成年大鼠和老年大鼠缺血侧和缺血对侧的SVZ区出现细胞增殖的加强,3d时增殖细胞明显增加,7d时达到高峰,之后逐渐减少; 两组相应时间点间相比较,老年大鼠的增殖细胞数明显低于成年大鼠。
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    Proliferative cells of SVZ and SGZ in aged rats were apparently less than those of adult rats under normal condition.
    正常老年大鼠侧脑室SVZ区和海马齿状回SGZ区的增殖细胞数明显少于正常成年大鼠。
短句来源
    Methods In middle cerebral artery occlusion (MCAO) models, bromodeoxyuridine (BrdU) was injected to label proliferative cells. The Y-type electronical maze was used to monitor the recovery of learning and memory of every adult rats. Then BrdU positive cells and nNOS positive cells in DG were observed with immunohistochemistry.
    方法大脑中动脉线栓法制作大鼠局灶性脑缺血再灌注模型,5溴脱氧尿核苷(BrdU)标记分裂增殖细胞,应用Y型电迷宫监测大鼠学习记忆能力,免疫组化单标和双标技术检测大鼠海马齿状回BrdU阳性细胞数和nNOS的表达。
短句来源
    Conclusion The focal cerebral ischemia markedly stimulated proliferation of neural stem cells in SVZ and SGZ in old rats,and some proliferative cells in SVZ can differentiate into neurons or glial cells.
    结论局灶性脑缺血可激活老年大鼠室管膜下区和颗粒下层的神经干细胞明显增殖,并且室管膜下区有部分增殖细胞可分化为神经元或神经胶质。
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  “增殖细胞”译为未确定词的双语例句
    Results of immunohistochemical double staining indicated: In SVZ BrdU labeled cells with GFAP expression in aged rats(12.56%) were much more than those in adult rats(6.29%), but BrdU labeled cells with NeuN expression in aged rats (0.98%) were less than those in adult rats(2.49%).
    增殖细胞定向分化研究结果显示:老年和成年大鼠SVZ有部分增殖细胞表达神经胶质标记物(GFAP),其阳性率是老年大鼠(12.56%)多于成年大鼠(6.29%); 仅有极少量表达神经元标记物(NeuN),其阳性率是老年大鼠(0.98%)明显少于成年大鼠(2.49%)。
短句来源
    Methods The cell proliferation of dentate gyrus of adult rats was observed by using BrdU(5-bromo-2-deoxyuridine,BrdU) to mark cell proliferation and ABC(avidin-biotin-complex,ABC)immunocytochemical technique after Y maze learning.
    方法通过Y迷宫训练,用5溴2脱氧尿嘧啶核苷(5bromo2deoxyuridine,BrdU)标记增殖细胞,用ABC免疫细胞化学方法观察成年大鼠海马齿状回细胞的增殖情况。
短句来源
    BrdU was injected intraperitoneally every 12h for 2 days to label dividing cells of the above ischemic rats, normal and sham-operated rats 3 days before sacrifice, and these rats were killed at 1 day after the last injection.
    在大鼠处死的前3天开始以BrdU腹腔注射标记增殖细胞,在最后一次注射后1天处死。 以大鼠神经功能障碍的出现作为脑缺血的整体评价;
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    Part II The effect of rhG-CSF on the cell proliferation and neovascularization after cerebral ischemia in ratsRats were subjected to 2 hours of MCAO.
    rhG一CSF在实验性脑缺血中的神经保护作用的初步研究摘要第二部分rh于CsF对大鼠脑缺血再灌注后脑内增殖细胞、新生血管和成熟神经细胞的影响
短句来源
    Materials and methods: The right middle cerebral artery of rats were occluded (MCAO) for 90 minutes to establish transient focal cerebral ischemia model.
    材料与方法:通过右侧大脑中动脉线栓法建立局灶性脑缺血再灌注模型; 用5-嗅脱氧尿核苷(BrdU)标记DNA合成期(S期)细胞即增殖细胞;
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  proliferative cells
Monoclonal antibodies (McAb) to Ki-67, BrdU and OKT9 were used in APAAP technique for determining the proliferative cells of 46 myelodysplastic syndromes (MDS) with 16 serving as normal controls.
      
The ratio of CD8+ in proliferative cells was analyzed by flow cytometry.
      
CD8+ cells, accounting for a high proportion in proliferative cells, had a specific cytotoxicity to leukemia cells from which antigen peptides were prepared, suggesting that these CD8+ cells were CTLs specific to leukemia cells.
      
Relative resistance of a strain to the hyperacute or high-dose mode of death is not necessarily correlated with resistance to the midlethal mode, which is believed to be the result of damage to the proliferative cells of the midgut.
      
Using novel inferential procedures, we estimate the generation-time distribution and the offspring distribution of proliferative cells, and the waiting-time distribution of resting cells.
      
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Objective To investigate the effects of human IL 4 gene modificated glioma cell on tumor growth.Methods Human IL 4 gene was introduced into human glioma cell line SHG 44 cell using retroviral vector PL IL 4 SN. The proliferation and cell cycle were analyzed by 3H thymidine incorportion and flow cytometry. 3H thymidine incorporation and 51 Cr release assay were used to detect the effects of IL 4 gene modification on the proliferation of peripheral blood mononuclear cell (PBMC)...

Objective To investigate the effects of human IL 4 gene modificated glioma cell on tumor growth.Methods Human IL 4 gene was introduced into human glioma cell line SHG 44 cell using retroviral vector PL IL 4 SN. The proliferation and cell cycle were analyzed by 3H thymidine incorportion and flow cytometry. 3H thymidine incorporation and 51 Cr release assay were used to detect the effects of IL 4 gene modification on the proliferation of peripheral blood mononuclear cell (PBMC) and cytotoxic T lympocytes(CTL) killing activity from health donors. Results The proliferation of tumor cells was significantly inhibited (P<0 05) and 79 29% of cell population was arrested in G0/G1 stage in IL 4 gene transfered tumor cells, compared with wild type tumor cells. The gene modificatin could enhance proliferating respones of PBMC and killing activities of tumor specific CTL(P<0 05), and promote CTLs or CTL precursors to secret IL 2. The CTL responses induced by IL 4 gene modification can be abolished by anti IL 4 Mab or anti IL 2 Mab. The effects of suppressing growth of tumor cells, promoting CTL killing activities and PBMC proliferation responses could be, also to some extent, induced by co culture of wild type tumor cells with the supernatants from the cultures of IL 4 gene modificated cells. Conclusions Modifacation with IL 4 gene can produce the anti tumor effects through directly inhibiting the proliferation of glioma cells or inducing the proliferation of PBMC and killing activity of CTL. The effect of IL 4 gene modification on CTL responses are probably related to induce secretion of IL 2.

目的 探讨人IL 4基因修饰对人脑胶质瘤的抑瘤效应及可能机制。方法 以逆转录病毒载体将人IL 4基因导入人脑胶质瘤细胞系SHG4 4细胞 ,用3H掺入法及流式细胞仪分析IL 4基因转染对人脑胶质瘤细胞增殖及细胞周期的影响 ;3H掺入法、51Cr释放法检测IL 4基因修饰瘤苗对健康人外周血单个核细胞 (PBMC)增殖、细胞毒性T细胞 (CTL)反应的影响。结果 与野生型瘤细胞比较 ,IL 4基因修饰瘤细胞增殖明显被抑制 (P <0 0 5 ) ,79 2 9%的瘤细胞滞留于G0 /G1期细胞 ,IL 4基因修饰瘤苗所诱导的PBMC增值反应及CTL杀伤活性分别是野生型瘤细胞的 3倍及 7倍 (P <0 0 5 ) ,并能促进瘤特异性CTL及其前体细胞分泌IL 2。用抗IL 4单克隆抗体 (Mab)可明显阻断其诱导的CTL反应 ,抗IL 2Mab则完全阻断此诱导反应。加入IL 4基因修饰瘤苗培养上清至野生型肿瘤培养中也能抑制肿瘤增殖、诱导PBMC增殖和CTL反应。结论 IL 4基因修饰可通过直接抑制脑胶质瘤细胞增殖 ,诱导PBMC增殖及CTL杀伤活性而发挥抗瘤效应 ,其对CTL杀伤活性的促进作用可能与诱导CTL...

目的 探讨人IL 4基因修饰对人脑胶质瘤的抑瘤效应及可能机制。方法 以逆转录病毒载体将人IL 4基因导入人脑胶质瘤细胞系SHG4 4细胞 ,用3H掺入法及流式细胞仪分析IL 4基因转染对人脑胶质瘤细胞增殖及细胞周期的影响 ;3H掺入法、51Cr释放法检测IL 4基因修饰瘤苗对健康人外周血单个核细胞 (PBMC)增殖、细胞毒性T细胞 (CTL)反应的影响。结果 与野生型瘤细胞比较 ,IL 4基因修饰瘤细胞增殖明显被抑制 (P <0 0 5 ) ,79 2 9%的瘤细胞滞留于G0 /G1期细胞 ,IL 4基因修饰瘤苗所诱导的PBMC增值反应及CTL杀伤活性分别是野生型瘤细胞的 3倍及 7倍 (P <0 0 5 ) ,并能促进瘤特异性CTL及其前体细胞分泌IL 2。用抗IL 4单克隆抗体 (Mab)可明显阻断其诱导的CTL反应 ,抗IL 2Mab则完全阻断此诱导反应。加入IL 4基因修饰瘤苗培养上清至野生型肿瘤培养中也能抑制肿瘤增殖、诱导PBMC增殖和CTL反应。结论 IL 4基因修饰可通过直接抑制脑胶质瘤细胞增殖 ,诱导PBMC增殖及CTL杀伤活性而发挥抗瘤效应 ,其对CTL杀伤活性的促进作用可能与诱导CTL及其前体细胞分泌IL 2有关

Objective To study the correlation between the telomerase activity expression and proliferation orapoptosis in glioma at different malignant degrees. Methods The activity of telomerase was detected by TRAP method. TuNEL and PCNA immunofluorescence staining and FLM methods were used to detect the positive celi rate of PCNA and TuNEL expression in 26 fresh gliomas at different malignant degrees and 8 normal brain tissues. Results The positive rate of telemorase expression and the average A A level that represents...

Objective To study the correlation between the telomerase activity expression and proliferation orapoptosis in glioma at different malignant degrees. Methods The activity of telomerase was detected by TRAP method. TuNEL and PCNA immunofluorescence staining and FLM methods were used to detect the positive celi rate of PCNA and TuNEL expression in 26 fresh gliomas at different malignant degrees and 8 normal brain tissues. Results The positive rate of telemorase expression and the average A A level that represents telomerase activity and the positive rate of PCNA were different between normal group and gliomas, between grades Ⅰ , Ⅱ and at grades Ⅲ, Ⅳ among gliomas (P < 0.05). The telomerase expression was negative in 4 normal brain tissues. The average A A level was correlated with increased as pathology degree becoming high., TuNEL positive rate that represent for the apoptosis of glioma decreased following increasing of malignant degree, demonstrating significant difference between normal group and other groups, between grades Ⅰ , Ⅱ and grades Ⅲ, Ⅳ (P<0.05). The average ZlA level and the positive rate of PCNA(r=0.78 , P< 0.05)were correlated with malignant degree (r=0.86 , P < 0.01). Conclusion High level telomerase activity and high positive rate of PCNA can be detected in malignant gliomas, which coan be viewed as the proof of malignant glioma. The level of telomerase activity and PCNA positive cell rate in glioma are correlated with malignant degree of glioma.

目的观察不同级别人脑胶质瘤中端粒酶活性表达及与增殖、凋亡的相关性。方法采集手术中切除的不同级别人脑新鲜胶质瘤标本26例,脑外伤内减压脑组织8例,用TRAP法及TUNEL法、PCNA免疫荧光染色流式细胞仪法检测不同级别脑胶质瘤端粒酶活性以及凋亡、增殖细胞百分率。结果脑胶质瘤中端粒酶活性阳性表达率及代表端粒酶活性的平均△A值,在Ⅰ、Ⅱ级和Ⅲ、Ⅳ级之间差别显著(P<0.05),各个级别与对照组之间均差别显著(P<0.05),对照组脑组织端粒酶活性均为阴性。平均PCNA阳性细胞率在正常组,Ⅰ、Ⅱ级和Ⅲ、Ⅳ级之间存在显著性差异(P<0.01)。TUNEL阳性细胞率在正常组与其余各组之间均存存显著差异(P<0.01),Ⅳ级与其余各组之间亦均存在显著差异(P<0.05)。代表端粒酶活性的平均△A值(r=0.78,P<0.05)以及平均PCNA阳性细胞率(r=0.86,P<0.01)分别与胶质瘤恶性级别呈正相关。结论脑胶质瘤中,端粒酶活性阳性及PCNA阳性表达细胞率可作为预测胶质瘤化疗效果和脑胶质瘤恶性程度的标志之一,端粒酶活性表达水平和增殖活性与胶质瘤细胞恶性级别具有相关性。

Objective To study the effect of bFGF on neurogenesis in brain of AD model rat with unilateral fimbria fornix transection. Methods We develop the AD model through unilateral fimbria fornix transection . AD model rats received bFGF or saline by infusion into the cerebroventricular space every day after being lesioned.After 7 days bFGF infusion , 5 BrdU was used to label the proliferation cells after bFGF infusion. TUNEL was used to label the apoptotic cell .Then we count the positive cells labeled for...

Objective To study the effect of bFGF on neurogenesis in brain of AD model rat with unilateral fimbria fornix transection. Methods We develop the AD model through unilateral fimbria fornix transection . AD model rats received bFGF or saline by infusion into the cerebroventricular space every day after being lesioned.After 7 days bFGF infusion , 5 BrdU was used to label the proliferation cells after bFGF infusion. TUNEL was used to label the apoptotic cell .Then we count the positive cells labeled for 5 BrdU or TUNEL in the dentate gyrus.Result Comparison to AD control group, the number of 5 BrdU positive cells in the dentate gyrus of AD treatment group was increased significantly .But the number of TUNEL positive cells was no difference from that of the AD control group'. The number of 5 BrdU positive cells and the number of TUNEL positive cells in the dentate gyrus of AD control group were no difference from that of the normal control group'. Conclusion It is showed that bFGF can acceleration the neurogenesis in the dentate gyrus of AD model rat with unilateral fimbria fornix transection.

目的 探讨碱性成纤维细胞生成因子 (bFGF)对海马伞切断造成的阿尔茨海默氏病 (AD)模型大鼠海马齿状回神经细胞增殖的影响。方法 AD处理组及AD对照组大鼠单侧海马伞切断制造阿尔茨海默病模型 ;正常对照组注射生理盐水。AD处理组造模后每天侧脑室注射bFGF共 7天 ;AD对照组及正常对照组同时间注射生理盐水。BrdU标记增殖细胞。TUNEL方法标记DNA片段 ,原位检测凋亡细胞。计数海马齿状回各区域BrdU阳性细胞与凋亡细胞数。结果 AD处理组大鼠与AD对照组大鼠相比 ,海马齿状回BrdU阳性细胞增加明显 (P <0 .0 1 ) ,而凋亡细胞差异不显著 (P >0 .0 5)。AD对照组大鼠与正常对照组大鼠相比 ,海马齿状回BrdU阳性细胞数及凋亡细胞数差异均不显著 (P >0 .0 5)。结论 bFGF可促进AD模型大鼠海马神经细胞的增殖。是治疗AD等神经缺损性疾病有希望的一种神经生长因子

 
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