It was shown that emodin can inhibit the growth of tumor strain such as Hela and K562. The aloe-emodin is a new selective antitumor compound, which shows inhibition against neuroectoderm tumor of immune deficient mouse without affecting to the animals or the growth of the normal fibroblast cell.
AIM: In order to find new type of antitumor compounds and study the contribution of hydroxyl groups on the sugar part to the antitumor activity of 8 Cl adenosine, the retinoid analogs of adenosine and the derivatives of 8 Cl adenosine were synthesized.
On the other hand, very low levels of HMPMM, generally considered to be a potentially active antitumor compound, were detected in the target tissues, whereas this hydroxylated metabolite was stable and easily determined in plasma.
A novel antitumor compound, N-β-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxybenzo[a]-phenazine-6-carboxamide sodium salt (NC-190) was evaluated for its antitumor activity in experimental murine tumor systems.
Given the novel mechanisms of action of new antitumor compounds coupled with their favorable toxicity profiles, however, continued improvements in survival and quality of life may be achieved in patients with advanced disease.
These antitumor compounds possess two trisaccharide chains attached at C-7 and C-10, each of them with structural variability, mainly at the distal deoxysugar moieties.
We examined several biochemical parameters that may contribute to the differential sensitivity of the cell lines used in our laboratory to the toxic effects of antitumor compounds.
More recently, research has suggested that it may also contain an anti-cancer compound.
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There is no hard data known to us that demonstrates that Gm-Csf increases the toxicity of any anti-cancer compound.
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1-acety-3-O-toluyl-5-fluorouracil orally administered to mice bearing tumor (S_(180), and U_(14) tumors) showed greater antitumor activitesthan did FT-207. A-OT-FU showed the very remarkable antitumor properties,being effective against Hep (H_(22)) cancer. A-OT-FU was found to be a veryefficaious (especially in Hep cancer), broad-spectrum compound. It might beconsidered to be a new generation of antitumor subject.
Agarose gel electrophoresis and spectroscopy were used to investigate the interaction of AD 89 with DNA. The effect of drug on intact cell DNA was evaluated by using alkaline elution technique.The results showed that AD 89 decreased the mobility of supercoiled PUC9 DNA significantly.The interaction of calf thymus DNA with AD 89 led to the red shift of the peaks of absorption,and the greater the ratio of DNA/AD 89 was the greater the red shift would be.These results are similar to those of mito xantro...
Abstract Three kinds of newly synthesized antitumor compounds (spirobromine, C 16 H 36 Br 2N 4·2HCl and C 17 H 38 Br 2N 4·2HCl) have been studied by normal and surface enhanced Raman spectroscopy. The assignments of the Raman modes have benn given. The Raman bands at 2834,2856,2903,2957,2977 cm -1 are characteristic of CH 2 stretching vibrations. The strong band at 1656 cm -1 is assigned to γ(C=0). Bands at 848,1292 and 1456 cm -1 are attributed to the C H stretching mo...