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癌抗原
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  carcinoma antigen
     Objectives: To investigate the clinical value of the serum levels of cancer antigen 125 (CA125), carbohydrate antigen 19 9 (CA19 9), cytokeratin 19 fragments (CYFRA21 1), squamous cell carcinoma antigen (SCC) and carcinoembryonic antigen (CEA) in patients with cervical cancer.
     目的: 鳞状上皮细胞癌抗原( SCC)、癌胚抗原( CEA)、细胞角质素19 ( CYFRA21 1)、癌抗原125(CA125)、糖链抗原19-9(CA19 9)在宫颈癌检测中的信息提示和临床应用价值。
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     Determination of serum IL-13, IgE and squamous cell carcinoma antigen in children with asthma
     哮喘患儿血清IL-13、IgE及鳞状细胞癌抗原水平测定
短句来源
     Aim: To explore variances and significances of serum IL-13, squamous cell carcinoma antigen (SccAg), and IgE in children with asthma.
     目的:探讨哮喘患儿血清IL-13、鳞状细胞癌抗原(SccAg)及IgE水平变化及意义。
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     Construction of DNA vaccine of human hepatocellular carcinoma antigen HCA661
     人肝细胞癌抗原HCA661 DNA疫苗的构建
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     The positive rate of squamous cell carcinoma antigen in the 165 patients with squamous cell carcinoma of the uterine cervix in serum was 64.2% (106/165).
     [结果]165例宫颈鳞癌患者血清鳞状细胞癌抗原阳性率为64.2% (106/165)。
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  cancer antigen
     Objectives: To investigate the clinical value of the serum levels of cancer antigen 125 (CA125), carbohydrate antigen 19 9 (CA19 9), cytokeratin 19 fragments (CYFRA21 1), squamous cell carcinoma antigen (SCC) and carcinoembryonic antigen (CEA) in patients with cervical cancer.
     目的: 鳞状上皮细胞癌抗原( SCC)、癌胚抗原( CEA)、细胞角质素19 ( CYFRA21 1)、癌抗原125(CA125)、糖链抗原19-9(CA19 9)在宫颈癌检测中的信息提示和临床应用价值。
短句来源
     Detection of Cervical Cancer Antigen in Human Sera with Monoclonal Antibody AU_(14-1)-ELISA Assay
     单克隆抗体AU_(14-1)测定人血清宫颈癌抗原
短句来源
     The cancer antigen 125(CA 125 ),cancer antigen 15~3 (CA 15~3 ) and serum ferritin (SF) in 51 cases of ovarian neplasma (36 cases cancer,15 cases benign tumor) and 28 normal controls were determined by enzyme immunoassay.
     对51例卵巢良、恶性肿瘤和28例对照者的血清进行癌抗原125(CA125),癌抗原15—3(CA15—3)和铁蛋白(SF)等指标检测。
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     Objective To study the differential diagnosis value of carcinoembryonic antigen(CEA), cancer antigen 199(CA199), cholesterol(Ch) and serum-ascites fluid albumen gradient(SAAG) for benign and malignant ascites fluid.
     目的探讨癌胚抗原(CEA)、癌抗原199(CA199)、胆固醇(Ch)和血清-腹水白蛋白梯度(SAAG)检测对良恶性腹水的鉴别价值。
短句来源
     Clinical significance of detecting cancer antigen 125 in peritoneal dialysis patients
     癌抗原125检测在腹膜透析中的临床意义
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  “癌抗原”译为未确定词的双语例句
     Objective To study the value of combined serum CA125,CA199 and CEA test in ovarian tumors diagnosis.
     目的探讨血清癌抗原125(CA125)、糖链抗原199(CA199)及癌胚抗原(CEA)联合检测在卵巢肿瘤诊断中的价值。
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     RESULTS: CTLs stimulated by the DC vaccine had high killing activity on autologous cervical cancer cells, with killing rates of 79.32%-89.27% which were obviously higher than that of lymphokine-activated killing cells (t≥2.89, P<0.05).
     结果:负载自体宫颈癌抗原DC诱导的特异性CTL对自体宫颈癌细胞的体外杀伤率高达79.32%~89.27%,显著高于淋巴因子激活的杀伤细胞(lymphokine-activatedkillingcells,LAK)的杀伤率(t≥2.89,P<0.05);
短句来源
     Detection of CA125 in endometriosis and its clinical significance
     子宫内膜异位症癌抗原(CA125)检测及其临床意义
短句来源
     Objective:To investigate the clinical value of CA15 3 and CEA in patients with breast cancer.
     目的 :探讨癌抗原 15 3 (CA15 3 )和癌胚抗原 (CEA)对乳腺癌的临床意义。
短句来源
     Establishment of an Enzyme Linked Immunosorbent Assay with a Monoclonal Antibody AU_(14-1)Detecting Soluble Antigen of Cervical Carcinoma
     单克隆抗体AU_(14-1)-ELISA测定可溶性宫颈癌抗原方法的建立
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  carcinoma antigen
Chorionic gonadotropin, α-fetoprotein and embryonal carcinoma antigen were negative in the cerebrospinal fluid of these patients.
      
When the cut-off value was defined as 2.0 ng/mL, CYFRA 21-1 had a higher positive ratio than that of either squamous cell carcinoma antigen (SCC-Ag) or carcinoembryonic antigen (CEA).
      
Blood samples for the determination of carcinoma antigen (CA) 15.3, CA 125, CA 19.9, carcinoembryonic antigen (CEA) and α-fetoprotein (a-FP) were collected from every subject.
      
Prognostic significance of serum concentration of squamous cell carcinoma antigen in anal epidermoid carcinoma
      
The prognostic significance of pre-treatment serum concentration of squamous cell carcinoma antigen (SCCAg) was investigated in a population of 60 patients with anal epidermoid cancer.
      
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  cancer antigen
The development of a correlation between lung cancer antigen expression and CT imanging
      
The roles of second-look laparotomy and cancer antigen 125 in the management of ovarian carcinoma
      
The use of cancer antigen 125 to monitor the course of the disease during treatment is widely accepted.
      
We investigated whether there are differences in plasma gastrin, as compared with carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9 between patients with proximal and distal colorectal cancer.
      
Elevated serum cancer antigen 125 levels in advanced abdominal tuberculosis
      
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A semiautomatic method of LAI assay was developed for studying the antigenicity of human cancer basic protein and ovarian cancer antigen.Seventy-one LAI assays were performed on 55 individuals. With cancer basic protein 5/6 of gastric cancer patients were positive for the test, while 4 healthy controls were all negative.With ovarian cancer antigen, 16/22 of ovarian cancer patients were positive and 12 normal persons negative.The advantages of this improved LAI test were discussed and it might be useful, for...

A semiautomatic method of LAI assay was developed for studying the antigenicity of human cancer basic protein and ovarian cancer antigen.Seventy-one LAI assays were performed on 55 individuals. With cancer basic protein 5/6 of gastric cancer patients were positive for the test, while 4 healthy controls were all negative.With ovarian cancer antigen, 16/22 of ovarian cancer patients were positive and 12 normal persons negative.The advantages of this improved LAI test were discussed and it might be useful, for identifying tumor antigens, as a relatively convenient in vitro test.

本研究提供了一个改进的 LAI试验,共研究55例血液标本,包括卵巢癌22例,正常人 16例,胃癌6例,其它恶性肿瘤5例,非恶性疾病6例。 结果显示:用肿瘤共同抗原,5/6例胃癌病人的LAI显示有意义。正常人4例全部阴性。用卵巢癌抗原,16/22例卵巢癌病人的 LAI 显示有意义,正常人12例全部阴性。 本实验提示:卵巢癌组织中存在一种抗原,可以用 LAI 试验来检出,胃癌组织中也存在肿瘤的共同抗原。

The hybridoma technique was invented in 1975 by Cesar Milstein and Georges Kohler working at the Medical Research Council's Labratory of Molecular Biology in Cambridge England. In the 8 years since their diseovery, monoclonal antibodies have proved to be valuable research tools. Now, investigators are attempting to take the next step-to move the antibodies from the research laboratory into the clinic. Research on the clinical use of monoclonal antibodies is still very young. To make monoclonal antibodies, researchers...

The hybridoma technique was invented in 1975 by Cesar Milstein and Georges Kohler working at the Medical Research Council's Labratory of Molecular Biology in Cambridge England. In the 8 years since their diseovery, monoclonal antibodies have proved to be valuable research tools. Now, investigators are attempting to take the next step-to move the antibodies from the research laboratory into the clinic. Research on the clinical use of monoclonal antibodies is still very young. To make monoclonal antibodies, researchers must first make hybridomas-hybrids of antibody-producing and mycloma cells. The workers obtained the antibody-producing cells from the spleens of mice that had been immunized with antigen. After the antibody-producing cells were fused with mouse myeloma cells, clones were grown from individ ual hybrids. The antibodies were produced by clones. In making monoclonal antibodies it is possible to produce virtually unlimited quantities of an antibody that rcacts specifically with a particular antigen. The immunoglobulin secretion rates varied from 1 to 100μg/ml. The advantage of a monocloal antibody is its repro-ducibility. Hence, you can develop a reagent that you can use forever. Within the past 2 or 3 years, researchers are turning up monoclonal antibodies with specificities that may be good enough for clinical use. Using monoclomal antibodies to screen blood samples for tumor antigens is one approach to caner detection. Another combines the specificity of the antibodies with the techniques of nuclear medicine or of computer assisted tomography (CAT) to locate concerous lesions in the patient's body. If monoclonal antibodies can carry radioactive tracers to tumors for the purpose of betection, the anibodies may also be able to deliver cellkillingagents-radioisotopes, drugs, or toxins. An agent that could be linked to monoclonal antibodies for the purpose of killing tumor cells, without destroying the normal cells. The antibodies are also probing or treating viruses and parasitic disease. The hybridoma technique are also probing the secrets of how plant viruses function. In a word, hybridoma technology-a potent new biotechnology with widespraed practical applications to agriculture, medicine and industry. Meanwhile, researchers all emphasize that the antibodies are providing tools with which to approach some of the fundamental problems of cell biology.

杂交瘤技术是Milstein和Kohler于1975年在英国剑桥医学研究委员会分子生物学实验室创建。八年来,已证实这项新技术是一种很重要的研究工具。目前,研究人员正在进行下一阶段的工作,他们试图把单克隆抗体从研究室,移植到临床实践中,单克隆抗体的临床应用研究才刚刚开始。为了制备单克隆抗体,研究人员必须首先制取杂交瘤—产生抗体的细胞和骨髓瘤细胞的杂交种。从免疫小鼠的脾脏取得产生抗体的细胞,然后,把这种产生抗体的细胞与小鼠骨髓瘤细胞融合在一起,形成杂交瘤细胞。再从这种杂交细胞生长出无性繁殖系,并且产生单克隆抗体。在制造单克隆抗体时,其数量不定,这种抗体能与特定抗原发生特异性反应。这种免疫球蛋白的产量从1ug/ml到100ug/ml不等。单克隆抗体的优越性,在于它能连续不断地产生。这样,人们就能研制一种可供长期使用的试剂。近2—3年来,研究人员正在研制能很好地应用于临床上的特异性单克隆抗体。用这种单克隆抗体来鉴定含癌抗原的血液样品是诊断癌症的一种方法。另一种方法是把核医学技术或使用计算机的X线断层照相术,(CAT)与抗体的特异性结合起来,以确定机体内肿瘤损伤的部位。单克隆抗体不仅能携带放射性示踪物鉴测肿...

杂交瘤技术是Milstein和Kohler于1975年在英国剑桥医学研究委员会分子生物学实验室创建。八年来,已证实这项新技术是一种很重要的研究工具。目前,研究人员正在进行下一阶段的工作,他们试图把单克隆抗体从研究室,移植到临床实践中,单克隆抗体的临床应用研究才刚刚开始。为了制备单克隆抗体,研究人员必须首先制取杂交瘤—产生抗体的细胞和骨髓瘤细胞的杂交种。从免疫小鼠的脾脏取得产生抗体的细胞,然后,把这种产生抗体的细胞与小鼠骨髓瘤细胞融合在一起,形成杂交瘤细胞。再从这种杂交细胞生长出无性繁殖系,并且产生单克隆抗体。在制造单克隆抗体时,其数量不定,这种抗体能与特定抗原发生特异性反应。这种免疫球蛋白的产量从1ug/ml到100ug/ml不等。单克隆抗体的优越性,在于它能连续不断地产生。这样,人们就能研制一种可供长期使用的试剂。近2—3年来,研究人员正在研制能很好地应用于临床上的特异性单克隆抗体。用这种单克隆抗体来鉴定含癌抗原的血液样品是诊断癌症的一种方法。另一种方法是把核医学技术或使用计算机的X线断层照相术,(CAT)与抗体的特异性结合起来,以确定机体内肿瘤损伤的部位。单克隆抗体不仅能携带放射性示踪物鉴测肿瘤的发生部位,而且还能释放所携带的细胞杀伤剂—放射性同位素、药物或毒素。这种与单克隆抗体相偶联的细胞杀伤剂能杀死肿瘤细胞,而不破坏正常细胞。单克隆抗体也能检测和治疗病毒病和寄生虫病,它还能揭示植物病毒如何起危害作用的奥秘。总之,杂交瘤技术是一种强有力的新的生物技术,它能广泛地应用于医学、农业和工业。研究人员认为,单克隆抗体可做为多种研究工具,去探索细胞生物学的一些基本问题。

The results of cancer antigen 125 (CA 125) and carcinoembryo-nic antigen (CEA) determination in the sera of 55 cases of malignant, bengin ovarian tumors, nonovarian malignant tumor and normal females were reported. The value of CA 125< 65U/ml and CEA<20ng/ml was defined as normal.Among 20 patients with malignant ovarian carcinoma, the CA 125 level was elevated (>65U/ml) in 60% (12/20), while the CEA level was elevated onlyin 25% (5/20). In 5 cases of nonovarian malignant tumors, the CA125 positive rate was 20%...

The results of cancer antigen 125 (CA 125) and carcinoembryo-nic antigen (CEA) determination in the sera of 55 cases of malignant, bengin ovarian tumors, nonovarian malignant tumor and normal females were reported. The value of CA 125< 65U/ml and CEA<20ng/ml was defined as normal.Among 20 patients with malignant ovarian carcinoma, the CA 125 level was elevated (>65U/ml) in 60% (12/20), while the CEA level was elevated onlyin 25% (5/20). In 5 cases of nonovarian malignant tumors, the CA125 positive rate was 20% (1/5), but the CEA positive rate was 80% (4/5). The positive rates of the CA 125 and the CEA were 6% (1/16) and 19% (3/16) respectively in ( 16 cases of benign ovarian tumors. However, none of the 14 health females showed values of CA 125 and CEA above normal.The results showed that the positive rate of the CA 125 was sigaif icantly higher than that of the CEA in malignant ovarian carcinoma, and suggested that the value of the CA 125 was better than that of the CEA for the diagnosis of ovarian carcinoma.

本文报告55例卵巢良性、恶性肿瘤,非卵巢恶性肿瘤及正常妇女的血清癌抗原(CA_(125))和癌胚抗原(CEA)的测定结果:以CA_(125)<65U/ml,CEA<20ng/ml为正常值。14例正常妇女CA_(125)及CEA值均正常。20例卵巢恶性肿瘤中CA_(125)阳性率为60%(12/20),CEA阳性率为25%(5/20);5例非卵巢恶性肿瘤中CA_(125)阳性率为20%(1/5),CEA阳性率为80%(4/5);16例卵巢良性肿瘤中CA_(125)阳性率6%(1/16),CEA阳性率为19%(3/16)。结果表明CA_(125)在卵巢恶性肿瘤中阳性率高(X~2=5.01 P<0.05);CEA在非卵巢恶性肿瘤中阳性率高(X~2=5.25 P<0.05);在卵巢良性肿瘤中二者无差异(X~2=1.14 P>0.250)。

 
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